An actin-based wave generator organizes cell motility (2007)
Weiner, Orion D, Marganski, William A, Wu, Lani F, Altschuler, Steven J, Kirschner, Marc W
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...
An Actin-Based Wave Generator Organizes Cell Motility (2007)
Orion D. Weiner, William A. Marganski, Lani F. Wu, Steven J. Altschuler, Marc W. Kirschner
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...
Demonstration of altered fibroblast contractile activity in hypertensive heart disease (2003)
Marganski, William A, De Biase, Vanessa M, Burgess, Maria L, Dembo, Micah
Objective: The aim of this study is to investigate the idea that altered fibroblast contractile activity is involved in the pathogenesis of hypertensive heart disease (HHD). Methods: Cell area and...
The Mechanics of Neutrophils: Synthetic Modeling of Three Experiments
Herant, Marc, Marganski, William A., Dembo, Micah
Much experimental data exist on the mechanical properties of neutrophils, but so far, they have mostly been approached within the framework of liquid droplet models. This has two main drawbacks: 1),...
Influence of Type I Collagen Surface Density on Fibroblast Spreading, Motility, and Contractility
Gaudet, Christianne, Marganski, William A., Kim, Sooyoung, Brown, Christopher T., Gunderia, Vaibhavi, Dembo, Micah, ...
We examine the relationships of three variables (projected area, migration speed, and traction force) at various type I collagen surface densities in a population of fibroblasts. We observe that cell...
Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force Generation
Shiu, Yan-Ting, Li, Song, Marganski, William A., Usami, Shunichi, Schwartz, Martin A., Wang, Yu-Li, ...
The migration of vascular endothelial cells in vivo occurs in a fluid dynamic environment due to blood flow, but the role of hemodynamic forces in cell migration is not yet completely understood....
Rajagopalan, Padmavathy, Marganski, William A., Brown, Xin Q., Wong, Joyce Y.
Native proteins are often substituted by short peptide sequences. These peptides can recapitulate key, but not all biofunctional properties of the native proteins. Here, we quantify the similarities...
The Mechanics of Neutrophils: Synthetic Modeling of Three Experiments
Herant, Marc, Marganski, William A., Dembo, Micah
Much experimental data exist on the mechanical properties of neutrophils, but so far, they have mostly been approached within the framework of liquid droplet models. This has two main drawbacks: 1),...
Influence of Type I Collagen Surface Density on Fibroblast Spreading, Motility, and Contractility
Gaudet, Christianne, Marganski, William A., Kim, Sooyoung, Brown, Christopher T., Gunderia, Vaibhavi, Dembo, Micah, ...
We examine the relationships of three variables (projected area, migration speed, and traction force) at various type I collagen surface densities in a population of fibroblasts. We observe that cell...
Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force Generation
Shiu, Yan-Ting, Li, Song, Marganski, William A., Usami, Shunichi, Schwartz, Martin A., Wang, Yu-Li, ...
The migration of vascular endothelial cells in vivo occurs in a fluid dynamic environment due to blood flow, but the role of hemodynamic forces in cell migration is not yet completely understood....
Rajagopalan, Padmavathy, Marganski, William A., Brown, Xin Q., Wong, Joyce Y.
Native proteins are often substituted by short peptide sequences. These peptides can recapitulate key, but not all biofunctional properties of the native proteins. Here, we quantify the similarities...
An Actin-Based Wave Generator Organizes Cell Motility
Weiner, Orion D, Marganski, William A, Wu, Lani F, Altschuler, Steven J, Kirschner, Marc W
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...