0.63 Micrometers Polarization Maintaining Optical Fiber Cable, (9999)
Yoshida,H., Kikuchi,Y., Tamaki,Y.
Polarization maintaining single mode optical fiber cable was developed with negligible small loss increase and high crosstalk for optical interferometric measuring system of JT-60 (Japan Atomic...
Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...
Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...
Khoma, MV, Imai, M, Karbovanets, OM, Kikuchi, Y, Saito, M, Haruyama, Y, ...
U Capture And Inelastic Cross-Sections (2007)
Report By The, V Olume, Y. Kanda, M. Baba, Y. Kikuchi, A. Hasegawa
this report are those of the authors only and do not necessarily represent the position of any Member country or international organisation. This report is published on the responsibility of the...
Neuromagnetic Fields Elicited By a Bimodal Input (2007)
Nishimura Kumagai Kikuchi, C. Nishimura, T. Kumagai, Y. Kikuchi, H. Endo
Introduction In recent years noninvasive measurement such as magnetoencephalography (MEG), functional magnetic resonance imaging (f-MRI) and positron emission tomography (PET) has revealed many...
Growth Mechanism and Selective Synthesis of SWNTs (2007)
Inoue, S., Nakajima, T., Nomura, K., Kikuchi, Y.
Ever since the landmark discovery of single-walled carbon nanotubes (SWNTs) in 1993, they have been considered as ideal materials for any kind of application based on their outstanding properties...
Wilkins, S. J., Yoong, S., Verkade, H., Mizoguchi, T., Plowman, S., Hancock, J. F., ...
The homeobox transcription factor Mtx2 is essential for epiboly, the first morphogenetic movement of gastrulation in zebrafish. Morpholino knockdown of Mtx2 results in stalling of epiboly and lysis...
Wilkins, S. J., Yoong, S., Verkade, H., Mizoguchi, T., Plowman, S., Hancock, J. F., ...
The homeobox transcription factor Mtx2 is essential for epiboly, the first morphogenetic movement of gastrulation in zebrafish. Morpholino knockdown of Mtx2 results in stalling of epiboly and lysis...
Spatiotemporal Brain Activity in Mental Rotation (2006)
H Kawamichi, Y Kikuchi, S Ueno, S Yoshizawa
There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the...
Spatiotemporal Brain Activity in Mental Rotation (2006)
H Kawamichi, Y Kikuchi, S Ueno, S Yoshizawa
There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the...
Spatiotemporal Brain Activity in Mental Rotation (2006)
H Kawamichi, Y Kikuchi, S Ueno, S Yoshizawa
There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the...
Spatiotemporal Brain Activity in Mental Rotation (2006)
H Kawamichi, Y Kikuchi, S Ueno, S Yoshizawa
There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the...
Kikuchi, Y., Finken, K. H., Jakubowski, M., Lehnen, M., Reiser, D., Sewell, G., ...
This version is available at the following Publisher URL: http://dx.doi.org/10.1088/0741-3335/48/2/001
Kikuchi, Y., Finken, K. H., Jakubowski, M., Jaspers, R., Koslowski, H. R., ...
This version is available at the following Publisher URL: http://prl.aps.org
Tearing mode physics studies applying the dynamic ergodic divertor on TEXTOR (2006)
Koslowski, H. R., Westerhof, E., De Bock, M., Classen, I., Jaspers, R., Kikuchi, Y., ...
This version is available at the following Publisher URL: http://dx.doi.org/10.1088/0741-3335/48/12B/S05
Growth Mechanism and Selective Synthesis of SWNTs (2006)
Inoue, S., Nakajima, T., Nomura, K., Kikuchi, Y.
Ever since the landmark discovery of single-walled carbon nanotubes (SWNTs) in 1993, they have been considered as ideal materials for any kind of application based on their outstanding properties...
Growth Mechanism and Selective Synthesis of SWNTs (2006)
Inoue, S., Nakajima, T., Nomura, K., Kikuchi, Y.
Ever since the landmark discovery of single-walled carbon nanotubes (SWNTs) in 1993, they have been considered as ideal materials for any kind of application based on their outstanding properties...
Overview of experiments with the dynamic ergodic divertor on TEXTOR (2006)
FINKEN, KH, ABDULLAEV, S, BIEL, W, DE BOCK, MFM, BREZINSEK, S, BUSCH, C, ...
Transport and divertor properties of the dynamic ergodic divertor (2005)
Lehnen, M., Abdullaev, S. S., Biehl, W., Brezinsek, S., Busch, C., Finken, K. H., ...
The definitive version is available at the following Publisher URL: http://www.iop.org .
Type IX collagen knock-out mouse shows progressive hearing loss (2005)
Suzuki,N., Asamura,K., Kikuchi,Y., Takumi,Y., Abe,S., Imamura,Y., ...
Huys, R, Ohtsuka, S, Conroy-Dalton, S, Kikuchi, Y
Two new sympatric species of Neotachidius Shen & Tai, 1963, N. coreanus sp. nov. and N. parvus sp. nov.: are described from plankton samples collected from brackish waters in Kwangyang Bay, South...
Type IX collagen knock-out mouse shows progressive hearing loss (2005)
Suzuki, N., Asamura, K., Kikuchi, Y., Takumi, Y., Abe, S., Imamura, Y., ...
Toroidal plasma rotation induced by the Dynamic Ergodic Divertor in the TEXTOR tokamak (2005)
Finken, K. H., Abdullaev, S. S., Von Hellermann, M., Jakubowski, M., Jaspers, R., ...
This version is available at the following Publisher URL: http://prl.aps.org
Toroidal plasma rotation induced by the Dynamic Ergodic Divertor in the TEXTOR tokamak (2005)
FINKEN, KH, ABDULLAEV, SS, DE BOCK, MFM, VON HELLERMANN, M, JAKUBOWSKI, M, JASPERS, R, ...
Transport and divertor properties of the dynamic ergodic divertor (2005)
LEHNEN, M, ABDULLAEV, S, BIEL, W, DE BOCK, MFM, BREZINSEK, S, BUSCH, C, ...
FINKEN, KH, ABDULLAEV, SS, BIEL, W, DE BOCK, MFM, BUSCH, C, FARSHI, E, ...
Suppression of Externally Induced Magnetic Island by Plasma Current Oscillation in HYBTOK-II (2003)
Kikuchi, Y., Takahashi, H., Uesugi, Y., Takamura, S.
Plasma Science, 2003. ICOPS 2003. p.382
CD180 (RP105) in rheumatic diseases (2001)
Koarada, S., Tada, Y., Kikuchi, Y., Ushiyama, O., Suzuki, N., Ohta, A., ...
RTP Payload Format for MPEG-4 Audio/Visual Systems (2000)
Y. Kikuchi, T. Nomura, S. Fukunaga, Y. Matsui, H. Kimata
This document describes Real-Time Transport Protocol (RTP) payload formats for carrying each of MPEG-4 Audio and MPEG-4 Visual bitstreams without using MPEG-4 Systems. For the purpose of directly...
Emulsion break-down : mechanisms and development of multi-layer membrane (1999)
Kawakatsu, T., Boom, R., Nabetani, H., Kikuchi, Y., Nakajima, M.
Viscoplastic Behavior of SUS 304 Stainless Steel Under Cyclic Loading at Room Temperature. (1998)
Yoshida, F., Kondo, J., Kikuchi, Y.
The stress controlled uniaxial creep-ratcheting tests were conducted at room temperature; effects of the prestrain and the cyclic stress condition, i.e. stress ratio, maximum stress and its hold...
Intergranular Liquation Cracking in an Advanced Austenitic Stainless Steel. (1998)
Lundin, C. D., Qiao, C. Y. P., Kikuchi, Y.
Laser welding, water quenched GTA welds and electric resistance spot welding techniques were used to investigate HAZ liquation cracking behavior in advanced austenitic stainless steels since rapid...
Hybridity and the oriental orientalism of Mingei theory (1997)
Orientalism is not a rigid one-way phenomenon projected on to the Orient from the Occident. It is an infectious phenomenon, open to appropriation by 'others', at least in the case of modern Japan....
Nishi, M, Miyake, H, Takeda, T, Yonemori, H, Hanai, J, Kikuchi, Y, ...
A report on evaluated `2`3`8U(n,#g) cross section. (1991)
Kanda, Y., Kikuchi, Y., Nakajima, Y., Sowerby, M.G., Moxon, M.C., Froehner, F.H., ...
Internat.Conf.on Nuclear Data for Science and Technology, Juelich, May 13-17, 1991
Hitoshi, Y., Mita, S., Tominaga, A., Kikuchi, Y., Sonoda, E., Takatsu, K., ...
Interferon.gamma (IFN-γ) is supposed to be produced by type 1 helper T cells (TH1) and inhibits IL-4-dependent B cell growth and differentiation. IL-5 (T cell-replacing factor, TRF), is a T cell-...
Characteristics of Heat and Flame Resistant Optical Fiber Cables, (1983)
Kikuchi,Y., Mogi,A., Kobayashi,T., Misono,N., Murayama,T.
Flame resistant and flame retardant properties of various types of optical cables are investigated. As a result of the tests, the authors conclude that it is not suitable to employ to conventional...
Numerical simulation of the blocking process / (1968)
Includes bibliographical references.
Kikuchi, Y, Yasue, T, Miyake, K, Kimoto, M, Takatsu, K
Mouse CD38 has been implicated in the regulation of both B-cell proliferation and protection of B cells from irradiation-induced apoptosis. CD38 ligation on B cells by CS/2, an anti-mouse CD38...
Doi, H, Kitajima, M, Watanabe, I, Kikuchi, Y, Matsuzawa, F, Aikawa, S, ...
Oligopeptidic permutations of the 20 amino acid residues give rise to proteins of diverse functions. Our long-term goal is to produce a lexicon of oligopeptides, classifying them into at least five...
Sogawa, K, Nakano, R, Kobayashi, A, Kikuchi, Y, Ohe, N, Matsushita, N, ...
Arnt (Ah receptor nuclear translocator) is a member of a transcription factor family having characteristic motifs designated bHLH (basic helix-loop-helix) and PAS and was originally found as a factor...
Kikuchi, Y, Sasaki, N, Ando-Yamagami, Y
The retrovirus-like particles of Drosophila are intermediates of retrotransposition of the transposable element copia. In these particles, a 39-nucleotide-long fragment from the 5' region of...
Kikuchi, Y, Tsujimoto, K, Kurahashi, O
In Escherichia coli, aroF, aroG, and aroH encode 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isozymes that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. In...
Characterization of a second lysine decarboxylase isolated from Escherichia coli.
Kikuchi, Y, Kojima, H, Tanaka, T, Takatsuka, Y, Kamio, Y
We report here on the existence of a new gene for lysine decarboxylase in Escherichia coli K-12. The hybridization experiments with a cadA probe at low stringency showed that the homologous region of...
Komiya, M, Kikuchi, Y, Tachibana, A, Yano, K
The pharmacokinetics of YM09330, a new semisynthetic cephamycin, were determined after intravenous and intramuscular administration to experimental animals. Mean plasma levels of YM09330 at 30 min...
Pharmacokinetics of cefotetan (YM09330) in humans.
Nakagawa, K, Koyama, M, Tachibana, A, Komiya, M, Kikuchi, Y, Yano, K
The pharmacokinetics and safety of cefotetan (YM09330) were examined after intravenous administration of single and multiple doses to normal volunteers. Cefotetan was well tolerated in single doses...
Kikuchi, Y, Nagata, Y, Hinata, M, Kimbara, K, Fukuda, M, Yano, K, ...
The nucleotide sequence of the downstream region of the bph operon from Pseudomonas sp. strain KKS102 was determined. Two open reading frames (ORF1 and ORF2) were found in this region, and the...
Kikuchi, Y, Yasukochi, Y, Nagata, Y, Fukuda, M, Takagi, M
Pseudomonas sp. strain KKS102 is able to degrade biphenyl and polychlorinated biphenyls via the meta-cleavage pathway. We sequenced the upstream region of the bphA1A2A3BCD (open reading frame 1...
Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae.
Yashiroda, H, Oguchi, T, Yasuda, Y, Toh-E, A, Kikuchi, Y
We characterized a temperature-sensitive mutant of Saccharomyces cerevisiae in which a mini-chromosome was unstable at a high temperature and cloned a new gene which encodes a basic and hydrophilic...
Ema, M, Morita, M, Ikawa, S, Tanaka, M, Matsuda, Y, Gotoh, O, ...
From a cDNA library of mouse skeletal muscle, we have isolated mouse Sim1 (mSim1) cDNA encoding a polypeptide of 765 amino acids with striking amino acid identify in basic helix-loop-helix (89%...
Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines.
Mita, S, Tominaga, A, Hitoshi, Y, Sakamoto, K, Honjo, T, Akagi, M, ...
Interleukin 5 (IL-5) is a glycosylated polypeptide that acts as a key factor for B-cell growth and differentiation. We demonstrated previously that there are two classes (high and low affinity) of...
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
Takatsu, K, Kikuchi, Y, Takahashi, T, Honjo, T, Matsumoto, M, Harada, N, ...
We describe an interleukin, termed interleukin 5, that is the recombinant product previously referred to as T-cell-replacing factor (TRF), B-cell growth factor II (BCGF II), or killer-helper factor...
Harada, N, Takahashi, T, Matsumoto, M, Kinashi, T, Ohara, J, Kikuchi, Y, ...
T-cell-replacing factor (TRF) is a T-cell-derived factor required for terminal differentiation of activated B cells to immunoglobulin-secreting cells. Previous studies have shown that a murine T-cell...
The yeast linear DNA killer plasmids, pGKL1 and pGKL2, possess terminally attached proteins.
Kikuchi, Y, Hirai, K, Hishinuma, F
The terminal structures of linear DNA killer plasmids from yeast, pGKL1 and pGKL2, were analyzed. Results obtained by exonuclease treatments of these plasmids show that both pGKL plasmids have free...
Kikuchi, Y, Tyc, K, Filipowicz, W, Sänger, H L, Gross, H J
A novel type of RNA ligase activity in extracts of wheat germ or Chlamydomonas requires 2', 3'-cyclic phosphate and 5'-phosphate ends for ligation to form a 2'-phosphomonoester, 3',5'-phosphodiester...
Kikuchi, Y, Yoda, K, Yamasaki, M, Tamura, G
The promoter and the amino-terminal region of phoA, the structural gene for alkaline phosphatase of Escherichia coli K12, was cloned by using a promoter cloning vector pMC1403. The nucleotide...
Site-specific cleavage of natural mRNA sequences by newly designed hairpin catalytic RNAs.
The negative strand of tobacco ringspot virus satellite RNA is a self-cleaving RNA. Its catalytic domain and substrate domain have been identified, and the catalytic domain has been named hairpin...
Artificial self-cleaving molecules consisting of a tRNA precursor and the catalytic RNA of RNase P.
Kikuchi, Y, Sasaki-Tozawa, N, Suzuki, K
We synthesized two types of chimeric RNAs between the catalytic RNA subunit of RNase P from Escherichia coli (M1 RNA) and a tRNA precursor (pre-tRNA); one had pre-tRNA at the 3' side to the M1 RNA...
Enzymatic synthesis of a segment of bacteriophage Qbeta coat protein gene.
The oligoribonucleotide, A-A-A-C-U-U-U-Gp, constituting a segment of RNA bacteriophage Qbeta coat protein gene was efficiently synthesized at a milligram scale by a combination of enzymatic methods...
A nuclear gene of Saccharomyces cerevisiae needed for stable maintenance of plasmids.
We have isolated host mutants of Saccharomyces cerevisiae in which the 2 microns plasmid is poorly maintained. All the mutants tested constituted one complementation group, which was designated map1...
Nicking-closing activity associated with bacteriophage lambda int gene product.
Integrative recombination of bacteriophage lambda requires the action of the protein Int, the product of the phage int gene. In this paper we show that highly purified Int relaxes supercoiled DNA....
Hoshino, S, Miyazawa, H, Enomoto, T, Hanaoka, F, Kikuchi, Y, Kikuchi, A, ...
A human homologue (GST1-Hs) of the yeast GST1 gene that encodes a new GTP-binding protein essential for the G1-to-S phase transition of the cell cycle was cloned from the cDNA library of human KB...
Addition of mononucleotides to oligoribonucleotide acceptors with T4 RNA ligase.
Kikuchi, Y, Hishinuma, F, Sakaguchi, K
RNA ligase induced by bacteriophage T4 catalyzed the addition of nucleoside 5',3'-diphosphates to oligoribonucleotide acceptors in the presence of ATP. The reactions proceeded in equimolar...
Rolink, A, Kudo, A, Karasuyama, H, Kikuchi, Y, Melchers, F
Cell lines and clones were established from PB76-positive mouse fetal liver at day 13 and 14 of gestation, which proliferated with division times of a day in serum-substituted cultures under the...
Kikuchi, Y, Shimatake, H, Kikuchi, A
A new temperature-sensitive mutant of Saccharomyces cerevisiae, gst1 (G1-to-S transition) was isolated. At nonpermissive temperature the mutant cells with large buds accumulated and DNA synthesis was...
Hairpin plasmid--a novel linear DNA of perfect hairpin structure.
Kikuchi, Y, Hirai, K, Gunge, N, Hishinuma, F
The terminal structures of deletion derivatives of linear DNA killer plasmid from yeast were analyzed. The yeast Kluyveromyces lactis harbors two unique double-stranded linear DNA killer plasmids,...
Imataka, H, Sogawa, K, Yasumoto, K, Kikuchi, Y, Sasano, K, Kobayashi, A, ...
The cDNAs for two DNA binding proteins of BTE, a GC box sequence in the promoter region of the P-450IA1(CYP1A1) gene, have been isolated from a rat liver cDNA library by using the BTE sequence as a...
The proteins in the hinge ligaments of molluscan bivalves were subjected to chemotaxonomic studies according to their amino acid compositions. The hinge-ligament protein is a new class of structure...
The source of oxygen in the reaction catalysed by collagen lysyl hydroxylase.
Kikuchi, Y, Suzuki, Y, Tamiya, N
The synthetic peptides (Pro-Pro-Gly)5 and (Ile-Lys-Gly)5-Phe were hydroxylated with collagen prolyl hydroxylase and lysyl hydroxylase in an 18O2 atmosphere. The oxygen atoms in the hydroxy groups of...
Kikuchi, Y., Fujimoto, D., Tamiya, N.
1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)5 (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)6 (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with...
The enzymic hydroxylation of protocollagen models
Kikuchi, Y., Fujimoto, D., Tamiya, N.
1. Synthetic polymers of l-prolyl-l-prolylglycine of defined chain length, (Pro-Pro-Gly)n, were found to be substrates for the enzyme protocollagen–proline hydroxylase, with optimum chain length...
Two zebrafish (Danio rerio) antizymes with different expression and activities.
Saito, T, Hascilowicz, T, Ohkido, I, Kikuchi, Y, Okamoto, H, Hayashi, S, ...
Cellular polyamines are regulated by a unique feedback mechanism involving ornithine decarboxylase (ODC) antizyme. The synthesis of mammalian antizyme requires a programmed translational frameshift...
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
Mizusawa, A, Ogawa, H, Kikuchi, Y, Hida, W, Kurosawa, H, Okabe, S, ...
1. An attempt has been made to test the hypothesis that, in the caudal part of nucleus tractus solitarii (NTS) where carotid sinus nerve (CSN) afferents project, L-glutamate (Glut) modulates the...
Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia.
Ogawa, H, Mizusawa, A, Kikuchi, Y, Hida, W, Miki, H, Shirato, K
1. We examined the role of nitric oxide (NO) in respiratory regulation in the nucleus tractus solitarii (NTS), where L-glutamate release associated with peripheral chemoreceptor activation modulates...
Role of the parabrachial nucleus in ventilatory responses of awake rats.
Mizusawa, A, Ogawa, H, Kikuchi, Y, Hida, W, Shirato, K
1. The parabrachial nucleus (PBN) is thought to play an important role in cardiorespiratory control. However, the circumstances under which it affects ventilation are still not known. The purpose of...
Tabb, A L, Utsugi, T, Wooten-Kee, C R, Sasaki, T, Edling, S A, Gump, W, ...
The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with...
Statistical issues on the no-observed-adverse-effect level in categorical response.
Yanagawa, T, Kikuchi, Y, Brown, K G
The determination of the value of the no-observed-adverse-effect level (NOAEL) when observed responses can be categorized by severity (categorical data) and sample sizes are small is discussed. The...
Kikuchi, Y, Yasue, T, Miyake, K, Kimoto, M, Takatsu, K
Mouse CD38 has been implicated in the regulation of both B-cell proliferation and protection of B cells from irradiation-induced apoptosis. CD38 ligation on B cells by CS/2, an anti-mouse CD38...
Doi, H, Kitajima, M, Watanabe, I, Kikuchi, Y, Matsuzawa, F, Aikawa, S, ...
Oligopeptidic permutations of the 20 amino acid residues give rise to proteins of diverse functions. Our long-term goal is to produce a lexicon of oligopeptides, classifying them into at least five...
Sogawa, K, Nakano, R, Kobayashi, A, Kikuchi, Y, Ohe, N, Matsushita, N, ...
Arnt (Ah receptor nuclear translocator) is a member of a transcription factor family having characteristic motifs designated bHLH (basic helix-loop-helix) and PAS and was originally found as a factor...
Kikuchi, Y, Sasaki, N, Ando-Yamagami, Y
The retrovirus-like particles of Drosophila are intermediates of retrotransposition of the transposable element copia. In these particles, a 39-nucleotide-long fragment from the 5' region of...
Kikuchi, Y, Tsujimoto, K, Kurahashi, O
In Escherichia coli, aroF, aroG, and aroH encode 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isozymes that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. In...
Characterization of a second lysine decarboxylase isolated from Escherichia coli.
Kikuchi, Y, Kojima, H, Tanaka, T, Takatsuka, Y, Kamio, Y
We report here on the existence of a new gene for lysine decarboxylase in Escherichia coli K-12. The hybridization experiments with a cadA probe at low stringency showed that the homologous region of...
Komiya, M, Kikuchi, Y, Tachibana, A, Yano, K
The pharmacokinetics of YM09330, a new semisynthetic cephamycin, were determined after intravenous and intramuscular administration to experimental animals. Mean plasma levels of YM09330 at 30 min...
Pharmacokinetics of cefotetan (YM09330) in humans.
Nakagawa, K, Koyama, M, Tachibana, A, Komiya, M, Kikuchi, Y, Yano, K
The pharmacokinetics and safety of cefotetan (YM09330) were examined after intravenous administration of single and multiple doses to normal volunteers. Cefotetan was well tolerated in single doses...
Kikuchi, Y, Nagata, Y, Hinata, M, Kimbara, K, Fukuda, M, Yano, K, ...
The nucleotide sequence of the downstream region of the bph operon from Pseudomonas sp. strain KKS102 was determined. Two open reading frames (ORF1 and ORF2) were found in this region, and the...
Kikuchi, Y, Yasukochi, Y, Nagata, Y, Fukuda, M, Takagi, M
Pseudomonas sp. strain KKS102 is able to degrade biphenyl and polychlorinated biphenyls via the meta-cleavage pathway. We sequenced the upstream region of the bphA1A2A3BCD (open reading frame 1...
Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae.
Yashiroda, H, Oguchi, T, Yasuda, Y, Toh-E, A, Kikuchi, Y
We characterized a temperature-sensitive mutant of Saccharomyces cerevisiae in which a mini-chromosome was unstable at a high temperature and cloned a new gene which encodes a basic and hydrophilic...
Ema, M, Morita, M, Ikawa, S, Tanaka, M, Matsuda, Y, Gotoh, O, ...
From a cDNA library of mouse skeletal muscle, we have isolated mouse Sim1 (mSim1) cDNA encoding a polypeptide of 765 amino acids with striking amino acid identify in basic helix-loop-helix (89%...
Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines.
Mita, S, Tominaga, A, Hitoshi, Y, Sakamoto, K, Honjo, T, Akagi, M, ...
Interleukin 5 (IL-5) is a glycosylated polypeptide that acts as a key factor for B-cell growth and differentiation. We demonstrated previously that there are two classes (high and low affinity) of...
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
Takatsu, K, Kikuchi, Y, Takahashi, T, Honjo, T, Matsumoto, M, Harada, N, ...
We describe an interleukin, termed interleukin 5, that is the recombinant product previously referred to as T-cell-replacing factor (TRF), B-cell growth factor II (BCGF II), or killer-helper factor...
Harada, N, Takahashi, T, Matsumoto, M, Kinashi, T, Ohara, J, Kikuchi, Y, ...
T-cell-replacing factor (TRF) is a T-cell-derived factor required for terminal differentiation of activated B cells to immunoglobulin-secreting cells. Previous studies have shown that a murine T-cell...
The yeast linear DNA killer plasmids, pGKL1 and pGKL2, possess terminally attached proteins.
Kikuchi, Y, Hirai, K, Hishinuma, F
The terminal structures of linear DNA killer plasmids from yeast, pGKL1 and pGKL2, were analyzed. Results obtained by exonuclease treatments of these plasmids show that both pGKL plasmids have free...
Kikuchi, Y, Tyc, K, Filipowicz, W, Sänger, H L, Gross, H J
A novel type of RNA ligase activity in extracts of wheat germ or Chlamydomonas requires 2', 3'-cyclic phosphate and 5'-phosphate ends for ligation to form a 2'-phosphomonoester, 3',5'-phosphodiester...
Kikuchi, Y, Yoda, K, Yamasaki, M, Tamura, G
The promoter and the amino-terminal region of phoA, the structural gene for alkaline phosphatase of Escherichia coli K12, was cloned by using a promoter cloning vector pMC1403. The nucleotide...
Site-specific cleavage of natural mRNA sequences by newly designed hairpin catalytic RNAs.
The negative strand of tobacco ringspot virus satellite RNA is a self-cleaving RNA. Its catalytic domain and substrate domain have been identified, and the catalytic domain has been named hairpin...
Artificial self-cleaving molecules consisting of a tRNA precursor and the catalytic RNA of RNase P.
Kikuchi, Y, Sasaki-Tozawa, N, Suzuki, K
We synthesized two types of chimeric RNAs between the catalytic RNA subunit of RNase P from Escherichia coli (M1 RNA) and a tRNA precursor (pre-tRNA); one had pre-tRNA at the 3' side to the M1 RNA...
Enzymatic synthesis of a segment of bacteriophage Qbeta coat protein gene.
The oligoribonucleotide, A-A-A-C-U-U-U-Gp, constituting a segment of RNA bacteriophage Qbeta coat protein gene was efficiently synthesized at a milligram scale by a combination of enzymatic methods...
A nuclear gene of Saccharomyces cerevisiae needed for stable maintenance of plasmids.
We have isolated host mutants of Saccharomyces cerevisiae in which the 2 microns plasmid is poorly maintained. All the mutants tested constituted one complementation group, which was designated map1...
Nicking-closing activity associated with bacteriophage lambda int gene product.
Integrative recombination of bacteriophage lambda requires the action of the protein Int, the product of the phage int gene. In this paper we show that highly purified Int relaxes supercoiled DNA....
Hoshino, S, Miyazawa, H, Enomoto, T, Hanaoka, F, Kikuchi, Y, Kikuchi, A, ...
A human homologue (GST1-Hs) of the yeast GST1 gene that encodes a new GTP-binding protein essential for the G1-to-S phase transition of the cell cycle was cloned from the cDNA library of human KB...
Addition of mononucleotides to oligoribonucleotide acceptors with T4 RNA ligase.
Kikuchi, Y, Hishinuma, F, Sakaguchi, K
RNA ligase induced by bacteriophage T4 catalyzed the addition of nucleoside 5',3'-diphosphates to oligoribonucleotide acceptors in the presence of ATP. The reactions proceeded in equimolar...
Rolink, A, Kudo, A, Karasuyama, H, Kikuchi, Y, Melchers, F
Cell lines and clones were established from PB76-positive mouse fetal liver at day 13 and 14 of gestation, which proliferated with division times of a day in serum-substituted cultures under the...
Kikuchi, Y, Shimatake, H, Kikuchi, A
A new temperature-sensitive mutant of Saccharomyces cerevisiae, gst1 (G1-to-S transition) was isolated. At nonpermissive temperature the mutant cells with large buds accumulated and DNA synthesis was...
Hairpin plasmid--a novel linear DNA of perfect hairpin structure.
Kikuchi, Y, Hirai, K, Gunge, N, Hishinuma, F
The terminal structures of deletion derivatives of linear DNA killer plasmid from yeast were analyzed. The yeast Kluyveromyces lactis harbors two unique double-stranded linear DNA killer plasmids,...
Imataka, H, Sogawa, K, Yasumoto, K, Kikuchi, Y, Sasano, K, Kobayashi, A, ...
The cDNAs for two DNA binding proteins of BTE, a GC box sequence in the promoter region of the P-450IA1(CYP1A1) gene, have been isolated from a rat liver cDNA library by using the BTE sequence as a...
The proteins in the hinge ligaments of molluscan bivalves were subjected to chemotaxonomic studies according to their amino acid compositions. The hinge-ligament protein is a new class of structure...
The source of oxygen in the reaction catalysed by collagen lysyl hydroxylase.
Kikuchi, Y, Suzuki, Y, Tamiya, N
The synthetic peptides (Pro-Pro-Gly)5 and (Ile-Lys-Gly)5-Phe were hydroxylated with collagen prolyl hydroxylase and lysyl hydroxylase in an 18O2 atmosphere. The oxygen atoms in the hydroxy groups of...
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
Mizusawa, A, Ogawa, H, Kikuchi, Y, Hida, W, Kurosawa, H, Okabe, S, ...
1. An attempt has been made to test the hypothesis that, in the caudal part of nucleus tractus solitarii (NTS) where carotid sinus nerve (CSN) afferents project, L-glutamate (Glut) modulates the...
Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia.
Ogawa, H, Mizusawa, A, Kikuchi, Y, Hida, W, Miki, H, Shirato, K
1. We examined the role of nitric oxide (NO) in respiratory regulation in the nucleus tractus solitarii (NTS), where L-glutamate release associated with peripheral chemoreceptor activation modulates...
Role of the parabrachial nucleus in ventilatory responses of awake rats.
Mizusawa, A, Ogawa, H, Kikuchi, Y, Hida, W, Shirato, K
1. The parabrachial nucleus (PBN) is thought to play an important role in cardiorespiratory control. However, the circumstances under which it affects ventilation are still not known. The purpose of...
Kikuchi, Y., Fujimoto, D., Tamiya, N.
1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)5 (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)6 (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with...
The enzymic hydroxylation of protocollagen models
Kikuchi, Y., Fujimoto, D., Tamiya, N.
1. Synthetic polymers of l-prolyl-l-prolylglycine of defined chain length, (Pro-Pro-Gly)n, were found to be substrates for the enzyme protocollagen–proline hydroxylase, with optimum chain length...
Two zebrafish (Danio rerio) antizymes with different expression and activities.
Saito, T, Hascilowicz, T, Ohkido, I, Kikuchi, Y, Okamoto, H, Hayashi, S, ...
Cellular polyamines are regulated by a unique feedback mechanism involving ornithine decarboxylase (ODC) antizyme. The synthesis of mammalian antizyme requires a programmed translational frameshift...
Tabb, A L, Utsugi, T, Wooten-Kee, C R, Sasaki, T, Edling, S A, Gump, W, ...
The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with...
Statistical issues on the no-observed-adverse-effect level in categorical response.
Yanagawa, T, Kikuchi, Y, Brown, K G
The determination of the value of the no-observed-adverse-effect level (NOAEL) when observed responses can be categorized by severity (categorical data) and sample sizes are small is discussed. The...
Yamashita, Y, Miyake, K, Kikuchi, Y, Takatsu, K, Noda, S, Kosugi, A, ...
A novel monoclonal antibody (mAb) was established in an attempt to look for a cell-surface molecule that delivered a signal regulating apoptotic cell death of B cells. Because spleen cells in resting...
Kasahara, M., Ikeda, H., Ogasawara, K., Ishikawa, N., Okuyama, T., Fukasawa, Y., ...
Recent studies using rabbit antisera to the separated HLA-DR α and β subunits have suggested that α chain-specific, but not β chain-specific, antisera inhibit T cell proliferative responses in...
Kikuchi, Y, Koarada, S, Tada, Y, Ushiyama, O, Morito, F, Suzuki, N, ...
BACKGROUND—It has previously been shown that RP105, a new B cell surface protein, is lost in activated human B cells. OBJECTIVE—To investigate whether there is a difference in B cell activation...
Miura, C, Hida, W, Miki, H, Kikuchi, Y, Chonan, T, Takishima, T
BACKGROUND: A high ratio of forced expiratory to forced inspiratory maximal flow at 50% of vital capacity (FEF50/FIF50) may identify upper airway dysfunction. Since hypercapnia increases the motor...
Effects of posture on carbon dioxide responsiveness in patients with obstructive sleep apnoea.
Satoh, M, Hida, W, Chonan, T, Okabe, S, Miki, H, Taguchi, O, ...
BACKGROUND--It is well known that upper airway resistance increases with postural change from a sitting to supine position in patients with obstructive sleep apnoea (OSA). It is not known, however,...
Role of hypoxia on increased blood pressure in patients with obstructive sleep apnoea.
Okabe, S, Hida, W, Kikuchi, Y, Taguchi, O, Ogawa, H, Mizusawa, A, ...
BACKGROUND--Cyclical changes in systemic blood pressure occur during apnoeic episodes in patients with obstructive sleep apnoea (OSA). Although several factors including arterial hypoxaemia,...
Hida, W, Okabe, S, Miki, H, Kikuchi, Y, Taguchi, O, Takishima, T, ...
BACKGROUND--It has previously been reported that short term submental stimulation can reduce the frequency of apnoea and improve sleep architecture in patients with obstructive sleep apnoea. The...
Does informed consent exempt Japanese doctors from reporting therapeutic deaths?
Ikegaya, H, Kawai, K, Kikuchi, Y, Yoshida, K
The Japanese Medical Act section 21 states that doctors must report unnatural deaths to the police, even though the term “unnatural death” is not defined by law. However, many doctors are...
A cross sectional study of the respiratory health of workers handling printing toner dust
Nakadate, T, Yamano, Y, Adachi, C, Kikuchi, Y, Nishiwaki, Y, Nohara, M, ...
Takebayashi, T, Varsier, N, Kikuchi, Y, Wake, K, Taki, M, Watanabe, S, ...
In a case–control study in Japan of brain tumours in relation to mobile phone use, we used a novel approach for estimating the specific absorption rate (SAR) inside the tumour, taking account of...
Takano, M, Kikuchi, Y, Yaegashi, N, Kuzuya, K, Ueki, M, Tsuda, H, ...
A retrospective analysis was performed to evaluate the clinical characteristics and prognostic factors in the patients with clear cell carcinoma (CCC) of the ovary. After central pathological review...