Scientific Commons: William N. Pappano

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605 (2009)

Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, ...

Abstract Background The insulin-like growth factor (IGF) axis is an important signaling pathway in the growth and survival of many cell and tissue types. This pathway has also been implicated in many...

Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases

Pappano, William N., Steiglitz, Barry M., Scott, Ian C., Keene, Douglas R., Greenspan, Daniel S.

Bone morphogenetic protein 1 (BMP-1) and mammalian Tolloid (mTLD), two proteinases encoded by Bmp1, provide procollagen C-proteinase (pCP) activity that converts procollagens I to III into the major...

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

Wolfman, Neil M., McPherron, Alexandra C., Pappano, William N., Davies, Monique V., Song, Kening, Tomkinson, Kathleen N., ...

Myostatin is a transforming growth factor β family member that acts as a negative regulator of skeletal muscle growth. Myostatin circulates in the blood of adult mice in a noncovalently held complex...

Procollagen C Proteinase Enhancer 1 Genes Are Important Determinants of the Mechanical Properties and Geometry of Bone and the Ultrastructure of Connective Tissues

Steiglitz, Barry M., Kreider, Jaclynn M., Frankenburg, Elizabeth P., Pappano, William N., Hoffman, Guy G., Meganck, Jeffrey A., ...

Procollagen C proteinases (pCPs) cleave type I to III procollagen C propeptides as a necessary step in assembling the major fibrous components of vertebrate extracellular matrix. The protein PCOLCE1...