Wilfried Grange

Quantitative time-resolved measurement of membrane protein–ligand interactions using microcantilever array sensors (2009)

Braun, Thomas, Ghatkesar, Murali Krishna, Backmann, Natalija, Grange, Wilfried, Boulanger, Pascale, Letellier, Lucienne, ...

Membrane proteins are central to many biological processes, and the interactions between transmembrane protein receptors and their ligands are of fundamental importance in medical research. However,...

VirE2: A Unique ssDNA-Compacting Molecular Machine (2008)

Wilfried Grange, Myriam Duckely, Sudhir Husale, Susan Jacob, Andreas Engel, Martin Hegner

The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis. Whereas...

Interaction of cationic surfactants with DNA: a single-molecule study (2008)

Husale, Sudhir, Grange, Wilfried, Karle, Marc, Bürgi, Stephan, Hegner, Martin

The interaction of cationic surfactants with single dsDNA molecules has been studied using force-measuring optical tweezers. For hydrophobic chains of length 12 and greater, pulling experiments show...

Temperature dependence of unbinding forces between complementary DNA strands.

Schumakovitch, Irina, Grange, Wilfried, Strunz, Torsten, Bertoncini, Patricia, Güntherodt, Hans-Joachim, Hegner, Martin

Force probe techniques such as atomic force microscopy can directly measure the force required to rupture single biological ligand receptor bonds. Such forces are related to the energy landscape of...

Temperature dependence of unbinding forces between complementary DNA strands.

Schumakovitch, Irina, Grange, Wilfried, Strunz, Torsten, Bertoncini, Patricia, Güntherodt, Hans-Joachim, Hegner, Martin

Force probe techniques such as atomic force microscopy can directly measure the force required to rupture single biological ligand receptor bonds. Such forces are related to the energy landscape of...

VirE2: A Unique ssDNA-Compacting Molecular Machine

Grange, Wilfried, Duckely, Myriam, Husale, Sudhir, Jacob, Susan, Engel, Andreas, Hegner, Martin

The translocation of single-stranded DNA (ssDNA) across membranes of two cells is a fundamental biological process occurring in both bacterial conjugation and Agrobacterium pathogenesis. Whereas...

Interaction of cationic surfactants with DNA: a single-molecule study

Husale, Sudhir, Grange, Wilfried, Karle, Marc, Bürgi, Stephan, Hegner, Martin

The interaction of cationic surfactants with single dsDNA molecules has been studied using force-measuring optical tweezers. For hydrophobic chains of length 12 and greater, pulling experiments show...