Bernd K. Fleischmann, Eugen Kolossov, Eugen Kolossov, Toktam Bostani, Wilhelm Roell, Martin Breitbach, ...
α–myosin heavy chain; ASMAC, α–smooth muscle actin; EB, embryoid body; EGFP, enhanced GFP; ES cell,
Perlecan is critical for heart stability (2008)
Sasse, Philipp, Malan, Daniela, Fleischmann, Michaela, Roell, Wilhelm, Gustafsson, Erika, Bostani, Toktam, ...
Aims Perlecan is a heparansulfate proteoglycan found in basement membranes, cartilage, and several mesenchymal tissues that form during development, tumour growth, and tissue repair. Loss-of-function...
Burghoff, Sandra, Ding, Zhaoping, Gödecke, Stefanie, Assmann, Alexander, Wirrwar, Andreas, Buchholz, Doris, ...
Aims Recent studies suggested that human umbilical vein endothelial cells (HUVECs) transdifferentiate into cardiomyocytes and smooth muscle cells in vitro. To test the functional relevance of this...
Olausson, Jenny, Meissner, Marcel, Bloch, Wilhelm, Mathar, Ilka, Philipp, Stephan E, ...
Mast cells are key effector cells in allergic reactions. Aggregation of the receptor FcepsilonRI in mast cells triggers the influx of calcium (Ca(2+)) and the release of inflammatory mediators. Here...
Schrickel, Jan W., Brixius, Klara, Herr, Claudia, Clemen, Christoph S., Sasse, Philipp, Reetz, Kathrin, ...
Objectives Annexin A7 is involved in cardiomyocyte membrane organization and Ca2+-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties...
Burghoff, Sandra, Ding, Zhaoping, Gödecke, Stefanie, Assmann, Alexander, Wirrwar, Andreas, Buchholz, Doris, ...
Aims Recent studies suggested that human umbilical vein endothelial cells (HUVECs) transdifferentiate into cardiomyocytes and smooth muscle cells in vitro. To test the functional relevance of this...
Burghoff, Sandra, Ding, Zhaoping, Gödecke, Stefanie, Assmann, Alexander, Wirrwar, Andreas, Buchholz, Doris, ...
Aims Recent studies suggested that human umbilical vein endothelial cells (HUVECs) transdifferentiate into cardiomyocytes and smooth muscle cells in vitro. To test the functional relevance of this...
Nenci, Arianna, Huth, Marion, Funteh, Alfred, Schmidt-Supprian, Marc, Bloch, Wilhelm, Metzger, Daniel, ...
NF-κB essential modulator (NEMO), the regulatory subunit of the IκB kinase, is essential for NF-κB activation. Mutations disrupting the X-linked NEMO gene cause incontinentia pigmenti (IP), a...
Nenci, Arianna, Huth, Marion, Funteh, Alfred, Schmidt-Supprian, Marc, Bloch, Wilhelm, Metzger, Daniel, ...
NF-κB Essential Modulator (NEMO), the regulatory subunit of the IκB kinase, is essential for NF-κB activation. Mutations disrupting the X-linked NEMO gene cause incontinentia pigmenti (IP), a...
Gu, Wenli, Gibert, Yann, Wirth, Thierry, Elischer, Andrea, Bloch, Wilhelm, Meyer, Axel, ...
Mutations in the leucine-rich, glioma-inactivated 1 gene, LGI1, cause autosomal-dominant lateral temporal lobe epilepsy via unknown mechanisms. LGI1 belongs to a subfamily of leucine-rich repeat...
Gu, Wenli, Gibert, Yann, Wirth, Thierry, Elischer, Andrea, Bloch, Wilhelm, Meyer, Axel, ...
Mutations in the leucine-rich, glioma-inactivated 1 gene, LGI1, cause autosomal-dominant lateral temporal lobe epilepsy (ADLTE) via unknown mechanisms. LGI1 belongs to a subfamily of leucine-rich...
Gu, Wenli, Gibert, Yann, Wirth, Thierry, Elischer, Andrea, Bloch, Wilhelm, Meyer, Axel, ...
Mutations in the leucine-rich, glioma-inactivated 1 gene, LGI1, cause autosomal-dominant lateral temporal lobe epilepsy via unknown mechanisms. LGI1 belongs to a subfamily of leucine-rich repeat...
Gu, Wenli, Gibert, Yann, Wirth, Thierry, Elischer, Andrea, Bloch, Wilhelm, Meyer, Axel, ...
Mutations in the leucine-rich, glioma-inactivated 1 gene, LGI1, cause autosomal-dominant lateral temporal lobe epilepsy (ADLTE) via unknown mechanisms. LGI1 belongs to a subfamily of leucine-rich...
Gross, Oliver, Schulze-Lohoff, Eckhard, Koepke, Marie-Louise, Beirowski, Bogdan, Addicks, Klaus, Bloch, Wilhelm, ...
BACKGROUND: Several studies have shown antifibrotic effects of angiotensin converting enzyme (ACE) inhibitors as well as of angiotensin receptor 1 (AT1) antagonists, however, prospective trials with...
Gross, Oliver, Schulze-Lohoff, Eckhard, Koepke, Marie-Louise, Beirowski, Bogdan, Addicks, Klaus, Bloch, Wilhelm, ...
Background. Several studies have shown antifibrotic effects of angiotensin converting enzyme (ACE) inhibitors as well as of angiotensin receptor 1 (AT1) antagonists, however, prospective trials with...
Gross, Oliver, Schulze-Lohoff, Eckhard, Koepke, Marie-Louise, Beirowski, Bogdan, Addicks, Klaus, Bloch, Wilhelm, ...
Background. Several studies have shown antifibrotic effects of angiotensin converting enzyme (ACE) inhibitors as well as of angiotensin receptor 1 (AT1) antagonists, however, prospective trials with...
Nieswandt, Bernhard, Bergmeier, Wolfgang, Schulte, Valerie, Takai, Toshiyuki, Baumann, Ulrich, Schmidt, Reinhold E., ...
Previous work on cellular destruction induced by several clinically relevant anti‐platelet IgG antibodies suggested antigen‐specific mechanisms in the development of immune thrombocytopenia...
Köln, Univ., Diss., 1994.
Ueber die Apoplexie in Secundärstadium der Lues / (1911)
Thesis (doctoral)--Universität München, 1911.
Cover title.
Kostka, Günter, Giltay, Richard, Bloch, Wilhelm, Addicks, Klaus, Timpl, Rupert, Fässler, Reinhard, ...
The extracellular matrix protein fibulin-1 is a distinct component of vessel walls and can be associated with other ligands present in basement membranes, microfibrils, and elastic fibers. Its...
β2 integrins are required for skin homing of primed T cells but not for priming naive T cells
Grabbe, Stephan, Varga, Georg, Beissert, Stefan, Steinert, Meike, Pendl, Gunther, Seeliger, Stephan, ...
β2 integrins are of critical importance for leukocyte extravasation through vascular endothelia and for T cell activation. To elucidate the role of β2 integrins in T cell–mediated immune...
Krampert, Monika, Bloch, Wilhelm, Sasaki, Takako, Bugnon, Philippe, Rülicke, Thomas, Wolf, Eckhard, ...
The matrix metalloproteinase stromelysin-2 is expressed in keratinocytes of the epithelial tongue of skin wounds, suggesting a role in keratinocyte migration. Here, we show that stromelysin-2...
Kostka, Günter, Giltay, Richard, Bloch, Wilhelm, Addicks, Klaus, Timpl, Rupert, Fässler, Reinhard, ...
The extracellular matrix protein fibulin-1 is a distinct component of vessel walls and can be associated with other ligands present in basement membranes, microfibrils, and elastic fibers. Its...
β2 integrins are required for skin homing of primed T cells but not for priming naive T cells
Grabbe, Stephan, Varga, Georg, Beissert, Stefan, Steinert, Meike, Pendl, Gunther, Seeliger, Stephan, ...
β2 integrins are of critical importance for leukocyte extravasation through vascular endothelia and for T cell activation. To elucidate the role of β2 integrins in T cell–mediated immune...
Krampert, Monika, Bloch, Wilhelm, Sasaki, Takako, Bugnon, Philippe, Rülicke, Thomas, Wolf, Eckhard, ...
The matrix metalloproteinase stromelysin-2 is expressed in keratinocytes of the epithelial tongue of skin wounds, suggesting a role in keratinocyte migration. Here, we show that stromelysin-2...
Plasmin Modulates Vascular Endothelial Growth Factor-A-Mediated Angiogenesis during Wound Repair
Roth, Detlev, Piekarek, Michael, Paulsson, Mats, Christ, Hildegard, Bloch, Wilhelm, Krieg, Thomas, ...
Plasmin-catalyzed cleavage of the vascular endothelial growth factor (VEGF)-A isoform VEGF165 results in loss of its carboxyl-terminal heparin-binding domain and significant loss in its bioactivity....
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
Lorenz, Katrin, Grashoff, Carsten, Torka, Robert, Sakai, Takao, Langbein, Lutz, Bloch, Wilhelm, ...
Integrin-linked kinase (ILK) links integrins to the actin cytoskeleton and is believed to phosphorylate several target proteins. We report that a keratinocyte-restricted deletion of the ILK gene...
Brixius, Klara, Bloch, Wilhelm, Pott, Christian, Napp, Andreas, Krahwinkel, Andreas, Ziskoven, Christoph, ...
β-adrenoceptors are important modulators of cardiac function. The present study investigated β3-adrenergic eNOS activation in human myocardium.We measured nitric oxide (NO) liberation...
Kolossov, Eugen, Bostani, Toktam, Roell, Wilhelm, Breitbach, Martin, Pillekamp, Frank, Nygren, Jens M., ...
Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which is the most promising cell source. Therefore, we...
Betz, Ulrich A.K., Bloch, Wilhelm, Van Den Broek, Maries, Yoshida, Kanji, Taga, Tetsuya, Kishimoto, Tadamitsu, ...
The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1...
β1 Integrin Is Essential for Teratoma Growth and Angiogenesis
Bloch, Wilhelm, Forsberg, Erik, Lentini, Sylvia, Brakebusch, Cord, Martin, Karl, Krell, Hans W., ...
Teratomas are benign tumors that form after ectopic injection of embryonic stem (ES) cells into mice and contain derivatives of all primitive germ layers. To study the role of β1 integrin during...
Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes
Costell, Mercedes, Gustafsson, Erika, Aszódi, Attila, Mörgelin, Matthias, Bloch, Wilhelm, Hunziker, Ernst, ...
Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan binds growth factors and...
Bloch, Wilhelm, Fan, Yun, Han, Ji, Xue, Sheng, Schöneberg, Torsten, Ji, Guanju, ...
β1 integrins play a crucial role as cytoskeletal anchorage proteins. In this study, the coupling of the cytoskeleton and intracellular signaling pathways was investigated in β1 integrin deficient...
Ludolph, Barbara, Bloch, Wilhelm, Kelm, Malte, Schulz, Rainer, Kleinbongard, Petra
Prevention and treatment of cardiovascular disorders by HMG-CoA reductase inhibitors (or statins), beyond their lipid-lowering properties, have been demonstrated including activation of the...
Peroxiredoxin 6 is required for blood vessel integrity in wounded skin
Kümin, Angelika, Schäfer, Matthias, Epp, Nikolas, Bugnon, Philippe, Born-Berclaz, Christiane, Oxenius, Annette, ...
Peroxiredoxin 6 (Prdx6) is a cytoprotective enzyme with largely unknown in vivo functions. Here, we use Prdx6 knockout mice to determine its role in UV protection and wound healing. UV-mediated...
Wang, Hao-Ven, Chang, Ling-Wei, Brixius, Klara, Wickström, Sara A., Montanez, Eloi, Thievessen, Ingo, ...
Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of β1 integrin and mediates...
Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
Koegel, Heidi, Von Tobel, Lukas, Schäfer, Matthias, Alberti, Siegfried, Kremmer, Elisabeth, Mauch, Cornelia, ...
The transcription factor serum response factor (SRF) plays a crucial role in the development of several organs. However, its role in the skin has not been explored. Here, we show that keratinocytes...