William J. McKenna

Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy (2009)

Gimeno, Juan R., Tomé-Esteban, Maite, Lofiego, Carla, Hurtado, José, Pantazis, Antonios, Mist, Bryan, ...

Background Non-sustained ventricular tachycardia (NSVT) during ambulatory electrocardiographic monitoring (typically occurring at rest or during sleep) is associated with an increased risk of sudden...

Part III: Molecular Basis of Cardiac (2008)

Silvia G. Priori, Jacques Barhanin, Wilhelm Haverkamp, J. Jongsma, André G. Kleber, ...

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EROC: A Toolkit for Building NEAT0 Query Optimizers (2008)

William J. Mckenna, Louis Burger, Chi Hoang, Melissa Truong

EROC (Extensible, Reusable Optimization Components) is a toolkit for building query optimizers. EROC’s components are C++ classes based on abstractions we have iden-tified as central to query...

Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families (2008)

Behr, Elijah R., Dalageorgou, Chrysoula, Christiansen, Michael, Syrris, Petros, Hughes, Sian, Tome Esteban, Maria T., ...

Aims At least 4% of sudden deaths are unexplained at autopsy [sudden arrhythmic death syndrome (SADS)] and a quarter may be due to inherited cardiac disease. We hypothesized that comprehensive...

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy (2008)

Jacques, Adam M., Briceno, Natalia, Messer, Andrew E., Gallon, Clare E., Jalilzadeh, Shapour, Garcia, Edwin, ...

Aim The aim of the study was to compare the functional and structural properties of the motor protein, myosin, and isolated myocyte contractility in heart muscle excised from hypertrophic...

Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases (2008)

Elliott, Perry, Andersson, Bert, Arbustini, Eloisa, Bilinska, Zofia, Cecchi, Franco, Charron, Philippe, ...

In biology, classification systems are used to promote understanding and systematic discussion through the use of logical groups and hierarchies. In clinical medicine, similar principles are used to...

Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease (2007)

Syrris, Petros, Ward, Deirdre, Asimaki, Angeliki, Evans, Alison, Sen-Chowdhry, Srijita, Hughes, Sian E., ...

Aims Mutations in the desmoglein-2 (DSG2) gene have been reported in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) but clinical information regarding the associated phenotype...

Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy (2006)

Elliott, Perry M., Gimeno, Juan R., Tomé, María T., Shah, Jaymin, Ward, Deirdre, Thaman, Rajesh, ...

Aims Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from SD in relation...

Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy (2006)

Elliott, Perry M., Gimeno, Juan R., Tomé, María T., Shah, Jaymin, Ward, Deirdre, Thaman, Rajesh, ...

Aims Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from SD in relation...

Natural history and familial characteristics of isolated left ventricular non-compaction (2005)

Murphy, Ross T., Thaman, Rajesh, Blanes, Juan Gimeno, Ward, Deirdre, Sevdalis, Elias, Papra, Efi, ...

Aims Non-compaction of the left ventricle (LVNC) is a disorder of endomyocardial morphogenesis that results in multiple trabeculations in the left ventricular myocardium. The current literature...

Actualización en miocardiopatía arritmogénica del ventrículo derecho: genética, diagnóstico, manifestaciones clínicas y estratificación de riesgo (2004)

Tomé Esteban, María T., García-Pinilla, José M., McKenna, William J.

La miocardiopatía o displasia arritmogénica del ventrículo derecho (MAVD) es una enfermedad del músculo cardíaco de origen genético cuyo diagnóstico supone a menudo un reto para el clínico....

Natural history and familial characteristics of isolated left ventricular non-compaction (2004)

Murphy, Ross T., Thaman, Rajesh, Blanes, Juan Gimeno, Ward, Deirdre, Sevdalis, Elias, Papra, Efi, ...

Aims Non-compaction of the left ventricle (LVNC) is a disorder of endomyocardial morphogenesis that results in multiple trabeculations in the left ventricular myocardium. The current literature...

Gadolinium enhanced cardiovascular magnetic resonance in Anderson-Fabry disease: Evidence for a disease specific abnormality of the myocardial interstitium (2003)

Moon, James C.C., Sachdev, Bhavesh, Elkington, Andrew G., McKenna, William J., Mehta, Atul, Pennell, Dudley J., ...

Aims Anderson-Fabry Disease (AFD), an X-linked disorder of sphingolipid metabolism, is a cause of idiopathic left ventricular hypertrophy but the mechanism of hypertrophy is poorly understood....

EROC: A Toolkit for Building NEATO Query Optimizers (1996)

William J. McKenna, Ol K. Ono, Raa Francois Raab, Tpc Benchmark D, P. Seshadri, ...

3] A. Chen, Y. F. Kao, M. Pong, D. Sak, S. Sharma, J. Vaishnav, and H. Zeller. Query processing in NonStop SQL. IEEE Data Eng. Bull., 16(4):29, December 1993. [CLR89] T. Cormen, C. Leiserson, and R....

Prospective, double-blind, placebo-controlled trial of low-dose amiodarone in patients with severe heart failure and asymptomatic frequent ventricular ectopy (1991)

Nicklas, John M., McKenna, William J., Stewart, Ralph A., Mickelson, Judith K., Das, Sunil K., Schork, M. Anthony, ...

Sudden cardiac death is a common cause of mortality in patients with congestive heart failure. To determine if low-dose amiodarone could reduce sudden death among these patients, a prospective,...

Good Prognosis for Dilated Cardiomyopathy Without Severe Heart Failure or Arrhythmia (1990)

STEWART, RALPH A. H., MCKENNA, WILLIAM J., OAKLEY, CELIA M.

In 124 patients with dilated cardiomyopathy, symptoms of heart failure and ventricular arrhythmia at initial assessment were related to outcome a mean of 43 months later. Using life table analysis,...

'Pseudo' systolic anterior motion in patients with hypertensive heart disease (1983)

DOI, YOSHINORI L., MCKENNA, WILLIAM J., OAKLEY, CELIA M., GOODWIN, JOHN F.

The systolic motion of the mitral apparatus in patients with hypertensive heart disease and hypertrophic cardiomyopathy was studied in order to quantify the difference. Twelve out of 37 patients with...

Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy

Arad, Michael, Benson, D. Woodrow, Perez-Atayde, Antonio R., McKenna, William J., Sparks, Elizabeth A., Kanter, Ronald J., ...

Mutations in PRKAG2, the gene for the γ2 regulatory subunit of AMP-activated protein kinase, cause cardiac hypertrophy and electrophysiologic abnormalities, particularly preexcitation...

Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations

Mogensen, Jens, Kubo, Toru, Duque, Mauricio, Uribe, William, Shaw, Anthony, Murphy, Ross, ...

Restrictive cardiomyopathy (RCM) is an uncommon heart muscle disorder characterized by impaired filling of the ventricles with reduced volume in the presence of normal or near normal wall thickness...

A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12

Solomon, Scott D., Vosberg, Hans-Peter, Hiller, Gudrun, Jarcho, John A., Morton, Cynthia C., ...

We report that a gene responsible for familial hypertrophic cardiomyopathy (HC) is closely linked to the cardiac α and β myosin heavy chain (MHC) genes on chromosome 14q11. We have recently shown...

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Associated with Mutations in the Desmosomal Gene Desmocollin-2

Syrris, Petros, Ward, Deirdre, Evans, Alison, Asimaki, Angeliki, Gandjbakhch, Estelle, Sen-Chowdhry, Srijita, ...

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited myocardial disorder associated with arrhythmias, heart failure, and sudden death. To date, mutations in four genes...

Similar prevalence of enteroviral genome within the myocardium from patients with idiopathic dilated cardiomyopathy and controls by the polymerase chain reaction

Keeling, Philip J, Jeffery, Stephen, Caforio, Alida L P, Taylor, Rohan, Bottazzo, Gian F, Davies, Michael J, ...

Objective—To assess the prevalence and significance of enteroviral genome within myocardial biopsy specimens taken from patients with idiopathic dilated cardiomyopathy and from controls.

Myocardial disarray in Noonan syndrome

Burch, Michael, Mann, Jessica M, Sharland, Michael, Shinebourne, Elliot A, Patton, Michael A, McKenna, William J

Objective—To characterise the histopathology of the left ventricular hypertrophy commonly associated with Noonan syndrome by assessing the extent of myocyte disarray and therefore to define one...