On peroxide antimalarials (2007)
IGOR OPSENICA, DEJAN OPSENICA, MILKA JADRANIN, KIRSTEN S. SMITH, WILBUR K. MILHOUS, MANOLIS STRATAKIS, ...
Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure–activity relationship of this kind of antimalarials. The tetraoxanes 2–5, obtained as a...
Happi, Christian T, Gbotosho, Grace O, Folarin, Onikepe A, Milner, Danny, Sarr, Ousmane, Sowunmi, Akintunde, ...
Abstract Background In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite...
IGOR OPSENICA, NATASA TERZIC, DEJAN OPSENICA, WILBUR K. MILHOUS, BOGDAN SOLAJA
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum...
DEJAN OPSENICA, DENNIS E. KYLE, WILBUR K. MILHOUS, BOGDAN A. SOLAJA
Mixed tetraoxanes of the 4-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, antiproliferatives and...
Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane (2002)
DEJAN OPSENICA, GABRIELLA POCSFALVI, WILBUR K. MILHOUS, BOGDAN A. SOLAJA
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in...
Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil, (1998)
Martin,Samuel K., Oduola,Ayo M., Milhous,Wilbur K.
The parasite Plasmodium falciparum, like neoplastic cells, develops resistance to multiple structurally unrelated drugs. If the mechanisms by which P. flaciparum and neoplastic cells become resistand...
Novel Antimalarial Dihydroartemisinin Derivatives. (1998)
Lin, Ai J., Klayman, Daniel L., Milhous, Wilbur K.
This invention relates to novel dihydroartemisinin derivatives, including their pharmaceutically-acceptable salts, which are therapeutically-effective in the pre-and post-treatment of malarial...
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 1983.
Shikimate pathway in apicomplexan parasites
Roberts, Craig W., Finnerty, John, Johnson, Jennifer J., Roberts, Fiona, Kyle, Dennis E., Krell, Tino, ...
No abstract available.
Vennerstrom, Jonathan L., Nuzum, Edwin O., Miller, Robert E., Dorn, Arnulf, Gerena, Lucia, Dande, Prasad A., ...
From the Walter Reed Army Institute of Research (WRAIR) inventory, thirteen 8-aminoquinoline analogs of primaquine were selected for screening against a panel of seven Plasmodium falciparum clones...
Riel, Michael A., Kyle, Dennis E., Bhattacharjee, Apurba K., Milhous, Wilbur K.
The substituted benzimidazoles omeprazole, lansoprazole, rabeprazole, and pantoprazole were found to have in vitro activity against three different isolates of Plasmodium falciparum: D6 (which is...
Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...
The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...
Happi, Christian T, Gbotosho, Grace O, Folarin, Onikepe A, Milner, Danny, Sarr, Ousmane, Sowunmi, Akintunde, ...
Vennerstrom, Jonathan L., Nuzum, Edwin O., Miller, Robert E., Dorn, Arnulf, Gerena, Lucia, Dande, Prasad A., ...
From the Walter Reed Army Institute of Research (WRAIR) inventory, thirteen 8-aminoquinoline analogs of primaquine were selected for screening against a panel of seven Plasmodium falciparum clones...
Riel, Michael A., Kyle, Dennis E., Bhattacharjee, Apurba K., Milhous, Wilbur K.
The substituted benzimidazoles omeprazole, lansoprazole, rabeprazole, and pantoprazole were found to have in vitro activity against three different isolates of Plasmodium falciparum: D6 (which is...
Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...
The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...
Happi, Christian T, Gbotosho, Grace O, Folarin, Onikepe A, Milner, Danny, Sarr, Ousmane, Sowunmi, Akintunde, ...
Shikimate pathway in apicomplexan parasites
Roberts, Craig W., Finnerty, John, Johnson, Jennifer J., Roberts, Fiona, Kyle, Dennis E., Krell, Tino, ...
No abstract available.
Li, Qigui, Kozar, Michael P., Shearer, Todd W., Xie, Lisa H., Lin, Ai J., Smith, Kirsten S., ...
Pyrroloquinazolinediamine (PQD) derivatives such as tetra-acetamide PQD (PQD-A4) and bis-ethylcarbamyl PQD (PQD-BE) were much safer (with therapeutic indices of 80 and 32, respectively) than their...
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo
Mui, Ernest J., Schiehser, Guy A., Milhous, Wilbur K., Hsu, Honghue, Roberts, Craig W., Kirisits, Michael, ...
Toxoplasmosis is a neglected tropical disease, an emerging disease as well as a significant problem in developed countries causing a substantial health burden. Better medicines with less toxicity are...