Y. Kimura

Publication List Details

Period

1981 - 9999

Number

142

Co-Authors

Development of High-Performance Composite Fiber-Optic Overhead Ground Wire, (9999)

Nakagaki,K., Masuda,Y., Ishikawa,M., Kimura,Y., Matsubara,I.

We have developed a new high-performance composite fiber-optic overhead ground wire (OPGW), which contains newly designed six-fiber units, for large capacity transmission and application to extra...

Online available since 2004/Apr/15 Image Reconstruction and Analysis of Three-Dimensional Fracture Surfaces Based on the Stereo Matching Method (2008)

M. Tanaka, Y. Kimura, A. Kayama, L. Chouanine, R. Kato, J. Taguchi

A computer program of the fractal analysis by the box-counting method was developed for the estimation of the fractal dimension of the three-dimensional fracture surface reconstructed by the stereo...

[6] H. C. Andersen, Rattle: A “velocity ” version of the Shake algorithm for (2008)

M. Alex, N. Levinger, M. Johnson, D. Ray, W. C. Lineberger, M. L. Alex, ...

halogen-carbon dioxide clusters and the fluoroformyloxyl radical by photodetachment of X; (CO 2)(X=I, Cl, Br) and FCO; 2, J. Chem. Phys. 102,

Multi-phase matching in the Grover algorithm (2008)

Toyama, F. M., Van Dijk, W., Nogami, Y., Tabuchi, M., Kimura, Y.

Phase matching has been studied for the Grover algorithm as a way of enhancing the efficiency of the quantum search. Recently Li and Li found that a particular form of phase matching yields, with a...

Optimising FTP Traffic in the Internet (2007)

K. Jayanthi, Glenn Mansfield, Y. Kimura, Thomas Johannsen, Y. Nemoto, S. Noguchi

Network configuration information can be very effectively used for network traffic optimization and improving network performance. FTP traffic, one of the largest consumers of network bandwidth, is...

On Internet Cartography (2007)

Glenn Mansfield, K. Jayanthi, S. Noguchi, Y. Kimura, Y.Nemoto, S. Noguchi

There is a need for a Network Map containing infrastructural and service related information about communication networks which is accessible from all places and at all times in a reasonably...

Calculation of Mechanical, Thermodynamic and Transport Properties of Metalic Glass formers (2007)

T. Cagin, Y. Qi, H. Li, Y. Kimura, H. Ikeda, W. L. Johnson, ...

Recently, wehave parametrized Sutton-Chen type empirical many body force elds for FCC transition metals to study the thermodynamic, mechanical, transport and phase behavior of metals and their...

High-Magnesian Andesite Produced by Two-Stage Magma Mixing: a Case Study from Hachimantai, Northern Honshu, Japan (2007)

Ohba, T., Kimura, Y., Fujimaki, H.

High-magnesian andesite occurs at Hachimantai, northern Honshu, Japan. Disequilibrium zoning features indicate that the phenocryst minerals were derived from three different magmas. Chemical...

High-Magnesian Andesite Produced by Two-Stage Magma Mixing: a Case Study from Hachimantai, Northern Honshu, Japan (2007)

Ohba, T., Kimura, Y., Fujimaki, H.

High-magnesian andesite occurs at Hachimantai, northern Honshu, Japan. Disequilibrium zoning features indicate that the phenocryst minerals were derived from three different magmas. Chemical...

High-Magnesian Andesite Produced by Two-Stage Magma Mixing: a Case Study from Hachimantai, Northern Honshu, Japan (2007)

Ohba, T., Kimura, Y., Fujimaki, H.

High-magnesian andesite occurs at Hachimantai, northern Honshu, Japan. Disequilibrium zoning features indicate that the phenocryst minerals were derived from three different magmas. Chemical...

Noncommutative Gauge Theory on Fuzzy Sphere from Matrix Model (2001)

Iso, S., Kimura, Y., Tanaka, K., Wakatsuki, K.

We derive a noncommutative U(1) and U(n) gauge theory on the fuzzy sphere from a three dimensional matrix model by expanding the model around a classical solution of the fuzzy sphere. Chern-Simons...

A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness (2001)

Sugauchi, F, Mizokami, M, Orito, E, Ohno, T, Kato, H, Suzuki, S, ...

There have been no reports of DNA sequences of hepatitis B virus (HBV) strains from Australian Aborigines, although the hepatitis B surface antigen (HBsAg) was discovered among them. To investigate...

A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness (2001)

Sugauchi, F., Mizokami, M., Orito, E., Ohno, T., Kato, H., Suzuki, S., ...

There have been no reports of DNA sequences of hepatitis B virus (HBV) strains from Australian Aborigines, although the hepatitis B surface antigen (HBsAg) was discovered among them. To investigate...

Real-time observation of spherical aberration-free phase image using high-speed image processing CCD video camera (2001)

Nishikata, K, Kawasaki, T, Kimura, Y, Takai, Y, Shimizu, R

Spherical aberration-free phase images have been observed at a time resolution of 1/30 s for the first time by using a defocus-image modulation processing electron microscope (DIMP-EM) combined with...

Supercurrent Interactions in Noncommutative Yang-Mills and IIB Matrix Model (2000)

Kimura, Y., Kitazawa, Y.

It is known that noncommutative Yang-Mills is equivalent to IIB matrix model with a noncommutative background, which is interpreted as a twisted reduced model. In noncommutative Yang-Mills, long...

The usefulness of a piezo-micromanipulator in intracytoplasmic sperm injection in humans (1999)

Yanagida, K., Katayose, H., Yazawa, H., Kimura, Y., Konnai, K., Sato, A.

Intracytoplasmic sperm injection (ICSI) has wide clinical application. In order to achieve good results with this method, it is important to restrict the possibility of oocyte injury as much as...

Successful fertilization and pregnancy following ICSI and electrical oocyte activation (1999)

Yanagida, K., Katayose, H., Yazawa, H., Kimura, Y., Sato, A., Yanagimachi, H., ...

In a total of 1048 intracytoplasmic sperm injection (ICSI) cycles, motile spermatozoa from four out of 424 patients (0.9%) failed to fertilize oocytes, despite an apparently successful ICSI...

Explosive Hot Consolidation of Alumina Powder; Influence on Structure. (1998)

Yoshida, M., Yoshioka, Y., Kimura, Y., Hirabayashi, H., Sawaoka, A. B.

Hot explosive compaction was applied for consolidation of alpha-Al2O3 powder. Cylindrical capsules containing the powder were heated and then brought into a cavity of the explosive charge. Additional...

High-Performance Boron-Nitride Fibers from Poly(Borazine) Preceramics. (1998)

Kimura, Y., Kubo, Y., Hayashi, N.

Boron-nitride (BN) fiber has been fabricated by utilizing the preceramic method. A melt-processable polymer precursor, poly(aminoborazinyl), was readily prepared by thermal condensation of...

Techniques for automated Network Map Generation using SNMP (1996)

Glenn Mansfield, M. Ouchi, K. Jayanthi, Y. Kimura, Kohei Ohta, Yoshiaki Nemoto

Network configuration information is useful in producing a visual map of the network complete in all details. The visual map is an essential component for network management and operations. It is...

III, \Viscosities of Liquid Metal Alloys from Nonequilibrium Molecular Dynamics," submitted. 62 (1990)

Y. Qi, T. Cagin, Y. Kimura, W. Goddard Iii, Phys Rev E, Yue Qi, ...

We have developed a nonequilibrium molecular dynamics (NEMD) approach to predict viscosity by including external shear rates directly into the Hamiltonian equations of motion. Using the quantum...

RAMAN STUDY OF La2-xBaxCuO4 (x= 0, 0.016) SINGLE CRYSTALS (1988)

Koshizuka, N., Unoki, H., Oka, K., Hayashi, K., Okuda, T., Kimura, Y.

Raman scattering of La2-xBaxCuO4 (x = 0, 0.016) single crystals has been measured at various temperatures in the frequency range between 100 and 5000 cm-1. Besides an A1g phonon line at 430 cm-1, the...

RAMAN STUDY OF La2-xBaxCuO4 (x= 0, 0.016) SINGLE CRYSTALS (1988)

Koshizuka, N., Unoki, H., Oka, K., Hayashi, K., Okuda, T., Kimura, Y.

Raman scattering of La2-xBaxCuO4 (x = 0, 0.016) single crystals has been measured at various temperatures in the frequency range between 100 and 5000 cm-1. Besides an A1g phonon line at 430 cm-1, the...

RAMAN STUDY OF La2-xBaxCuO4 (x= 0, 0.016) SINGLE CRYSTALS (1988)

Koshizuka, N., Unoki, H., Oka, K., Hayashi, K., Okuda, T., Kimura, Y.

Raman scattering of La2-xBaxCuO4 (x = 0, 0.016) single crystals has been measured at various temperatures in the frequency range between 100 and 5000 cm-1. Besides an A1g phonon line at 430 cm-1, the...

Glycine reductase selenoprotein A is not a glycoprotein: the positive periodic acid-Schiff reagent test is the result of peptide bond cleavage and carbonyl group generation.

Kimura, Y, Stadtman, T C

The complete amino acid sequence of Clostridium sticklandii selenoprotein A, a selenocysteine-containing protein component of the glycine reductase complex, has been established. Both the intact...

Genetically engineered rice resistant to rice stripe virus, an insect-transmitted virus.

Hayakawa, T, Zhu, Y, Itoh, K, Kimura, Y, Izawa, T, Shimamoto, K, ...

The coat protein (CP) gene of rice stripe virus was introduced into two japonica varieties of rice by electroporation of protoplasts. The resultant transgenic plants expressed the CP at high levels...

Protective Roles of γδ T Cells and Interleukin-15 in Escherichia coli Infection in Mice

Takano, M., Nishimura, H., Kimura, Y., Mokuno, Y., Washizu, J., Itohara, S., ...

The number of γδ T cells in the peritoneal cavity was increased after an intraperitoneal (i.p.) infection with Escherichia coli in lipopolysaccharide (LPS)-responsive C3H/HeN mice but not in...

Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vectors.

Shimizu, H, Yagi, R, Kimura, Y, Makino, K, Terato, H, Ohyama, Y, ...

alpha-2'-Deoxyadenosine (alpha) is a major adenine lesion produced by gamma-ray irradiation of DNA under anoxic conditions. In this study, single-stranded recombinant M13 vectors containing alpha...

A Novel Class of Herbicides (Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase).

Mori, I., Fonne-Pfister, R., Matsunaga, Si., Tada, S., Kimura, Y., Iwasaki, G., ...

A new mode of herbicidal action was established by finding specific inhibitors of imidazoleglycerol phosphate dehydratase, an enzyme of histidine (His) biosynthesis. Three triazole phosphonates...

Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.

Kitamura, A, Hoshino, K, Kimura, Y, Hayakawa, I, Sato, K

Inhibitory effects of five quinolones against DNA gyrases purified from four quinolone-resistant clinical isolates of Pseudomonas aeruginosa and the quinolone-susceptible strain PAO1 were examined....

Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives.

Baba, M, Okamoto, M, Makino, M, Kimura, Y, Ikeuchi, T, Sakaguchi, T, ...

We have found novel piperazinyloxoquinoline derivatives to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in both acutely and chronically infected...

Molecular cloning of the gene which encodes beta-N-acetylglucosaminidase from a marine bacterium, Alteromonas sp. strain O-7.

Tsujibo, H, Fujimoto, K, Tanno, H, Miyamoto, K, Kimura, Y, Imada, C, ...

The gene encoding the periplasmic beta-N-acetylglucosaminidase (GlcNAcase B) from a marine Alteromonas sp. strain, O-7, was cloned and sequenced. The protein sequence of GlcNAcase B revealed a highly...

Propionyl coenzyme A carboxylase is required for development of Myxococcus xanthus.

Kimura, Y, Sato, R, Mimura, K, Sato, M

A dcm-1 mutant, obtained by transposon mutagenesis of Myxococcus xanthus, could aggregate and form mounds but was unable to sporulate under nutrient starvation. A sequence analysis of the site of...

Inhibition by quinolones of DNA gyrase from Staphylococcus aureus.

Tanaka, M, Sato, K, Kimura, Y, Hayakawa, I, Osada, Y, Nishino, T

In order to clarify the mechanism of action of quinolones against Staphylococcus aureus, the subunit A and B proteins of DNA gyrase were separately purified from a crude extract of S. aureus FDA...

Characterization of a porcine kidney cell line resistant to influenza virus infection.

Kimura, Y, Yokochi, T, Miyadai, T, Yoshida, K, Yokoo, J, Matsumoto, K

A mutant cell line of porcine kidney cells that resists the cytopathic effect of influenza virus has been obtained and characterized. These cells, designated ESK-R, were originally obtained by...

In vivo effects of bacterial lipopolysaccharide on proliferation of macrophage colony-forming cells in bone marrow and peripheral lymphoid tissues.

Yokochi, T, Nakashima, I, Kato, N, Miyadai, T, Yoshida, K, Kimura, Y

Changes in the number of macrophage colony-forming cells in various tissues of mice injected with lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli, or Salmonella enteritidis were...

Bacteriological study of periodontal lesions in two sisters with juvenile periodontitis and their mother.

Okuda, K, Naito, Y, Ohta, K, Fukumoto, Y, Kimura, Y, Ishikawa, I, ...

A total of five bacteriological samples from the periodontal pockets of two sisters with localized juvenile periodontitis and their mother with advanced periodontitis was studied. Gram-negative...

Enzyme-linked immunosorbent assay of antibody to group A Streptococcus-specific C carbohydrate with trypsin-pronase-treated whole cells as antigen.

Todome, Y, Ohkuni, H, Yokomuro, K, Kimura, Y, Hamada, S, Johnston, K H, ...

We describe the measurement by enzyme-linked immunosorbent assay of antibody to group A Streptococcus C carbohydrate in immunized rabbits and human sera, with trypsin-pronase-treated group A...

Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.

Akahane, K, Kimura, Y, Tsutomi, Y, Hayakawa, I

The combination of some new quinolone antibacterial agents with 4-biphenylacetic acid (BPAA), a metabolite of fenbufen, is known to specifically induce functional blockade of the gamma-aminobutyric...

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J

Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...

Retention of bacterial lipopolysaccharide at the site of subcutaneous injection.

Yokochi, T, Inoue, Y, Yokoo, J, Kimura, Y, Kato, N

The tissue distribution of Klebsiella pneumoniae O3 lipopolysaccharide (KO3 LPS) was studied in mice injected subcutaneously (s.c.) or intraperitoneally (i.p.) with 125I-labeled KO3 LPS. Marked...

Involvement of a cis-element that binds an H2TF-1/NF kappa B like factor(s) in the virus-induced interferon-beta gene expression.

Fujita, T, Miyamoto, M, Kimura, Y, Hammer, J, Taniguchi, T

Interferon-beta (IFN-beta) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts. In the previous studies, regulatory DNA sequences that mediate the...

Natural interferon-producing cells in mice.

Ito, Y, Aoki, H, Kimura, Y, Takano, M, Shimokata, K, Maeno, K

When mouse lymphoid cells derived from untreated C57BL/6 mice were cocultivated in liquid cultures with L-cell monolayers for 3 h, overlaid with soft agar, and then further incubated for 12 h,...

Mechanism of immune interferon production in vitro: interaction between immune interferon-producing cells and antigenic cells.

Ito, Y, Aoki, H, Kimura, Y, Shimokata, K, Maeno, K

Various processes of in vitro immune interferon production by sensitized spleen cells stimulated with allogeneic cells were investigated. When L cells, an interferon-inducing antigen, were fixed with...

Temperature-sensitive virus derived from BHK cells persistently infected with HVJ (Sendai virus).

Kimura, Y, Ito, Y, Shimokata, K, Nishiyama, Y, Nagata, I

BHK-HVJ cells, a cell line of baby hamster kidney cells persistantly infected with HVJ (Sendai virus), started to produce infectious virus by shifting down the incubation temperature from 38 to 32 C....

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.

Minami, Y, Kimura, Y, Kawasaki, H, Suzuki, K, Yahara, I

The majority of mouse HSP90 exists as alpha-alpha and beta-beta homodimers. Truncation of the 15-kDa carboxy-terminal region of mouse HSP90 by digestion with the Ca(2+)-dependent protease m-calpain...

Interferon-producing capacity of germfree mice.

Ito, Y, Nisiyama, Y, Shimokata, K, Kimura, Y, Nagata, I

The general capacity of germfree mouse spleen cells to produce interferon in vitro in response to various stimuli was investigated. The interferon response of germfree mouse spleen cells in vitro,...

Pathogenesis of Sendai virus infection in the central nervous system of mice.

Shimokata, K, Nishiyama, Y, Ito, Y, Kimura, Y, Nagata, I

The present study was aimed to clarify the pathogenesis of Sendai virus infection to the central nervous system (CNS) of mice. One-to 2-day-old suckling and 4-week-old mice were inoculated...

Affinity of Sendai virus for the inner ear of mice.

Shimokata, K, NISHIYAMA, Y, Ito, V, Kimura, Y, Nagata, I

The direct immunofluorescent antibody method revealed that Sendai virus, which was thought to be most prevalent in respiratory diseases in mice, infected the inner ear of mice when the virus was...

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

Fujita, T, Sakakibara, J, Sudo, Y, Miyamoto, M, Kimura, Y, Taniguchi, T

Transcription of the human interferon-beta (IFN-beta) gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. In this study, we describe a nuclear factor, termed interferon...

Enumeration of immune interferon-producing cells induced by allogeneic stimulation.

Ito, Y, Aoki, H, Kimura, Y, Takano, M, Maeno, K, Shimokata, K

We succeeded in enumerating interferon-producing cells induced by allogeneic stimulation, and proved that they were indeed T lymphocytes. The peak level of these cells in spleen was attained on day 5...

Effect of guanosine triphosphate on the release and uptake of Ca2+ in saponin-permeabilized macrophages and the skeletal-muscle sarcoplasmic reticulum.

Hamachi, T, Hirata, M, Kimura, Y, Ikebe, T, Ishimatsu, T, Yamaguchi, K, ...

The effects of GTP, with or without polyethylene glycol (PEG), on the release and uptake of Ca2+ were examined by using saponin-treated macrophages and sarcoplasmic reticulum isolated from skeletal...

Possible physiological role of guanosine triphosphate and inositol 1,4,5-trisphosphate in Ca2+ release in macrophages stimulated with chemotactic peptide.

Kimura, Y, Hirata, M, Hamachi, T, Koga, T

The release of Ca2+ induced by inositol 1,4,5-trisphosphate (InsP3) in the presence of GTP was examined by using saponin-permeabilized macrophages. The origin and the amount of mobilized Ca2+ in...

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

Hirata, M, Kimura, Y, Ishimatsu, T, Yanaga, F, Shuto, T, Sasaguri, T, ...

Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] analogues were synthesized and their effects on [3H]Ins(1,3,4,5)P4 5-phosphatase, [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]inositol...

Cation binding sites on the projected structure of bacteriorhodopsin.

Katre, N V, Kimura, Y, Stroud, R M

Divalent cations are involved in the function of bacteriorhodopsin (bR) as a light-driven proton pump. If cations are removed from purple membranes they become blue. Divalent cations such as Ca2+ or...

Anisotropic electric properties of purple membrane and their change during the photoreaction cycle.

Kimura, Y, Fujiwara, M, Ikegami, A

Purple membrane suspension shows two different orientations in electric fields of different frequencies. The orientation at low frequencies (less than or equal to approximately 10 Hz), with the...

Glycine reductase selenoprotein A is not a glycoprotein: the positive periodic acid-Schiff reagent test is the result of peptide bond cleavage and carbonyl group generation.

Kimura, Y, Stadtman, T C

The complete amino acid sequence of Clostridium sticklandii selenoprotein A, a selenocysteine-containing protein component of the glycine reductase complex, has been established. Both the intact...

Genetically engineered rice resistant to rice stripe virus, an insect-transmitted virus.

Hayakawa, T, Zhu, Y, Itoh, K, Kimura, Y, Izawa, T, Shimamoto, K, ...

The coat protein (CP) gene of rice stripe virus was introduced into two japonica varieties of rice by electroporation of protoplasts. The resultant transgenic plants expressed the CP at high levels...

Protective Roles of γδ T Cells and Interleukin-15 in Escherichia coli Infection in Mice

Takano, M., Nishimura, H., Kimura, Y., Mokuno, Y., Washizu, J., Itohara, S., ...

The number of γδ T cells in the peritoneal cavity was increased after an intraperitoneal (i.p.) infection with Escherichia coli in lipopolysaccharide (LPS)-responsive C3H/HeN mice but not in...

Replication bypass and mutagenic effect of alpha-deoxyadenosine site-specifically incorporated into single-stranded vectors.

Shimizu, H, Yagi, R, Kimura, Y, Makino, K, Terato, H, Ohyama, Y, ...

alpha-2'-Deoxyadenosine (alpha) is a major adenine lesion produced by gamma-ray irradiation of DNA under anoxic conditions. In this study, single-stranded recombinant M13 vectors containing alpha...

A Novel Class of Herbicides (Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase).

Mori, I., Fonne-Pfister, R., Matsunaga, Si., Tada, S., Kimura, Y., Iwasaki, G., ...

A new mode of herbicidal action was established by finding specific inhibitors of imidazoleglycerol phosphate dehydratase, an enzyme of histidine (His) biosynthesis. Three triazole phosphonates...

Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.

Kitamura, A, Hoshino, K, Kimura, Y, Hayakawa, I, Sato, K

Inhibitory effects of five quinolones against DNA gyrases purified from four quinolone-resistant clinical isolates of Pseudomonas aeruginosa and the quinolone-susceptible strain PAO1 were examined....

Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives.

Baba, M, Okamoto, M, Makino, M, Kimura, Y, Ikeuchi, T, Sakaguchi, T, ...

We have found novel piperazinyloxoquinoline derivatives to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in both acutely and chronically infected...

Molecular cloning of the gene which encodes beta-N-acetylglucosaminidase from a marine bacterium, Alteromonas sp. strain O-7.

Tsujibo, H, Fujimoto, K, Tanno, H, Miyamoto, K, Kimura, Y, Imada, C, ...

The gene encoding the periplasmic beta-N-acetylglucosaminidase (GlcNAcase B) from a marine Alteromonas sp. strain, O-7, was cloned and sequenced. The protein sequence of GlcNAcase B revealed a highly...

Propionyl coenzyme A carboxylase is required for development of Myxococcus xanthus.

Kimura, Y, Sato, R, Mimura, K, Sato, M

A dcm-1 mutant, obtained by transposon mutagenesis of Myxococcus xanthus, could aggregate and form mounds but was unable to sporulate under nutrient starvation. A sequence analysis of the site of...

Inhibition by quinolones of DNA gyrase from Staphylococcus aureus.

Tanaka, M, Sato, K, Kimura, Y, Hayakawa, I, Osada, Y, Nishino, T

In order to clarify the mechanism of action of quinolones against Staphylococcus aureus, the subunit A and B proteins of DNA gyrase were separately purified from a crude extract of S. aureus FDA...

Characterization of a porcine kidney cell line resistant to influenza virus infection.

Kimura, Y, Yokochi, T, Miyadai, T, Yoshida, K, Yokoo, J, Matsumoto, K

A mutant cell line of porcine kidney cells that resists the cytopathic effect of influenza virus has been obtained and characterized. These cells, designated ESK-R, were originally obtained by...

In vivo effects of bacterial lipopolysaccharide on proliferation of macrophage colony-forming cells in bone marrow and peripheral lymphoid tissues.

Yokochi, T, Nakashima, I, Kato, N, Miyadai, T, Yoshida, K, Kimura, Y

Changes in the number of macrophage colony-forming cells in various tissues of mice injected with lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli, or Salmonella enteritidis were...

Bacteriological study of periodontal lesions in two sisters with juvenile periodontitis and their mother.

Okuda, K, Naito, Y, Ohta, K, Fukumoto, Y, Kimura, Y, Ishikawa, I, ...

A total of five bacteriological samples from the periodontal pockets of two sisters with localized juvenile periodontitis and their mother with advanced periodontitis was studied. Gram-negative...

Enzyme-linked immunosorbent assay of antibody to group A Streptococcus-specific C carbohydrate with trypsin-pronase-treated whole cells as antigen.

Todome, Y, Ohkuni, H, Yokomuro, K, Kimura, Y, Hamada, S, Johnston, K H, ...

We describe the measurement by enzyme-linked immunosorbent assay of antibody to group A Streptococcus C carbohydrate in immunized rabbits and human sera, with trypsin-pronase-treated group A...

Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.

Akahane, K, Kimura, Y, Tsutomi, Y, Hayakawa, I

The combination of some new quinolone antibacterial agents with 4-biphenylacetic acid (BPAA), a metabolite of fenbufen, is known to specifically induce functional blockade of the gamma-aminobutyric...

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J

Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...

Retention of bacterial lipopolysaccharide at the site of subcutaneous injection.

Yokochi, T., Inoue, Y., Yokoo, J., Kimura, Y., Kato, N.

The tissue distribution of Klebsiella pneumoniae O3 lipopolysaccharide (KO3 LPS) was studied in mice injected subcutaneously (s.c.) or intraperitoneally (i.p.) with 125I-labeled KO3 LPS. Marked...

Involvement of a cis-element that binds an H2TF-1/NF kappa B like factor(s) in the virus-induced interferon-beta gene expression.

Fujita, T, Miyamoto, M, Kimura, Y, Hammer, J, Taniguchi, T

Interferon-beta (IFN-beta) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts. In the previous studies, regulatory DNA sequences that mediate the...

Natural interferon-producing cells in mice.

Ito, Y, Aoki, H, Kimura, Y, Takano, M, Shimokata, K, Maeno, K

When mouse lymphoid cells derived from untreated C57BL/6 mice were cocultivated in liquid cultures with L-cell monolayers for 3 h, overlaid with soft agar, and then further incubated for 12 h,...

Mechanism of immune interferon production in vitro: interaction between immune interferon-producing cells and antigenic cells.

Ito, Y, Aoki, H, Kimura, Y, Shimokata, K, Maeno, K

Various processes of in vitro immune interferon production by sensitized spleen cells stimulated with allogeneic cells were investigated. When L cells, an interferon-inducing antigen, were fixed with...

Temperature-sensitive virus derived from BHK cells persistently infected with HVJ (Sendai virus).

Kimura, Y, Ito, Y, Shimokata, K, Nishiyama, Y, Nagata, I

BHK-HVJ cells, a cell line of baby hamster kidney cells persistantly infected with HVJ (Sendai virus), started to produce infectious virus by shifting down the incubation temperature from 38 to 32 C....

The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.

Minami, Y, Kimura, Y, Kawasaki, H, Suzuki, K, Yahara, I

The majority of mouse HSP90 exists as alpha-alpha and beta-beta homodimers. Truncation of the 15-kDa carboxy-terminal region of mouse HSP90 by digestion with the Ca(2+)-dependent protease m-calpain...

Interferon-producing capacity of germfree mice.

Ito, Y, Nisiyama, Y, Shimokata, K, Kimura, Y, Nagata, I

The general capacity of germfree mouse spleen cells to produce interferon in vitro in response to various stimuli was investigated. The interferon response of germfree mouse spleen cells in vitro,...

Pathogenesis of Sendai virus infection in the central nervous system of mice.

Shimokata, K, Nishiyama, Y, Ito, Y, Kimura, Y, Nagata, I

The present study was aimed to clarify the pathogenesis of Sendai virus infection to the central nervous system (CNS) of mice. One-to 2-day-old suckling and 4-week-old mice were inoculated...

Affinity of Sendai virus for the inner ear of mice.

Shimokata, K, NISHIYAMA, Y, Ito, V, Kimura, Y, Nagata, I

The direct immunofluorescent antibody method revealed that Sendai virus, which was thought to be most prevalent in respiratory diseases in mice, infected the inner ear of mice when the virus was...

Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements.

Fujita, T, Sakakibara, J, Sudo, Y, Miyamoto, M, Kimura, Y, Taniguchi, T

Transcription of the human interferon-beta (IFN-beta) gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. In this study, we describe a nuclear factor, termed interferon...

Enumeration of immune interferon-producing cells induced by allogeneic stimulation.

Ito, Y, Aoki, H, Kimura, Y, Takano, M, Maeno, K, Shimokata, K

We succeeded in enumerating interferon-producing cells induced by allogeneic stimulation, and proved that they were indeed T lymphocytes. The peak level of these cells in spleen was attained on day 5...

Effect of guanosine triphosphate on the release and uptake of Ca2+ in saponin-permeabilized macrophages and the skeletal-muscle sarcoplasmic reticulum.

Hamachi, T, Hirata, M, Kimura, Y, Ikebe, T, Ishimatsu, T, Yamaguchi, K, ...

The effects of GTP, with or without polyethylene glycol (PEG), on the release and uptake of Ca2+ were examined by using saponin-treated macrophages and sarcoplasmic reticulum isolated from skeletal...

Possible physiological role of guanosine triphosphate and inositol 1,4,5-trisphosphate in Ca2+ release in macrophages stimulated with chemotactic peptide.

Kimura, Y, Hirata, M, Hamachi, T, Koga, T

The release of Ca2+ induced by inositol 1,4,5-trisphosphate (InsP3) in the presence of GTP was examined by using saponin-permeabilized macrophages. The origin and the amount of mobilized Ca2+ in...

Synthetic inositol 1,3,4,5-tetrakisphosphate analogues.

Hirata, M, Kimura, Y, Ishimatsu, T, Yanaga, F, Shuto, T, Sasaguri, T, ...

Inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] analogues were synthesized and their effects on [3H]Ins(1,3,4,5)P4 5-phosphatase, [3H]Ins(1,3,4,5)P4 3-phosphatase and [3H]inositol...

Cation binding sites on the projected structure of bacteriorhodopsin.

Katre, N V, Kimura, Y, Stroud, R M

Divalent cations are involved in the function of bacteriorhodopsin (bR) as a light-driven proton pump. If cations are removed from purple membranes they become blue. Divalent cations such as Ca2+ or...

Anisotropic electric properties of purple membrane and their change during the photoreaction cycle.

Kimura, Y, Fujiwara, M, Ikegami, A

Purple membrane suspension shows two different orientations in electric fields of different frequencies. The orientation at low frequencies (less than or equal to approximately 10 Hz), with the...

Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection.

Arai, T, Hiromatsu, K, Nishimura, H, Kimura, Y, Kobayashi, N, Ishida, H, ...

Interleukin-10 (IL-10) is a cytokine that regulates various macrophage functions. To elucidate the involvement of endogenous IL-10 in the early stage of murine salmonellosis, we examined the effect...

Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.

Kimura, Y, Tomida, S, Matsumoto, Y, Hiromatsu, K, Yoshikai, Y

We have previously reported that heat-shock protein (hsp) 60-reactive T-cell receptor (TCR)gamma delta+ T cells appear in the peritoneal cavity during the early stage of infection with Listeria...

Further studies on rat mast cell degranulation by IgE—anti-IgE and the inhibitory effect of drugs related to cAMP

Kimura, Y., Inoue, Yoshie, Honda, H.

With a modified rat mast cell degranulation (RMCD) technique developed by Korotzer, Haddad and Lopapa (1971), the mechanism of mast cell degranulation by IgE—anti-IgE reaction and the inhibitory...

Expression of occludin, tight-junction-associated protein, in human digestive tract.

Kimura, Y., Shiozaki, H., Hirao, M., Maeno, Y., Doki, Y., Inoue, M., ...

The tight junction seals cells together at a subapical location and functionally separates the plasma membrane into an apical and a basolateral domain. This junction is one of the most characteristic...

Beta-catenin expression in human cancers.

Takayama, T., Shiozaki, H., Shibamoto, S., Oka, H., Kimura, Y., Tamura, S., ...

Cell-cell adhesion in tissue is mainly regulated by homotypic interaction of cadherin molecules, which are anchored to the cytoskeleton via cytoplasmic proteins, including alpha- and beta-catenin....

Responses to intravenous sedation by elderly patients at the Hokkaido University Dental Hospital.

Kitagawa, E., Iida, A., Kimura, Y., Kumagai, M., Nakamura, M., Kamekura, N., ...

Geriatric patients who undergo intravenous sedation require careful intraoperative management, because respiratory and circulatory depression usually accompanies the administration of recommended...

Simulated swimming: a useful tool for evaluation the VO2 max of swimmers in the laboratory.

Kimura, Y, Yeater, R A, Martin, R B

This study was designed to develop a simulated swimming exercise (SS) so that peak VO2 would be assessed on swimmers in a laboratory setting. The subjects assumed a prone position on an incline bench...

Interleukin-15 production at the early stage after oral infection with Listeria monocytogenes in mice

MITANI, A, NISHIMURA, H, HIROSE, K, WASHIZU, J, KIMURA, Y, TANAKA, S, ...

We previously reported that exogenous interleukin-15 (IL-15) induces proliferation and activation of intestinal intraepithelial lymphocytes (i-IEL) in naive mice. To investigate the ability of...

腸「チブス」ノ一小統計的觀察

志方, 一郞, 木村, 雄藏, Shikata, I., Kimura, Y.

大正十一年夏當附屬醫院ニ流行セシ腸「チフス」ノ疫學的・細菌學的並ビニ臨床的觀察ヲ記シ、其傳染原ヲ一腸「チフス」患者ノ食器ニ附着セル病...

An immunoradiometric assay of tumour-antigen 4 (TA-4): a comparison with conventional radioimmunoassay.

Mino-Miyagawa, N., Kimura, Y., Hamamoto, K.

The serum level of tumour-antigen 4 (TA-4) was measured in 181 patients with squamous cell carcinoma (SCC) of various organs (71 lung, 24 uterus, 16 oesophagus, 64 head and neck and six skin), 34...

Serum CA125 level is a good prognostic indicator in lung cancer.

Kimura, Y., Fujii, T., Hamamoto, K., Miyagawa, N., Kataoka, M., Iio, A.

The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell...