William A. Barton

Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells (2006)

Barton, William A., Tzvetkova-Robev, Dorothea, Erdjument-Bromage, Hediye, Tempst, Paul, Nikolov, Dimitar B.

The advent of the multiwavelength anomalous diffraction phasing method has significantly accelerated crystal structure determination and has become the norm in protein crystallography. This method...

Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells (2006)

Barton, William A., Tzvetkova-Robev, Dorothea, Erdjument-Bromage, Hediye, Tempst, Paul, Nikolov, Dimitar B.

The advent of the multiwavelength anomalous diffraction phasing method has significantly accelerated crystal structure determination and has become the norm in protein crystallography. This method...

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling (2004)

Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, ...

This paper was part of our studies of Eph structure-function, in this case analysing the ability of Eph proteins to bind a number of ephrin ligands. Citations = 43

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling (2004)

Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, ...

This paper was part of our studies of Eph structure-function, in this case analysing the ability of Eph proteins to bind a number of ephrin ligands. Citations = 43

Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC (2003)

Lesniak, Jacob, Barton, William A., Nikolov, Dimitar B.

The osmotically inducible protein OsmC, like its better-characterized homolog, the organic hydroperoxide protein Ohr, is involved in defense against oxidative stress caused by exposure to organic...

Reciprocal Activation by Cyclin-Dependent Kinases 2 and 7 Is Directed by Substrate Specificity Determinants outside the T Loop

Garrett, Sarah, Barton, William A., Knights, Ronald, Jin, Pei, Morgan, David O., Fisher, Robert P.

Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of the metazoan CDK-activating kinase (CAK), which activates CDKs, such as CDC2 and CDK2, through phosphorylation of a conserved threonine...

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

Barton, William A., Biggins, John B., Jiang, Jiqing, Thorson, Jon S., Nikolov, Dimitar B.

In vitro “glycorandomization” is a chemoenzymatic approach for generating diverse libraries of glycosylated biomolecules based on natural product scaffolds. This technology makes use of...

Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr

Lesniak, Jacob, Barton, William A., Nikolov, Dimitar B.

Bacteria have developed complex strategies to detoxify and repair damage caused by reactive oxygen species. These compounds, produced during bacterial aerobic respiration as well as by the host...

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins

Barton, William A., Liu, Betty P., Tzvetkova, Dorothea, Jeffrey, Philip D., Fournier, Alyson E., Sah, Dinah, ...

The myelin-derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell-surface proteins signal through multi-subunit neuronal receptors that...

Reciprocal Activation by Cyclin-Dependent Kinases 2 and 7 Is Directed by Substrate Specificity Determinants outside the T Loop

Garrett, Sarah, Barton, William A., Knights, Ronald, Jin, Pei, Morgan, David O., Fisher, Robert P.

Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of the metazoan CDK-activating kinase (CAK), which activates CDKs, such as CDC2 and CDK2, through phosphorylation of a conserved threonine...

Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering

Barton, William A., Biggins, John B., Jiang, Jiqing, Thorson, Jon S., Nikolov, Dimitar B.

In vitro “glycorandomization” is a chemoenzymatic approach for generating diverse libraries of glycosylated biomolecules based on natural product scaffolds. This technology makes use of...

Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr

Lesniak, Jacob, Barton, William A., Nikolov, Dimitar B.

Bacteria have developed complex strategies to detoxify and repair damage caused by reactive oxygen species. These compounds, produced during bacterial aerobic respiration as well as by the host...

Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins

Barton, William A., Liu, Betty P., Tzvetkova, Dorothea, Jeffrey, Philip D., Fournier, Alyson E., Sah, Dinah, ...

The myelin-derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell-surface proteins signal through multi-subunit neuronal receptors that...

Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells

Barton, William A., Tzvetkova-Robev, Dorothea, Erdjument-Bromage, Hediye, Tempst, Paul, Nikolov, Dimitar B.

The advent of the multiwavelength anomalous diffraction phasing method has significantly accelerated crystal structure determination and has become the norm in protein crystallography. This method...

Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC

Lesniak, Jacob, Barton, William A., Nikolov, Dimitar B.

The osmotically inducible protein OsmC, like its better-characterized homolog, the organic hydroperoxide protein Ohr, is involved in defense against oxidative stress caused by exposure to organic...