Mast cells jump start K/BxN serum transfer arthritis via IL-1 (2007)
Nigrovic, PA, Johnsen, A, Binstadt, BA, Monach, PA, Gurish, M, Iwakura, Y, ...
No abstract available.
Molecular mechanisms of Fas ligand-induced inflammation (2006)
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells (2006)
OSullivan, B. J., Thomas, H. E., Pai, S., Santamaria, P., Iwakura, Y., Steptoe, R. J., ...
IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is...
The role of IL-17 in the development of arthritis in mouse models (2003)
Iwakura, Y, Nakae, S, Horai, R, Saijo, S
No abstract available.
Organ Infectivity of Toxoplasma gondii in Interferon-γ Knockout Mice (2001)
K. Norose, F. Aosai, M. Chen, H. Hata, Y. Tagawa, ...
To determine the influence of interferon (IFN)-γ on the organ infectivity and on the genetic susceptibility of susceptible (C57BL/6) and resistant (BALB/c) strains after peroral infection with cysts...
Nishijima, I, Nakahata, T, Hirabayashi, Y, Inoue, T, Kurata, H, Miyajima, A, ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by GM-CSF...
SV40 vector with early gene replacement efficient in transducing exogenous DNA into mammalian cells.
Asano, M, Iwakura, Y, Kawade, Y
An early replacement SV40 vector, SV40-Mu beta, was constructed by replacing part of the early genes of the virus with mouse interferon-beta (IFN-beta) cDNA. Upon transfection of COS-7 cells with...
Iwakura, Y, Asano, M, Nishimune, Y, Kawade, Y
As an approach to elucidating the roles of interferon (IFN) in the normal physiology and diseases of animals, transgenic mice carrying extra mouse IFN-beta genes under the control of a mouse...
Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.
Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...
We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...
Asano, M, Furukawa, K, Kido, M, Matsumoto, S, Umesaki, Y, Kochibe, N, ...
Carbohydrate chains on a glycoprotein are important not only for protein conformation, transport and stability, but also for cell-cell and cell-matrix interactions. UDP-Gal:N-acetylglucosamine...
Kotani, N, Asano, M, Iwakura, Y, Takasaki, S
To understand the contribution of beta 1,4-galactosyltransferase (beta 4Gal-T)-1 to galactosylation in vivo, N-glycans of hepatic membrane glycoproteins and plasma glycoproteins from beta 4Gal-T1...
Molecular mechanisms of Fas ligand-induced inflammation
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
Nishijima, I, Nakahata, T, Hirabayashi, Y, Inoue, T, Kurata, H, Miyajima, A, ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by GM-CSF...
SV40 vector with early gene replacement efficient in transducing exogenous DNA into mammalian cells.
Asano, M, Iwakura, Y, Kawade, Y
An early replacement SV40 vector, SV40-Mu beta, was constructed by replacing part of the early genes of the virus with mouse interferon-beta (IFN-beta) cDNA. Upon transfection of COS-7 cells with...
Iwakura, Y, Asano, M, Nishimune, Y, Kawade, Y
As an approach to elucidating the roles of interferon (IFN) in the normal physiology and diseases of animals, transgenic mice carrying extra mouse IFN-beta genes under the control of a mouse...
Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.
Fujisawa, K, Asahara, H, Okamoto, K, Aono, H, Hasunuma, T, Kobata, T, ...
We have recently demonstrated Fas-mediated apoptosis in the synovium, of patients with rheumatoid arthritis (RA) and suggested that it may be one factor responsible for the regression of RA. To...
Asano, M, Furukawa, K, Kido, M, Matsumoto, S, Umesaki, Y, Kochibe, N, ...
Carbohydrate chains on a glycoprotein are important not only for protein conformation, transport and stability, but also for cell-cell and cell-matrix interactions. UDP-Gal:N-acetylglucosamine...
Kotani, N, Asano, M, Iwakura, Y, Takasaki, S
To understand the contribution of beta 1,4-galactosyltransferase (beta 4Gal-T)-1 to galactosylation in vivo, N-glycans of hepatic membrane glycoproteins and plasma glycoproteins from beta 4Gal-T1...
Molecular mechanisms of Fas ligand-induced inflammation
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells
OSullivan, BJ, Thomas, HE, Pai, S, Santamaria, P, Iwakura, Y, Steptoe, RJ, ...
IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is...
Miyazato, A, Kawakami, K, Iwakura, Y, Saito, A
To elucidate the pathogenic mechanisms of human T-lymphotropic virus type 1 (HTLV-1)-associated lung inflammation, we conducted a histopathological and molecular analysis study using transgenic mice...
Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice
Ito, R, Shin-Ya, M, Kishida, T, Urano, A, Takada, R, Sakagami, J, ...
Cytokines may be crucially involved in the pathogenesis of inflammatory bowel diseases (IBD), but it remains controversial whether interferon (IFN)-γ, a typical proinflammatory cytokine, is an...