Crystal structure of human protein-tyrosine phosphatase SHP-1 (2002)
Yang, Jian, Liu, Lijun, He, Dandan, Song, Xi, Liang, Xiaoshan, Zhao, Zhizhuang Joe, ...
SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as a negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the...
Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1 (2000)
Yang, Jian, Cheng, Zhiliang, Niu, Tian-Qi, Liang, Xiaoshan, Zhao, Zhizhuang Joe, Zhou, G. Wayne
The substrate specificity of the catalytic domain of SHP-1, an important regulator in the proliferation and development of hematopoietic cells, is critical for understanding the physiological...
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1 (1998)
Yang, Jian, Liang, Xiaoshan, Niu, Tian-Qi, Meng, Wuyi, Zhao, Zhizhuang Joe, Zhou, G. Wayne
The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic domain and the complex it forms with the substrate analogue tungstate have been determined and refined to crystallographic R...