Adler, Melanie, Müller, Katja, Rached, Eva, Dekant, Wolfgang, Mally, Angela
Ochratoxin A (OTA) is a potent renal carcinogen, but little is known regarding the mechanism of OTA carcinogenicity. Early histopathological alterations induced by OTA in rat kidney include single...
Rached, Eva, Hoffmann, Dana, Blumbach, Kai, Weber, Klaus, Dekant, Wolfgang, Mally, Angela
The kidney is one of the main targets of xenobiotic-induced toxicity, but early detection of renal damage is difficult. Recently, several novel biomarkers of nephrotoxicity have been identified by...
Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats (2007)
Rached, Eva, Hard, Gordon C., Blumbach, Kai, Weber, Klaus, Draheim, Regina, Lutz, Werner K., ...
Ochratoxin A (OTA) is nephrotoxic and a potent renal carcinogen. Male rats are most susceptible to OTA toxicity, and chronic administration of OTA (70 and 210 μg/kg bw) for 2 years has been shown to...
Baird, Alan W, Blaauboer, Bas J, Castell Ripoll, Jose Vicente, Corvi, Raffaella, Dekant, Wolfgang, ...
ECVAM, Institute for Health & Consumer Protection, European Joint Research Centre, 21020 Ispra (VA), Italy.
Rached, Eva, Pfeiffer, Erika, Dekant, Wolfgang, Mally, Angela
Ochratoxin A (OTA) is a potent nephrotoxin and causes high incidences of renal tumors in rodents. The molecular events leading to tumor formation by OTA are not well defined. Early pathological...
Toxicokinetics of Tetrabromobisphenol A in Humans and Rats After Oral Administration (2006)
Schauer, Ute M. D., Völkel, Wolfgang, Dekant, Wolfgang
Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and is suspected to be stable in the environment with possible widespread human exposures. This study reports the characterization of...
Rached, Eva, Pfeiffer, Erika, Dekant, Wolfgang, Mally, Angela
Ochratoxin A (OTA) is a potent nephrotoxin and causes high incidences of renal tumors in rodents. The molecular events leading to tumor formation by OTA are not well defined. Early pathological...
Toxicokinetics of Tetrabromobisphenol A in Humans and Rats after Oral Administration (2006)
Schauer, Ute M. D., Völkel, Wolfgang, Dekant, Wolfgang
Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and is suspected to be stable in the environment with possible widespread human exposures. This study reports the characterization of...
Ellen Angela Straube's thesis (doctoral) - Universität, Würzburg.
Licata, Amy Collins, Dekant, Wolfgang, Smith, Charles E., Borghoff, Susan J.
Methyl tert-butyl ether (MTBE) is added to gasoline to reduce carbon monoxide and ozone precursors from automobile emissions. The objectives of this study were to verify the ability of a...
Disposition and Biotransformation of the Estrogenic Isoflavone Daidzein in Rats (2001)
Bayer, Tanja, Colnot, Thomas, Dekant, Wolfgang
Daidzein is an estrogenic isoflavone present in many plants and therefore consumed in relatively high doses by humans. Daidzein has a low affinity for the estrogen receptor (3 orders of magnitude...
Ochratoxin A-Induced Tumor Formation: Is There a Role of Reactive Ochratoxin A Metabolites? (2001)
Zepnik, Herbert, Pähler, Axel, Schauer, Ute, Dekant, Wolfgang
Ochratoxin A is a nephrotoxic and tumorigenic mycotoxin which contaminates a variety of food items, resulting in chronic human exposure. Biotransformation reactions have been implicated in the...
Toxicokinetics of Methyl tert-Butyl Ether and Its Metabolites in Humans after Oral Exposure (2001)
Amberg, Alexander, Rosner, Elisabeth, Dekant, Wolfgang
Methyl tert-butyl ether (MTBE) is widely used as an additive to gasoline, to increase oxygen content and reduce tailpipe emission of pollutants. Widespread human exposure to MTBE may occur due to...
Biotransformation and Kinetics of Excretion of Ethyl tert-Butyl Ether in Rats and Humans (2000)
Amberg, Alexander, Rosner, Elisabeth, Dekant, Wolfgang
Ethyl tert-butyl ether (ETBE) may be used in the future as an additive to gasoline to increase oxygen content and reduce tailpipe emissions of pollutants. Therefore, widespread human exposure may...
Blumbach, Kai, Pähler, Axel, Deger, H. M., Dekant, Wolfgang
Dimethyl methylphosphonate (DMMP) is a widely used chemical. Diethyl ethylphosphonate (DEEP) has been proposed as a replacement for DMMP in several applications. A long-term carcinogenesis study with...
Amberg, Alexander, Rosner, Elisabeth, Dekant, Wolfgang
tert-Amyl methyl ether (TAME) may be widely used as an additive to gasoline in the future. The presence of this ether in gasoline reduces the tail pipe emission of pollutants. Therefore, widespread...
Biotransformation of the Fungicide Chlorthalonil by Glutathione Conjugation (1996)
ROSNER, ELISABETH, KLOS, CHRISTA, DEKANT, WOLFGANG
The biotransformation of the nephrotoxic fungicide chlorthalonil (2,4,5,6-tetrachloroisophthalonitril) has been studied in the rat and in rat liver subcellular fractions. In rat liver cytosol,...
Würzburg, Univ., Habil.-Schr., 1988.
Mikroreprod. e. Ms. 144 Bl. : graph. Darst.