Mechanism of meningeal invasion by Neisseria meningitidis (2008)
No abstract available.
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins (2004)
Morand,Philippe C., Bille,Emmanuelle, Morelle,Sandrine, Eugene,Emmanuel, Beretti,Jean-Luc, Wolfgang,Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins (2004)
Morand, Philippe C., Bille, Emmanuelle, Morelle, Sandrine, Eugene, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Méningites bactériennes : stratégies de traitement et de prévention (1996)
Clavaud, Renée, Geslin, Pierre, Gicquel, Brigitte, Guerin, Nicole, Livartowski, Alain, Nassif, Xavier, ...
152 pages, figures, illustrations en couleurs, graphiques
Pujol, Céline, Eugène, Emmanuel, Marceau, Michaël, Nassif, Xavier
The ability of Neisseria meningitidis (MC) to interact with cellular barriers is essential to its pathogenesis. With epithelial cells, this process has been modeled in two steps. The initial stage of...
Role of Glycosylation at Ser63 in Production of Soluble Pilin in Pathogenic Neisseria
Marceau, Michael, Nassif, Xavier
Pilus-mediated adhesion is essential in the pathogenesis of Neisseria meningitidis (MC) and Neisseria gonorrhoeae (GC). Pili are assembled from a protein subunit called pilin. Pilin is a...
Perrin, Agnes, Nassif, Xavier, Tinsley, Colin
Neisseria meningitidis and Neisseria gonorrhoeae give rise to dramatically different diseases. Their interactions with the host, however, do share common characteristics: they are both human...
Klee, Silke R., Nassif, Xavier, Kusecek, Barica, Merker, Petra, Beretti, Jean-Luc, Achtman, Mark, ...
The pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae cause dramatically different diseases despite strong relatedness at the genetic and biochemical levels. N. meningitidis can...
Bonacorsi, Stéphane Pierre Paul, Clermont, Olivier, Tinsley, Colin, Le Gall, Isabelle, Beaudoin, Jean-Christophe, Elion, Jacques, ...
Specific virulence factors associated with the pathogenesis of Escherichia coli strains causing neonatal meningitis (ECNM), such as the K1 capsular polysaccharide, the S fimbriae, and the Ibe10...
Mutagenesis of Neisseria meningitidis by In Vitro Transposition of Himar1 mariner
Pelicic, Vladimir, Morelle, Sandrine, Lampe, David, Nassif, Xavier
Now that the meningococcal genome sequence has been completed, the lack of a suitable method for saturation mutagenesis remains a major obstacle to the unraveling of the pathogenic propensity of...
Houdouin, Véronique, Bonacorsi, Stéphane, Brahimi, Naima, Clermont, Olivier, Nassif, Xavier, Bingen, Edouard
We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI IC5 that is similar to the PAI IIJ96 of uropathogenic E. coli...
Blanc-Potard, Anne-Beatrice, Tinsley, Colin, Scaletsky, Isabel, Le Bouguenec, Chantal, Guignot, Julie, Servin, Alain L., ...
Diffusely adhering Escherichia coli strains harboring Afa/Dr adhesins (Afa/Dr DAEC) have been associated with diarrhea and urinary tract infections (UTIs). The present work is the first extensive...
Perrin, Agnès, Bonacorsi, Stéphane, Carbonnelle, Etienne, Talibi, Driss, Dessen, Philippe, Nassif, Xavier, ...
Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges. The...
Neisseria meningitidis RTX Proteins Are Not Required for Virulence in Infant Rats
Forman, Stanislav, Linhartova, Irena, Osicka, Radim, Nassif, Xavier, Sebo, Peter, Pelicic, Vladimir
RTX cytotoxins play an important role in virulence of numerous gram-negative pathogens. Unexpectedly, however, we show here that the RTX proteins of Neisseria meningitidis are dispensable for...
Morelle, Sandrine, Carbonnelle, Etienne, Nassif, Xavier
Interaction with host cells is essential in meningococcal pathogenesis especially at the blood-brain barrier. This step is likely to involve a common regulatory pathway allowing coordinate regulation...
Nègre, Valérie Lefranc, Bonacorsi, Stéphane, Schubert, Soren, Bidet, Philippe, Nassif, Xavier, Bingen, Edouard
Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in...
Culture-Negative Pericarditis Caused by Neisseria meningitidis Serogroup C
Moumile, Kaoutar, Carbonnelle, Etienne, Dessemme, Philippe, Tamisier, Daniel, Iserin, Franck, Houdouin, Véronique, ...
We describe a case of primary purulent culture-negative pericarditis caused by Neisseria meningitidis serogroup C occurring in an 8-month-old previously healthy boy, which was detected in pericardial...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins
Morand, Philippe C, Bille, Emmanuelle, Morelle, Sandrine, Eugène, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Geoffroy, Marie-Claude, Floquet, Stéphanie, Métais, Arnaud, Nassif, Xavier, Pelicic, Vladimir
The biologic role of a majority of the Neisseria meningitidis 2100 predicted coding regions is still to be assigned or experimentally confirmed. Determining the phenotypic effect of gene disruption...
Pujol, Céline, Eugène, Emmanuel, Marceau, Michaël, Nassif, Xavier
The ability of Neisseria meningitidis (MC) to interact with cellular barriers is essential to its pathogenesis. With epithelial cells, this process has been modeled in two steps. The initial stage of...
Role of Glycosylation at Ser63 in Production of Soluble Pilin in Pathogenic Neisseria
Marceau, Michael, Nassif, Xavier
Pilus-mediated adhesion is essential in the pathogenesis of Neisseria meningitidis (MC) and Neisseria gonorrhoeae (GC). Pili are assembled from a protein subunit called pilin. Pilin is a...
Perrin, Agnes, Nassif, Xavier, Tinsley, Colin
Neisseria meningitidis and Neisseria gonorrhoeae give rise to dramatically different diseases. Their interactions with the host, however, do share common characteristics: they are both human...
Klee, Silke R., Nassif, Xavier, Kusecek, Barica, Merker, Petra, Beretti, Jean-Luc, Achtman, Mark, ...
The pathogenic species Neisseria meningitidis and Neisseria gonorrhoeae cause dramatically different diseases despite strong relatedness at the genetic and biochemical levels. N. meningitidis can...
Bonacorsi, Stéphane Pierre Paul, Clermont, Olivier, Tinsley, Colin, Le Gall, Isabelle, Beaudoin, Jean-Christophe, Elion, Jacques, ...
Specific virulence factors associated with the pathogenesis of Escherichia coli strains causing neonatal meningitis (ECNM), such as the K1 capsular polysaccharide, the S fimbriae, and the Ibe10...
Mutagenesis of Neisseria meningitidis by In Vitro Transposition of Himar1 mariner
Pelicic, Vladimir, Morelle, Sandrine, Lampe, David, Nassif, Xavier
Now that the meningococcal genome sequence has been completed, the lack of a suitable method for saturation mutagenesis remains a major obstacle to the unraveling of the pathogenic propensity of...
Houdouin, Véronique, Bonacorsi, Stéphane, Brahimi, Naima, Clermont, Olivier, Nassif, Xavier, Bingen, Edouard
We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI IC5 that is similar to the PAI IIJ96 of uropathogenic E. coli...
Blanc-Potard, Anne-Beatrice, Tinsley, Colin, Scaletsky, Isabel, Le Bouguenec, Chantal, Guignot, Julie, Servin, Alain L., ...
Diffusely adhering Escherichia coli strains harboring Afa/Dr adhesins (Afa/Dr DAEC) have been associated with diarrhea and urinary tract infections (UTIs). The present work is the first extensive...
Perrin, Agnès, Bonacorsi, Stéphane, Carbonnelle, Etienne, Talibi, Driss, Dessen, Philippe, Nassif, Xavier, ...
Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges. The...
Neisseria meningitidis RTX Proteins Are Not Required for Virulence in Infant Rats
Forman, Stanislav, Linhartova, Irena, Osicka, Radim, Nassif, Xavier, Sebo, Peter, Pelicic, Vladimir
RTX cytotoxins play an important role in virulence of numerous gram-negative pathogens. Unexpectedly, however, we show here that the RTX proteins of Neisseria meningitidis are dispensable for...
Morelle, Sandrine, Carbonnelle, Etienne, Nassif, Xavier
Interaction with host cells is essential in meningococcal pathogenesis especially at the blood-brain barrier. This step is likely to involve a common regulatory pathway allowing coordinate regulation...
Nègre, Valérie Lefranc, Bonacorsi, Stéphane, Schubert, Soren, Bidet, Philippe, Nassif, Xavier, Bingen, Edouard
Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in...
Culture-Negative Pericarditis Caused by Neisseria meningitidis Serogroup C
Moumile, Kaoutar, Carbonnelle, Etienne, Dessemme, Philippe, Tamisier, Daniel, Iserin, Franck, Houdouin, Véronique, ...
We describe a case of primary purulent culture-negative pericarditis caused by Neisseria meningitidis serogroup C occurring in an 8-month-old previously healthy boy, which was detected in pericardial...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins
Morand, Philippe C, Bille, Emmanuelle, Morelle, Sandrine, Eugène, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Geoffroy, Marie-Claude, Floquet, Stéphanie, Métais, Arnaud, Nassif, Xavier, Pelicic, Vladimir
The biologic role of a majority of the Neisseria meningitidis 2100 predicted coding regions is still to be assigned or experimentally confirmed. Determining the phenotypic effect of gene disruption...
Bidet, Philippe, Metais, Arnaud, Mahjoub-Messai, Farah, Durand, Lionel, Dehem, Marie, Aujard, Yannick, ...
Closely related Escherichia coli B2 strains O1:K1, O2:K1, O18:K1, and O45:K1 constitute a major subgroup causing extraintestinal infections. A DNA pathoarray analysis was used to develop a PCR...
Durant, Lionel, Metais, Arnaud, Soulama-Mouze, Coralie, Genevard, Jean-Marie, Nassif, Xavier, Escaich, Sonia
Extraintestinal pathogenic Escherichia coli (ExPEC) strains cause a large spectrum of infections. The majority of ExPEC strains are closely related to the B2 or the D phylogenetic group. The aim of...
Carbonnelle, Etienne, Beretti, Jean-Luc, Cottyn, Stéphanie, Quesne, Gilles, Berche, Patrick, Nassif, Xavier, ...
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) of intact bacteria yields a reproducible spectrum depending upon growth conditions, strain, or species....
Doulet, Nicolas, Donnadieu, Emmanuel, Laran-Chich, Marie-Pierre, Niedergang, Florence, Nassif, Xavier, Couraud, Pierre Olivier, ...
Neisseria meningitidis elicits the formation of membrane protrusions on vascular endothelial cells, enabling its internalization and transcytosis. We provide evidence that this process interferes...
Mairey, Emilie, Genovesio, Auguste, Donnadieu, Emmanuel, Bernard, Christine, Jaubert, Francis, Pinard, Elisabeth, ...
Neisseria meningitidis is a commensal bacterium of the human nasopharynx. Occasionally, this bacterium reaches the bloodstream and causes meningitis after crossing the blood–brain barrier by an...
Chamot-Rooke, Julia, Rousseau, Benoit, Lanternier, Fanny, Mikaty, Guillain, Mairey, Emilie, Malosse, Christian, ...
The importance of protein glycosylation in the interaction of pathogenic bacteria with their host is becoming increasingly clear. Neisseria meningitidis, the etiological agent of cerebrospinal...
A chromosomally integrated bacteriophage in invasive meningococci
Bille, Emmanuelle, Zahar, Jean-Ralph, Perrin, Agnes, Morelle, Sandrine, Kriz, Paula, Jolley, Keith A., ...
Cerebrospinal meningitis is a feared disease that can cause the death of a previously healthy individual within hours. Paradoxically, the causative agent, Neisseria meningitidis, is a common...
Helaine, Sophie, Dyer, David H., Nassif, Xavier, Pelicic, Vladimir, Forest, Katrina T.
Type IV pili (Tfp) are widespread filamentous bacterial organelles that mediate multiple virulence-related phenotypes. They are composed mainly of pilin subunits, which are processed before filament...
Hoffmann, Isabelle, Eugène, Emmanuel, Nassif, Xavier, Couraud, Pierre-Olivier, Bourdoulous, Sandrine
ErbB2 is a receptor tyrosine kinase belonging to the family of epidermal growth factor (EGF) receptors which is generally involved in cell differentiation, proliferation, and tumor growth, and...