Wolfgang Maier

Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial (2009)

Perroud, Nader, Uher, Rudolf, Marusic, Andrej, Rietschel, Marcella, Mors, Ole, Henigsberg, Neven, ...

Abstract Background Suicidal thoughts and behaviours during antidepressant treatment, especially during the first weeks of treatment, have prompted warnings by regulatory bodies. The aim of the...

The German MultiCare-study: Patterns of multimorbidity in primary health care – protocol of a prospective cohort study (2009)

Schäfer, Ingmar, Hansen, Heike, Schön, Gerhard, Maier, Wolfgang, Höfels, Susanne, Altiner, Attila, ...

Abstract Background Multimorbidity is a highly frequent condition in older people, but well designed longitudinal studies on the impact of multimorbidity on patients and the health care system have...

Un Algorithme d'Analyse de Type Earley pour Grammaires à Concaténation d'Intervalles (2009)

Kallmeyer, Laura, Maier, Wolfgang, Parmentier, Yannick

Nous présentons ici différents algorithmes d'analyse pour grammaires à concaténation d'intervalles (Range Concatenation Grammar, RCG), dont un nouvel algorithme de type Earley, dans le paradigme...

Un Algorithme d'Analyse de Type Earley pour Grammaires à Concaténation d'Intervalles (2009)

Kallmeyer, Laura, Maier, Wolfgang, Parmentier, Yannick

Nous présentons ici différents algorithmes d'analyse pour grammaires à concaténation d'intervalles (Range Concatenation Grammar, RCG), dont un nouvel algorithme de type Earley, dans le paradigme...

Noradrenergic enhancement of amygdala responses to fear (2009)

Onur, Oezguer A., Walter, Henrik, Schlaepfer, Thomas E., Rehme, Anne K., Schmidt, Christoph, Keysers, Christian, ...

Multiple lines of evidence implicate the basolateral amygdala (BLA) and the noradrenergic (norepinephrine, NE) system in responding to stressful stimuli such as fear signals, suggesting hyperfunction...

Reduced 5-HT2A receptor signaling following selective bilateral amygdala damage (2009)

Hurlemann, René, Schlaepfer, Thomas E., Matusch, Andreas, Reich, Harald, Shah, Nadim J., Zilles, Karl, ...

Neurobiological evidence implicates the amygdala as well as serotonergic (serotonin, 5-HT) signaling via postsynaptic 5-HT2A receptors as essential substrates of anxiety behaviors. Assuming a...

Abstract Transition to Schizophrenia and Related Disorders: Toward a Taxonomy of Risk (2008)

Wolfgang Maier, Barbara A. Cornblatt, Kathleen R. Merijamgas

The early detection and prevention of schizophrenia and other psychotic disorders are receiving rapidly growing attention subsequent to the suggestion that poorer outcome is associated with delayed...

TuLiPA: Towards a Multi-Formalism Parsing Environment for Grammar Engineering (2008)

Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Parmentier, Yannick, Dellert, Johannes, Evang, Kilian

In this paper, we present an open-source parsing environment (Tuebingen Linguistic Parsing Architecture, TuLiPA) which uses Range Concatenation Grammar (RCG) as a pivot formalism, thus opening the...

Rare extracranial localization of primary intracranial neoplasm (2008)

Arndt, Susan, Wiech, Thorsten, Mader, Irina, Aschendorff, Antje, Maier, Wolfgang

Abstract Meningioma, craniopharyngeoma and glioma are mainly intracranial lesions. Nevertheless, in rare cases these entities may occur solely as extracranial lesions that may present as...

G72 and its association with major depression and neuroticism in large population-based groups from Germany (2008)

Rietschel, Marcella, Beckmann, Lars, Strohmeier, Jana, Georgi, Alexander, Karpushova, Anna, Schirmbeck, Frederike, ...

OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be...

Developing a TT-MCTAG for German with an RCG-based Parser (2008)

Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Parmentier, Yannick, Dellert, Johannes

Developing linguistic resources, in particular grammars, is known to be a complex task in itself, because of (amongst others) redundancy and consistency issues. Furthermore some languages can reveal...

Developing a TT-MCTAG for German with an RCG-based Parser (2008)

Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Parmentier, Yannick, Dellert, Johannes

Developing linguistic resources, in particular grammars, is known to be a complex task in itself, because of (amongst others) redundancy and consistency issues. Furthermore some languages can reveal...

TuLiPA: Towards a Multi-Formalism Parsing Environment for Grammar Engineering (2008)

Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Parmentier, Yannick, Dellert, Johannes, Evang, Kilian

In this paper, we present an open-source parsing environment (Tuebingen Linguistic Parsing Architecture, TuLiPA) which uses Range Concatenation Grammar (RCG) as a pivot formalism, thus opening the...

TuLiPA: A Syntax-Semantics Parsing Environment for Mildly Context-Sensitive Formalisms (2008)

Parmentier, Yannick, Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Dellert, Johannes

In this paper we present a parsing architecture that allows processing of different mildly context-sensitive formalisms, in particular Tree-Adjoining Grammar (TAG), Multi-Component Tree-Adjoining...

TuLiPA: Towards a Multi-Formalism Parsing Environment for Grammar Engineering (2008)

Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Parmentier, Yannick, Dellert, Johannes, Evang, Kilian

In this paper, we present an open-source parsing environment (Tuebingen Linguistic Parsing Architecture, TuLiPA) which uses Range Concatenation Grammar (RCG) as a pivot formalism, thus opening the...

TuLiPA: A Syntax-Semantics Parsing Environment for Mildly Context-Sensitive Formalisms (2008)

Parmentier, Yannick, Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang, Dellert, Johannes

In this paper we present a parsing architecture that allows processing of different mildly context-sensitive formalisms, in particular Tree-Adjoining Grammar (TAG), Multi-Component Tree-Adjoining...

Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)

Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder (2008)

Cichon, Sven, Winge, Ingeborg, Mattheisen, Manuel, Georgi, Alexander, Karpushova, Anna, Freudenberg, Jan, ...

The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is controlled by...

Polyphyly and two emerging lineages in the rust genera Puccinia and Uromyces (2007)

Maier, Wolfgang, Wingfield, Brenda D., Mennicken, Mechthilde, Wingfield, Michael J.

The phylogenetic validity of Puccinia and Uromyces, Pucciniaceae, and closely related genera was evaluated using nucLSU rDNA sequences. Using a wide range of rust species with different life cycles...

Polyphyly and two emerging lineages in the rust genera Puccinia and Uromyces (2007)

Maier, Wolfgang, Wingfield, Brenda D., Mennicken, Mechthilde, Wingfield, Michael J.

The phylogenetic validity of Puccinia and Uromyces, Pucciniaceae, and closely related genera was evaluated using nucLSU rDNA sequences. Using a wide range of rust species with different life cycles...

XMG: eXtending MetaGrammars to MCTAG (2007)

Parmentier, Yannick, Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang

In this paper, we introduce an extension of the XMG system (eXtensible MetaGrammar) in order to allow for the description of Multi-Component Tree Adjoining Grammars. In particular, we introduce the...

XMG: eXtending MetaGrammars to MCTAG (2007)

Parmentier, Yannick, Kallmeyer, Laura, Lichte, Timm, Maier, Wolfgang

In this paper, we introduce an extension of the XMG system (eXtensible MetaGrammar) in order to allow for the description of Multi-Component Tree Adjoining Grammars. In particular, we introduce the...

Dynamische Darstellung der Colonmotilität mittels funktioneller cine-MRT (2006)

Maier, Wolfgang

Gastrointestinale Störungen sind ein weit verbreitetes Problem in der Bevöl-kerung. Die diagnostischen Möglichkeiten zur Darstellung der Colonmotilität sind allerdings bisher unzureichend. Diese...

Dynamische Darstellung der Colonmotilität mittels funktioneller cine-MRT (2006)

Maier, Wolfgang

Gastrointestinale Störungen sind ein weit verbreitetes Problem in der Bevöl-kerung. Die diagnostischen Möglichkeiten zur Darstellung der Colonmotilität sind allerdings bisher unzureichend. Diese...

Radiation-induced leiomyosarcoma of the oropharynx (2006)

Pfeiffer, Jens, Boedeker, Carsten, Ridder, Gerd, Maier, Wolfgang, Kayser, Gian

Abstract Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the...

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. (2006)

Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...

Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...

A disease epidemic on Zizyphus mucronata in the Kruger National Park caused by Coniodictyum chevalieri (2006)

Wolfgang Maier, Thembi Khoza, Neil Harmse, Brenda D. Wingfield, Michael J. Wingfield

This study records a severe outbreak of a disease on Zizyphus mucronata (Rhamnaceae) in Greater Kruger National Park, South Africa. The causal agent of the disease was found to be Coniodictyum...

A disease epidemic on Zizyphus mucronata in the Kruger National Park caused by Coniodictyum chevalieri (2006)

Wolfgang Maier, Thembi Khoza, Neil Harmse, Brenda D. Wingfield, Michael J. Wingfield

This study records a severe outbreak of a disease on Zizyphus mucronata (Rhamnaceae) in Greater Kruger National Park, South Africa. The causal agent of the disease was found to be Coniodictyum...

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. (2006)

Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...

Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...

Is it really that difficult to parse German (2006)

Ra Kübler, Erhard W. Hinrichs, Wolfgang Maier

This paper presents a comparative study of probabilistic treebank parsing of German, using the Negra and TüBa-D/Z treebanks. Experiments with the Stanford parser, which uses a factored PCFG and...

3.2 Two-Stack Pushdown Automata (2-SA) (2006)

Hauptseminar Wintersemester, Laura Kallmeyer, Wolfgang Maier

Shieber et al. (1995), especially sections 1–4: Application of parsing schemata to various algorithms.

Annotation schemes and their influence on parsing results (2006)

Wolfgang Maier

Most of the work on treebank-based statistical parsing exclusively uses the Wall-Street-Journal part of the Penn treebank for evaluation purposes. Due to the presence of this quasi-standard, the...

Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. (2006)

Etain, Bruno, Mathieu, Flavie, Rietschel, Marcella, Maier, Wolfgang, Albus, Margot, Mckeon, Patrick, ...

Preliminary studies suggested that age at onset (AAO) may help to define homogeneous bipolar affective disorder (BPAD) subtypes. This candidate symptom approach might be useful to identify...

Cognitive Improvement in Schizophrenic Patients does not Require a Serotonergic Mechanism: Randomized Controlled (2005)

Michael Wagner, Boris B Quednow, Jens Westheide, Thomas E Schlaepfer, Wolfgang Maier, ...

Combined serotonin-2A (5-HT2A) and dopamine-2 (D2) receptor blockade has been proposed as a candidate mechanism by which second-generation antipsychotics (SGAs) improve both cognition and negative...

Whole genome linkage scan of recurrent depressive disorder from the depression network study (2005)

McGuffin, Peter, Knight, Jo, Breen, Gerome, Brewster, Shyama, Boyd, Peter R., Craddock, Nick, ...

Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where...

The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study (2004)

Farmer, Anne, Breen, Gerome, Brewster, Shyama, Craddock, Nick, Gill, Mike, Korszun, Ania, ...

Abstract Background The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in...

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia (2003)

Lewis, Cathryn M, Levinson, Douglas F, Wise, Lesley H, DeLisi, Lynn E, Straub, Richard E, Hovatta, Iiris, ...

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Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence (2003)

Franke,Petra, Wendel,Birgit, Knapp,Michael, Schwab,Sybille G., Neef,Daniela, Maier,Wolfgang, ...

Objective: In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer...

Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence (2003)

Franke, Petra, Wendel, Birgit, Knapp, Michael, Schwab, Sybille G., Neef, Daniela, Maier, Wolfgang, ...

Objective: In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer...

Can long-range microsatellite data be used to predict short-range linkage disequilibrium? (2002)

Schulze, Thomas G., Chen, Yu-Sheng, Akula, Nirmala, Hennessy, Kathleen, Badner, Judith A., McInnis, Melvin G., ...

The distribution of linkage disequilibrium (LD) across the genome is highly complex. Little is known about the relationship between long-range and short-range LD in a genomic region. We assessed...

A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q (2001)

Cichon, Sven, Schumacher, Johannes, Müller, Daniel J., Hürter, Martina, Windemuth, Christine, Strauch, Konstantin, ...

Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of...

Die Evolution der Halbaffen und Affen (2000)

Maier, Wolfgang

Studium Generale Vorlesung im WS 2000/2001; Donnerstag, 02. November 2000

Die Evolution der Halbaffen und Affen (2000)

Maier, Wolfgang

Studium Generale Vorlesung im WS 2000/2001; Donnerstag, 02. November 2000

Adverse effects associated with the short-term treatment of panic disorder with imipramine, alprazolam or placebo (1994)

Cassano, Giovanni B., Toni, Cristina, Petracca, Alberto, Deltito, Joseph, Benkert, Otto, Curtis, George C, ...

Side effects play a significant role in the selection of drugs to be used in panic disorder/agoraphobia whose polyphobic symptomatology often includes a suspiciousness about taking drugs and a fear...

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

McQueen, Matthew B., Devlin, B., Faraone, Stephen V., Nimgaonkar, Vishwajit L., Sklar, Pamela, Smoller, Jordan W., ...

Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis...

Radiation-induced leiomyosarcoma of the oropharynx

Pfeiffer, Jens, Boedeker, Carsten Christof, Ridder, Gerd Jürgen, Maier, Wolfgang, Kayser, Gian

Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international...

On the development of the shoulder girdle in Crocidura russula (Soricidae) and other placental mammals: evolutionary and functional aspects

Großmann, Martin, Sánchez-Villagra, Marcelo R, Maier, Wolfgang

The development of the shoulder girdle was studied in embryonic stages and a neonate of Crocidura russula using histological sections and 3-D reconstructions. Neonatal stages of Suncus etruscus and...

Support for Association of Schizophrenia with Genetic Variation in the 6p22.3 Gene, Dysbindin, in Sib-Pair Families with Linkage and in an Additional Sample of Triad Families

Schwab, Sibylle G., Knapp, Michael, Mondabon, Stephanie, Hallmayer, Joachim, Borrmann-Hassenbach, Margitta, Albus, Margot, ...

Genetic variants in a gene on 6p22.3, dysbindin, have been shown recently to be associated with schizophrenia (Straub et al. 2002a). There is no doubt that replication in other independent samples...

The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease

Van Den Bogaert, Ann, Schumacher, Johannes, Schulze, Thomas G., Otte, Andreas C., Ohlraun, Stephanie, Kovalenko, Svetlana, ...

We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of...

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

Lewis, Cathryn M., Levinson, Douglas F., Wise, Lesley H., DeLisi, Lynn E., Straub, Richard E., Hovatta, Iiris, ...

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To...

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder

Segurado, Ricardo, Detera-Wadleigh, Sevilla D., Levinson, Douglas F., Lewis, Cathryn M., Gill, Michael, ...

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an...

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

McQueen, Matthew B., Devlin, B., Faraone, Stephen V., Nimgaonkar, Vishwajit L., Sklar, Pamela, Smoller, Jordan W., ...

Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis...

Radiation-induced leiomyosarcoma of the oropharynx

Pfeiffer, Jens, Boedeker, Carsten Christof, Ridder, Gerd Jürgen, Maier, Wolfgang, Kayser, Gian

Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international...

On the development of the shoulder girdle in Crocidura russula (Soricidae) and other placental mammals: evolutionary and functional aspects

Großmann, Martin, Sánchez-Villagra, Marcelo R, Maier, Wolfgang

The development of the shoulder girdle was studied in embryonic stages and a neonate of Crocidura russula using histological sections and 3-D reconstructions. Neonatal stages of Suncus etruscus and...

A disease epidemic on Zizyphus mucronata in the Kruger National Park caused by Coniodictyum chevalieri

Maier, Wolfgang, Khoza, Thembi, Harmse, Neil, Wingfield, Brenda D., Wingfield, Michael J.

This study records a severe outbreak of a disease on Zizyphus mucronata (Rhamnaceae) in Greater Kruger National Park, South Africa. The causal agent of the disease was found to be Coniodictyum...

Rare extracranial localization of primary intracranial neoplasm

Arndt, Susan, Wiech, Thorsten, Mader, Irina, Aschendorff, Antje, Maier, Wolfgang

Meningioma, craniopharyngeoma and glioma are mainly intracranial lesions. Nevertheless, in rare cases these entities may occur solely as extracranial lesions that may present as intranasal/sinusoidal...

Clinical Features of Paraganglioma Syndromes

Boedeker, Carsten Christof, Neumann, Hartmut P.H., Offergeld, Christian, Maier, Wolfgang, Falcioni, Maurizio, Berlis, Ansgar, ...

Head and neck paragangliomas (HNPs) and pheochromocytomas are rare tumors. Sporadic and hereditary forms are recognized. Four different paraganglioma syndromes (PGLs 1–4) have been described: PGL 1...

Juxtacondylar Approach in Temporal Paraganglioma Surgery: When and Why?

Schipper, Joerg, Spetzger, Uwe, Tatagiba, Marcos, Rosahl, Steffen, Neumann, Hartmut P.H., Boedeker, Carsten Christof, ...

As it became clear that patients with paraganglioma (PGL) syndromes had a higher risk of multifocal tumors, we changed our surgical strategy to avoid the possibility of bilateral cranial nerve...