Systematic identification of regulatory proteins critical for T-cell activation (2003)
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Abstract Background The activation of T cells, mediated by the T-cell receptor (TCR), activates a battery of specific membrane-associated, cytosolic and nuclear proteins. Identifying the signaling...
Systematic identification of regulatory proteins critical for T-cell activation
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Systematic identification of regulatory proteins critical for T-cell activation
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Holland, Sacha J., Liao, X. Charlene, Mendenhall, Marcy K., Zhou, Xiulan, Pardo, Jorge, Chu, Peter, ...
In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed and performed a large-scale retroviral-based functional screen to select for proteins that...
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
Liao, X. Charlene, Fournier, Sylvie, Killeen, Nigel, Weiss, Arthur, Allison, James P., Littman, Dan R.
CD28 is a cell surface molecule that mediates a costimulatory signal crucial for T cell proliferation and lymphokine production. The signal transduction mechanisms of CD28 are not well understood....
Itk and Fyn Make Independent Contributions to T Cell Activation
Liao, X. Charlene, Littman, Dan R., Weiss, Arthur
Itk is a member of the Btk/Tec/Itk family of nonreceptor protein tyrosine kinases (PTKs), and has been implicated in T cell antigen receptor (TCR) signal transduction. Lck and Fyn are the Src-family...