Chen, Y. D., Zhang, Q., Yang, T., Xu, C., Chen, X., Jiang, T.
Trends and variations of the extreme water levels defined as exceeding/falling below certain thresholds (mean ± std) across the Pearl River Delta (PRD) are systematically explored using the linear...
Chen, Y. D., Chen, X., Shao, Q.
Daily precipitation series at station or local scales is a critical input for rainfall-runoff modelling which, in turn, plays a vital role in the assessment of climate change impact on hydrologic...
Chen, Y. D., Zhang, Q., Yang, T., Xu, C., Chen, X., Jiang, T.
Trends and variations of the extreme water levels defined as exceeding/falling below certain thresholds (mean ± std) across the Pearl River Delta (PRD) are systematically explored using the linear...
Chen, Y. D., Chen, X., Shao, Q.
Daily precipitation series at station or local scales is a critical input for rainfall-runoff modelling which, in turn, plays a vital role in the assessment of climate change impact on hydrologic...
Charge, strangeness and radius of strangelets (2007)
Wen, X. J., Peng, G. X., Chen, Y. D.
We investigate, at both zero and finite temperature, the properties of strangelets versus the electric charge Z and strangeness S. The strangelet radius is not a monotonic function of either charge...
New solutions for the color-flavor locked strangelets (2005)
Peng, G. X., Wen, X. J., Chen, Y. D.
Recent publications rule out the negatively charged beta equilibrium strangelets in ordinary phase, and the color-flavor locked (CFL) strangelets are reported to be also positively charged. This...
Molecular classification of cutaneous malignant melanoma by gene expression profiling (2000)
Bittner, M., Meltzer, P.S.J., Chen, Y.D., Jiang, Y., Seftor, E., Hendrix, M., ...
Molecular classification of cutaneous malignant melanoma by gene expression profiling (2000)
Bittner, M., Meltzer, P.S.J., Chen, Y.D., Jiang, Y., Seftor, E., Hendrix, M., ...
The most common human cancers are malignant neoplasms of the skin(1,2). Incidence of cutaneous melanoma is rising especially steeply, with minimal progress in non-surgical treatment of advanced...
On the regeneration of the actin-myosin power stroke in contracting muscle.
The transient behavior of muscle in double-or multiple-step length perturbations [Lombardi, V., Piazzesi, G. & Linari, M. (1992) Nature (London) 355, 638-641] is simulated with a "conventional"...
Warden, C H, Daluiski, A, Bu, X, Purcell-Huynh, D A, De Meester, C, Shieh, B H, ...
Although it has been hypothesized that the synteny between mouse and human genes provides an approach to the localization of genes that determine quantitative traits in humans, this has yet to be...
Reaven, G M, Chen, Y D, Jeppesen, J, Maheux, P, Krauss, R M
Subjects characterized by a predominance of small LDL particles (pattern B) have changes in plasma triglyceride (TG) and HDL-cholesterol concentrations consistent with the presence of resistance to...
Theoretical studies on oscillations in microtubule polymerization.
Oscillations in the polymerization of microtubules have been studied theoretically, using differential equations and (more realistically) Monte Carlo simulations. There is gross qualitative agreement...
Chen, Y D, Jeng, C Y, Hollenbeck, C B, Wu, M S, Reaven, G M
The changes in hepatic glucose production (Ra), tissue glucose disposal (Rd), and plasma glucose and insulin concentration that took place over a 16-h period from 10 to 2 p.m. were documented in 14...
Can free energy be transduced from electric noise?
Astumian, R D, Chock, P B, Tsong, T Y, Chen, Y D, Westerhoff, H V
Recently, it was shown that free energy can be transduced from a regularly oscillating electric field to do chemical or transport work when coupled through an enzyme with appropriate electrical...
Asymmetry and external noise-induced free energy transduction.
The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties...
How enzymes can capture and transmit free energy from an oscillating electric field.
Westerhoff, H V, Tsong, T Y, Chock, P B, Chen, Y D, Astumian, R D
Recently, it has been demonstrated that free energy from an alternating electric field can drive the active transport of Rb+ by way of the Na+, K+-ATPase. In the present work, it is shown why many...
Uptake of low density lipoproteins by rat tissues. Special emphasis on the luteinized ovary.
Reaven, E, Chen, Y D, Spicher, M, Hwang, S F, Mondon, C E, Azhar, S
The aim of this study was to determine how luteal cells of the hormone-primed (luteinized) ovary process low density lipoproteins (LDL). Ovary uptake of perfused 125I-LDL was assessed by tissue...
We consider a phase transition "loop," obtained from a mean field type of approximate treatment of a closed steady-state Ising system. Where is the cut (stable path) across the loop located? The...
Interacting enzyme systems at steady state: further Monte Carlo calculations on two-state molecules.
In this work, Monte Carlo calculations were made on a 10 x 10 lattice of two-state, steady-state enzyme molecules in two special cases for which the Bragg-Williams (mean field) approximation had...
Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.
Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier...
Reaven, E, Chen, Y D, Spicher, M, Azhar, S
Although it is clear that high density lipoproteins (HDL) can support steroidogenesis in several rat cell systems, questions still arise as to how HDL are processed by cells. In particular, it is not...
Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams.
Over a long time period, the rate constants for cycle completions (one-way fluxes) in steady-state biochemical diagrams can be expressed explicitly in terms of the elementary rate constants for...
Matrix method for fluctuations and noise in kinetic systems.
In a series of papers we were concerned with the question of how to calculate the concentration noise power spectra of an ensemble of multi-state linear kinetic systems when the rate constants of the...
Wu, D A, Bu, X, Warden, C H, Shen, D D, Jeng, C Y, Sheu, W H, ...
Resistance to insulin-mediated glucose disposal is a common finding in patients with non-insulin-dependent diabetes mellitus (NIDDM), as well as in nondiabetic individuals with hypertension. In an...
Recognition and processing of randomly fluctuating electric signals by Na,K-ATPase.
Xie, T D, Marszalek, P, Chen, Y D, Tsong, T Y
Previous work has shown that Na,K-ATPase of human erythrocytes can extract free energy from sinusoidal electric fields to pump cations up their respective concentration gradients. Because regularly...
Fluorescence dequenching kinetics of single cell-cell fusion complexes.
Chen, Y D, Rubin, R J, Szabo, A
In an earlier paper which models the cell-cell (or virus-cell) fusion complex as two partial spherical vesicles joined at a narrow neck (Rubin, R. J., and Yi-der Chen. 1990. Biophys. J....
Characterization of a caldesmon fragment that competes with myosin-ATP binding to actin.
Velaz, L, Chen, Y D, Chalovich, J M
The protein caldesmon inhibits actin-activated ATP hydrolysis of myosin and inhibits the binding of myosin.ATP to actin. A fragment isolated from a chymotryptic digest of caldesmon contains features...
A mosaic multiple-binding model for the binding of caldesmon and myosin subfragment-1 to actin.
Binding of caldesmon to actin causes a decrease in the quantity of bound myosin and results in a reduction in the rate of actin-activated adenosine triphosphate hydrolysis. It is generally assumed...
The kinetics of redistribution of lipid-like molecules between the membranes of two fused spherical vesicles is studied by solving the time-dependent diffusion equation of the system. The effects on...
Theoretical formalism for kinesin motility I. Bead movement powered by single one-headed kinesins.
The directional movement on a microtubule of a plastic bead connected elastically to a single one-headed kinesin motor is studied theoretically. The kinesin motor can bind and unbind to periodic...
Some self-consistent two-state sliding filament models of muscle contraction.
Hill, T L, Eisenberg, E, Chen, Y D, Podolsky, R J
The general formalism required to treat two-state sliding filament models of muscle contraction, including free energy considerations, is first reviewed and amplified. This formalism is then used to...
Differentiation of channel models by noise analysis.
Differentiation of membrane channel models based on fluctuation (or noise) analysis is discussed. The theory is particularly useful in distinguishing a single-conductance model (Hodgkin-Huxley...
Differentiation between equilibrium and nonequilibrium kinetic systems by noise analysis.
Methods for the differentiation between equilibrium and nonequilibrium steady-state kinetic mechanisms based on fluctuation and noise analysis are discussed. Specifically, the "sharpening" in the...
On the regeneration of the actin-myosin power stroke in contracting muscle.
The transient behavior of muscle in double-or multiple-step length perturbations [Lombardi, V., Piazzesi, G. & Linari, M. (1992) Nature (London) 355, 638-641] is simulated with a "conventional"...
Warden, C H, Daluiski, A, Bu, X, Purcell-Huynh, D A, De Meester, C, Shieh, B H, ...
Although it has been hypothesized that the synteny between mouse and human genes provides an approach to the localization of genes that determine quantitative traits in humans, this has yet to be...
Reaven, G M, Chen, Y D, Jeppesen, J, Maheux, P, Krauss, R M
Subjects characterized by a predominance of small LDL particles (pattern B) have changes in plasma triglyceride (TG) and HDL-cholesterol concentrations consistent with the presence of resistance to...
Theoretical studies on oscillations in microtubule polymerization.
Oscillations in the polymerization of microtubules have been studied theoretically, using differential equations and (more realistically) Monte Carlo simulations. There is gross qualitative agreement...
Chen, Y D, Jeng, C Y, Hollenbeck, C B, Wu, M S, Reaven, G M
The changes in hepatic glucose production (Ra), tissue glucose disposal (Rd), and plasma glucose and insulin concentration that took place over a 16-h period from 10 to 2 p.m. were documented in 14...
Can free energy be transduced from electric noise?
Astumian, R D, Chock, P B, Tsong, T Y, Chen, Y D, Westerhoff, H V
Recently, it was shown that free energy can be transduced from a regularly oscillating electric field to do chemical or transport work when coupled through an enzyme with appropriate electrical...
Asymmetry and external noise-induced free energy transduction.
The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties...
How enzymes can capture and transmit free energy from an oscillating electric field.
Westerhoff, H V, Tsong, T Y, Chock, P B, Chen, Y D, Astumian, R D
Recently, it has been demonstrated that free energy from an alternating electric field can drive the active transport of Rb+ by way of the Na+, K+-ATPase. In the present work, it is shown why many...
Uptake of low density lipoproteins by rat tissues. Special emphasis on the luteinized ovary.
Reaven, E, Chen, Y D, Spicher, M, Hwang, S F, Mondon, C E, Azhar, S
The aim of this study was to determine how luteal cells of the hormone-primed (luteinized) ovary process low density lipoproteins (LDL). Ovary uptake of perfused 125I-LDL was assessed by tissue...
We consider a phase transition "loop," obtained from a mean field type of approximate treatment of a closed steady-state Ising system. Where is the cut (stable path) across the loop located? The...
Interacting enzyme systems at steady state: further Monte Carlo calculations on two-state molecules.
In this work, Monte Carlo calculations were made on a 10 x 10 lattice of two-state, steady-state enzyme molecules in two special cases for which the Bragg-Williams (mean field) approximation had...
Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.
Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier...
Reaven, E, Chen, Y D, Spicher, M, Azhar, S
Although it is clear that high density lipoproteins (HDL) can support steroidogenesis in several rat cell systems, questions still arise as to how HDL are processed by cells. In particular, it is not...
Stochastics of cycle completions (fluxes) in biochemical kinetic diagrams.
Over a long time period, the rate constants for cycle completions (one-way fluxes) in steady-state biochemical diagrams can be expressed explicitly in terms of the elementary rate constants for...
Matrix method for fluctuations and noise in kinetic systems.
In a series of papers we were concerned with the question of how to calculate the concentration noise power spectra of an ensemble of multi-state linear kinetic systems when the rate constants of the...
Wu, D A, Bu, X, Warden, C H, Shen, D D, Jeng, C Y, Sheu, W H, ...
Resistance to insulin-mediated glucose disposal is a common finding in patients with non-insulin-dependent diabetes mellitus (NIDDM), as well as in nondiabetic individuals with hypertension. In an...
Recognition and processing of randomly fluctuating electric signals by Na,K-ATPase.
Xie, T D, Marszalek, P, Chen, Y D, Tsong, T Y
Previous work has shown that Na,K-ATPase of human erythrocytes can extract free energy from sinusoidal electric fields to pump cations up their respective concentration gradients. Because regularly...
Fluorescence dequenching kinetics of single cell-cell fusion complexes.
Chen, Y D, Rubin, R J, Szabo, A
In an earlier paper which models the cell-cell (or virus-cell) fusion complex as two partial spherical vesicles joined at a narrow neck (Rubin, R. J., and Yi-der Chen. 1990. Biophys. J....
Characterization of a caldesmon fragment that competes with myosin-ATP binding to actin.
Velaz, L, Chen, Y D, Chalovich, J M
The protein caldesmon inhibits actin-activated ATP hydrolysis of myosin and inhibits the binding of myosin.ATP to actin. A fragment isolated from a chymotryptic digest of caldesmon contains features...
A mosaic multiple-binding model for the binding of caldesmon and myosin subfragment-1 to actin.
Binding of caldesmon to actin causes a decrease in the quantity of bound myosin and results in a reduction in the rate of actin-activated adenosine triphosphate hydrolysis. It is generally assumed...
The kinetics of redistribution of lipid-like molecules between the membranes of two fused spherical vesicles is studied by solving the time-dependent diffusion equation of the system. The effects on...
Theoretical formalism for kinesin motility I. Bead movement powered by single one-headed kinesins.
The directional movement on a microtubule of a plastic bead connected elastically to a single one-headed kinesin motor is studied theoretically. The kinesin motor can bind and unbind to periodic...
Some self-consistent two-state sliding filament models of muscle contraction.
Hill, T L, Eisenberg, E, Chen, Y D, Podolsky, R J
The general formalism required to treat two-state sliding filament models of muscle contraction, including free energy considerations, is first reviewed and amplified. This formalism is then used to...
Differentiation of channel models by noise analysis.
Differentiation of membrane channel models based on fluctuation (or noise) analysis is discussed. The theory is particularly useful in distinguishing a single-conductance model (Hodgkin-Huxley...
Differentiation between equilibrium and nonequilibrium kinetic systems by noise analysis.
Methods for the differentiation between equilibrium and nonequilibrium steady-state kinetic mechanisms based on fluctuation and noise analysis are discussed. Specifically, the "sharpening" in the...