Dissecting p53 tumor suppressing functions in vivo [microform] / (2002)
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2002.
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
Tolbert, Dawn, Lu, Xiangdong, Yin, Chaoying, Tantama, Mathew, Van Dyke, Terry
Recent studies have shown the p19ARF tumor suppressor to be involved in the response to oncogenic stress by regulating the activity of p53. This response is mediated by antagonizing the function of...
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
Tolbert, Dawn, Lu, Xiangdong, Yin, Chaoying, Tantama, Mathew, Van Dyke, Terry
Recent studies have shown the p19ARF tumor suppressor to be involved in the response to oncogenic stress by regulating the activity of p53. This response is mediated by antagonizing the function of...
Qian, Ye, Conway, Kara L., Lu, Xiangdong, Seitz, Heather M., Matsushima, Glenn K., Clarke, Stephen H.
Murine autoreactive anti-Smith (Sm) B cells are negatively regulated by anergy and developmental arrest, but are also positively selected into the marginal zone (MZ) and B-1 B-cell populations....
Lu, Xiangdong, Kovalev, Grigoriy I., Chang, Hua, Kallin, Eric, Knudsen, Geoffrey, Xia, Li, ...
Dynamic changes in chromatin structure through ATP-dependent remodeling and covalent modifications on histones play important roles in transcription regulation. Among the many chromatin modifiers...