William O'Brien

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. (2008)

Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, ...

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the...

In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle

Lee, Brendan, Yu, Hong, Jahoor, Farook, O'Brien, William, Beaudet, Arthur L., Reeds, Peter

Urea cycle disorders are a group of inborn errors of hepatic metabolism that result in often life-threatening hyperammonemia and hyperglutaminemia. Clinical and laboratory diagnosis of partial...

In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle

Lee, Brendan, Yu, Hong, Jahoor, Farook, O'Brien, William, Beaudet, Arthur L., Reeds, Peter

Urea cycle disorders are a group of inborn errors of hepatic metabolism that result in often life-threatening hyperammonemia and hyperglutaminemia. Clinical and laboratory diagnosis of partial...

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

Shao, Haifeng, Burrage, Lindsay C., Sinasac, David S., Hill, Annie E., Ernest, Sheila R., O'Brien, William, ...

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the...

Gene-environment interactions reveal a homeostatic role for cholesterol metabolism during dietary folate perturbation in mice

Kitami, Toshimori, Rubio, Renee, O'Brien, William, Quackenbush, John, Nadeau, Joseph H.

Dietary folate supplementation can dramatically reduce the severity and incidence of several common birth defects and adult diseases that are associated with anomalies in homocysteine and folate...

Dried-Plasma Transport Using a Novel Matrix and Collection System for Human Immunodeficiency Virus and Hepatitis C Virus Virologic Testing▿

Lloyd, R. M., Burns, D. A., Huong, J. T., Mathis, R. L., Winters, M. A., Tanner, M., ...

A novel method for the collection and transportation of dried-blood-plasma samples, SampleTanker (ST), was developed and compared to standard shipping protocols for frozen-plasma specimens containing...