Tissue concentrations: do we ever learn? (2008)
Mouton, Johan W., Theuretzbacher, Ursula, Craig, William A., Tulkens, Paul M., Derendorf, Hartmut, Cars, Otto
Over the last decades, numerous papers have appeared—and still are appearing—that describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent based on these...
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance (2005)
Ryan T. Cirz, Jodie K. Chin, David R. Andes, William A. Craig, Floyd E. Romesberg
The evolution of bacterial resistance to antibiotics presents a serious public-health threat, but may be inevitable because mutation is stimulated by exposure to some antibiotics. Inhibition of...
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance (2005)
Ryan T. Cirz, Jodie K. Chin, David R. Andes, William A. Craig, Floyd E. Romesberg
The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire...
Alexander,Roland T., Carmichael,Terence J., Craig,William A., High,John T., Inouye,Don M.
The conceptual development and design of a general warehouse module for the Norfolk, Virginia area was accomplished. A life cycle cost analysis was made to furnish the Department of Defense with...
A General Warehouse Module Conceptual Design and Cost Analysis. Volume I. Executive Summary. (2002)
Alexander,Roland T., Carmichael,Terence J., Craig,William A., High,John T., Inouye,Dom M
The conceptual development and design of a general warehouse module for the Norfolk, Virginia area was accomplished. A life cycle cost analysis was made to furnish the Department of Defense with...
Dagan, Ron, Klugman, Keith P., Craig, William A., Baquero, Fernando
Clinical outcome is dependent upon antibiotic-mediated bacterial eradication in a number of infections. However, in respiratory tract infections, the need for bacterial eradication has been...
Persistent suppression of bacterial growth, called the post-antibiotic effect (PAE), has been studied in six different animal infection models. Prolonged in-vivo PAEs are observed for all...
Pharmacodynamics of amikacin in vitro and in mouse thigh and lung infections (1991)
Craig, William A., Redington, Jay, Ebert, Steven C.
A variety of in-vitro and animal studies were performed to define the pharmacodynamic characteristics of amikacin against Gram-negative bacilli and to determine the impact of the dosing regimen on...
Use of Pharmacodynamic Indices To Predict Efficacy of Combination Therapy In Vivo
Mouton, Johan W., Van Ogtrop, Marc L., Andes, David, Craig, William A.
Although combination therapy with antimicrobial agents is often used, no available method explains or predicts the efficacies of these combinations satisfactorily. Since the efficacies of...
McKinney, Tanya K., Sharma, Vijay K., Craig, William A., Archer, Gordon L.
Resistance to β-lactam antibiotics in staphylococci is mediated by mecA and blaZ, genes encoding a penicillin-binding protein (PBP2a) with low β-lactam affinity and β-lactamase, respectively. The...
mecA-blaZ Corepressors in Clinical Staphylococcus aureus Isolates
Rosato, Adriana E., Kreiswirth, Barry N., Craig, William A., Eisner, William, Climo, Michael W., Archer, Gordon L.
The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique...
Barbhaiya, Rashmi H., Gerber, Andreas U., Craig, William A., Welling, Peter G.
The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic...
Greenfield, Ronald A., Kurzynski, Terrence A., Craig, William A.
The in vitro susceptibility of 20 isolates of Clostridium difficile to cefotaxime, moxalactam, and cefoperazone was determined by a standard agar dilution method. The median minimal inhibitory...
Frimodt-Möller, Niels, Maigaard, Sven, Toothaker, Roger D., Bundtzen, Robert W., Brodey, Mitchell V., Craig, William A., ...
The pharmacokinetics of mezlocillin were examined after single 2- and 4-g intravenous injections to three groups of male patients with creatinine clearances of I ≥ 60, II = 21 to 59, and III ≤ 20...
Bioavailability of Tetracycline and Doxycycline in Fasted and Nonfasted Subjects
Welling, Peter G., Koch, Patricia A., Lau, Curtis C., Craig, William A.
The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human...
Evaluation of New Urinary Tract Infection Screening Devices
Craig, William A., Kunin, Calvin M., DeGroot, Jane
Several new methods for detection of bacteriuria were studied to evaluate their usefulness as screening procedures. A new filter paper device incorporating dehydrated media and tetrazolium was found...
Quantitative Urine Culture Method Using a Plastic „Paddle” Containing Dual Media
Craig, William A., Kunin, Calvin M.
A new dip-inoculum method for quantitative urine culture is described which utilizes a dual-chambered plastic „paddle” housing both a general purpose and differential medium. Comparative...
Craig, William A., Turner, James H., Kunin, Calvin M.
Pretreatment with multiple doses of polymyxin B and colistimethate was evaluated as to its ability to sequester sufficient antibiotic in tissues to neutralize the effects of endotoxin in three animal...
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Cirz, Ryan T, Chin, Jodie K, Andes, David R, Craig, William A, Romesberg, Floyd E
The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire...
Quantitation of mecA Transcription in Oxacillin-Resistant Staphylococcus aureus Clinical Isolates
Rosato, Adriana E., Craig, William A., Archer, Gordon L.
The transcription of mecA, the gene required for oxacillin resistance in staphylococci, was quantified in a collection of 65 geographically and genetically diverse clinical and 8 defined laboratory...
Use of Pharmacodynamic Indices To Predict Efficacy of Combination Therapy In Vivo
Mouton, Johan W., Van Ogtrop, Marc L., Andes, David, Craig, William A.
Although combination therapy with antimicrobial agents is often used, no available method explains or predicts the efficacies of these combinations satisfactorily. Since the efficacies of...
McKinney, Tanya K., Sharma, Vijay K., Craig, William A., Archer, Gordon L.
Resistance to β-lactam antibiotics in staphylococci is mediated by mecA and blaZ, genes encoding a penicillin-binding protein (PBP2a) with low β-lactam affinity and β-lactamase, respectively. The...
mecA-blaZ Corepressors in Clinical Staphylococcus aureus Isolates
Rosato, Adriana E., Kreiswirth, Barry N., Craig, William A., Eisner, William, Climo, Michael W., Archer, Gordon L.
The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique...
Quantitation of mecA Transcription in Oxacillin-Resistant Staphylococcus aureus Clinical Isolates
Rosato, Adriana E., Craig, William A., Archer, Gordon L.
The transcription of mecA, the gene required for oxacillin resistance in staphylococci, was quantified in a collection of 65 geographically and genetically diverse clinical and 8 defined laboratory...
Barbhaiya, Rashmi H., Gerber, Andreas U., Craig, William A., Welling, Peter G.
The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic...
Greenfield, Ronald A., Kurzynski, Terrence A., Craig, William A.
The in vitro susceptibility of 20 isolates of Clostridium difficile to cefotaxime, moxalactam, and cefoperazone was determined by a standard agar dilution method. The median minimal inhibitory...
Frimodt-Möller, Niels, Maigaard, Sven, Toothaker, Roger D., Bundtzen, Robert W., Brodey, Mitchell V., Craig, William A., ...
The pharmacokinetics of mezlocillin were examined after single 2- and 4-g intravenous injections to three groups of male patients with creatinine clearances of I ≥ 60, II = 21 to 59, and III ≤ 20...
Bioavailability of Tetracycline and Doxycycline in Fasted and Nonfasted Subjects
Welling, Peter G., Koch, Patricia A., Lau, Curtis C., Craig, William A.
The influence of various test meals and fluid volumes on the relative bioavailability of commercial formulations of doxycycline hyclate and tetracycline hydrochloride was studied in healthy human...
Evaluation of New Urinary Tract Infection Screening Devices
Craig, William A., Kunin, Calvin M., DeGroot, Jane
Several new methods for detection of bacteriuria were studied to evaluate their usefulness as screening procedures. A new filter paper device incorporating dehydrated media and tetrazolium was found...
Quantitative Urine Culture Method Using a Plastic „Paddle” Containing Dual Media
Craig, William A., Kunin, Calvin M.
A new dip-inoculum method for quantitative urine culture is described which utilizes a dual-chambered plastic „paddle” housing both a general purpose and differential medium. Comparative...
Craig, William A., Turner, James H., Kunin, Calvin M.
Pretreatment with multiple doses of polymyxin B and colistimethate was evaluated as to its ability to sequester sufficient antibiotic in tissues to neutralize the effects of endotoxin in three animal...
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Cirz, Ryan T, Chin, Jodie K, Andes, David R, Craig, William A, Romesberg, Floyd E
The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire...
In Vivo Pharmacodynamic Activity of the Glycopeptide Dalbavancin▿
Andes, David, Craig, William A.
Dalbavancin is a lipoglycopeptide antibiotic with broad-spectrum activity against gram-positive cocci and a markedly prolonged serum elimination half-life. We used the neutropenic murine thigh and...
Ambrose, Paul G., Forrest, Alan, Craig, William A., Rubino, Chistopher M., Bhavnani, Sujata M., Drusano, George L., ...
We determined the pharmacokinetic-pharmacodynamic (PK-PD) measure most predictive of gatifloxacin efficacy and the magnitude of this measure necessary for survival in a murine Bacillus anthracis...
LaPlante, Kerry L., Leonard, Steven N., Andes, David R., Craig, William A., Rybak, Michael J.
Controversy exists about the most effective treatment options for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and about the ability of these strains to develop...