William J. Cook

An unexpected phosphate binding site in Glyceraldehyde 3-Phosphate Dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvumenzyme (2009)

Cook, William J, Senkovich, Olga, Chattopadhyay, Debasish

Abstract Background The structure, function and reaction mechanism of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) have been extensively studied. Based on these studies, three anion binding sites...

On a symmetry of the category of integrable modules (2009)

Cook, William J., Sadowski, Christopher

Haisheng Li showed that given a module (W,Y_W(\cdot,x)) for a vertex algebra (V,Y(\cdot,x)), one can obtain a new V-module W^{\Delta} = (W,Y_W(\Delta(x)\cdot,x)) if \Delta(x) satisfies certain...

Generalized domino-parity inequalities for the TSP (2008)

William J. Cook, Daniel Espinoza, Marcos Goycoolea

We extend the work of Letchford (2000) by introducing a new class of valid inequalities for the traveling salesman problem, called the generalized domino-parity (GDP) constraints. Just as...

A recurrence relation for characters of highest weight integrable modules for affine Lie algebras (2005)

Cook, William J., Li, Haisheng, Misra, Kailash C.

Using certain results for the vertex operator algebras associated with affine Lie algebras we obtain recurrence relations for the characters of integrable highest weight irreducible modules for an...

On the constructive inverse problem in differential Galois theory (2005)

William J. Cook, Claude Mitschi, Michael F. Singer

We give sufficient conditions for a differential equation to have a given semisimple group as its Galois group. For any group G with G 0 = G1 ·... · Gr where each Gi is a simple group of type Aℓ,...

On the constructive inverse problem in differential Galois theory (2005)

William J. Cook, Claude Mitschi, Michael F. Singer

We give sufficient conditions for a differential equation to have a given semisimple group as its Galois group. For any group G with G 0 = G 1 · ·· · ·G r, where each G i is a simple group of...

On the Constructive Inverse Problem in Differential Galois Theory (2004)

Cook, William J., Mitschi, Claude, Singer, Michael F.

We give sufficient conditions for a linear differential equation to have a given semisimple group as its Galois group. For any linear algebraic group G given as a semidirect product of a finite...

AL-amyloidosis is underdiagnosed in renal biopsies (2004)

Novak, Lea, Cook, William J., Herrera, Guillermo A., Sanders, Paul W.

Background. Renal amyloidosis is associated with a variety of underlying disease processes. Although amyloid is identical in appearance in these diseases, the precursor proteins are different....

AL-amyloidosis is underdiagnosed in renal biopsies (2004)

Novak, Lea, Cook, William J., Herrera, Guillermo A., Sanders, Paul W.

Background. Renal amyloidosis is associated with a variety of underlying disease processes. Although amyloid is identical in appearance in these diseases, the precursor proteins are different....

A Polyhedral Approach to Surface Reconstruction from Planar Contours. (2002)

Althaus, Ernst, Fink, Christian, Cook, William J., Schulz, Andreas S.

We investigate the problem of reconstruction a surface given its contours on parallel slices. We present a branch-and-cut algorithm which computes the surface with the minimal area. This surface is...

Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing (2002)

Cook, William J., Zell, Alan, Watt, Dean D., Ealick, Steven E.

Centruroides sculpturatus Ewing variant 2 toxin (CsE-v2) is a neurotoxin isolated from the venom of a scorpion native to the Arizona desert. The structure of CsE-v2 was solved in two different...

Structure and humanization of a rat monoclonal Fab to human interleukin-5 (1996)

Cook, William J., Walter, Leigh J., Murgolo, Nicholas J., Chou, Chuan-Chu, Petro, Mary, Zavodny, Paul J., ...

The X-ray crystal structure of a rat monoclonal Fab JES1-39D10, raised against recombinant human interleukin-5, has been determined with the use of molecular replacement techniques and refined at 2.7...

Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing

Cook, William J., Zell, Alan, Watt, Dean D., Ealick, Steven E.

Centruroides sculpturatus Ewing variant 2 toxin (CsE-v2) is a neurotoxin isolated from the venom of a scorpion native to the Arizona desert. The structure of CsE-v2 was solved in two different...