A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Analysis of differences in gene expression between primate species suggests that the majority of them are selectively neutral and likely to have little or no functional consequences.
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
A Neutral Model of Transcriptome Evolution (2004)
Khaitovich, Phillip, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Kristian Almstrup, Ute Wirkner, Jonathon Blake, Christian Schwager, Wilhelm Ansorge, ...
Carcinoma in situ (CIS) is the common precursor of histologically heterogeneous testicular germ cell tumors (TGCTs), which in recent decades have markedly increased and now are the most common...
Optimization of oligonucleotide-based DNA microarrays (2002)
Relógio, Angela, Schwager, Christian, Richter, Alexandra, Ansorge, Wilhelm, Valcárcel, Juan
Oligonucleotide-based DNA microarrays are becoming increasingly useful for the analysis of gene expression and single nucleotide polymorphisms. Here we report a systematic study of the sensitivity,...
Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...
Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...
Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
Non-radioactive, solid phase DNase I footprints analyzed on an A. L. F. DNA sequencer (1994)
Sandaltzopoulos, R., Ansorge, Wilhelm, Becker, Peter B., Voss, H.
Separation of up to 1000 bases on a modified A.L.F. DNA sequencer (1993)
Grothues, Dietmar, Voss, Hartmut, Stegemann, Josef, Wiemann, Stefan, Sensen, Christoph, Zimmermann, Jürgen, ...
Voss, Hartmut, Schwager, Christian, Wirkner, Ute, Sproat, Brian, Zimmermann, Jurgen, Rosenthal, Andre, ...
In vitro amplification of genomic DNA and total RNA, as well as recombinant DNA, using one fluorescently labelled and one unlabelled primer during amplification, together with on-line analysis of the...
Schickedanz, Jörg, Philipson, Lennart, Ansorge, Wilhelm, Pepperkok, Rainer, Klein, Rüdiger, Koszinowski, Ulrich H.
The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE...
Ansorge, Wilhelm, Sproat, Brian, Stegemann, Josef, Schwager, Christian, Zenke, Martin
A simple system has been designed enabling ultrasensitive on-line detection of fluorescently labelled macromolecules, e.g. nucleic acids, proteins and peptides during electrophoretic separations in...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
Kal, Arnoud J., Van Zonneveld, Anton Jan, Benes, Vladimir, Van Den Berg, Marlene, Koerkamp, Marian Groot, Albermann, Kaj, ...
We describe a genome-wide characterization of mRNA transcript levels in yeast grown on the fatty acid oleate, determined using Serial Analysis of Gene Expression (SAGE). Comparison of this SAGE...
Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells
Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk
c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...
Characterization of SRp46, a Novel Human SR Splicing Factor Encoded by a PR264/SC35 Retropseudogene
Soret, Johann, Gattoni, Renata, Guyon, Cécile, Sureau, Alain, Popielarz, Michel, Le Rouzic, Erwann, ...
The highly conserved SR family contains a growing number of phosphoproteins acting as both essential and alternative splicing factors. In this study, we have cloned human genomic and cDNA sequences...
Optimization of oligonucleotide-based DNA microarrays
Relógio, Angela, Schwager, Christian, Richter, Alexandra, Ansorge, Wilhelm, Valcárcel, Juan
Oligonucleotide-based DNA microarrays are becoming increasingly useful for the analysis of gene expression and single nucleotide polymorphisms. Here we report a systematic study of the sensitivity,...
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription
Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...
Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...
Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, ...
The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
Sequence, gene mapping, and expression data corresponding to 910 genes transcribed in human skeletal muscle have been integrated to form the muscle module of the Genexpress IMAGE Knowledge Base....
Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...
With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
An estimate of large-scale sequencing accuracy
Hill, Fergal, Gemünd, Christine, Benes, Vladimir, Ansorge, Wilhelm, Gibson, Toby J.
The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated...
Point mutation of bacterial artificial chromosomes by ET recombination
Muyrers, Joep P.P., Zhang, Youming, Benes, Vladimir, Testa, Giuseppe, Ansorge, Wilhelm, Stewart, A. Francis
Bacterial artificial chromosomes (BACs) offer many advantages for functional studies of large eukaryotic genes. To utilize the potential applications of BACs optimally, new approaches that allow...
Fukami, Maki, Kirsch, Stefan, Schiller, Simone, Richter, Alexandra, Benes, Vladimir, Franco, Brunella, ...
X-linked nonspecific mental retardation (MRX) has a frequency of 0.15% in the male population and is caused by defects in several different genes on the human X chromosome. Genotype-phenotype...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
Kal, Arnoud J., Van Zonneveld, Anton Jan, Benes, Vladimir, Van Den Berg, Marlene, Koerkamp, Marian Groot, Albermann, Kaj, ...
We describe a genome-wide characterization of mRNA transcript levels in yeast grown on the fatty acid oleate, determined using Serial Analysis of Gene Expression (SAGE). Comparison of this SAGE...
Complex Functions of AP-1 Transcription Factors in Differentiation and Survival of PC12 Cells
Leppä, Sirpa, Eriksson, Minna, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk
c-Jun activation by mitogen-activated protein kinases has been implicated in various cellular signal responses. We investigated how JNK and c-Jun contribute to neuronal differentiation, cell...
Characterization of SRp46, a Novel Human SR Splicing Factor Encoded by a PR264/SC35 Retropseudogene
Soret, Johann, Gattoni, Renata, Guyon, Cécile, Sureau, Alain, Popielarz, Michel, Le Rouzic, Erwann, ...
The highly conserved SR family contains a growing number of phosphoproteins acting as both essential and alternative splicing factors. In this study, we have cloned human genomic and cDNA sequences...
Optimization of oligonucleotide-based DNA microarrays
Relógio, Angela, Schwager, Christian, Richter, Alexandra, Ansorge, Wilhelm, Valcárcel, Juan
Oligonucleotide-based DNA microarrays are becoming increasingly useful for the analysis of gene expression and single nucleotide polymorphisms. Here we report a systematic study of the sensitivity,...
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription
Westermarck, Jukka, Weiss, Carsten, Saffrich, Rainer, Kast, Jürgen, Musti, Anna-Maria, Wessely, Matthias, ...
Tandem affinity purification (TAP) and mass spectrometric peptide sequencing showed that the DEAD-box RNA helicase RHII/Gu is a functional interaction partner of c-Jun in human cells. The N-terminal...
Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, ...
The c-myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F-dependent transcription and cell growth. We have...
Piétu, Geneviève, Mariage-Samson, Régine, Fayein, Nicole-Adeline, Matingou, Christiane, Eveno, Eric, Houlgatte, Rémi, ...
Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative...
Piétu, Geneviève, Eveno, Eric, Soury-Segurens, Béatrice, Fayein, Nicole-Adeline, Mariage-Samson, Régine, Matingou, Christiane, ...
Sequence, gene mapping, and expression data corresponding to 910 genes transcribed in human skeletal muscle have been integrated to form the muscle module of the Genexpress IMAGE Knowledge Base....
Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...
With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
An estimate of large-scale sequencing accuracy
Hill, Fergal, Gemünd, Christine, Benes, Vladimir, Ansorge, Wilhelm, Gibson, Toby J.
The accuracy of large-scale DNA sequencing is difficult to estimate without redundant effort. We have found that the mobile genetic element IS10, a component of the transposon Tn10, has contaminated...
Point mutation of bacterial artificial chromosomes by ET recombination
Muyrers, Joep P.P., Zhang, Youming, Benes, Vladimir, Testa, Giuseppe, Ansorge, Wilhelm, Stewart, A. Francis
Bacterial artificial chromosomes (BACs) offer many advantages for functional studies of large eukaryotic genes. To utilize the potential applications of BACs optimally, new approaches that allow...
Fukami, Maki, Kirsch, Stefan, Schiller, Simone, Richter, Alexandra, Benes, Vladimir, Franco, Brunella, ...
X-linked nonspecific mental retardation (MRX) has a frequency of 0.15% in the male population and is caused by defects in several different genes on the human X chromosome. Genotype-phenotype...
Microinjection of Anti-coilin Antibodies Affects the Structure of Coiled Bodies
Almeida, Fátima, Saffrich, Rainer, Ansorge, Wilhelm, Carmo-Fonseca, Maria
The coiled body is a distinct subnuclear domain enriched in small nuclear ribonucleoprotein particles (snRNPs) involved in processing of pre-mRNA. Although the function of the coiled body is still...