Xia Wang

Publication List Details

Period

1994 - 2009

Number

79

Co-Authors

Multipathogen infections in hospitalized children with acute respiratory infections (2009)

Peng, Dan, Zhao, Dongchi, Liu, Jingtao, Wang, Xia, Yang, Kun, Xicheng, Hong, ...

Abstract Background To explore the epidemiologic and clinical features of, and interactions among, multipathogen infections in hospitalized children with acute respiratory tract infection (ARTI). A...

oWSD: A Tool for Word Sense Disambiguation in Its Ontology Context (2009)

Xia Wang

Word sense disambiguation (abbr. WSD) is very important to the semantic web/web 2.0. However, there is still no easy-to-use tool available. As a remedy, here a simple and very efficient tool called...

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib (2009)

Steverding, Dietmar, Wang, Xia

Abstract The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei . The concentrations of bortezomib required to...

Animal Model Morpho-Regulation of Ectodermal Organs Integument Pathology and Phenotypic Variations in K14-Noggin Engineered Mice through Modulation of Bone Morphogenic Protein Pathway (2009)

Maksim Plikus, Wen Pin Wang, Jian Liu, Xia Wang, Ting-xin Jiang

Ectodermal organs are composed of keratinocytes organized in different ways during induction, morphogenesis, differentiation, and regenerative stages. We hypothesize that an imbalance of fundamental...

Specification Synthesis for Monitoring and Analysis of MANET Protocols (2008)

Natalia Stakhanova, Samik Basu, Wensheng Zhang, Xia Wang, Johnny Wong

This paper introduces an approach to automatic synthesis of the specification models of routing protocol behavior from the observed flow of the network traffic. In particular, our technique...

Specification Synthesis for Monitoring and Analysis of MANET Protocols (2008)

Natalia Stakhanova, Samik Basu, Wensheng Zhang, Xia Wang, Johnny Wong

This paper introduces an approach to automatic synthesis of the specification models of routing protocol behavior from the observed flow of the network traffic. In particular, our technique...

Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites (2008)

Wang, Xia, Jobe, Momodou, Tyler, Kevin M, Steverding, Dietmar

Abstract The disinfectants TriGene, bleach, ethanol and liquid hand soap, and water and temperature were tested for their ability to kill bloodstream forms of Trypanosoma brucei , epimastigotes of...

Criminal Justice Sentencing in Context: The Effect of Social Environment on Courtroom Decision-Making (2008)

Wang, Xia

This dissertation contributes to an emerging literature in criminology on sentencing and contextual effects, first by unpacking the direct and conditioning effects of social context on sentencing...

Preference and Performance of Anagrus nilaparvatae (Hymenoptera: Mymaridae): Effect of Infestation Duration and Density by Nilaparvata lugens (Homoptera: Delphacidae) (2008)

Caiyu Xiang, Nan Ren, Xia Wang, Afsheen Sumera, Jiaan Cheng, Yonggen Lou

The effect of Nilaparvata lugens (Stål) infestation duration and density on the host preference and performance of Anagrus nilaparvatae Pang et Wang, an egg parasitoid of rice planthoppers, was...

Thesis: Can ECN Be Used to Differentiate Congestion Losses from Wireless Losses? (2008)

Xia Wang, Advisor Professor, Johnny S. Wong

interests response, key management, TCP performance and congestion control in wireless networks.

Similarity Measurement about Ontology-based Semantic Web Services (2008)

Xia Wang

Measurement of semantic similarity between Web services is an important factor for Web service discovery, composition, and even execution. Semantic Web services (SWS) are usually specified based on...

Specification Synthesis for Monitoring and Analysis of MANET Protocols (2008)

Natalia Stakhanova, Samik Basu, Wensheng Zhang, Xia Wang, Johnny Wong

This paper introduces an approach to automatic synthesis of the specification models of routing protocol behavior from the observed flow of the network traffic. In particular, our technique...

Feature Selection in Intrusion Detection System over Mobile Ad-hoc Network (2008)

Xia Wang, Tu-liang Lin, Johnny Wong

As Mobile ad-hoc network (MANET) has become a very important technology the security problem, especially, intrusion detection technique research has attracted many people’s effort. MANET is more...

Persistent spin currents in electron systems with spin-orbit interaction (2008)

Zhou, Xiang, Hu, Cheng-Zheng, Zhang, Zhenyu, Miao, Ling, Wang, Xia

We investigate the persistent spin currents in one- and two-dimensional electron systems with spin-orbit interaction in thermodynamics equilibrium at absolute zero temperature. The persistent spin...

Feature Selection in Mobile Ad-hoc Network Intrusion Detection System (2008)

Xia Wang, Tu-liang Lin

As Mobile ad-hoc network (MANET) has become a very important technology the security problem, especially, intrusion detection technique research has attracted many people’s effort. MANET is more...

6-Amino-3-methyl-4-(4-nitrophenyl)-1-phenylpyrazolo[3,4-b]pyridine-5-carbonitrile (2008)

Xin-Ying Zhang, Xiao-Yan Li, Xia Wang, Xue-Sen Fan, Gui-Rong Qu

The title compound, C20H14N6O2, contains four rings. The dihedral angle between the pyridine ring and the pyrazole ring is 1.9 (1)°, i.e. almost coplanar, which gives rise to a conjugated...

2-[(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-yl)(4-chlorophenyl)methyl]malononitrile (2008)

Xin-Ying Zhang, Xiao-Yan Li, Xia Wang, Dong-Fang Li, Xue-Sen Fan

In the crystal structure of the title compound, C20H16ClN5, the dihedral angle between the pyrazole ring and the phenyl ring is 54.7 (1)° and that between the pyrazole ring and the...

6,7-Dihydro-4-(4-methoxyphenyl)-3-methyl-6-oxo-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (2008)

Xin-Ying Zhang, Xiao-Yan Li, Xia Wang, Dong-Fang Li, Xue-Sen Fan

In the title compound, C21H16N4O2, the dihedral angle between the methoxy-substituted benzene ring and the ring system formed by the pyridinone ring and the pyrazole ring is 57.4 (1)°, and...

4-(4-Bromophenyl)-4,5,6,7-tetrahydro-3-methyl-6-oxo-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile ethanol solvate (2008)

Xue-Sen Fan, Xiao-Yan Li, Xia Wang, Dong-Fang Li, Xin-Ying Zhang

In the structure of the title compound, C20H15BrN4O·C2H6O, the hydrogenated pyridinone ring adopts an envelope conformation. The dihedral angle between the bromo-substituted phenyl ring and the...

Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells (2007)

Chen, Wenshu, Wang, Xia, Zhuang, Jianguo, Zhang, Lin, Lin, Yong

The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this...

Icosahedral quasicrystals for visible wavelengths by optical interference holography (2007)

Xu, Jun, Ma, Rui, Wang, Xia, Tam, Wing Yim

Quasicrystals, realized in metal alloys, are a class of lattices exhibiting symmetries that fall outside the usual classification for periodic crystals. They do not have translational symmetry and...

Three essays on technological capabilities and strategies in the United States biotechnology industry (2007)

Wang, Xia

The emergence of high-tech industries has created great interest in research on the firm's technological capabilities. This dissertation contributes to this line of research by empirically examining...

Investigation of Hoxa2 Gene Function in Palate Development Using a Retroviral Gene Delivery System (2006)

Wang, Xia

Cleft palate is a common human birth defect caused by any process which interferes with palatogenesis. Studies in Hoxa2 mutant (Hoxa2-/-) mice which exhibit a secondary cleft palate were reported to...

I.: A qos-aware selection model for semantic web services (2006)

Xia Wang, Tomas Vitvar, Mick Kerrigan, Ioan Toma

Abstract. Automating Service Oriented Architectures by augmenting them with semantics will form the basis of the next generation of computing. Selection of service still is an important challenge,...

The Wound-Response Mutant suppressor of prosystemin-mediated responses6 (spr6) Is a Weak Allele of the Tomato Homolog of CORONATINE-INSENSITIVE1 (COI1) (2006)

Li, Changbao, Zhao, Jiuhai, Jiang, Hongling, Wu, Xiaoyan, Sun, Jiaqiang, Zhang, Chunqing, ...

Systemic defense response of tomato plant in response to insect attack and wounding is regulated by the 18-amino-acid peptide systemin and the phytohormone jasmonic acid (JA). Recent genetic analyses...

The Wound Response Mutant suppressor of prosystemin-mediated responses6 (spr6) is a Weak Allele of the Tomato Homolog of CORONATINE-INSENSITIVE1 (COI1) (2006)

Li, Changbao, Zhao, Jiuhai, Jiang, Hongling, Wu, Xiaoyan, Sun, Jiaqiang, Zhang, Chunqing, ...

The systemic defense response of tomato plant in response to insect attack and wounding is regulated by the 18 amino acid peptide systemin and the phytohormone jasmonic acid (JA). Recent genetic...

Technological Characteristics and R&D Alliance Form: Evidence from the U.S. Biotechnology Industry (2005)

Wang, Xia

This study seeks to advance and test the knowledge-based theory of the firm as it applies to explaining the governance structure of R&D alliances. Unlike transaction-cost economics, the...

The Educational Deficiencies Of Florida's Juvenile Justice Students (2004)

Wang, Xia

The prior literature addressing delinquency and education while diverse consistently documents the relationship between poor school performance and delinquent behavior. However, the specific causes...

Can ECN Be Used to Differentiate Congestion Losses from Wireless Losses? (2004)

Saâd Biaz, Xia Wang

TCP was designed and tuned to work well on networks where losses are mainly congestion losses. The performance of TCP decreases dramatically when a TCP connection traverses a wireless link on which...

Specific inhibition of mouse oocyte nuclear protein phosphatase-1 stimulates germinal vesicle breakdown (2003)

Swain, Jason E., Wang, Xia, Saunders, Thomas L., Dunn, Rodney L., Smith, Gary D.

Okadaic acid (OA)-induced germinal vesicle breakdown (GVBD) and localization of protein phosphatase-1 (PP1) in oocyte nuclei are suggestive of PP1's role in regulating oocyte GVBD. To explore this...

Glycogen synthase kinase-3 regulates mouse oocyte homologue segregation (2003)

Wang, Xia, Liu, Xiao-Tie, Dunn, Rodney L., Ohl, Dana A., Smith, Gary D.

Intracellular regulation of oocyte meiosis is not completely understood. However, reversible phosphorylation, which involves serine/threonine protein kinases and phosphatases (PP), is an important...

RED for Improving TCP over Wireless Networks (2003)

Saâd Biaz, Xia Wang

TCP was designed and tuned to work well on networks where losses are mainly congestion losses. The performance of TCP decreases dramatically when a TCP connection traverses a wireless link on which...

Software Fault Tree and Colored Petri Net Based Specification, Design and Implementation of Agent-Based Intrusion Detection Systems (2002)

Guy Helmer, Johnny Wong, Mark Slagell, Vasant Honavar, Les Miller, Yanxin Wang, ...

Abstract: The integration of Software Fault Tree (SFT) which describes intrusions and Colored Petri Nets (CPNs) which specifies design, is examined for an Intrusion Detection System (IDS). The IDS...

Software Fault Tree and Colored Petri Net Based Specification, Design and Implementation of Agent-Based Intrusion Detection Systems (2002)

Guy Helmer, Johnny Wong, Mark Slagell, Vasant Honavar, Les Miller, Yanxin Wang, ...

The integration of Software Fault Tree (SFT) which describes intrusions and Colored Petri Nets (CPNs) which specifies design, is examined for an Intrusion Detection System (IDS). The IDS under...

Relationship between oxidative stress and embryotoxicity of hydrosalpingeal fluid (2002)

Bedaiwy, Mohamed A., Goldberg, Jeffrey M., Falcone, Tommaso, Singh, Mamta, Nelson, David, Azab, Hamdy, ...

BACKGROUND: Oxidative stress mechanisms are involved in the pathophysiology of many reproductive disorders. The objective of this study was to characterize oxidative stress parameters in...

Research in TCP performance and congestion control techniques in wireless network. (1999)

Xia Wang

Research of Interest Network security, intrusion detection system, TCP performance, congestion control, wireless ad hoc networks, and

Malignant Hemangiopericytoma Arising in Neurofibromatosis: A Case Report with Histological, Immunohistochemical and Ultrastructural Studies (1999)

Jun Wang, Hernan Vargas, Karl Gaal, Xia Wang, Shi-Kaung Peng

Subject. A 27-year-old Hispanic male with clinical manifestation of neurofibromatosis type 1 developed chronic constipation and urination difficulty along with recently increased abdominal bloating...

Fractionation of Drosophila RNA polymerase II transcription factors and molecular cloning of RNAP II transcription factordTFIIE (1996)

Wang, Xia

RNA polymerase II requires multiple general transcription factors to initiate site-specific transcription. The precise structure/function relationships within this system have yet to be elucidated....

Drosophila TFIIE: Purification, cloning, and functional reconstitution

Wang, Xia, Hansen, Stig K., Ratts, Ryan, Zhou, Sharleen, Snook, Amy J., Zehring, William

We present a physical and molecular genetic characterization of Drosophila melanogaster TFIIE (dTFIIE), a component of the basal RNA polymerase II transcription apparatus. We have purified dTFIIE to...

Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis

Whitman, Stephanie, Wang, Xia, Shalaby, Refaat, Shtivelman, Emma

The human gene CC3 is a metastasis suppressor for small cell lung carcinoma (SCLC) in vivo. The ability of CC3 to impair the apoptotic resistance of tumor cells is likely to contribute to metastasis...

Activation of the PAK-Related Kinase by Human Immunodeficiency Virus Type 1 Nef in Primary Human Peripheral Blood Lymphocytes and Macrophages Leads to Phosphorylation of a PIX-p95 Complex

Brown, Amanda, Wang, Xia, Sawai, Earl, Cheng-Mayer, Cecilia

Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication in both primary T lymphocytes and monocyte-derived macrophages. This enhancement phenotype has been linked to the ability of...

Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)

Ghosh, Siddhartha S., Lu, Yang, Lee, Sung W., Wang, Xia, Guha, Chandan, Roy-Chowdhury, Jayanta, ...

Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin. UGT1A1 deficiency causes CN-1...

Modeling for Gellan Gum Production by Sphingomonas paucimobilis ATCC 31461 in a Simplified Medium

Wang, Xia, Xu, Ping, Yuan, Yong, Liu, Changlong, Zhang, Dezhong, Yang, Zhengting, ...

Gellan gum production was carried out by Sphingomonas paucimobilis ATCC 31461 in a simplified medium with a short incubation time, and a kinetic model for understanding, controlling, and optimizing...

Drosophila TFIIE: Purification, cloning, and functional reconstitution

Wang, Xia, Hansen, Stig K., Ratts, Ryan, Zhou, Sharleen, Snook, Amy J., Zehring, William

We present a physical and molecular genetic characterization of Drosophila melanogaster TFIIE (dTFIIE), a component of the basal RNA polymerase II transcription apparatus. We have purified dTFIIE to...

Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis

Whitman, Stephanie, Wang, Xia, Shalaby, Refaat, Shtivelman, Emma

The human gene CC3 is a metastasis suppressor for small cell lung carcinoma (SCLC) in vivo. The ability of CC3 to impair the apoptotic resistance of tumor cells is likely to contribute to metastasis...

Activation of the PAK-Related Kinase by Human Immunodeficiency Virus Type 1 Nef in Primary Human Peripheral Blood Lymphocytes and Macrophages Leads to Phosphorylation of a PIX-p95 Complex

Brown, Amanda, Wang, Xia, Sawai, Earl, Cheng-Mayer, Cecilia

Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication in both primary T lymphocytes and monocyte-derived macrophages. This enhancement phenotype has been linked to the ability of...

Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)

Ghosh, Siddhartha S., Lu, Yang, Lee, Sung W., Wang, Xia, Guha, Chandan, Roy-Chowdhury, Jayanta, ...

Bilirubin glucuronidation, catalysed by UGT1A1 [UGT (UDP glucuronosyltransferase) isoform 1A1, EC 2.4.1.17], is critical for biliary elimination of bilirubin. UGT1A1 deficiency causes CN-1...

Modeling for Gellan Gum Production by Sphingomonas paucimobilis ATCC 31461 in a Simplified Medium

Wang, Xia, Xu, Ping, Yuan, Yong, Liu, Changlong, Zhang, Dezhong, Yang, Zhengting, ...

Gellan gum production was carried out by Sphingomonas paucimobilis ATCC 31461 in a simplified medium with a short incubation time, and a kinetic model for understanding, controlling, and optimizing...

Morpho-Regulation of Ectodermal Organs : Integument Pathology and Phenotypic Variations in K14-Noggin Engineered Mice through Modulation of Bone Morphogenic Protein Pathway

Plikus, Maksim, Wang, Wen Pin, Liu, Jian, Wang, Xia, Jiang, Ting-Xin, Chuong, Cheng-Ming

Ectodermal organs are composed of keratinocytes organized in different ways during induction, morphogenesis, differentiation, and regenerative stages. We hypothesize that an imbalance of fundamental...

Alanine–glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer

Salido, Eduardo C., Li, Xiao M., Lu, Yang, Wang, Xia, Santana, Alfredo, Roy-Chowdhury, Namita, ...

Mutations in the alanine–glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads...

Glycogen synthase kinase-3 regulation of chromatin segregation and cytokinesis in mouse preimplantation embryos

Acevedo, Nicole, Wang, Xia, Dunn, Rodney L., Smith, Gary D.

Glycogen synthase kinase-3 (GSK-3) is a highly conserved serine/threonine protein kinase implicated in diverse cellular processes. Activity of GSK-3 is essential for meiotic chromatin segregation in...

Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila

Wang, Xia, Green, David S., Roberts, Stephen P., De Belle, J. Steven

Environmental stress (nutritive, chemical, electromagnetic and thermal) has been shown to disrupt central nervous system (CNS) development in every model system studied to date. However, empirical...

Thermal Disruption of Mushroom Body Development and Odor Learning in Drosophila

Wang, Xia, Green, David S., Roberts, Stephen P., De Belle, J. Steven

Environmental stress (nutritive, chemical, electromagnetic and thermal) has been shown to disrupt central nervous system (CNS) development in every model system studied to date. However, empirical...

SDG714, a Histone H3K9 Methyltransferase, Is Involved in Tos17 DNA Methylation and Transposition in Rice[W]

Ding, Yong, Wang, Xia, Su, Lei, Zhai, JiXian, Cao, ShouYun, Zhang, DongFen, ...

Although the role of H3K9 methylation in rice (Oryza sativa) is unclear, in Arabidopsis thaliana the loss of histone H3K9 methylation by mutation of Kryptonite [also known as SU(VAR)3-9 homolog]...

Degradation of Carbazole by Microbial Cells Immobilized in Magnetic Gellan Gum Gel Beads▿

Wang, Xia, Gai, Zhonghui, Yu, Bo, Feng, Jinhui, Xu, Changyong, Yuan, Yong, ...

Polycyclic aromatic heterocycles, such as carbazole, are environmental contaminants suspected of posing human health risks. In this study, we investigated the degradation of carbazole by immobilized...

Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway

Li, Yan, Yin, Wei, Wang, Xia, Zhu, Wenbo, Huang, Yijun, Yan, Guangmei

Malignant gliomas are one of the leading causes of cancer deaths worldwide, but chemoprevention strategies for them are few and poorly investigated. Here, we show that cholera toxin, the traditional...

Arabidopsis MICROTUBULE-ASSOCIATED PROTEIN18 Functions in Directional Cell Growth by Destabilizing Cortical Microtubules

Wang, Xia, Zhu, Lei, Liu, Baoquan, Wang, Che, Jin, Lifeng, Zhao, Qian, ...

Microtubule-associated proteins (MAPs) play important roles in the regulation of microtubule function in cells. We describe Arabidopsis thaliana MAP18, which binds to microtubules and inhibits...

Epstein-Barr Virus Latent Membrane Protein 1 Induces Cellular MicroRNA miR-146a, a Modulator of Lymphocyte Signaling Pathways▿ †

Cameron, Jennifer E., Yin, Qinyan, Fewell, Claire, Lacey, Michelle, McBride, Jane, Wang, Xia, ...

The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential...

Malignant Hemangiopericytoma Arising in Neurofibromatosis: A Case Report with Histological, Immunohistochemical and Ultrastructural Studies

Wang, Jun, Vargas, Hernan, Gaal, Karl, Wang, Xia, Peng, Shi-Kaung

Subject. A 27-year-old Hispanic male with clinical manifestation of neurofibromatosis type 1 developed chronic constipation and urination difficulty along with recently increased abdominal bloating...

GLOBAL PROPERTIES OF A MODEL OF IMMUNE EFFECTOR RESPONSES TO VIRAL INFECTIONS

XIA WANG, XINYU SONG

This article proposes a mathematical model which has been used to investigate the importance of lytic and non-lytic immune responses for the control of viral infections. By means of Lyapunov...

Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites

Wang, Xia, Jobe, Momodou, Tyler, Kevin M, Steverding, Dietmar

The disinfectants TriGene, bleach, ethanol and liquid hand soap, and water and temperature were tested for their ability to kill bloodstream forms of Trypanosoma brucei, epimastigotes of Trypanosoma...

Technological Characteristics and R&D Alliance Form: Evidence from the U.S. Biotechnology Industry

Xia Wang

This study seeks to advance and test the knowledge-based theory of the firm as it applies to explaining the governance structure of R&D alliances. Unlike transaction-cost economics, the...

MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways▿ †

Yin, Qinyan, McBride, Jane, Fewell, Claire, Lacey, Michelle, Wang, Xia, Lin, Zhen, ...

The cellular microRNA miR-155 has been shown to be involved in lymphocyte activation and is expressed in Epstein-Barr virus (EBV)-infected cells displaying type III latency gene expression but not...

Conserved C-Terminal Motifs Required for Avirulence and Suppression of Cell Death by Phytophthora sojae effector Avr1b[W]

Dou, Daolong, Kale, Shiv D., Wang, Xinle, Chen, Yubo, Wang, Qunqing, Wang, Xia, ...

The sequenced genomes of oomycete plant pathogens contain large superfamilies of effector proteins containing the protein translocation motif RXLR-dEER. However, the contributions of these effectors...

RXLR-Mediated Entry of Phytophthora sojae Effector Avr1b into Soybean Cells Does Not Require Pathogen-Encoded Machinery[W]

Dou, Daolong, Kale, Shiv D., Wang, Xia, Jiang, Rays H.Y., Bruce, Nathan A., Arredondo, Felipe D., ...

Effector proteins secreted by oomycete and fungal pathogens have been inferred to enter host cells, where they interact with host resistance gene products. Using the effector protein Avr1b of...

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib

Steverding, Dietmar, Wang, Xia

The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the...

Actin filament dynamics are dominated by rapid growth and severing activity in the Arabidopsis cortical array

Staiger, Christopher J., Sheahan, Michael B., Khurana, Parul, Wang, Xia, McCurdy, David W., Blanchoin, Laurent

Metazoan cells harness the power of actin dynamics to create cytoskeletal arrays that stimulate protrusions and drive intracellular organelle movements. In plant cells, the actin cytoskeleton is...

Identification of small-molecule inducers of pancreatic β-cell expansion

Wang, Weidong, Walker, John R., Wang, Xia, Tremblay, Matthew S., Lee, Jae Wook, Wu, Xu, ...

To identify small molecules that can induce β-cell replication, a large chemical library was screened for proliferation of growth-arrested, reversibly immortalized mouse β cells by using an...