Xavier Didelot

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring (2009)

Zhang, Junlong, Zhang, Fang, Didelot, Xavier, Bruce, Kimberley D, Cagampang, Felino R, Vatish, Manu, ...

Abstract Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is...

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring (2009)

Zhang, Junlong, Zhang, F. (Fang), Didelot, Xavier, Bruce, Kimberley D., Cagampang, Felino R., Vatish, Manu, ...

Background miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known...

Inferring genomic flux in bacteria (2009)

Didelot, Xavier, Darling, Aaron, Falush, Daniel

Acquisition and loss of genetic material are essential forces in bacterial microevolution. They have been repeatedly linked with adaptation of lineages to new lifestyles, and in particular,...

SimMLST: simulation of multi-locus sequence typing data under a neutral model (2009)

Didelot, Xavier, Lawson, Daniel, Falush, Daniel

Summary: Multi-locus sequence typing (MLST) is a widely used method of characterization of bacterial isolates. It has been applied to over 50 000 isolates in over 50 different species. Here, we...

Lineage specific recombination rates and microevolution in Listeria monocytogenes (2008)

Den Bakker, Henk C, Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin

Abstract Background The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread...

Lineage specific recombination rates and microevolution in Listeria monocytogenes (2008)

Den Bakker, Henk C., Didelot, Xavier, Fortes, Esther D, Nightingale, Kendra K, Wiedmann, Martin

Background: The bacterium Listeria monocytogenes is a saprotroph as well as an opportunistic human foodborne pathogen, which has previously been shown to consist of at least two widespread lineages...

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: Convergence or divergence by homologous recombination? (2007)

Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel

All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...

Multilocus sequence typing, BURST, genealogical inference, comparative genomics, recombination (2006)

Xavier Didelot, Daniel Falush, Key Words, Daniel Falush

We describe a model-based method for using multilocus sequence data to infer the clonal relation-ships of bacteria and the chromosomal position of homologous recombination events that disrupt a...

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: Convergence or divergence by homologous recombination (2006)

Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel

All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...

Inference of Bacterial Microevolution Using Multilocus Sequence Data

Didelot, Xavier, Falush, Daniel

We describe a model-based method for using multilocus sequence data to infer the clonal relationships of bacteria and the chromosomal position of homologous recombination events that disrupt a clonal...

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: Convergence or divergence by homologous recombination?

Didelot, Xavier, Achtman, Mark, Parkhill, Julian, Thomson, Nicholas R., Falush, Daniel

All Salmonella can cause disease but severe systemic infections are primarily caused by a few lineages. Paratyphi A and Typhi are the deadliest human restricted serovars, responsible for ∼600,000...

Mismatch induced speciation in Salmonella: model and data

Falush, Daniel, Torpdahl, Mia, Didelot, Xavier, Conrad, Donald F, Wilson, Daniel J, Achtman, Mark

In bacteria, DNA sequence mismatches act as a barrier to recombination between distantly related organisms and can potentially promote the cohesion of species. We have performed computer simulations...

Mosaic DNA Imports with Interspersions of Recipient Sequence after Natural Transformation of Helicobacter pylori

Kulick, Stefan, Moccia, Claudia, Didelot, Xavier, Falush, Daniel, Kraft, Christian, Suerbaum, Sebastian

Helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. H. pylori is naturally competent for transformation by exogenous DNA, and...

Inferring genomic flux in bacteria

Didelot, Xavier, Darling, Aaron, Falush, Daniel

Acquisition and loss of genetic material are essential forces in bacterial microevolution. They have been repeatedly linked with adaptation of lineages to new lifestyles, and in particular,...