Essential role for Vav1 in activation, but not development, of {gamma}{delta} T cells (2003)
Swat, Wojciech, Xavier, Ramnik, Mizoguchi, Atsushi, Mizoguchi, Emiko, Fredericks, Jessica, Fujikawa, Keiko, ...
Vav1 is a guanine nucleotide exchange factor essential in the development and function of αβ lineage T cells. Here we report that in contrast to profound effects on pre‐TCR‐ or αβ...
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow (1998)
Wang, Li Chun, Swat, Wojciech, Fujiwara, Yuko, Davidson, Laurie, Visvader, Jane, Kuo, Frank, ...
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., ...
Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the...
Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
Shaw, Albert C., Swat, Wojciech, Davidson, Laurie, Alt, Frederick W.
During B cell development, rearrangement and expression of Ig heavy chain (HC) genes promote development and expansion of pre-B cells accompanied by the onset of Ig light chain (LC) variable region...
Vav Family Proteins Couple to Diverse Cell Surface Receptors
Moores, Sheri L., Selfors, Laura M., Fredericks, Jessica, Breit, Timo, Fujikawa, Keiko, Alt, Frederick W., ...
Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins contain...
Vav3 is regulated during the cell cycle and effects cell division
Fujikawa, Keiko, Inoue, Yoshiro, Sakai, Masaharu, Koyama, Yoshikazu, Nishi, Shinzo, Funada, Ryo, ...
Vav3 is a member of the family of guanine nucleotide exchange factors implicated in the regulation of Rho GTPases. Although the exact in vivo function of Vav3 is unknown, evidence from several...
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow
Wang, Li Chun, Swat, Wojciech, Fujiwara, Yuko, Davidson, Laurie, Visvader, Jane, Kuo, Frank, ...
The TEL (translocation–Ets–leukemia or ETV6) locus, which encodes an Ets family transcription factor, is frequently rearranged in human leukemias of myeloid or lymphoid origins. By gene targeting...
Hunter, Sonja G., Zhuang, Guanglei, Brantley-Sieders, Dana, Swat, Wojciech, Cowan, Christopher W., Chen, Jin
Angiogenesis, the process by which new blood vessels are formed from preexisting vasculature, is critical for vascular remodeling during development and contributes to the pathogenesis of diseases...
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice
Borghesani, Paul R., Alt, Frederick W., Bottaro, Andrea, Davidson, Laurie, Aksoy, Saime, Rathbun, Gary A., ...
Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia–telangiectasia (A-T), which is caused by mutations in the...
Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
Shaw, Albert C., Swat, Wojciech, Davidson, Laurie, Alt, Frederick W.
During B cell development, rearrangement and expression of Ig heavy chain (HC) genes promote development and expansion of pre-B cells accompanied by the onset of Ig light chain (LC) variable region...
Vav Family Proteins Couple to Diverse Cell Surface Receptors
Moores, Sheri L., Selfors, Laura M., Fredericks, Jessica, Breit, Timo, Fujikawa, Keiko, Alt, Frederick W., ...
Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins contain...
Vav3 is regulated during the cell cycle and effects cell division
Fujikawa, Keiko, Inoue, Yoshiro, Sakai, Masaharu, Koyama, Yoshikazu, Nishi, Shinzo, Funada, Ryo, ...
Vav3 is a member of the family of guanine nucleotide exchange factors implicated in the regulation of Rho GTPases. Although the exact in vivo function of Vav3 is unknown, evidence from several...
The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow
Wang, Li Chun, Swat, Wojciech, Fujiwara, Yuko, Davidson, Laurie, Visvader, Jane, Kuo, Frank, ...
The TEL (translocation–Ets–leukemia or ETV6) locus, which encodes an Ets family transcription factor, is frequently rearranged in human leukemias of myeloid or lymphoid origins. By gene targeting...
Hunter, Sonja G., Zhuang, Guanglei, Brantley-Sieders, Dana, Swat, Wojciech, Cowan, Christopher W., Chen, Jin
Angiogenesis, the process by which new blood vessels are formed from preexisting vasculature, is critical for vascular remodeling during development and contributes to the pathogenesis of diseases...
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
Mahoney, Zhen X., Sammut, Bénédicte, Xavier, Ramnik J., Cunningham, Jeanette, Go, Gloriosa, Brim, Karry L., ...
Discs-large homolog 1 (DLGH1) is a mouse ortholog of the Drosophila discs-large (DLG) tumor suppressor protein, a founding member of the PDZ and MAGUK protein families. DLG proteins play important...
Essential role of PI3Kδ and PI3Kγ in thymocyte survival
Swat, Wojciech, Montgrain, Vivianne, Doggett, Teresa A., Douangpanya, Jason, Puri, Kamal, Vermi, William, ...
Class 1 phosphoinositide 3-kinases (PI3Ks), consisting of PI3Kα, β, γ, and δ, are a family of intracellular signaling molecules that play important roles in cell-mediated immune responses. In...
Graham, Daniel B., Robertson, Charles M., Bautista, Jhoanne, Mascarenhas, Francesca, Diacovo, M. Julia, Montgrain, Vivianne, ...
Oxidative burst, a critical antimicrobial mechanism of neutrophils, involves the rapid generation and release of reactive oxygen intermediates (ROIs) by the NADPH oxidase complex. Genetic mutations...
DLGH1 Is a Negative Regulator of T-Lymphocyte Proliferation▿ †
Stephenson , Linda M., Sammut, Bénédicte, Graham, Daniel B., Chan-Wang, Joaquim, Brim, Karry L., Huett, Alan S., ...
Discs large homolog 1 (DLGH1), a founding member of the membrane-associated guanylate kinase family of proteins containing PostSynaptic Density-95/Discs large/Zona Occludens-1 domains, is an ortholog...
Discs large (Dlg1) complexes in lymphocyte activation
Xavier, Ramnik, Rabizadeh, Shahrooz, Ishiguro, Kazuhiro, Andre, Niko, Ortiz, J. Bernabe, Wachtel, Heather, ...
T cell antigen recognition involves the formation of a structured interface between antigen-presenting and T cells that facilitates the specific transmission of activating and desensitizing stimuli....
Vav GEFs are required for β2 integrin-dependent functions of neutrophils
Gakidis, M. Angelica Martinez, Cullere, Xavier, Olson, Timothy, Wilsbacher, Julie L., Zhang, Bin, Moores, Sheri L., ...
Integrin regulation of neutrophils is essential for appropriate adhesion and transmigration into tissues. Vav proteins are Rho family guanine nucleotide exchange factors that become tyrosine...
Differential Requirements for Vav Proteins in DAP10- and ITAM-mediated NK Cell Cytotoxicity
Cella, Marina, Fujikawa, Keiko, Tassi, Ilaria, Kim, Sunjin, Latinis, Kevin, Nishi, Shinzo, ...
Natural killer (NK) cells express multiple activating receptors that initiate signaling cascades through DAP10- or immunoreceptor tyrosine-based activation motif–containing adapters, including...
Fujikawa, Keiko, Miletic, Ana V., Alt, Frederick W., Faccio, Roberta, Brown, Tracie, Hoog, Jeremy, ...
The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte antigen receptors. Elucidation of Vav function has been obscured thus far...
Vav proteins control MyD88-dependent oxidative burst
Miletic, Ana V., Graham, Daniel B., Montgrain, Vivianne, Fujikawa, Keiko, Kloeppel, Tracie, Brim, Karry, ...
The importance of reactive oxygen intermediate (ROI) production in antimicrobial responses is demonstrated in human patients who suffer from chronic granulomatous disease (CGD) due to defective NADPH...
Shaw, Albert C., Swat, Wojciech, Ferrini, Roger, Davidson, Laurie, Alt, Frederick W.
To elucidate the intracellular pathways that mediate early B cell development, we directed expression of activated Ras to the B cell lineage in the context of the recombination-activating gene 1...
Tillman, Robert E., Wooley, Andrea L., Hughes, Maureen M., Wehrly, Tara D., Swat, Wojciech, Sleckman, Barry P.
Antigen receptor loci are composed of numerous variable (V), diversity (D), and joining (J) gene segments, each flanked by recombination signal sequences (RSSs). The V(D)J recombination reaction...
Aifantis, Iannis, Pivniouk, Vadim I., Gärtner, Frank, Feinberg, Jacqueline, Swat, Wojciech, Alt, Frederick W., ...
Signaling via the pre-T cell receptor (TCR) is required for the proliferative expansion and maturation of CD4−CD8− double-negative (DN) thymocytes into CD4+CD8+ double-positive (DP) cells and for...
Graham, Daniel B., Stephenson, Linda M., Lam, Siu Kit, Brim, Karry, Lee, Hyang Mi, Bautista, Jhoanne, ...
Dendritic cells (DC) possess a unique capacity for presenting exogenous antigen on major histocompatibility class I, a process that is referred to as cross-presentation, which serves a critical role...