Y. Kasuya

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.

Yanagisawa, M, Inoue, A, Ishikawa, T, Kasuya, Y, Kimura, S, Kumagaye, S, ...

Endothelin is a potent vasoconstrictor/pressor peptide, which we recently characterized from the conditioned culture medium of porcine aortic endothelial cells. We report here the cloning and partial...

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

Inoue, A, Yanagisawa, M, Kimura, S, Kasuya, Y, Miyauchi, T, Goto, K, ...

Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the...

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

Goto, K, Kasuya, Y, Matsuki, N, Takuwa, Y, Kurihara, H, Ishikawa, T, ...

Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the...

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

Takuwa, Y, Kasuya, Y, Takuwa, N, Kudo, M, Yanagisawa, M, Goto, K, ...

The mechanisms of endothelin-1 (ET) actions were investigated in cultured rat aortic vascular smooth muscle A-10 cells. The A-10 cells have a single class of high affinity binding sites for ET with...

Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.

Yanagisawa, M, Inoue, A, Ishikawa, T, Kasuya, Y, Kimura, S, Kumagaye, S, ...

Endothelin is a potent vasoconstrictor/pressor peptide, which we recently characterized from the conditioned culture medium of porcine aortic endothelial cells. We report here the cloning and partial...

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

Inoue, A, Yanagisawa, M, Kimura, S, Kasuya, Y, Miyauchi, T, Goto, K, ...

Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the...

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

Goto, K, Kasuya, Y, Matsuki, N, Takuwa, Y, Kurihara, H, Ishikawa, T, ...

Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the...

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

Takuwa, Y, Kasuya, Y, Takuwa, N, Kudo, M, Yanagisawa, M, Goto, K, ...

The mechanisms of endothelin-1 (ET) actions were investigated in cultured rat aortic vascular smooth muscle A-10 cells. The A-10 cells have a single class of high affinity binding sites for ET with...

Loss of contractile activity of endothelin-1 induced by electrical field stimulation-generated free radicals.

Yasuda, N, Kasuya, Y, Yamada, G, Hama, H, Masaki, T, Goto, K

1. Electrical field stimulation (EFS; 10 V, 10 Hz, 2 ms) of porcine coronary artery strips precontracted with 10 nM endothelin-1 (ET-1) for 5 min caused a biphasic response, consisting of a slight...

Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats.

Kamata, K., Miyata, N., Kasuya, Y.

1. Acetylcholine (ACh)-induced relaxation of aortic strips with endothelium and production of cyclic GMP between streptozotocin-induced diabetic and age-matched control rats were compared. 2. The...

Endothelium-dependent vasodilator effects of platelet activating factor on rat resistance vessels.

Kamata, K., Mori, T., Shigenobu, K., Kasuya, Y.

1. To elucidate the mechanisms of the powerful and long-lasting hypotension produced by platelet activating factor (PAF), its effects on perfusion pressure in the perfused mesenteric arterial bed of...

A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle.

Kasuya, Y., Takuwa, Y., Yanagisawa, M., Masaki, T., Goto, K.

1. Endothelin-1 (ET-1)-induced contraction of porcine coronary artery strips may be mediated via at least two intracellular signalling mechanisms, the activation of dihydropyridine-sensitive...

Preservation of endothelium-dependent relaxation in cholesterol-fed and streptozotocin-induced diabetic mice by the chronic administration of cholestyramine.

Kamata, K., Sugiura, M., Kojima, S., Kasuya, Y.

1. Experiments were designed to investigate the effects of the low density lipoprotein (LDL)-lowering drugs cholestyramine on serum LDL levels and endothelium-dependent relaxation to acetylcholine...

failure' of agrarian reform in transitional democracy, Philippines 1986-1992

KASUYA, Y.

agrarian reform; democratization; political leadership; obstacles to development; Philippines;

Studies on the in Vitro Interaction of Electrical Stimulation and Ca++ Movement in Sarcoplasmic Reticulum

Lee, Kwang S., Ladinsky, Herbert, Choi, Sin J., Kasuya, Y.

Sarcoplasmic reticulum fragments (S.R.F.) were isolated from skeletal and heart muscles. These fragments were found to take up Ca++ very actively from media. When monophasic square waves were passed...

The 'Failure' of Agrarian Reform in Transitional Democracy, Philippines 1986-1992.

Kasuya, Y.

AGRARIAN REFORM;DEMOCRACY