Y. Kiso

Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins.

Kageyama, S, Anderson, B D, Hoesterey, B L, Hayashi, H, Kiso, Y, Flora, K P, ...

KNI-272 represents a peptide-based protease inhibitor having potent antiretroviral activity against human immunodeficiency virus (HIV) in vitro. The structure contains allophenylnorstatine...

An approach to the targeted attachment of peptides and proteins to solid supports.

Hofmann, K, Kiso, Y

A novel approach to affinity columns is described that is based on the high avidity of biotinylated molecules for avidin attached to solid supports. Biocytin amide [Nepsilon-(+)-biotinyllysine amide]...

Glycosphingolipid composition of rat placenta: changes associated with stage of pregnancy.

Itonori, S, Shirai, T, Kiso, Y, Ohashi, Y, Shiota, K, Ogawa, T

The composition of glycolipids and their changes in the placenta were investigated in the normal pregnant rat. Total lipid fractions extracted from the placenta between days 12 and 20 of pregnancy...

Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of proteins.

Kageyama, S, Anderson, B D, Hoesterey, B L, Hayashi, H, Kiso, Y, Flora, K P, ...

KNI-272 represents a peptide-based protease inhibitor having potent antiretroviral activity against human immunodeficiency virus (HIV) in vitro. The structure contains allophenylnorstatine...

An approach to the targeted attachment of peptides and proteins to solid supports.

Hofmann, K, Kiso, Y

A novel approach to affinity columns is described that is based on the high avidity of biotinylated molecules for avidin attached to solid supports. Biocytin amide [Nepsilon-(+)-biotinyllysine amide]...

Glycosphingolipid composition of rat placenta: changes associated with stage of pregnancy.

Itonori, S, Shirai, T, Kiso, Y, Ohashi, Y, Shiota, K, Ogawa, T

The composition of glycolipids and their changes in the placenta were investigated in the normal pregnant rat. Total lipid fractions extracted from the placenta between days 12 and 20 of pregnancy...

Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor.

Velazquez-Campoy, A., Luque, I., Todd, M. J., Milutinovich, M., Kiso, Y., Freire, E.

KNI-272 is a powerful HIV-1 protease inhibitor with a reported inhibition constant in the picomolar range. In this paper, a complete experimental dissection of the thermodynamic forces that define...