Cardiac {alpha}1-adrenergic drive in pathological remodelling (2008)
Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E., Graham, Robert M.
The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation of cardiac function via sympathetically released catecholamines acting on cardiomyocyte adrenergic...
Cardiac {alpha}1-adrenergic drive in pathological remodelling (2007)
Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E., Graham, Robert M.
The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation of cardiac function via sympathetically released catecholamines acting on cardiomyocyte adrenergic...
Cardiac {alpha}1-adrenergic drive in pathological remodelling (2007)
Woodcock, Elizabeth A., Du, Xiao-Jun, Reichelt, Melissa E., Graham, Robert M.
The heart is richly innervated by sympathetic nerves, and both acute and chronic regulation of cardiac function via sympathetically released catecholamines acting on cardiomyocyte adrenergic...
Du, Xiao-Jun, Gao, Xiao-Ming, Kiriazis, Helen, Moore, Xiao-Lei, Ming, Ziqiu, Su, Yidan, ...
Objective: Myocardial contractility is enhanced in transgenic (TG) mice with cardiac-restricted overexpression of the 1A-adrenergic receptors (1A-AR). We tested the hypothesis that this enhanced...
Kanellakis, Peter, Slater, Nicholas J., Du, Xiao-Jun, Bobik, Alex, Curtis, David J.
Objective The aims of this study were, first, to determine if granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) improved left ventricular function in the setting of a...
Gao, Xiao-Ming, Xu, Qi, Kiriazis, Helen, Dart, Anthony M., Du, Xiao-Jun
Objective: Recent studies on mice with surgically induced acute myocardial infarction (AMI) have documented the frequent occurrence of ventricular rupture, an event not previously reported in other...
Gender modulates cardiac phenotype development in genetically modified mice (2004)
Recent research using genetically modified mice has revealed significant sex differences in cardiac phenotypes. In the majority of strains, females display a lower mortality, less severe hypertrophy,...
Du, Xiao-Jun, Samuel, Chrishan S, Gao, Xiao-Ming, Zhao, Ling, Parry, Laura J, Tregear, Geoffrey W
Objective: To investigate cardiac phenotypes in mice deficient in the peptide hormone relaxin by gene targeting. Methods: Echocardiography and cardiac catheterization were performed on male and...
Sheridan, Desmond J., Autelitano, Dominic J., Wang, Binghui, Percy, Elodie, Woodcock, Elizabeth A., Du, Xiao-Jun
Objective: The α-myosin heavy chain (α-MHC) promoter is frequently used to direct cardiac specific transgene expression. We studied whether transgene expression controlled by this promoter was...
Gao, Xiao-Ming, Dart, Anthony M, Dewar, Elizabeth, Jennings, Garry, Du, Xiao-Jun
Objective: To test the usage of serial echocardiography in mice with induced myocardial infarct (MI) and to characterize the mouse model of MI. Methods: C57 mice underwent open-chest surgery to...
Du, Xiao-Jun, Cox, Helen S., Dart, Anthony M., Esler, Murray D.
Objective: To seek direct evidence for a cause–effect relation between sympathetic activation and arrhythmogenesis. Methods: Rats underwent open-chest surgery with either coronary artery occlusion...
Du, Xiao-Jun, Riemersma, Rudolph A., Dart, Anthony M.
Experimental studies have provided evidence that the autonomic nervous activity is modulated by oestrogen. Such modulation at central and peripheral levels tends to suppress sympathetic but elevate...
Mechanisms of noradrenaline release in the anoxic heart of the rat (1993)
Objective: The aim was to examine the time course of exocytotic and “spontaneous” noradrenaline overflow and the influence of an Uptake1, inhibitor, desipramine, in rat hearts subjected to anoxic...
Impaired Cardiac Contractility Response to Hemodynamic Stress in S100A1-Deficient Mice
Du, Xiao-Jun, Cole, Timothy J., Tenis, Nora, Gao, Xiao-Ming, Köntgen, Frank, Kemp, Bruce E., ...
Ca2+ signaling plays a central role in cardiac contractility and adaptation to increased hemodynamic demand. We have generated mice with a targeted deletion of the S100A1 gene coding for the major...
Impaired Cardiac Contractility Response to Hemodynamic Stress in S100A1-Deficient Mice
Du, Xiao-Jun, Cole, Timothy J., Tenis, Nora, Gao, Xiao-Ming, Köntgen, Frank, Kemp, Bruce E., ...
Ca2+ signaling plays a central role in cardiac contractility and adaptation to increased hemodynamic demand. We have generated mice with a targeted deletion of the S100A1 gene coding for the major...
Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter
Percy, Elodie, Kaye, David M, Lambert, Gavin W, Gruskin, Sara, Esler, Murray D, Du, Xiao-Jun
We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET)...
Du, Xiao-Jun, Feng, Xinheng, Gao, Xiao-Ming, Tan, Tze Ping, Kiriazis, Helen, Dart, Anthony M
Ivabradine selectively reduces heart rate (HR) by inhibiting the cardiac pacemaker If current, thus prolonging the duration of spontaneous depolarization in the sinus node. The activity of ivabradine...