Regulation of ATR Signaling by CINP and RPA (2009)
Genetic instability is a hallmark of cancer. The ATR-ATRIP complex functions at the apex of a cell cycle checkpoint signaling pathway that is critical during every cell division cycle to maintain...
Regulation of ATR Signaling by CINP and RPA (2009)
Genetic instability is a hallmark of cancer. The ATR-ATRIP complex functions at the apex of a cell cycle checkpoint signaling pathway that is critical during every cell division cycle to maintain...
We develop and validate a density functional, XYG3, based on the adiabatic connection formalism and the Görling–Levy coupling-constant perturbation expansion to the second order (PT2). XYG3 is a...
Xu, Xin, Melcher, John, Basak, Sudipta, Reifenberger, R., Raman, Arvind
Atomic Force microscope (AFM) cantilevers commonly used for imaging soft biological samples in liquids experience a momentary excitation of the higher eigenmodes at each tap. This transient response...
Liu, Chen-yu, Hsu, Yi-Hsiang, Wu, Ming-Tsang, Pan, Pi-Chen, Ho, Chi-Kung, Su, Li, ...
Abstract Background Consumption of cured/smoked meat and fish leads to the formation of carcinogenic N- nitroso compounds in the acidic stomach. This study investigated whether consumed cured/smoked...
Microarray datasets typically contain large number of columns but small number of rows. Association rules have been proved to be useful in analyzing such datasets. However, most existing association...
Heterozygosity increases microsatellite mutation rate, linking it to demographic history (2008)
Amos, William, Flint, Jonathan, Xu, Xin
Abstract Background Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it...
Multiple impact regimes in liquid environment dynamic atomic force microscopy (2008)
Melcher, John, Xu, Xin, Raman, Arvind
A canonical assumption in dynamic atomic force microscopy is that the probe tip interacts with the sample once per oscillation cycle. We show this key ansatz breaks down for soft cantilevers in...
Xu, Xin, Carrasco, Carolina, Jose De Pablo, Pedro, Gomez-Herrero, Julio, Raman, Arvind
Dynamic atomic force microscopy is widely used for the imaging of soft biological materials in liquid environments; yet very little is known about the peak forces exerted by the oscillating probe...
In this paper, we propose a new model for coherent clustering of gene expression data called reg-cluster. The proposed model allows (1) the expression profiles of genes in a cluster to follow any...
Finding Time-lagged 3D Clusters (2008)
XU, Xin, LU, Ying, TAN, Kian-Lee, TUNG, Anthony K. H.
Existing 3D clustering algorithms on $gene\times sample\times time$ expression data do not consider the \emph{time lags} between correlated gene expression patterns. Besides, they either ignore the...
Xin Xu, Tao Xie, Dewen Hu, Xicheng Lu, Xin Xu, Tao Xie, ...
Kernel methods have attracted many research interests recently since by utilizing Mercer kernels, non-linear and non-parametric versions of conventional supervised or unsupervised learning algorithms...
Abstract: In recent years, intrusion detection has emerged as an important technique for network security. Due to the large volumes of security audit data as well as complex and dynamic properties of...
Zhang, Hai-Ming, Xie, Zhao-Xiong, Long, La-Sheng, Zhong, Hui-Ping, Zhao, Wei, Mao, Bing-Wei, ...
In this paper, a kind of robust self-assembled monolayer (SAM) directed by lateral triple hydrogen bonding interactions was prepared by a one-step reaction of cyanuric acid (CA) and melamine (M)...
In this paper, we propose a new model for coherent clustering of gene expression data called reg-cluster. The proposed model allows (1) the expression profiles of genes in a cluster to follow any...
In this paper, we propose a new model for coherent clustering of gene expression data called reg-cluster. The proposed model allows (1) the expression profiles of genes in a cluster to follow any...
Redetermination of dicerium(III) tris(sulfate) tetrahydrate (2008)
Ce2(SO4)3(H2O)4 was obtained hydrothermally from an aqueous solution of cerium(III) oxide, trimethylamine and sulfuric acid. The precision of the structure determination has been significantly...
Bis(1-adamantylammonium) hexafluoridogermanate (2008)
The title compound, (C10H18N)2[GeF6], was obtained hydrothermally from an aqueous solution of GeO2, H3BO3, NiCl2, adamantylammonium chloride, butanol and hydrofluoric acid. The structure consists of...
Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia (2008)
Liu, Chen-yu, Hsu, Yi-Hsiang, Pan, Pi-Chen, Wu, Ming-Tsang, Ho, Chi-Kung, Su, Li, ...
The aldo-keto reductase 1C3 (AKR1C3) gene located on chromosome 10p15-p14, a regulator of myeloid cell proliferation and differentiation, represents an important candidate gene for studying human...
Robust Speech Spectra Restoration against Unspecific Noise Conditions for Pitch Detection (2008)
XU, Xin, HAYASAKA, Noboru, MIYANAGA, Yoshikazu
This paper proposes a new algorithm named Adaptive Running Spectrum Filtering (ARSF) to restore the amplitude spectra of speech corrupted by additive noises. Based on the pre-hand noise estimation,...
EFBAT: exact family-based association tests (2007)
Schneiter, Kady, Degnan, James H, Corcoran, Christopher, Xu, Xin, Laird, Nan
Abstract Background Family-based association tests are important tools for investigating genetic risk factors of complex diseases. These tests are especially valuable for being robust to population...
Microarray datasets typically contain large number of columns but small number of rows. Association rules have been proved to be useful in analyzing such datasets. However, most existing association...
Efficient Reinforcement Learning Using Recursire Least-Squares Methods (2007)
The recursive least-squares (RLS) algorithm is one of the most well-known algorithms used in adaptive filtering, system identification and adaptive control. Its popularity is mainly due to its fast...
Computational Studies On Formation And Properties Of Carbon (2007)
Nanotubes Weiqiao Deng, Weiqiao Deng, Jianwei Che, Xin Xu, Tahir Çagin, William A Goddard
The discovery of lower dimensional forms of Carbon with unique mechanical and electronic properties has generated new possibilities in many areas of technology especially in nanotechnology. Recent...
Semantic Mining and Analysis of Gene Expression Data (2007)
Xin Xu, Gao Cong, Beng Chin, Ooi Kian-lee, Tan Anthony, K. H. Tung
Association rules can reveal biological relevant relationship between genes and environments / categories. However, most existing association rule mining algorithms are rendered impractical on gene...
Magnetic, acoustic, and thermal (Brownian motion induced) excitations are commonly used for dynamic atomic force microscopy (AFM) in liquids, yet the fundamental differences in microcantilever...
The strategic impacts of ICT service innovation on consumers (2007)
Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007
Porter, Keith A., Krishnan, Swaminathan, Xu, Xin
This study presents an estimate of the probability that a single earthquake could cause simultaneous operational failure of geographically disperse data centers operated by a California utility....
A novel framework for sib pair linkage analysis. Am J Hum Genet 78:222-230 (2006)
G David Poznik, Katarzyna Adamska, Xin Xu, Andrzej Krolewski, John Rogus
I would like to thank my supervisor Dr. Anthony K.H. Tung for years of profes-sional guidance and his invaluable advice and comments for the thesis during my ph.d. study. Especially thanks go to...
A variance component analysis on recombination rate in the COGA pedigrees (2005)
Abstract We estimated the crossover frequency in 1,232 gametes from 356 subjects in pedigrees from the Collaborative Study on the Genetics on Alcoholism. We examined the effect of covariates...
Wang, Lin, Liu, Simin, Niu, Tianhua, Xu, Xin
Abstract Background Single nucleotide polymorphisms (SNPs) provide an important tool in pinpointing susceptibility genes for complex diseases and in unveiling human molecular evolution. Selection and...
Xu, Xin, Zhang, Qingsong, Muller, Richard P.
We derive here the form for the exact exchange energy density for a density that decays with Gaussian-type behavior at long range. This functional is intermediate between the B88 and the PW91...
Madeira, Pedro, Xin Xu, You-Ting Wu, Teixeira, J. A., Macedo, Eugénia
The modified Wilson equation, developed in a previous publication, for the excess Gibbs energy of aqueous polymer solutions, is extended to multicomponent mixtures. The model provides a flexible...
Thesis (Ph. D., Management)--University of California, Irvine, 2005.
Cubic nonlinear oscillation control in the frequency domain [electronic resource] / (2005)
Summary:Most strategies in the structural control literature are aimed at improving performance of the primary structural system, but may have limited or even adverse effect on nonstructural...
Cubic nonlinear oscillation control in the frequency domain (2005)
Thesis (M.S.)--State University of New York at Buffalo, 2005.
CURLER: Finding and visualizing nonlinear correlated clusters (2005)
While much work has been done in finding linear correlation among subsets of features in high-dimensional data, work on detecting nonlinear correlation has been left largely untouched. In this paper,...
CURLER: Finding and visualizing nonlinear correlated clusters (2005)
While much work has been done in finding linear correlation among subsets of features in high-dimensional data, work on detecting nonlinear correlation has been left largely untouched. In this paper,...
Density functional theory (DFT) has become the method of choice for many applications of quantum mechanics to the study of the electronic properties of molecules and solids. Despite the enormous...
We derive the form for an exact exchange energy density for a density decaying with Gaussian-like behavior at long range. Based on this, we develop the X3LYP (extended hybrid functional combined with...
Contemporary architecture design in China : architecture and historic context / (2004)
Thesis (M. Arch.)--State University of New York at Buffalo, 2004.
Logistic regression and boosting for labeled bags of instances (2004)
In this paper we upgrade linear logistic regression and boosting to multi-instance data, where each example consists of a labeled bag of instances. This is done by connecting predictions for...
Logistic regression and boosting for labeled bags of instances (2004)
In this paper we upgrade linear logistic regression and boosting to multi-instance data, where each example consists of a labeled bag of instances. This is done by connecting predictions for...
Logistic regression and boosting for labeled bags of instances (2004)
Abstract. In this paper we upgrade linear logistic regression and boosting to multi-instance data, where each example consists of a labeled bag of instances. This is done by connecting predictions...
Logistic regression and boosting for labeled bags of instances (2004)
Abstract. In this paper we upgrade linear logistic regression and boosting to multi-instance data, where each example consists of a labeled bag of instances. This is done by connecting predictions...
Logistic regression and boosting for labeled bags of instances (2004)
Abstract. In this paper we upgrade linear logistic regression and boosting to multi-instance data, where each example consists of a labeled bag of instances. This is done by connecting predictions...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Hao, Ke, Wang, Xiaobin, Niu, Tianhua, Xu, Xin, Li, Ang, Chang, Weili, ...
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and...
Applying propositional learning algorithms to multi-instance data (2003)
Multi-instance learning is commonly tackled using special-purpose algorithms. Development of these algorithms has started because early experiments with standard propositional learners have failed to...
Applying propositional learning algorithms to multi-instance data (2003)
Multi-instance learning is commonly tackled using special-purpose algorithms. Development of these algorithms has started because early experiments with standard propositional learners have failed to...
Xin Xu, Madeira, Pedro, Teixeira, J. A., Macedo, Eugénia
A local composition model based on the lattice theory and two-fluid theory, considering the excess heat capacity, which is a modified Wilson equation, is developed for the excess Gibbs energy of...
Developing input solutions for next generation mobile devices / (2003)
SMA 6390: IMST Theme Project.
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Applying propositional learning algorithms to multi-instance data (2003)
Multi-instance learning is commonly tackled using special-purpose algorithms.
ReaxFF sio reactive force field for silicon and silicon oxide systems (2003)
Ro Strachan, Shannon Stewman, Qingsong Zhang, Xin Xu, William A. Goddard
To predict the structures, properties, and chemistry of materials involving silicon and silicon oxides; interfaces between these materials; and hydrolysis of such systems, we have developed the...
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
China and East Asia : reshaping power and identity in the post-cold war era / (2003)
Thesis (Ph. D.)--Cornell University, August, 2003.
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
A multivariate family-based association test using generalized estimating equations: FBAT-GEE (2003)
Lange, Christoph, Silverman, Edwin K., Xu, Xin, Weiss, Scott T., Laird, Nan M.
In this paper we propose a multivariate extension of family‐based association tests based on generalized estimating equations. The test can be applied to multiple phenotypes and to phenotypic...
Combining dependent tests for linkage or association across multiple phenotypic traits (2003)
A robust statistical method to detect linkage or association between a genetic marker and a set of distinct phenotypic traits is to combine univariate trait‐specific test statistics for a more...
Statistical learning in multiple instance problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Statistical Learning in Multiple Instance Problems (2003)
Multiple instance (MI) learning is a relatively new topic in machine learning. It is concerned with supervised learning but differs from normal supervised learning in two points: (1) it has multiple...
Efficient reinforcement learning using recursive least-squares methods (2002)
The recursive least-squares (RLS) algorithm is one of the most well-known algorithms used in adaptive filtering, system identification and adaptive control. Its popularity is mainly due to its fast...
Efficient reinforcement learning using recursive least-squares methods (2002)
The recursive least-squares (RLS) algorithm is one of the most well-known algorithms used in adaptive filtering, system identification and adaptive control. Its popularity is mainly due to its fast...
Supervisory control automata as a new paradigm to make malicious executables ineffectual / (2002)
Thesis (M.S.)--Louisiana Tech University, 2002.
RePS: A Sequence Assembler That Masks Exact Repeats Identified from the Shotgun Data (2002)
Wang, Jun, Wong, Gane Ka-Shu, Ni, Peixiang, Han, Yujun, Huang, Xiangang, Zhang, Jianguo, ...
Effects of delay jitter and clock slippage on network echo cancellation [microform]. (2001)
Thesis (M. Eng.)--Carleton University, 2000.
Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome (2001)
Buller, Cody, Xu, Xin, Marquis, Victoria, Schwanke, Ryan, Xu, Pin-Xian
Eya1 is a critical gene for mammalian organogenesis. Mutations in human EYA1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by varying combinations of...
Thesis (Ph. D.)--University of Wyoming, 2000.
Decreased expression of SPRR3 in Chinese human oesophageal cancer (2000)
Chen, Bao-Sheng, Wang, Ming-Rong, Cai, Yan, Xu, Xin, Xu, Zhi-Xiong, Han, Ya-Ling, ...
cDNA fragments that were differentially expressed between human oesophageal carcinomas and matched normal adjacent mucosa were isolated using an improved mRNA differential display technique. One of...
VREUGDENHIL, DICK, XU, XIN, JUNG, CHUN S., EWING, ELMER E.
Cell division and cell expansion during early stages of tuber development were studied using developing axillary buds on single-leaf cuttings from potato (Solanum tuberosum L.). Cuttings taken from...
Investigating Digital Optical Computing with Spatial Light Rebroadcasters. (1998)
McAulay, Alastair D., Wang, Junqing, Xu, Xin
Spatial light rebroadcasters (SLRs), consisting of thin films of luminescing electron trapping materials, are explored for digital optical computing. The status of optical computing is reviewed...
Direct manipulations of B-spline, NURBS curves and surfaces using geometric constraints / (1996)
Typescript.
Identification and characterization of two closely linked GST pi genes in mouse /--Xin Xu. (1995)
Includes abstract.
Design of ultrafast optical logic gate using the nonlinear phenomena of optical fiber / (1992)
Typescript.
A neural network model, its properties and applications /--by Xin Xu. (1990)
Thesis (Ph. D.)--University of Minnesota, 1990.
Effects of Title IX and Sports Participation on Girls' Physical Activity and Weight
In this study, we examined the association between girls%u2019 participation in high school sports and the physical activity, weight, body mass and body composition of adolescent females during the...
Xu, Xin, Vermeer, Evert, Vreugdenhil, Dick
The effects of plant hormones and sucrose (Suc) on potato (Solanum tuberosum L.) tuberization were studied using in vitro cultured single-node cuttings. Tuber-inducing (high Suc) and -noninducing...
Mechanism for antibody catalysis of the oxidation of water by singlet dioxygen
Datta, Deepshikha, Vaidehi, Nagarajan, Xu, Xin, Goddard, William A.
Wentworth et al. [Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A. & Lerner, R. A. (2001) Science 293,...
The gas phase reaction of singlet dioxygen with water: A water-catalyzed mechanism
Xu, Xin, Muller, Richard P., Goddard, William A.
Stimulated by the recent surprising results from Wentworth et al. [Wentworth, A. D., Jones, L. H., Wentworth, P., Janda, K. D. & Lerner, R. A. (2000) Proc. Natl. Acad. Sci. USA 97, 10930–10935]...
Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver
Zhang, Huang-Ge, Xie, Jinfu, Xu, Liang, Yang, Pingar, Xu, Xin, Sun, Sheher, ...
A major limitation of adenovirus (Ad) gene therapy product expression in the liver is subsequent elimination of the hepatocytes expressing the gene therapy product. This elimination is caused by both...
Peroxone chemistry: Formation of H2O3 and ring-(HO2)(HO3) from O3/H2O2
The recent observation [Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A. & Lerner, R. A. (2001) Science...
RePS: A Sequence Assembler That Masks Exact Repeats Identified from the Shotgun Data
Wang, Jun, Wong, Gane Ka-Shu, Ni, Peixiang, Han, Yujun, Huang, Xiangang, Zhang, Jianguo, ...
We describe a sequence assembler, RePS (repeat-masked Phrap with scaffolding), that explicitly identifies exact 20mer repeats from the shotgun data and removes them prior to the assembly. The...
Liu, Zhongyu, Xu, Xin, Hsu, Hui-Chen, Tousson, Albert, Yang, Ping-Ar, Wu, Qi, ...
Previously, we described an APC-adenovirus (APC-Ad) FasL cell gene therapy method which could be used to deplete autoreactive T cells in vivo. FasL was toxic, however, and controlled regulation of...
Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma
Stone, Julie A., Xu, Xin, Winchell, Gregory A., Deutsch, Paul J., Pearson, Paul G., Migoya, Elizabeth M., ...
The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 μCi) of [3H]caspofungin to healthy men, plasma, urine, and...
We derive the form for an exact exchange energy density for a density decaying with Gaussian-like behavior at long range. Based on this, we develop the X3LYP (extended hybrid functional combined with...
Disposition of Caspofungin, a Novel Antifungal Agent, in Mice, Rats, Rabbits, and Monkeys
Sandhu, Punam, Xu, Xin, Bondiskey, Peter J., Balani, Suresh K., Morris, Michael L., Tang, Yui S., ...
The metabolism, excretion, and pharmacokinetics of caspofungin (Cancidas; Merck & Co., Inc.) were investigated after administration of a single intravenous dose to mice, rats, rabbits, and monkeys....
A Genomewide Search for Quantitative-Trait Loci Underlying Asthma
Xu, Xin, Fang, Zhian, Wang, Binyan, Chen, Changzhong, Guang, Wenwei, Jin, Yongtang, ...
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes...
A Unified Haseman-Elston Method for Testing Linkage with Quantitative Traits
Xu, Xin, Weiss, Scott, Xu, Xiping, Wei, L. J.
The Haseman and Elston (H-E) method uses a simple linear regression to model the squared trait difference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage...
A Novel Framework for Sib Pair Linkage Analysis
Poznik, G. David, Adamska, Katarzyna, Xu, Xin, Krolewski, Andrzej S., Rogus, John J.
Sib pair linkage analysis of a dichotomous trait is a popular method for narrowing the search for genes that influence complex diseases. Although the pedigree structures are uncomplicated and the...
Power evaluations for family-based tests of association with incomplete parental genotypes.
Yang, Qiong, Xu, Xin, Laird, Nan
While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data...
Polymorphism in Maternal LRP8 Gene Is Associated with Fetal Growth
Wang, Lin, Wang, Xiaobin, Laird, Nan, Zuckerman, Barry, Stubblefield, Philip, Xu, Xin
Fetal growth restriction (FGR) affects >200,000 pregnancies in the United States annually and is associated with increased perinatal mortality and morbidity, as well as poorer long-term health for...
Xu, Xin, Vermeer, Evert, Vreugdenhil, Dick
The effects of plant hormones and sucrose (Suc) on potato (Solanum tuberosum L.) tuberization were studied using in vitro cultured single-node cuttings. Tuber-inducing (high Suc) and -noninducing...
Mechanism for antibody catalysis of the oxidation of water by singlet dioxygen
Datta, Deepshikha, Vaidehi, Nagarajan, Xu, Xin, Goddard, William A.
Wentworth et al. [Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A. & Lerner, R. A. (2001) Science 293,...
The gas phase reaction of singlet dioxygen with water: A water-catalyzed mechanism
Xu, Xin, Muller, Richard P., Goddard, William A.
Stimulated by the recent surprising results from Wentworth et al. [Wentworth, A. D., Jones, L. H., Wentworth, P., Janda, K. D. & Lerner, R. A. (2000) Proc. Natl. Acad. Sci. USA 97, 10930–10935]...
Hepatic DR5 Induces Apoptosis and Limits Adenovirus Gene Therapy Product Expression in the Liver
Zhang, Huang-Ge, Xie, Jinfu, Xu, Liang, Yang, Pingar, Xu, Xin, Sun, Sheher, ...
A major limitation of adenovirus (Ad) gene therapy product expression in the liver is subsequent elimination of the hepatocytes expressing the gene therapy product. This elimination is caused by both...
Peroxone chemistry: Formation of H2O3 and ring-(HO2)(HO3) from O3/H2O2
The recent observation [Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A. & Lerner, R. A. (2001) Science...
RePS: A Sequence Assembler That Masks Exact Repeats Identified from the Shotgun Data
Wang, Jun, Wong, Gane Ka-Shu, Ni, Peixiang, Han, Yujun, Huang, Xiangang, Zhang, Jianguo, ...
We describe a sequence assembler, RePS (repeat-masked Phrap with scaffolding), that explicitly identifies exact 20mer repeats from the shotgun data and removes them prior to the assembly. The...
Liu, Zhongyu, Xu, Xin, Hsu, Hui-Chen, Tousson, Albert, Yang, Ping-Ar, Wu, Qi, ...
Previously, we described an APC-adenovirus (APC-Ad) FasL cell gene therapy method which could be used to deplete autoreactive T cells in vivo. FasL was toxic, however, and controlled regulation of...
Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma
Stone, Julie A., Xu, Xin, Winchell, Gregory A., Deutsch, Paul J., Pearson, Paul G., Migoya, Elizabeth M., ...
The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 μCi) of [3H]caspofungin to healthy men, plasma, urine, and...
We derive the form for an exact exchange energy density for a density decaying with Gaussian-like behavior at long range. Based on this, we develop the X3LYP (extended hybrid functional combined with...
Disposition of Caspofungin, a Novel Antifungal Agent, in Mice, Rats, Rabbits, and Monkeys
Sandhu, Punam, Xu, Xin, Bondiskey, Peter J., Balani, Suresh K., Morris, Michael L., Tang, Yui S., ...
The metabolism, excretion, and pharmacokinetics of caspofungin (Cancidas; Merck & Co., Inc.) were investigated after administration of a single intravenous dose to mice, rats, rabbits, and monkeys....
Feng, Yan, Niu, Tianhua, Xing, Houxun, Xu, Xin, Chen, Changzhong, Peng, Shaojie, ...
Nicotine is the major addictive substance in cigarettes, and genes involved in sensing nicotine are logical candidates for vulnerability to nicotine addiction. We studied six single-nucleotide...
A Genomewide Search for Quantitative-Trait Loci Underlying Asthma
Xu, Xin, Fang, Zhian, Wang, Binyan, Chen, Changzhong, Guang, Wenwei, Jin, Yongtang, ...
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes...
A Unified Haseman-Elston Method for Testing Linkage with Quantitative Traits
Xu, Xin, Weiss, Scott, Xu, Xiping, Wei, L. J.
The Haseman and Elston (H-E) method uses a simple linear regression to model the squared trait difference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage...
A Novel Framework for Sib Pair Linkage Analysis
Poznik, G. David, Adamska, Katarzyna, Xu, Xin, Krolewski, Andrzej S., Rogus, John J.
Sib pair linkage analysis of a dichotomous trait is a popular method for narrowing the search for genes that influence complex diseases. Although the pedigree structures are uncomplicated and the...
Power evaluations for family-based tests of association with incomplete parental genotypes.
Yang, Qiong, Xu, Xin, Laird, Nan
While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data...
Polymorphism in Maternal LRP8 Gene Is Associated with Fetal Growth
Wang, Lin, Wang, Xiaobin, Laird, Nan, Zuckerman, Barry, Stubblefield, Philip, Xu, Xin
Fetal growth restriction (FGR) affects >200,000 pregnancies in the United States annually and is associated with increased perinatal mortality and morbidity, as well as poorer long-term health for...
Rosner, Andrea, Miyoshi, Keiko, Landesman-Bollag, Esther, Xu, Xin, Seldin, David C., Moser, Amy R., ...
To study phenotype-genotype correlations, ErbB/Ras pathway tumors (transgenic for ErbB2, c-Neu, mutants of c-Neu, polyomavirus middle T antigene (PyV-mT), Ras, and bi-transgenic for ErbB2/Neu with...
EFBAT: exact family-based association tests
Schneiter, Kady, Degnan, James H, Corcoran, Christopher, Xu, Xin, Laird, Nan
The dynamics of political and economic interactions between Mainland China and Taiwan
Zhaoyong Zhang, Xin Xu, Wei-Bin Zhang
The purpose of this article is to examine the trade and economic linkages across the Taiwan straits from the dynamic economic and political perspectives. In particular, we study the pattern and...
GANG FU, XIAODONG YI, CHUANJING HUANG, XIN XU, WEIZHENG WENG, WENSHENG XIA, ...
Selective oxidation of light alkanes remains to be a great challenge for the wider use of alkanes as feedstocks. To achieve high activity and at the same time high selectivity, some key issues have...
HF(v′ = 3) forward scattering in the F + H2 reaction: Shape resonance and slow-down mechanism
Wang, Xingan, Dong, Wenrui, Qiu, Minghui, Ren, Zefeng, Che, Li, Dai, Dongxu, ...
Crossed molecular beam experiments and accurate quantum dynamics calculations have been carried out to address the long standing and intriguing issue of the forward scattering observed in the F + H2...
The dynamics of political and economic interactions between Mainland China and Taiwan
Zhaoyong Zhang, Xin Xu, Wei-Bin Zhang
The purpose of this article is to examine the trade and economic linkages across the Taiwan straits from the dynamic economic and political perspectives. In particular, we study the pattern and...
Ren, Zefeng, Che, Li, Qiu, Minghui, Wang, Xingan, Dong, Wenrui, Dai, Dongxu, ...
Reaction resonances are transiently trapped quantum states along the reaction coordinate in the transition state region of a chemical reaction that could have profound effects on the dynamics of the...
The dynamics of political and economic interactions between Mainland China and Taiwan
Zhaoyong Zhang, Xin Xu, Wei-Bin Zhang
The purpose of this article is to examine the trade and economic linkages across the Taiwan straits from the dynamic economic and political perspectives. In particular, we study the pattern and...
The dynamics of political and economic interactions between Mainland China and Taiwan
Zhaoyong Zhang, Xin Xu, Wei-Bin Zhang
The purpose of this article is to examine the trade and economic linkages across the Taiwan straits from the dynamic economic and political perspectives. In particular, we study the pattern and...
Xu, Xin, Vaithiyalingam, Sivaraja, Glick, Gloria G., Mordes, Daniel A., Chazin, Walter J., Cortez, David
ATR kinase activation requires the recruitment of the ATR-ATRIP and RAD9-HUS1-RAD1 (9-1-1) checkpoint complexes to sites of DNA damage or replication stress. Replication protein A (RPA) bound to...
Xu, Xin, Carrasco, Carolina, De Pablo, Pedro Jose, Gomez-Herrero, Julio, Raman, Arvind
Dynamic atomic force microscopy is widely used for the imaging of soft biological materials in liquid environments; yet very little is known about the peak forces exerted by the oscillating probe...
Zhang, Ying, Xu, Xin, Goddard, William A.
We develop and validate a density functional, XYG3, based on the adiabatic connection formalism and the Görling–Levy coupling-constant perturbation expansion to the second order (PT2). XYG3 is a...
Food prices and obesity: long-run effect in US metropolitan areas
Xu, Xin, Variyam, Jayachandran N., Zhao, Jenny, Chaloupka, Frank
Once considered as a serious public health issue only in developed countries, now overweight and obesity have dramatically increased in low- and middle-income countries, especially in urban settings...
A Large-Scale Genome-Wide Linkage Analysis to Map Loci Linked to Stature in Chinese Population
Hong, Xiumei, Tsai, Hui-Ju, Liu, Xin, Li, Zhiping, Liu, Xue, Tang, Genfu, ...
Context: A number of genome-wide scans of stature have been reported previously, but with inconsistent results. The inconsistency may be partly due to differential population characteristics and...