penalizedSVM: a R-package for feature selection SVM classification (2009)
Becker, Natalia, Werft, Wiebke, Toedt, Grischa, Lichter, Peter, Benner, Axel
Summary: Support vector machine (SVMs) classification is a widely used and one of the most powerful classification techniques. However, a major limitation is that SVM cannot perform automatic gene...
Off-target effects of siRNA specific for GFP (2008)
Tschuch, Cordula, Schulz, Angela, Pscherer, Armin, Werft, Wiebke, Benner, Axel, Hotz-Wagenblatt, Agnes, ...
Abstract Background Gene knock down by RNAi is a highly effective approach to silence gene expression in experimental as well as therapeutic settings. However, this widely used methodology entails...
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
Pfister, Stefan, Janzarik, Wibke G., Remke, Marc, Ernst, Aurélie, Werft, Wiebke, Becker, Natalia, ...
The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis of...