Xiaorong Lin, Anastasia P. Litvintseva, Kirsten Nielsen, Sweta Patel, Anna Floyd, Thomas G. Mitchell, ...
Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction...
Many Globally Isolated AD Hybrid Strains of Cryptococcus neoformans Originated in Africa (2007)
Anastasia P. Litvintseva, Xiaorong Lin, Irka Templeton, Joseph Heitman, Thomas G. Mitchell
Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of...
Xiaorong Lin, Johnny C. Huang, Thomas G. Mitchell, Joseph Heitman
Cryptococcus neoformans is a fungal human pathogen with a bipolar mating system. It undergoes a dimorphic transition from a unicellular yeast to hyphal filamentous growth during mating and...
Typescript.
SwoHp, a Nucleoside Diphosphate Kinase, Is Essential in Aspergillus nidulans
Lin, Xiaorong, Momany, Cory, Momany, Michelle
The temperature-sensitive swoH1 mutant of Aspergillus nidulans was previously identified in a screen for mutants with defects in polar growth. In the present work, we found that the swoH1 mutant...
Chlamydospore Formation during Hyphal Growth in Cryptococcus neoformans
Lin, Xiaorong, Heitman, Joseph
Cryptococcus neoformans, a basidiomycetous fungal pathogen, infects hosts through inhalation and can cause fatal meningoencephalitis in individuals if untreated. This fungus undergoes a dimorphic...
The Aspergillus nidulans swoC1 mutant shows defects in growth and development.
Lin, Xiaorong, Momany, Michelle
Previous work identified swoC1 as a single-gene mutant with defects in polarity establishment. In this study swoC1 was shown to have defects in endocytosis, compartmentation, nuclear distribution,...
Lin, Xiaorong, Huang, Johnny C, Mitchell, Thomas G, Heitman, Joseph
Cryptococcus neoformans is a fungal human pathogen with a bipolar mating system. It undergoes a dimorphic transition from a unicellular yeast to hyphal filamentous growth during mating and...
SwoHp, a Nucleoside Diphosphate Kinase, Is Essential in Aspergillus nidulans
Lin, Xiaorong, Momany, Cory, Momany, Michelle
The temperature-sensitive swoH1 mutant of Aspergillus nidulans was previously identified in a screen for mutants with defects in polar growth. In the present work, we found that the swoH1 mutant...
Chlamydospore Formation during Hyphal Growth in Cryptococcus neoformans
Lin, Xiaorong, Heitman, Joseph
Cryptococcus neoformans, a basidiomycetous fungal pathogen, infects hosts through inhalation and can cause fatal meningoencephalitis in individuals if untreated. This fungus undergoes a dimorphic...
The Aspergillus nidulans swoC1 mutant shows defects in growth and development.
Lin, Xiaorong, Momany, Michelle
Previous work identified swoC1 as a single-gene mutant with defects in polarity establishment. In this study swoC1 was shown to have defects in endocytosis, compartmentation, nuclear distribution,...
Lin, Xiaorong, Huang, Johnny C, Mitchell, Thomas G, Heitman, Joseph
Cryptococcus neoformans is a fungal human pathogen with a bipolar mating system. It undergoes a dimorphic transition from a unicellular yeast to hyphal filamentous growth during mating and...
Many Globally Isolated AD Hybrid Strains of Cryptococcus neoformans Originated in Africa
Litvintseva, Anastasia P, Lin, Xiaorong, Templeton, Irka, Heitman, Joseph, Mitchell, Thomas G
Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of...
αADα Hybrids of Cryptococcus neoformans: Evidence of Same-Sex Mating in Nature and Hybrid Fitness
Lin, Xiaorong, Litvintseva, Anastasia P, Nielsen, Kirsten, Patel, Sweta, Floyd, Anna, Mitchell, Thomas G, ...
Cryptococcus neoformans is a ubiquitous human fungal pathogen that causes meningoencephalitis in predominantly immunocompromised hosts. The fungus is typically haploid, and sexual reproduction...
Rutherford, Julian C., Lin, Xiaorong, Nielsen, Kirsten, Heitman, Joseph
The conserved AmtB/Mep/Rh family of proteins mediate the transport of ammonium across cellular membranes in a wide range of organisms. Certain fungal members of this group are required to initiate...
Impact of Mating Type, Serotype, and Ploidy on the Virulence of Cryptococcus neoformans▿ †
Lin, Xiaorong, Nielsen, Kirsten, Patel, Sweta, Heitman, Joseph
Hybridization with polyploidization is a significant biological force driving evolution. The effect of combining two distinct genomes in one organism on the virulence potential of pathogenic fungi is...
Jackson, Jennifer C., Higgins, Laura A., Lin, Xiaorong
The greater wax moth Galleria mellonella has been widely used as a heterologous host for a number of fungal pathogens including Candida albicans and Cryptococcus neoformans. A positive correlation in...
Lin, Xiaorong, Patel, Sweta, Litvintseva, Anastasia P., Floyd, Anna, Mitchell, Thomas G., Heitman, Joseph
The ubiquitous environmental human pathogen Cryptococcus neoformans is traditionally considered a haploid fungus with a bipolar mating system. In nature, the α mating type is overwhelmingly...
Bui, Tien, Lin, Xiaorong, Malik, Richard, Heitman, Joseph, Carter, Dee
Sexual reproduction and genetic exchange are important for the evolution of fungal pathogens and for producing potentially infective spores. Studies to determine whether sex occurs in the pathogenic...