Xiao-he Chen

Combination of 768-well microplate array diagonal gel electrophoresis with duplex PCR of X and Y chromosome markers for quality control of epidemiological DNA banks (2006)

Huang, Shuwen, Chen, Xiao-he, Day, Ian N.M.

Large DNA banks for human epidemiological studies have become an increasingly important research tool. The power of genotype-phenotype studies is dependent both on the quality of phenotyping and of...

A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys (2006)

Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...

OBJECTIVES: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...

Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes (2006)

Rodríguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, David I.W., ...

Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH*5 and tagged by allele...

A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys (2006)

Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...

Objectives: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...

Replication of IGF2-INS-TH(*)5 haplotype effect on obesity in older men and study of related phenotypes (2006)

Rodriguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, Davide I.W., ...

Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by...

Madge-based technologies for identification of unknown mutations at the population level: MeltMADGE and EndoVII-MADGE (2006)

Smith, Mathew J., Alharbi, Khalid K., Aldahmesh, Mohammed A., Hou, Guangwei, Chen, Xiao-he, ...

CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents (2005)

Huang, Shuwen, Cook, Derek G., Hinks, Lesley J., Chen, Xiao-he, Ye, Shu, Gilg, Julie A., ...

Objectives: Smoking is a major cause of death and often initiates in adolescence. Mutations in CYP2A6 slow metabolism of nicotine to cotinine. Haploinsufficiency in adults is associated with lower...

Combination of His-tagged T4 endonuclease VII with microplate array diagonal gel electrophoresis for high-throughput mutation scanning (2005)

Smith, Matt J., Alharbi, Khalid K., Chen, Xiao-he, Day, Ian N.M., Fox, Keith R.

Various physical mutation-scanning methods have been developed to avoid unnecessary resequencing of long stretches of DNA (1)(2)(3)(4)(5)(6). Protein-based mutation-scanning techniques include...

MeltMADGE: economical very high-throughput mutation scanning using thermal ramp electrophoresis in conjunction with MADGE (microplate array) gels (2005)

Day, Ian N.M., Aldahmesh, Mohammed A., Haddad, Lema, Alharbi, Khalid K., Chen, Xiao-he, Rassoulian, Hamid, ...

Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK (2005)

Rodriguez, Santiago, Chen, Xiao-he, Miller, George J., Day, Ian N.

Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been...

Combination of His-tagged T4 endonuclease VII with microplate array diagonal gel electrophoresis for high-throughput mutation scanning (2005)

Smith, Matt J., Alharbi, Khalid K., Chen, Xiao-he, Day, Ian N.M., Fox, Keith R.

Various physical mutation-scanning methods have been developed to avoid unnecessary resequencing of long stretches of DNA (1–6). Protein-based mutation-scanning techniques include enzymatic...

Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population (2005)

Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...

We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...

Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population (2005)

Alharbi, Khalid K., Aldahmesh, Mohammed A, Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A, Chen, Xiao-he, ...

We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...

Mutation scanning by meltMADGE: Validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population (2005)

Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...

We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...

Microplate array diagonal gel electrophoresis for SNP and microsatellite genotyping and for mutation scanning (2004)

Day, Ian N.M., Gaunt, Tom R., Chen, Xiao-he, Ganderton, Rosalind H.

Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster (2004)

Day, Ian N. M., Chen, Xiao-He, Gaunt, Tom R., King, Tabitha H. T., Voropanov, Anca, Ye, Shu, ...

Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...

MADGE-based technologies for identification of unknown mutations at the population level: MeltMADGE and EndoVII-MADGE (2004)

Smith, Matthew J., Alharbi, Khalid K., Aldahmesh, Mohammed A., Hou, Guangwei, Chen, Xiao-he, ...

Evidence of admixture from haplotyping in an epidemiological study of UK Caucasian males: implications for association analyses (2004)

Chen, Xiao-He, Rodriguez, Santiago, Hawe, Emma, Talmud, Philippa J., Miller, George J., Underhill, Peter, ...

OBJECTIVE: Cohort and case-control genetic association studies offer the greatest power to detect small genotypic influences on disease phenotypes, relative to family-based designs. However, genetic...

Typing dinucleotide repeat loci using microplate array diagonal gel electrophoresis: proof of principle (2004)

Rodriguez, Santiago, Chen, Xiao-he, Day, Ian N.M.

Polymorphic dinucleotide repeat loci (microsatellite markers) are found in varying abundance throughout the genomes of most organisms. They have been extensively used for genetic studies, but...

Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster (2004)

Day, Ian N., Chen, Xiao-he, Gaunt, Tom R., King, Tabitha H.T., Voropanov, Anca, Ye, Shu, ...

Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...

risk (2004)

Santiago Rodríguez, Tom R. Gaunt, Ra D. O’dell, Xiao-he Chen, Emma Hawe, George J Miller, ...

analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2-INS-TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed haplotype...

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2–INS–TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed...

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits (2004)

Rodríguez, Santiago, Gaunt, Tom R., O'Dell, Sandra D., Chen, Xiao-he, Gu, Dongfeng, Hawe, Emma, ...

The IGF2-INS-TH genomic region has been implicated in various common disorders including the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present detailed haplotype...

Common polymorphism in the growth hormone gene cluster and its relationship with cardiovascular disease and metabolic syndrome (2003)

Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...

Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)

Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...

BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...

Insulin-like growth factor-I genotype and birthweight (2002)

Day, Ian N.M., King, Tabitha H.T., Chen, Xiao-he, Voropanov, Anca M., Ye, Shu, Syddall, Holly E., ...

Microplate array diagonal gel electrophoresis for cohort studies of microsatellite loci (2002)

Chen, Xiao-He, O'Dell, Sandra D., Day, Ian N.M.

After PCR amplification, we have achieved precise sizing of trinucleotide and tetranucleotide microsatellite alleles on 96-well open-faced polyacrylamide microplate array diagonal gel electrophoresis...

Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11 (2002)

Gu, Dongfeng, O'Dell, Sandra D., Chen, Xiao-he, Miller, George J., Day, Ian N.

Abstract. The subtelomeric region of 11p harbours three closely linked genes, TH, INS and IGF2, that have been associated with obesity, size at birth, type I diabetes, polycystic ovary syndrome,...

Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)

Aihie-Sayer, Avan, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-He, Briggs, Patricia J., Briggs, R., ...

BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...

Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)

Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...

Background: grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...

New developments in microsatellite genotyping and genetic epidemiological studies. (2001)

Chen, Xiao-he.

Thesis (Ph. D.)--University of Southampton, 2001.

Mutation scanning by meltMADGE: Validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population

Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...

We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...

Mutation scanning by meltMADGE: Validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population

Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...

We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...