Xavier Didelot

Lineage specific recombination rates and microevolution in Listeria monocytogenes (2008)

Den Bakker, Henk C, Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin

Abstract Background The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread...

Inference of Bacterial Microevolution Using Multilocus Sequence Data

Didelot, Xavier, Falush, Daniel

We describe a model-based method for using multilocus sequence data to infer the clonal relationships of bacteria and the chromosomal position of homologous recombination events that disrupt a clonal...

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: Convergence or divergence by homologous recombination?

Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel

All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...

Mismatch induced speciation in Salmonella: model and data

Falush, Daniel, Torpdahl, Mia, Didelot, Xavier, Conrad, Donald F, Wilson, Daniel J, Achtman, Mark

In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations...

Mosaic DNA Imports with Interspersions of Recipient Sequence after Natural Transformation of Helicobacter pylori

Kulick, Stefan, Moccia, Claudia, Didelot, Xavier, Falush, Daniel, Kraft, Christian, Suerbaum, Sebastian

Helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. H. pylori is naturally competent for transformation by exogenous DNA, and...