Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches (2009)
Rudy J. Castellani, Xiongwei Zhu, Hyoung-Gon Lee, Mark A. Smith, George Perry
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Molecular Pathogenesis of Alzheimer's Disease: Reductionist versus Expansionist Approaches. (2009)
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer's disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
Mark A. Smith, George Perry, Xiongwei Zhu, Abdelali Haoudi, Neurodegenerative Diseases, Mark A. Smith, ...
distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Abstract Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
The role of metabotropic glutamate receptors in Alzheimer’s disease (2008)
Neu Obiologi E, Hyoung-gon Lee, Xiongwei Zhu, Michael J. O’neill, Gemma Casadesus, ...
Abstract. While glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in Alzheimer’s disease (AD), the role of glutamate...
Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...
Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Pathology's New Role: Defining Disease Process and Protective Responses. (2008)
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
ABSTRACT: Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
Wang, Xinglong, Su, Bo, Fujioka, Hisashi, Zhu, Xiongwei
Mitochondrial function relies heavily on its morphology and distribution, alterations of which have been increasingly implicated in neurodegenerative diseases, such as Alzheimer's disease (AD). In...
Teresa A. Evans, Sandra L. Siedlak, Liang Lu, Xiaoming Fu, Zeneng Wang, Woody R. McGinnis, ...
Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and...
Wang, Xinglong, Su, Bo, Siedlak, Sandra L., Moreira, Paula I., Fujioka, Hisashi, Wang, Yang, ...
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease (2007)
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
Abstract Background Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. (2007)
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
BACKGROUND: Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly...
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. (2007)
Evans, Teresa A., Raina, Arun K., Delacourte, Andr, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, ...
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many...
LRRK2 in Parkinson's disease and dementia with Lewy bodies (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD)....
Webber, Kate M, Stocco, Douglas M, Casadesus, Gemma, Bowen, Richard L, Atwood, Craig S, Previll, Laura A, ...
Abstract Background Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological...
Oxidative damage to RNA in neurodegenerative diseases. (2006)
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
LRRK2 in Parkinson's disease and dementia with Lewy bodies. (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
BACKGROUND: Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To...
Neurodegenerative diseases: mechanisms and therapies. (2006)
Smith, Mark A., Perry, George, Zhu, Xiongwei, Haoudi, Abdelali
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! (2006)
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
Webber, Kate M, Stocco, Douglas M, Casadesus, Gemma, Bowen, Richard L, Atwood, Craig S, Previll, Laura A, ...
BACKGROUND: Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data...
Heme deficiency in Alzheimer's disease: a possible connection to porphyria. (2006)
Dwyer, Barney E., Stone, Meghan L., Zhu, Xiongwei, Perry, George, Smith, Mark A.
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Heme Deficiency in Alzheimer's Disease: A Possible Connection to Porphyria (2006)
Barney E. Dwyer, Meghan L. Stone, Xiongwei Zhu, George Perry, Mark A. Smith
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Oxidative Damage to RNA in Neurodegenerative Diseases (2006)
Akihiko Nunomura, Kazuhiro Honda, Atsushi Takeda, Keisuke Hirai, Xiongwei Zhu, Mark A. Smith, ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Staying connected: synapses in Alzheimer disease. (2004)
Lee, Hyoung-gon, Moreira, Paula I., Zhu, Xiongwei, Smith, Mark A., Perry, George
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Hibernation, a model of neuroprotection. (2001)
Zhou, Fang, Zhu, Xiongwei, Castellani, Rudy J., Stimmelmayr, Raphaela, Perry, George, Smith, Mark A., ...
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may...
The role of MAPK pathways in Alzheimer's disease / (2001)
Thesis (Ph. D.)--Case Western Reserve University, 2002.
Heme Deficiency in Alzheimer's Disease: A Possible Connection to Porphyria
Dwyer, Barney E., Stone, Meghan L., Zhu, Xiongwei, Perry, George, Smith, Mark A.
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Webber, Kate M, Stocco, Douglas M, Casadesus, Gemma, Bowen, Richard L, Atwood, Craig S, Previll, Laura A, ...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Heme Deficiency in Alzheimer's Disease: A Possible Connection to Porphyria
Dwyer, Barney E., Stone, Meghan L., Zhu, Xiongwei, Perry, George, Smith, Mark A.
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Webber, Kate M, Stocco, Douglas M, Casadesus, Gemma, Bowen, Richard L, Atwood, Craig S, Previll, Laura A, ...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Neurodegenerative Diseases: Mechanisms and Therapies
Smith, Mark A., Perry, George, Zhu, Xiongwei, Haoudi, Abdelali
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
Staying Connected: Synapses in Alzheimer Disease
Lee, Hyoung-gon, Moreira, Paula I., Zhu, Xiongwei, Smith, Mark A., Perry, George
Amyloid-β Vaccination: Testing the Amyloid Hypothesis? : Heads We Win, Tails You Lose!
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease
Evans, Teresa A., Raina, Arun K., Delacourte, André, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, ...
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many...
Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Hibernation, a Model of Neuroprotection
Zhou, Fang, Zhu, Xiongwei, Castellani, Rudy J., Stimmelmayr, Raphaela, Perry, George, Smith, Mark A., ...
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may...
Smith, Mark A., Zhu, Xiongwei, Lee, Hyoung-gon, Harris, Peggy L.R., Fortino, Anne E., Perry, George, ...
A number of recent studies have suggested that cardiac myocytes, previously considered post-mitotic, re-enter the cell cycle and possess the ability to proliferate with certain pathogenic stimuli. To...
Pathology's New Role: Defining Disease Process and Protective Responses
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β...
Wang, Xinglong, Su, Bo, Fujioka, Hisashi, Zhu, Xiongwei
Mitochondrial function relies heavily on its morphology and distribution, alterations of which have been increasingly implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD). In...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Wang, Xinglong, Su, Bo, Siedlak, Sandra L., Moreira, Paula I., Fujioka, Hisashi, Wang, Yang, ...
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...
The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
Lee, Hyoung-gon, Casadesus, Gemma, Nunomura, Akihiko, Zhu, Xiongwei, Castellani, Rudy J., Richardson, Sandy L., ...
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an...
Lee, Hyoung-gon, Chen, Qun, Wolfram, Julie A., Richardson, Sandy L., Liner, Anna, Siedlak, Sandra L., ...
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a “fetal re-expression” pattern, the functional role of Myc in...