Y. Hirakata

Regional variation in the prevalence of extended-spectrum b-lactamase-producing clinical isolates in the Asia-Pacific region (SENTRY 1998-2002) (2005)

Hirakata, Y., Matsuda, J., Miyazaki, Y., Kamihira, S., Kawakama, S., Miyazawa, Y., ...

Regional variation in the prevalence of extended-spectrum b-lactamase-producing clinical isolates in the Asia-Pacific region (SENTRY 1998-2002) (2005)

Hirakata, Y., Matsuda, J., Miyazaki, Y., Kamihira, S., Kawakama, S., Miyazawa, Y., ...

Evaluation of the contemporary occurrence rates of metallo-b-lactamases in multidrug-resistant Gram-negative bacilli in Japan: report from the SENTRY antimicrobial surveillance program (1998-2002) (2004)

Jones, R. N., Deshpande, L. M., Bell, J. M., Turnidge, J. D., Kohno, S., Hirakata, Y., ...

Evaluation of the contemporary occurrence rates of metallo-b-lactamases in multidrug-resistant Gram-negative bacilli in Japan: report from the SENTRY antimicrobial surveillance program (1998-2002) (2004)

Jones, R. N., Deshpande, L. M., Bell, J. M., Turnidge, J. D., Kohno, S., Hirakata, Y., ...

Evaluation of the contemporary occurrence rates of metallo-b-lactamases in multidrug-resistant Gram-negative bacilli in Japan: report from the SENTRY antimicrobial surveillance program (1998-2002) (2004)

Jones, R. N., Deshpande, L. M., Bell, J. M., Turnidge, J. D., Kohno, S., Hirakata, Y., ...

Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay.

Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...

Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...

Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.

Matsumoto, T, Tateda, K, Miyazaki, S, Furuya, N, Ohno, A, Ishii, Y, ...

We evaluated the protective effect of fosfomycin (FOM) and an enantiomer of fosfomycin [FOM (+); an isomer of FOM with no bactericidal activity] on murine gut-derived sepsis caused by Pseudomonas...

Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads.

Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...

We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...

Effects of sub-MICs of erythromycin and other macrolide antibiotics on serum sensitivity of Pseudomonas aeruginosa.

Tateda, K, Hirakata, Y, Furuya, N, Ohno, A, Yamaguchi, K

We examined the effects of sub-MICs of erythromycin (EM) and other macrolide antibiotics on the serum sensitivity of Pseudomonas aeruginosa. P. aeruginosa S-6 grown for 36 and 48 h on agar with 10...

Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.

Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...

We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...

Potential effects of erythromycin on host defense systems and virulence of Pseudomonas aeruginosa.

Hirakata, Y, Kaku, M, Mizukane, R, Ishida, K, Furuya, N, Matsumoto, T, ...

We evaluated several potential effects of erythromycin (EM) on host defense systems and the virulence of Pseudomonas aeruginosa. Peritoneal macrophages obtained from mice given 250 mg of EM per kg of...

Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia.

Mitsutake, K, Miyazaki, T, Tashiro, T, Yamamoto, Y, Kakeya, H, Otsubo, T, ...

We compared the specificities and sensitivities of four tests used for the serodiagnosis of candidemia in 39 patients with candidemia, including 10 patients with superficial Candida colonization, 10...

Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.

Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...

Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...

In vivo production of exotoxin A and its role in endogenous Pseudomonas aeruginosa septicemia in mice.

Hirakata, Y, Furuya, N, Tateda, K, Kaku, M, Yamaguchi, K

We have examined the production of Pseudomonas aeruginosa exotoxin A (ETA) and its role in endogenous bacteremia in mice. Mice given P. aeruginosa D4 orally died of bacteremia between days 10 and 13...

Comparative in vitro exoenzyme-suppressing activities of azithromycin and other macrolide antibiotics against Pseudomonas aeruginosa.

Mizukane, R, Hirakata, Y, Kaku, M, Ishii, Y, Furuya, N, Ishida, K, ...

The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were...

Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo

Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...

We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...

Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay.

Takemura, H, Kaku, M, Kohno, S, Hirakata, Y, Tanaka, H, Yoshida, R, ...

Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new...

Immunomodulating effect of fosfomycin on gut-derived sepsis caused by Pseudomonas aeruginosa in mice.

Matsumoto, T, Tateda, K, Miyazaki, S, Furuya, N, Ohno, A, Ishii, Y, ...

We evaluated the protective effect of fosfomycin (FOM) and an enantiomer of fosfomycin [FOM (+); an isomer of FOM with no bactericidal activity] on murine gut-derived sepsis caused by Pseudomonas...

Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads.

Sawai, T, Tomono, K, Yanagihara, K, Yamamoto, Y, Kaku, M, Hirakata, Y, ...

We describe a novel mouse model of acute staphylococcal pneumonia induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. For comparison, we also used various strains of...

Effects of sub-MICs of erythromycin and other macrolide antibiotics on serum sensitivity of Pseudomonas aeruginosa.

Tateda, K, Hirakata, Y, Furuya, N, Ohno, A, Yamaguchi, K

We examined the effects of sub-MICs of erythromycin (EM) and other macrolide antibiotics on the serum sensitivity of Pseudomonas aeruginosa. P. aeruginosa S-6 grown for 36 and 48 h on agar with 10...

Efficacy of erythromycin lactobionate for treating Pseudomonas aeruginosa bacteremia in mice.

Hirakata, Y, Kaku, M, Tomono, K, Tateda, K, Furuya, N, Matsumoto, T, ...

We induced endogenous Pseudomonas aeruginosa bacteremia by administering cyclophosphamide and ampicillin to specific pathogen-free mice fed P. aeruginosa. Using this model, we evaluated the efficacy...

Potential effects of erythromycin on host defense systems and virulence of Pseudomonas aeruginosa.

Hirakata, Y, Kaku, M, Mizukane, R, Ishida, K, Furuya, N, Matsumoto, T, ...

We evaluated several potential effects of erythromycin (EM) on host defense systems and the virulence of Pseudomonas aeruginosa. Peritoneal macrophages obtained from mice given 250 mg of EM per kg of...

Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia.

Mitsutake, K, Miyazaki, T, Tashiro, T, Yamamoto, Y, Kakeya, H, Otsubo, T, ...

We compared the specificities and sensitivities of four tests used for the serodiagnosis of candidemia in 39 patients with candidemia, including 10 patients with superficial Candida colonization, 10...

Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia.

Hirakata, Y, Tomono, K, Tateda, K, Matsumoto, T, Furuya, N, Shimoguchi, K, ...

Bacteremia in immunocompromised hosts often arises from their endogenous intestinal flora. We produced experimental endogenous bacteremia by administering cyclophosphamide and ampicillin to...

In vivo production of exotoxin A and its role in endogenous Pseudomonas aeruginosa septicemia in mice.

Hirakata, Y, Furuya, N, Tateda, K, Kaku, M, Yamaguchi, K

We have examined the production of Pseudomonas aeruginosa exotoxin A (ETA) and its role in endogenous bacteremia in mice. Mice given P. aeruginosa D4 orally died of bacteremia between days 10 and 13...

Comparative in vitro exoenzyme-suppressing activities of azithromycin and other macrolide antibiotics against Pseudomonas aeruginosa.

Mizukane, R, Hirakata, Y, Kaku, M, Ishii, Y, Furuya, N, Ishida, K, ...

The inhibitory effects of azithromycin (AZM), a new 15-membered macrolide antibiotic, on the production of exotoxin A, total protease, elastase, and phospholipase C by Pseudomonas aeruginosa were...

Virulence of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa In Vitro and In Vivo

Aoki, S., Hirakata, Y., Kondoh, A., Gotoh, N., Yanagihara, K., Miyazaki, Y., ...

We evaluated the virulence of Pseudomonas aeruginosa carrying blaIMP, a metallo-β-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia...

Acute infection with influenza virus enhances susceptibility to fatal pneumonia following Streptococcus pneumoniae infection in mice with chronic pulmonary colonization with Pseudomonas aeruginosa

SEKI, M, HIGASHIYAMA, Y, TOMONO, K, YANAGIHARA, K, OHNO, H, KANEKO, Y, ...

We established a mouse model in which fatal pneumonia was induced by pneumococcal superinfection following influenza virus infection in chronic Pseudomonas aeruginosa infected mice. In this mouse...