Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain (2009)
Grear, Karrie E, Ling, I-Fang, Simpson, James F, Furman, Jennifer L, Simmons, Christopher R, Peterson, Shawn L, ...
Abstract Background Variations in sortilin-related receptor (SORL1) expression and function have been implicated in Alzheimers Disease (AD). Here, to gain insights into SORL1, we evaluated SORL1...
Weissman, Lior, Jo, Dong-Gyu, Sørensen, Martin M., Markesbery, William R., Mattson, Mark P., ...
Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair...
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease (2007)
Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, ...
Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study...
Healthy ageing in the Nun Study: definition and neuropathologic correlates (2007)
Tyas, Suzanne L., Snowdon, David A., Desrosiers, Mark F., Riley, Kathryn P., Markesbery, William R.
Background: although the concept of healthy ageing has stimulated considerable interest, no generally accepted definition has been developed nor has its biological basis been determined. Objective:...
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease (2007)
Lovell, Mark A., Markesbery, William R.
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer's disease (AD). Attack of DNA by reactive oxygen species (ROS),...
Forman, Mark S., Mackenzie, Ian R., Cairns, Nigel J., Swanson, Eric, Boyer, Philip J., Drachman, David A., ...
Frontotemporal dementia (FTD) with inclusion body myopathy and Paget disease of bone (IBMPFD) is a rare, autosomal-dominant disorder caused by mutations in the valosin-containing protein (VCP) gene,...
Genetic and expression profiles of cerebellar liponeurocytomas (2004)
Horstmann, Sonia, Perry, Arie, Reifenberger, Guido, Giangaspero, Felice, Huang, Herve, Hara, Akira, ...
Cerebellar liponeurocytoma, a rare, newly identified CNS neoplasm of adults, is characterized by advanced neuronal/neurocytic and focal lipomatous differentiation, low proliferative potential and a...
Blalock, Eric M., Geddes, James W., Chen, Kuey Chu, Porter, Nada M., Markesbery, William R., Landfield, Philip W.
The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the complexity of AD and the overlap of its early-stage markers with normal aging. Gene microarrays...
Blalock, Eric M., Geddes, James W., Chen, Kuey Chu, Porter, Nada M., Markesbery, William R., Landfield, Philip W.
The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the complexity of AD and the overlap of its early-stage markers with normal aging. Gene microarrays...
Anantharaman, Muthuswamy, Tangpong, Jitbanjong, Keller, Jeffery N., Murphy, Michael P., Markesbery, William R., Kiningham, Kelley K., ...
Alzheimer’s disease is a multifactorial, progressive, age-related neurodegenerative disease. In familial Alzheimer’s disease, Aβ is excessively produced and deposited because of mutations in the...
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease
Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, ...
Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study...
Montine, Thomas J., Markesbery, William R., Zackert, William, Sanchez, Stephanie C., Roberts, L. Jackson, Morrow, Jason D.
Numerous post mortem studies have demonstrated increased accumulation of lipid peroxidation products in diseased regions of Alzheimer’s disease (AD) brain; however, few have used techniques that...
Reich, Erin E., Markesbery, William R., Roberts, L. Jackson, Swift, Larry L., Morrow, Jason D., Montine, Thomas J.
Isoprostanes (IsoP) are produced exclusively from free radical damage to arachidonic acid, a fatty acid that is evenly distributed throughout white matter and gray matter, whereas neuroprostanes...
Weissman, Lior, Jo, Dong-Gyu, Sørensen, Martin M., Markesbery, William R., Mattson, Mark P., ...
Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair...
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease
Lovell, Mark A., Markesbery, William R.
Increasing evidence supports a role for oxidative DNA damage in aging and several neurodegenerative diseases including Alzheimer's disease (AD). Attack of DNA by reactive oxygen species (ROS),...