William F. Gregory

Immuno-epidemiology of human Schistosoma haematobiuminfection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden (2006)

Mutapi, Francisca, Mduluza, Takafira, Gomez-Escobar, Natalia, Gregory, William F, Fernandez, Cecilia, Midzi, Nicholas, ...

Abstract Background Schistosomiasis is a major parasitic disease affecting over 200 million people in the developing world with a further 400 million people at risk of infection. The aim of this...

Caenorhabditis Elegans—Applications to Nematode Genomics (2003)

William F. Gregory, John Parkinson

The complete genome sequence of the free-living nematode Caenorhabditis elegans was published 4 years ago. Since then, we have seen great strides in technologies that seek to exploit this data. Here...

Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences (2002)

Fernandez, Cecilia, Gregory, William F, Loke, P’ng, Maizels, Rick

The tissue-dwelling larval stages of the cestode Echinococcus granulosus are intimately associated with the host, implying that a range of molecular mediators may be secreted by the parasite into the...

Abundant larval transcript-1 and -2 genes from Brugia malayi : diversity of genomic environments but conservation of 5ı promoter sequences functional in Caenorhabditis elegansı (2002)

Gomez-Escobar, Natalia, Gregory, William F, Britton, Collette, Murray, Linda, Corton, Craig, Hall, Neil, ...

The genomic organisation of two abundant larval transcript (alt) genes from the filarial nematode Brugia malayi has been defined. The products of these genes are 78% identical in amino acid sequence,...

Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences (2002)

Fernandez, Cecilia, Gregory, William F, Loke, P’ng, Maizels, Rick

The tissue-dwelling larval stages of the cestode Echinococcus granulosus are intimately associated with the host, implying that a range of molecular mediators may be secreted by the parasite into the...

Abundant larval transcript-1 and -2 genes from Brugia malayi : diversity of genomic environments but conservation of 5ı promoter sequences functional in Caenorhabditis elegansı (2002)

Gomez-Escobar, Natalia, Gregory, William F, Britton, Collette, Murray, Linda, Corton, Craig, Hall, Neil, ...

The genomic organisation of two abundant larval transcript (alt) genes from the filarial nematode Brugia malayi has been defined. The products of these genes are 78% identical in amino acid sequence,...

Immune evasion genes from filarial nematodes (2001)

Maizels, Rick, Gomez-Escobar, Natalia, Gregory, William F, William, Janice, Zang, Xingxing

Helminth parasites have large genomes (~108 bp) which are likely to encode a spectrum of products able to block or divert the host immune response. We have employed three parallel approaches to...

Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing (2001)

Manoury, Benedicte, Gregory, William F, Maizels, Rick, Watts, Colin

While interference with the class I MHC pathway by homologous to pathogen-encoded gene products, especially those of viruses, has been well documented, few examples type 2 cystatins were recently...

Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins (2001)

Murray, Janice, Gregory, William F, Gomez-Escobar, Natalia, Kurniawan Atmadja, Agnes, Maizels, Rick

Several important nematode parasites have been found to express members of a gene family variously termed as venom allergen antigen homologue (vah) or Ancylostoma secreted protein (asp). In some...

Immune evasion genes from filarial nematodes (2001)

Maizels, Rick, Gomez-Escobar, Natalia, Gregory, William F, William, Janice, Zang, Xingxing

Helminth parasites have large genomes (~108 bp) which are likely to encode a spectrum of products able to block or divert the host immune response. We have employed three parallel approaches to...

Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing (2001)

Manoury, Benedicte, Gregory, William F, Maizels, Rick, Watts, Colin

While interference with the class I MHC pathway by homologous to pathogen-encoded gene products, especially those of viruses, has been well documented, few examples type 2 cystatins were recently...

Expression and immune recognition of Brugia malayi VAL-1, a homologue of vespid venom allergens and Ancylostoma secreted proteins (2001)

Murray, Janice, Gregory, William F, Gomez-Escobar, Natalia, Kurniawan Atmadja, Agnes, Maizels, Rick

Several important nematode parasites have been found to express members of a gene family variously termed as venom allergen antigen homologue (vah) or Ancylostoma secreted protein (asp). In some...

Identification of tgh-2, a Filarial Nematode Homolog of Caenorhabditis elegans daf-7 and Human Transforming Growth Factor β, Expressed in Microfilarial and Adult Stages of Brugia malayi

Gomez-Escobar, Natalia, Gregory, William F., Maizels, Rick M.

A novel member of the transforming growth factor β (TGF-β) family has been identified in the filarial nematode parasite Brugia malayi by searching the recently developed Expressed Sequence Tag...

The Abundant Larval Transcript-1 and -2 Genes of Brugia malayi Encode Stage-Specific Candidate Vaccine Antigens for Filariasis

Gregory, William F., Atmadja, Agnes K., Allen, Judith E., Maizels, Rick M.

Lymphatic filariasis is a major tropical disease caused by the mosquito-borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute...

Identification of tgh-2, a Filarial Nematode Homolog of Caenorhabditis elegans daf-7 and Human Transforming Growth Factor β, Expressed in Microfilarial and Adult Stages of Brugia malayi

Gomez-Escobar, Natalia, Gregory, William F., Maizels, Rick M.

A novel member of the transforming growth factor β (TGF-β) family has been identified in the filarial nematode parasite Brugia malayi by searching the recently developed Expressed Sequence Tag...

The Abundant Larval Transcript-1 and -2 Genes of Brugia malayi Encode Stage-Specific Candidate Vaccine Antigens for Filariasis

Gregory, William F., Atmadja, Agnes K., Allen, Judith E., Maizels, Rick M.

Lymphatic filariasis is a major tropical disease caused by the mosquito-borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute...

Caenorhabditis Elegans—Applications to Nematode Genomics

Gregory, William F., Parkinson, John

The complete genome sequence of the free-living nematode Caenorhabditis elegans was published 4 years ago. Since then, we have seen great strides in technologies that seek to exploit this data. Here...