William R. Morton

Limited Breadth of the Protective Immunity Elicited by Simian Immunodeficiency Virus SIVmne gp160 Vaccines in a Combination Immunization Regimen

Polacino, Patricia, Stallard, Virginia, Klaniecki, James E., Montefiori, David C., Langlois, Alphonse J., Richardson, Barbra A., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against an intravenous challenge by the cloned homologous...

Protection of Macaques against Intrarectal Infection by a Combination Immunization Regimen with Recombinant Simian Immunodeficiency Virus SIVmne gp160 Vaccines

Polacino, Patricia, Stallard, Virginia, Montefiori, David C., Brown, Charles R., Richardson, Barbra A., Morton, William R., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous...

Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment

Tsai, Che-Chung, Emau, Peter, Follis, Kathryn E., Beck, Thomas W., Benveniste, Raoul E., Bischofberger, Norbert, ...

(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA), an acyclic nucleoside phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we showed that PMPA treatment for 28 days...

Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost

Gorelick, Robert J., Benveniste, Raoul E., Lifson, Jeffrey D., Yovandich, Jason L., Morton, William R., Kuller, LaRene, ...

Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the...

Role of Immune Responses against the Envelope and the Core Antigens of Simian Immunodeficiency Virus SIVmne in Protection against Homologous Cloned and Uncloned Virus Challenge in Macaques

Polacino, Patricia S., Stallard, Virginia, Klaniecki, James E., Pennathur, Sridhar, Montefiori, David C., Langlois, Alphonse J., ...

We previously showed that envelope (gp160)-based vaccines, used in a live recombinant virus priming and subunit protein boosting regimen, protected macaques against intravenous and intrarectal...

Limited Breadth of the Protective Immunity Elicited by Simian Immunodeficiency Virus SIVmne gp160 Vaccines in a Combination Immunization Regimen

Polacino, Patricia, Stallard, Virginia, Klaniecki, James E., Montefiori, David C., Langlois, Alphonse J., Richardson, Barbra A., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against an intravenous challenge by the cloned homologous...

Protection of Macaques against Intrarectal Infection by a Combination Immunization Regimen with Recombinant Simian Immunodeficiency Virus SIVmne gp160 Vaccines

Polacino, Patricia, Stallard, Virginia, Montefiori, David C., Brown, Charles R., Richardson, Barbra A., Morton, William R., ...

We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous...

Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment

Tsai, Che-Chung, Emau, Peter, Follis, Kathryn E., Beck, Thomas W., Benveniste, Raoul E., Bischofberger, Norbert, ...

(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA), an acyclic nucleoside phosphonate analog, is one of a new class of potent antiretroviral agents. Previously, we showed that PMPA treatment for 28 days...

Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost

Gorelick, Robert J., Benveniste, Raoul E., Lifson, Jeffrey D., Yovandich, Jason L., Morton, William R., Kuller, LaRene, ...

Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the...

Role of Immune Responses against the Envelope and the Core Antigens of Simian Immunodeficiency Virus SIVmne in Protection against Homologous Cloned and Uncloned Virus Challenge in Macaques

Polacino, Patricia S., Stallard, Virginia, Klaniecki, James E., Pennathur, Sridhar, Montefiori, David C., Langlois, Alphonse J., ...

We previously showed that envelope (gp160)-based vaccines, used in a live recombinant virus priming and subunit protein boosting regimen, protected macaques against intravenous and intrarectal...

Rapid Shift from Virally Infected Cells to Germinal Center-Retained Virus after HIV-2 Infection of Macaques

Eitner, Frank, Cui, Yan, Grouard-Vogel, Géraldine, Hudkins, Kelly L., Schmidt, Ann, Birkebak, Ted, ...

Lymphoid tissues are the primary target during the initial virus dissemination that occurs in HIV-1-infected individuals. Recent advances in antiretroviral therapy and techniques to monitor virus...

Thrombotic Microangiopathy in the HIV-2-Infected Macaque

Eitner, Frank, Cui, Yan, Hudkins, Kelly L., Schmidt, Ann, Birkebak, Ted, Agy, Michael B., ...

Thrombotic microangiopathy (TMA) has been increasingly reported in human immunodeficiency virus (HIV)-infected humans over the past decade. The pathogenesis is unknown. We prospectively analyzed the...