Xinsheng Zhu

In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts (2005)

Schmidt, Ulrich, Zhu, Xinsheng, Lebeche, Djamel, Huq, Fawzia, Guerrero, J. Luis, Hajjar, Roger J.

Objective: Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin...

Downregulation of CIITA Function by Protein Kinase A (PKA)-Mediated Phosphorylation: Mechanism of Prostaglandin E, Cyclic AMP, and PKA Inhibition of Class II Major Histocompatibility Complex Expression in Monocytic Lines

Li, Guoxuan, Harton, Jonathan A., Zhu, Xinsheng, Ting, Jenny P.-Y.

Prostaglandins, pleiotropic immune modulators that induce protein kinase A (PKA), inhibit gamma interferon induction of class II major histocompatibility complex (MHC) genes. We show that...

p38 MAPK Regulates IL-1β Induced IL-6 Expression Through mRNA Stability in Osteoblasts

Patil, Chetan, Zhu, Xinsheng, Rossa, Carlos, Kim, Young Joon, Kirkwood, Keith L.

Osteoblast-derived IL-6 functions in coupled bone turnover by supporting osteoclastogenesis favoring bone resorption instead of bone deposition. Gene regulation of IL-6 is complex occurring both at...

Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3.

Nabhani, Thomas, Zhu, Xinsheng, Simeoni, Ilenia, Sorrentino, Vincenzo, Valdivia, Héctor H, García, Jesús

Most adult mammalian skeletal muscles contain only one isoform of ryanodine receptor (RyR1), whereas neonatal muscles contain two isoforms (RyR1 and RyR3). Membrane depolarization fails to evoke...

Downregulation of CIITA Function by Protein Kinase A (PKA)-Mediated Phosphorylation: Mechanism of Prostaglandin E, Cyclic AMP, and PKA Inhibition of Class II Major Histocompatibility Complex Expression in Monocytic Lines

Li, Guoxuan, Harton, Jonathan A., Zhu, Xinsheng, Ting, Jenny P.-Y.

Prostaglandins, pleiotropic immune modulators that induce protein kinase A (PKA), inhibit gamma interferon induction of class II major histocompatibility complex (MHC) genes. We show that...

Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3.

Nabhani, Thomas, Zhu, Xinsheng, Simeoni, Ilenia, Sorrentino, Vincenzo, Valdivia, Héctor H, García, Jesús

Most adult mammalian skeletal muscles contain only one isoform of ryanodine receptor (RyR1), whereas neonatal muscles contain two isoforms (RyR1 and RyR3). Membrane depolarization fails to evoke...