William A. Day

Poly-gamma-Glutamate Capsule-Degrading Enzyme Treatment Enhances Phagocytosis and Killing of Encapsulated Bacillus Anthracis (2007)

Scorpio, Angelo, Chabot, Donald J., Day, William A., O'Brien, David K., Vietri, Nicholas J., Itoh, Yoshifumi, ...

The poly gamma-D-glutamic acid capsule confers antiphagocytic properties on Bacillus anthracis and is essential for virulence. In this study, we showed that two recombinant glutamylases: CapD, a...

Role of Catalase in Campylobacter jejuni Intracellular Survival

Day, William A., Sajecki, Jaime L., Pitts, Todd M., Joens, Lynn A.

The ability of Campylobacter jejuni to penetrate normally nonphagocytic host cells is believed to be a key virulence determinant. Recently, kinetics of C. jejuni intracellular survival have been...

Shigella flexneri LuxS Quorum-Sensing System Modulates virB Expression but Is Not Essential for Virulence

Day, William A., Maurelli, Anthony T.

Quorum-sensing systems regulate the expression of virulence factors in a wide variety of plant and animal pathogens, including members of the Enterobacteriaceae. Studies of Shigella virulence gene...

Pathoadaptive Mutations That Enhance Virulence: Genetic Organization of the cadA Regions of Shigella spp.

Day, William A., Fernández, Reinaldo E., Maurelli, Anthony T.

Pathoadaptive mutations improve the fitness of pathogenic species by modification of traits that interfere with factors (virulence and ancestral) required for survival in host tissues. A demonstrated...

MxiE Regulates Intracellular Expression of Factors Secreted by the Shigella flexneri 2a Type III Secretion System

Kane, Colleen D., Schuch, Raymond, Day, William A., Maurelli, Anthony T.

The mxi-spa locus on the virulence plasmid of Shigella flexneri encodes components of the type III secretion system. mxiE, a gene within this locus, encodes a protein that is homologous to the...

Role of Catalase in Campylobacter jejuni Intracellular Survival

Day, William A., Sajecki, Jaime L., Pitts, Todd M., Joens, Lynn A.

The ability of Campylobacter jejuni to penetrate normally nonphagocytic host cells is believed to be a key virulence determinant. Recently, kinetics of C. jejuni intracellular survival have been...

Shigella flexneri LuxS Quorum-Sensing System Modulates virB Expression but Is Not Essential for Virulence

Day, William A., Maurelli, Anthony T.

Quorum-sensing systems regulate the expression of virulence factors in a wide variety of plant and animal pathogens, including members of the Enterobacteriaceae. Studies of Shigella virulence gene...

Pathoadaptive Mutations That Enhance Virulence: Genetic Organization of the cadA Regions of Shigella spp.

Day, William A., Fernández, Reinaldo E., Maurelli, Anthony T.

Pathoadaptive mutations improve the fitness of pathogenic species by modification of traits that interfere with factors (virulence and ancestral) required for survival in host tissues. A demonstrated...

MxiE Regulates Intracellular Expression of Factors Secreted by the Shigella flexneri 2a Type III Secretion System

Kane, Colleen D., Schuch, Raymond, Day, William A., Maurelli, Anthony T.

The mxi-spa locus on the virulence plasmid of Shigella flexneri encodes components of the type III secretion system. mxiE, a gene within this locus, encodes a protein that is homologous to the...

Poly-γ-Glutamate Capsule-Degrading Enzyme Treatment Enhances Phagocytosis and Killing of Encapsulated Bacillus anthracis▿

Scorpio, Angelo, Chabot, Donald J., Day, William A., O'Brien, David K., Vietri, Nicholas J., Itoh, Yoshifumi, ...

The poly-γ-d-glutamic acid capsule confers antiphagocytic properties on Bacillus anthracis and is essential for virulence. In this study, we showed that CapD, a γ-polyglutamic acid depolymerase...

Microarray Analysis of Transposon Insertion Mutations in Bacillus anthracis: Global Identification of Genes Required for Sporulation and Germination▿ †

Day, William A., Rasmussen, Suzanne L., Carpenter, Beth M., Peterson, Scott N., Friedlander, Arthur M.

A transposon site hybridization (TraSH) assay was developed for functional analysis of the Bacillus anthracis genome using a mini-Tn10 transposon which permitted analysis of 82% of this pathogen's...