William Jou

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors (2009)

Craig, Anthony T, Gavrilova, Oksana, Dwyer, Nancy K, Jou, William, Pack, Stephanie, Liu, Eric, ...

Abstract Background Pancreatic islet transplantation is a promising treatment for type I diabetes mellitus, but current immunosuppressive strategies do not consistently provide long-term survival of...

Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids

Irie, Hiroshi, Krukenkamp, Irvin B., Brinkmann, Joep F. F., Gaudette, Glenn R., Saltman, Adam E., Jou, William, ...

Long-chain fatty acid uptake, which provides a large part of myocardial energy, is impaired in human and murine hearts deficient in the membrane fatty acid translocase, FAT/CD36. We examined...

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency

Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...

The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...

Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids

Irie, Hiroshi, Krukenkamp, Irvin B., Brinkmann, Joep F. F., Gaudette, Glenn R., Saltman, Adam E., Jou, William, ...

Long-chain fatty acid uptake, which provides a large part of myocardial energy, is impaired in human and murine hearts deficient in the membrane fatty acid translocase, FAT/CD36. We examined...

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency

Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...

The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

Guo, Tingqing, Jou, William, Chanturiya, Tatyana, Portas, Jennifer, Gavrilova, Oksana, McPherron, Alexandra C.

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in muscle mass,...

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth

Jo, Junghyo, Gavrilova, Oksana, Pack, Stephanie, Jou, William, Mullen, Shawn, Sumner, Anne E., ...

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the...

Persistent Diet-Induced Obesity in Male C57BL/6 Mice Resulting from Temporary Obesigenic Diets

Guo, Juen, Jou, William, Gavrilova, Oksana, Hall, Kevin D.

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors

Craig, Anthony T, Gavrilova, Oksana, Dwyer, Nancy K, Jou, William, Pack, Stephanie, Liu, Eric, ...