Shuto, Tsuyoshi, Xu, Haidong, Wang, Beinan, Han, Jiahuai, Kai, Hirofumi, Gu, Xin-Xing, ...
Nontypeable Hemophilus influenzae (NTHi) is an important human pathogen in both children and adults. In children, it causes otitis media, the most common childhood infection and the leading cause of...
Ueyama, Tomoyo, Gu, Xin-Xing, Tsai, Chao-Ming, Karpas, Arthur B., Lim, David J.
Twenty-one murine monoclonal antibodies (MAbs) were induced by nontypeable Haemophilus influenzae (NTHi) 9274. Nineteen MAbs were specific for the lipooligosaccharide (LOS) as determined by...
Nontypeable Haemophilus influenzae (NTHi) is a common cause of otitis media and respiratory tract infections. Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of...
Hu, Wei-Gang, Chen, Jing, McMichael, John C., Gu, Xin-Xing
A monoclonal antibody (MAb), designated MAb 8E7 (immunoglobulin G3), specific for Moraxella catarrhalis lipooligosaccharide (LOS) was evaluated for its functional activity in vitro and in a mouse...
Hu, Wei-Gang, Chen, Jing, Battey, James F., Gu, Xin-Xing
Moraxella catarrhalis strain 25238 detoxified lipooligosaccharide (dLOS)-protein conjugates induced a significant rise of bactericidal anti-LOS antibodies in animals. This study reports the effect of...
Gu, Xin-Xing, Chen, Jing, Barenkamp, Stephen J., Robbins, John B., Tsai, Chao-Ming, Lim, David J., ...
Moraxella (Branhamella) catarrhalis is an important cause of otitis media and sinusitis in children and of lower respiratory tract infections in adults. Lipooligosaccharide (LOS) is a major surface...
Jiao, Xinan, Hirano, Takashi, Hou, Yingchun, Gu, Xin-Xing
Moraxella catarrhalis is an important human mucosal pathogen. This study investigated the effect of intranasal immunization with a detoxified-lipooligosaccharide-cross-reactive mutant of diphtheria...
Moraxella catarrhalis is an important cause of otitis media in children and respiratory tract infections in the elderly. Lipooligosaccharide (LOS) is a major surface antigen of the bacterium that...
Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate
Peng, Daxin, Hong, Wenzhou, Choudhury, Biswa P., Carlson, Russell W., Gu, Xin-Xing
Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on...
Peng, Daxin, Choudhury, Biswa P., Petralia, Ronald S., Carlson, Russell W., Gu, Xin-Xing
Lipooligosaccharide (LOS), a major outer membrane component of Moraxella catarrhalis, is a possible virulence factor in the pathogenesis of human infections caused by the organism. However,...
Shuto, Tsuyoshi, Xu, Haidong, Wang, Beinan, Han, Jiahuai, Kai, Hirofumi, Gu, Xin-Xing, ...
Nontypeable Hemophilus influenzae (NTHi) is an important human pathogen in both children and adults. In children, it causes otitis media, the most common childhood infection and the leading cause of...
Ueyama, Tomoyo, Gu, Xin-Xing, Tsai, Chao-Ming, Karpas, Arthur B., Lim, David J.
Twenty-one murine monoclonal antibodies (MAbs) were induced by nontypeable Haemophilus influenzae (NTHi) 9274. Nineteen MAbs were specific for the lipooligosaccharide (LOS) as determined by...
Nontypeable Haemophilus influenzae (NTHi) is a common cause of otitis media and respiratory tract infections. Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of...
Hu, Wei-Gang, Chen, Jing, McMichael, John C., Gu, Xin-Xing
A monoclonal antibody (MAb), designated MAb 8E7 (immunoglobulin G3), specific for Moraxella catarrhalis lipooligosaccharide (LOS) was evaluated for its functional activity in vitro and in a mouse...
Hu, Wei-Gang, Chen, Jing, Battey, James F., Gu, Xin-Xing
Moraxella catarrhalis strain 25238 detoxified lipooligosaccharide (dLOS)-protein conjugates induced a significant rise of bactericidal anti-LOS antibodies in animals. This study reports the effect of...
Gu, Xin-Xing, Chen, Jing, Barenkamp, Stephen J., Robbins, John B., Tsai, Chao-Ming, Lim, David J., ...
Moraxella (Branhamella) catarrhalis is an important cause of otitis media and sinusitis in children and of lower respiratory tract infections in adults. Lipooligosaccharide (LOS) is a major surface...
Jiao, Xinan, Hirano, Takashi, Hou, Yingchun, Gu, Xin-Xing
Moraxella catarrhalis is an important human mucosal pathogen. This study investigated the effect of intranasal immunization with a detoxified-lipooligosaccharide-cross-reactive mutant of diphtheria...
Moraxella catarrhalis is an important cause of otitis media in children and respiratory tract infections in the elderly. Lipooligosaccharide (LOS) is a major surface antigen of the bacterium that...
Peng, Daxin, Choudhury, Biswa P., Petralia, Ronald S., Carlson, Russell W., Gu, Xin-Xing
Lipooligosaccharide (LOS), a major outer membrane component of Moraxella catarrhalis, is a possible virulence factor in the pathogenesis of human infections caused by the organism. However,...
Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate
Peng, Daxin, Hong, Wenzhou, Choudhury, Biswa P., Carlson, Russell W., Gu, Xin-Xing
Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on...
Moraxella catarrhalis is an important bacterial cause of otitis media in children and respiratory tract infections in the elderly. Lipooligosaccharide (LOS), a major surface antigen of this...
Yu, Shengqing, Xie, Hang, Datta, Anup, Naidu, Natasha, Gu, Xin-Xing
Lipooligosaccharide (LOS) from Moraxella catarrhalis has the potential to elicit bactericidal antibodies against the pathogen. We generated LOS-based conjugate vaccines that elicited bactericidal...
Rahman, M.Mahbubur, Gu, Xin-Xing, Tsai, Chao-Ming, Kolli, V.S.Kumar, W.Carlson, Russell
Nontypeable Haemophilus influenzae (NTHi)is an important pathogen responsible for otitis media in childrenand of pneumonitis in adults with depressed resistance. NTHi is acapsularand, therefore,...