The balance of Polo-like kinase 1 in tumorigenesis (2009)
Abstract Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression....
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP (2006)
Yu, Xiaochun, Fu, Shuang, Lai, Maoyi, Baer, Richard, Chen, Junjie
BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains...
Yu, Xiaochun, Sharma, Kailash D., Takahashi, Tsuyoshi, Iwamoto, Ryo, Mekada, Eisuke
Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by which EGFR...
Vanden Wymelenberg, Amber, Denman, Stuart, Dietrich, Diane, Bassett, Jennifer, Yu, Xiaochun, Atalla, Rajai, ...
Phanerochaete chrysosporium cellulase genes were cloned and characterized. The cel61A product was structurally similar to fungal endoglucanases of glycoside hydrolase family 61, whereas the cel9A...
The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Yu, Xiaochun, Sharma, Kailash D., Takahashi, Tsuyoshi, Iwamoto, Ryo, Mekada, Eisuke
Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by which EGFR...
Vanden Wymelenberg, Amber, Denman, Stuart, Dietrich, Diane, Bassett, Jennifer, Yu, Xiaochun, Atalla, Rajai, ...
Phanerochaete chrysosporium cellulase genes were cloned and characterized. The cel61A product was structurally similar to fungal endoglucanases of glycoside hydrolase family 61, whereas the cel9A...
The BRCA1 C-terminal (BRCT) domain has recently been implicated as a phospho-protein binding domain. We demonstrate here that a CTBP-interacting protein CtIP interacts with BRCA1 BRCT domains in a...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
Yu, Xiaochun, Fu, Shuang, Lai, Maoyi, Baer, Richard, Chen, Junjie
BRCA1 (Breast Cancer Susceptibility Gene 1) possesses an N-terminal Ring domain and tandem C-terminal BRCT motifs. While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains...
Privette, Lisa M, Weier, Jingly Fung, Nguyen, Ha Nam, Yu, Xiaochun, Petty, Elizabeth M
CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the role of CHFR in genomic stability, by...
The balance of Polo-like kinase 1 in tumorigenesis
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays...
Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression▿ ‡
Lu, Lin-Yu, Wood, Jamie L., Minter-Dykhouse, Katherine, Ye, Lin, Saunders, Thomas L., Yu, Xiaochun, ...
Polo-like kinases (Plks) are serine/threonine kinases that are highly conserved in organisms from yeasts to humans. Previous reports have shown that Plk1 is critical for all stages of mitosis and may...
Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response▿ †
Wu, Jiaxue, Huen, Michael S. Y., Lu, Lin-Yu, Ye, Lin, Dou, Yali, Ljungman, Mats, ...
Histone ubiquitination participates in multiple cellular processes, including the DNA damage response. However, the molecular mechanisms involved are not clear. Here, we have identified that...
Aurora A Is Essential for Early Embryonic Development and Tumor Suppression*S⃞
Lu, Lin-Yu, Wood, Jamie L., Ye, Lin, Minter-Dykhouse, Katherine, Saunders, Thomas L., Yu, Xiaochun, ...
Aurora A is a serine/threonine kinase that functions in various stages of mitosis. Accumulating evidence has demonstrated that gene amplification and overexpression of Aurora A are linked to...