Scientific Commons: William Jarra

Studies on the induction and expression of protective immunity in rodent malaria : Plasmodium b.berghei and P.c.chabaudi infections of inbred mice. (1982)

Jarra, William.

Thesis (Ph. D.)--Brunel University, 1982.

Antibody Recognition of Rodent Malaria Parasite Antigens Exposed at the Infected Erythrocyte Surface: Specificity of Immunity Generated in Hyperimmune Mice

Mota, Maria M., Brown, K. Neil, Do Rosário, Virgilio E., Holder, Anthony A., Jarra, William

In regions where malaria is endemic, inhabitants remain susceptible to repeated reinfection as they develop and maintain clinical immunity. This immunity includes responses to surface-exposed...

Plasmodium chabaudi-Infected Erythrocytes Adhere to CD36 and Bind to Microvascular Endothelial Cells in an Organ-Specific Way

Mota, Maria M., Jarra, William, Hirst, Elizabeth, Patnaik, Pradeep K., Holder, Anthony A.

Adherence of erythrocytes infected with Plasmodium falciparum to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis....

Only Viable Parasites Are Detected by PCR following Clearance of Rodent Malarial Infections by Drug Treatment or Immune Responses

Jarra, William, Snounou, Georges

Detection and analysis of pathogens by PCR plays an important role in infectious disease research. The value of these studies would be diminished if nuclear material from dead parasites were found to...

Acute Plasmodium chabaudi chabaudi Malaria Infection Induces Antibodies Which Bind to the Surfaces of Parasitized Erythrocytes and Promote Their Phagocytosis by Macrophages In Vitro

Mota, Maria M., Brown, K. Neil, Holder, Anthony A., Jarra, William

CBA/Ca mice infected with 5 × 104 Plasmodium chabaudi chabaudi AS-parasitized erythrocytes experience acute but self-limiting infections of relatively short duration. Parasitemia peaks (∼40%...

Cerebral Edema and Cerebral Hemorrhages in Interleukin-10-Deficient Mice Infected with Plasmodium chabaudi

Sanni, Latifu A., Jarra, William, Li, Ching, Langhorne, Jean

During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage...

Antibodies against MAEBL Ligand Domains M1 and M2 Inhibit Sporozoite Development In Vitro

Preiser, Peter, Rénia, Laurent, Singh, Naresh, Balu, Bharath, Jarra, William, Voza, Tatiana, ...

MAEBL is a type 1 membrane protein that is implicated in the merozoite invasion of erythrocytes and sporozoite invasion of mosquito salivary glands. This apical organelle protein is structurally...

Distinct Trafficking and Localization of STEVOR Proteins in Three Stages of the Plasmodium falciparum Life Cycle

McRobert, Louisa, Preiser, Peter, Sharp, Sarah, Jarra, William, Kaviratne, Mallika, Taylor, Martin C., ...

The genome of Plasmodium falciparum harbors three extensive multigene families, var, rif, and stevor (for subtelomeric variable open reading frame), located mainly in the subtelomeric regions of the...

Epitope-Specific Regulation of Immunoglobulin Class Switching in Mice Immunized with Malarial Merozoite Surface Proteins

Tongren, Jon Eric, Corran, Patrick H., Jarra, William, Langhorne, Jean, Riley, Eleanor M.

Antibodies that bind to Fc receptors and activate complement are implicated in the efficient control of pathogens, but the processes that regulate their induction are still not well understood. To...