William J. Sullivan

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii   - A Review (2009)

Sullivan Jr., William J., Smith, Aaron T., Joyce, Bradley R.

Parasite differentiation from proliferating tachyzoites into latent bradyzoites is central to pathogenesis and transmission of the intracellular protozoan pathogen Toxoplasma gondii   . The presence...

IMP dehydrogenase from the protozoan parasite Toxoplasma gondii (2005)

William J. Sullivan, Stacy E. Dixon, Catherine Li, Boris Striepen, Sherry F. Queener

The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which...

MYST Family Histone Acetyltransferases in the Protozoan Parasite (2005)

Toxoplasma Gondii, Aaron T. Smith, Alan H. Fairlamb, William J. Sullivan

The restructuring of chromatin precedes tightly regulated events such as DNA transcription, replication, and repair. One type of chromatin remodeling involves the covalent modification of nucleosomes...

Practical arts building construction. (1954)

Sullivan, William J.

Thesis (M.S.)--Buffalo State College for Teachers, 1954.

A study of corrective arithmetic in the fundamental process of multiplication with an eighth grade class. (1941)

Sullivan, William J.

Submitted to the faculty of the State Teachers College at Fitchburg in partial fulfillment of the requirements for the degree of Master in Education.

IMP Dehydrogenase from the Protozoan Parasite Toxoplasma gondii

Sullivan, William J., Dixon, Stacy E., Li, Catherine, Striepen, Boris, Queener, Sherry F.

The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which...

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control.

Sullivan, William J, Narasimhan, Jana, Bhatti, Micah M, Wek, Ronald C

The ubiquitous intracellular parasite Toxoplasma gondii (phylum Apicomplexa) differentiates into an encysted form (bradyzoite) that can repeatedly re-emerge as a life-threatening acute infection...

Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii†

Saksouk, Nehmé, Bhatti, Micah M., Kieffer, Sylvie, Smith, Aaron T., Musset, Karine, Garin, Jérôme, ...

Pathogenic apicomplexan parasites like Toxoplasma and Plasmodium (malaria) have complex life cycles consisting of multiple stages. The ability to differentiate from one stage to another requires...

MYST Family Histone Acetyltransferases in the Protozoan Parasite Toxoplasma gondii

Smith, Aaron T., Tucker-Samaras, Samantha D., Fairlamb, Alan H., Sullivan, William J.

The restructuring of chromatin precedes tightly regulated events such as DNA transcription, replication, and repair. One type of chromatin remodeling involves the covalent modification of nucleosomes...

Pair of Unusual GCN5 Histone Acetyltransferases and ADA2 Homologues in the Protozoan Parasite Toxoplasma gondii

Bhatti, Micah M., Livingston, Meredith, Mullapudi, Nandita, Sullivan, William J.

GCN5 is a histone acetyltransferase (HAT) essential for development in mammals and critical to stress responses in yeast. The protozoan parasite Toxoplasma gondii is a serious opportunistic pathogen....

IMP Dehydrogenase from the Protozoan Parasite Toxoplasma gondii

Sullivan, William J., Dixon, Stacy E., Li, Catherine, Striepen, Boris, Queener, Sherry F.

The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which...

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control.

Sullivan, William J, Narasimhan, Jana, Bhatti, Micah M, Wek, Ronald C

The ubiquitous intracellular parasite Toxoplasma gondii (phylum Apicomplexa) differentiates into an encysted form (bradyzoite) that can repeatedly re-emerge as a life-threatening acute infection...

Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii†

Saksouk, Nehmé, Bhatti, Micah M., Kieffer, Sylvie, Smith, Aaron T., Musset, Karine, Garin, Jérôme, ...

Pathogenic apicomplexan parasites like Toxoplasma and Plasmodium (malaria) have complex life cycles consisting of multiple stages. The ability to differentiate from one stage to another requires...

MYST Family Histone Acetyltransferases in the Protozoan Parasite Toxoplasma gondii

Smith, Aaron T., Tucker-Samaras, Samantha D., Fairlamb, Alan H., Sullivan, William J.

The restructuring of chromatin precedes tightly regulated events such as DNA transcription, replication, and repair. One type of chromatin remodeling involves the covalent modification of nucleosomes...

Pair of Unusual GCN5 Histone Acetyltransferases and ADA2 Homologues in the Protozoan Parasite Toxoplasma gondii

Bhatti, Micah M., Livingston, Meredith, Mullapudi, Nandita, Sullivan, William J.

GCN5 is a histone acetyltransferase (HAT) essential for development in mammals and critical to stress responses in yeast. The protozoan parasite Toxoplasma gondii is a serious opportunistic pathogen....

Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii▿

Smith, Aaron T., Livingston, Meredith R., Mai, Antonello, Filetici, Patrizia, Queener, Sherry F., Sullivan, William J.

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However,...

Azurin-Like Protein Blocks Invasion of Toxoplasma gondii through Potential Interactions with Parasite Surface Antigen SAG1▿

Naguleswaran, Arunasalam, Fialho, Arsenio M., Chaudhari, Anita, Hong, Chang Soo, Chakrabarty, Ananda M., Sullivan, William J.

Some pathogenic bacteria produce factors that have evolved a capacity to neutralize competing microbes. The cupredoxin family protein azurin, produced by Pseudomonas aeruginosa, exhibits a remarkable...

The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements

Behnke, Michael S, Radke, Josh B, Smith, Aaron T, Sullivan, William J, White, Michael W

Experimental evidence suggests that apicomplexan parasites possess bipartite promoters with basal and regulated cis-elements similar to other eukaryotes. Using a dual luciferase model adapted for...

Translation Regulation by Eukaryotic Initiation Factor-2 Kinases in the Development of Latent Cysts in Toxoplasma gondii*S⃞

Narasimhan, Jana, Joyce, Bradley R., Naguleswaran, Arunasalam, Smith, Aaron T., Livingston, Meredith R., Dixon, Stacy E., ...

A key problem in the treatment of numerous pathogenic eukaryotes centers on their development into latent forms during stress. For example, the opportunistic protist Toxoplasma gondii converts to...