Y. Kobayashi

Publication List Details

Period

1932 - 2009

Number

298

Co-Authors

Traffic Flow Measuring System by Image Processing (2009)

K. Takahashi, T. Kitamura, M. Takatoo, Y. Kobayashi, Y. Satoh

In this paper, we show anew image sensor for measuring traffic flow. The image sensor is set at an intersection. The image sensor measures trafic flow by vehicle tracking. The tracking is done by...

Search for Sc-K line emission from RX J0852.0--4622 Supernova remnant with Suzaku (2009)

Hiraga, Junko S., Kobayashi, Y., Tamagawa, T., Hayato, A., Bamba, A., Terada, Y., ...

We searched for evidence of line emission around 4keV from the northwestern rim of the supernova remnant RX J0852.0-4622 using Suzaku XIS data. Several papers have reported the detection of an...

NMR Studies on the Superconducting Symmetry of Iron Pnictide Systems (2009)

Kobayashi, Y., Kawabata, A., Lee, S. C., Moyoshi, T., Sato, M.

NMR longitudinal relaxation rates 1/T1 and Knight shifts K have been measured for superconducting samples of LaFe1-yCoyAsO1-xFx with y=0.0 and 0.0075 and for a nonsuperconducting metallic sample with...

Low-intensity pulsed ultrasound stimulates cell proliferation, proteoglycan synthesis and expression of growth factor-related genes in human nucleus pulposus cell line (2009)

Y Kobayashi, D Sakai, T Iwashina, S Iwabuchi, J Mochida

Low-intensity pulsed ultrasound (LIPUS) stimulation has been shown to effect differentiation and activation of human chondrocytes. A study involving stimulation of rabbit disc cells with LIPUS...

ABSTRACTS (2009)

Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...

Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...

Distinct transport behaviors of LaFe1-yCoyAsO1-xFx (x=0.11) between the superconducting and nonsuperconducting metallic y regions divided by y ~ 0.05 (2008)

Lee, S. C., Kawabata, A., Moyoshi, T., Kobayashi, Y., Sato, M.

Electrical resistivities, Hall coefficients and thermoelectric powers have been measured for polycrystalline samples of LaFe1-yCoyAsO1-xFx (x=0.11) with various values of y. The results show that...

Element-Specific Phonon Density of States of Iron in LaFeAsO_{1-x}F_{x} and La_{1-x}Ca_{x}FePO (2008)

Higashitaniguchi, S., Seto, M., Kitao, S., Kobayashi, Y., Saito, M., Masuda, R., ...

We have measured element-specific Fe-phonon densities of states (Fe-PDOS) of LaFeAsO_{1-x}F_{x} (x = 0, 0.11) and La_{1-x}Ca_{x}FePO (x = 0.13) by using nuclear resonant inelastic scattering of...

Spin Ordering in LaOFeAs and Its Suppression in Superconductor LaO0.89F0.11FeAs Probed by M\"ossbauer Spectroscopy (2008)

Kitao, S., Kobayashi, Y., Higashitaniguchi, S., Saito, M., Kamihara, Y., Hirano, M., ...

The 57Fe M\"ossbauer spectroscopy was applied to an iron-based layered superconductor LaO0.89F0.11FeAs with a transition temperature of 26 K and its parent material LaOFeAs. Throughout the...

Horizontal Vestibuloocular Reflex (VOR) Head Velocity Estimation in Purkinje Cell Degeneration (pcd/pcd) Mutant Mice (2008)

R. E. Kettner, S. Mahamud, N. Sitkoff, J. C. Houk, B. W. Peterson, ...

You might find this additional information useful... This article cites 69 articles, 22 of which you can access free at:

Fe-57 diffusion in n-type Si after GeV implantation of Mn-57 (2007)

Yoshida, Y, Kobayashi, Y, Yukihira, K, Hayakawa, K, Suzuki, K, Yoshida, A, ...

At the RI-beam facility of the RIKEN, Mn-57/Fe-57 isotopes are separated and implanted into n-type FZ-Si (6 x 10(16) As/cm(3)), and subsequently the atomic jump processes of Fe-57 in the Si matrix...

RECENT STUDIES ON BEAM-PHOTOELECTRON INSTABILITY IN BEPC (2007)

Y. H. Chin, H. Fukuma, S. Hiramatsu, M. Izawa, T. Kasuga, E. Kikutani, ...

An experiment investigating the photoelectron instability has been performed in BEPC at IHEP, China. The betatron oscillation of each bunch was observed and recorded by a single pass beam position...

Microscopic thickness determination of thin graphite films formed on SiC from quantized oscillation in reflectivity of low-energy electrons (2007)

Hibino, H., Kageshima, H., Maeda, F., Nagase, M., Kobayashi, Y., Yamaguchi, H.

Low-energy electron microscopy (LEEM) was used to measure the reflectivity of low-energy electrons from graphitized SiC(0001). The reflectivity shows distinct quantized oscillations as a function of...

Interannual environmental-soil thawing rate variation and its control on transpiration from Larix cajanderi, Central Yakutia, Eastern Siberia (2007)

Lopez, M.L.C., Saito, H., Kobayashi, Y., Shirota, T., Iwahana, G., Maximov, T.C., ...

Sapflow measurements were carried out in a larch forest in eastern Siberia, an area of wide permafrost distribution. Canopy transpiration and canopy conductance were scaled up from these values. The...

Interannual environmental-soil thawing rate variation and its control on transpiration from Larix cajanderi, Central Yakutia, Eastern Siberia (2007)

Lopez, M.L.C., Saito, H., Kobayashi, Y., Shirota, T., Iwahana, G., Maximov, T.C., ...

Sapflow measurements were carried out in a larch forest in eastern Siberia, an area of wide permafrost distribution. Canopy transpiration and canopy conductance were scaled up from these values. The...

The Infrared Cloud Monitor for the MAGNUM Robotic Telescope at Haleakala (2007)

Suganuma, M., Kobayashi, Y., Okada, N., Yoshii, Y., Minezaki, T., Aoki, T., ...

We present the most successful infrared cloud monitor for a robotic telescope. This system was originally developed for the MAGNUM 2-m telescope, which has been achieving unmanned and automated...

Studies on fibrolytic bacterium Butyrivibrio fibrisolvens isolated from sheep rumen (2007)

Sawanon, S., Kobayashi, Y.

Fibrolytic Butyrivibrio fibrisolvens was an attractive target for genetic engineering in rumen bacteria. The experiment was initiated in making culture collection of this species, some of which may...

Hard X-ray Detector (HXD) on Board Suzaku (2006)

Takahashi, T., Abe, K., Endo, M., Endo, Y., Ezoe, Y., Fukazawa, Y., ...

The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely...

Japanese Virtual Observatory (JVO) as an advanced astronomical research enviroment (2006)

Shirasaki, Y., Tanaka, M., Kawanomoto, S., Honda, S., Ohishi, M., Mizumoto, Y., ...

We present the design and implementation of the Japanese Virtual Observatory (JVO) system. JVO is a portal site to various kinds of astronomical resources distributed all over the world. We have...

First Detection of Near-Infrared Intraday Variations in the Seyfert 1 Nucleus NGC4395 (2006)

Minezaki, T., Yoshii, Y., Kobayashi, Y., Enya, K., Suganuma, M., Tomita, H., ...

We carried out a one-night optical V and near-infrared JHK monitoring observation of the least luminous Seyfert 1 galaxy, NGC4395, on 2004 May 1, and detected for the first time the intraday flux...

Magnetic and Metal-Insulator Transitions in beta-Na0.5CoO2 and gamma-K0.5CoO2 -NMR and Neutron Diffraction Studies- (2006)

Watanabe, H., Mori, Y., Yokoi, M., Moyoshi, T., Soda, M., Yasui, Y., ...

Co-oxides beta-Na0.5CoO2 and gamma-K0.5CoO2 have been prepared by the Na de-intercalation from alpha-NaCoO2 and by the floating-zone method, respectively. It has been found that successive phase...

Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis (2006)

Naruko, T., Ueda, M., Ehara, S., Itoh, A., Haze, K., Shirai, N., ...

Objective-Recently, elevated levels of plasma oxidized low-density lipoprotein (LDL) have been shown to relate to plaque instability in human atherosclerotic lesions. We investigated prospectively...

Evolution of talking plants in a tritrophic context: Conditions for uninfested plants to attract predators prior to herbivore attack (2006)

Kobayashi, Y., Yamamura, N., Sabelis, M.W.

Abstract: Herbivory induces plants to emit volatile chemicals that attract enemies of the herbivores (bodyguards of plants). In this way, the plant acquires protection and the bodyguards gain food....

Long-term follow-up results of no initial therapy for ocular adnexal MALT lymphoma (2006)

Tanimoto, K., Kaneko, A., Suzuki, S., Sekiguchi, N., Maruyama, D., Kim, S. W., ...

Background: The majority of lymphomas in the ocular adnexa are low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma). Although radiotherapy is the most frequently applied...

Toxoplasma gondii Does Not Persist In Goldfish (Carassius auratus) (2005)

Y. Omata, Y. Umeshita, T. Murao, R. Kano, H. Kamiya, A. Kudo, ...

Recent reports of toxoplasmosis in marine mammals raise concern that cold-blooded marine animals are a potential source of Toxoplasma gondii infection. To examine the transmissibility of T. gondii to...

Reverberation Measurements of the Inner Radius of the Dust Torus in Nearby Seyfert 1 Galaxies (2005)

Suganuma, M., Yoshii, Y., Kobayashi, Y., Minezaki, T., Enya, K., Tomita, H., ...

The most intense monitoring observations yet made in the optical (UBV) and near-infrared (JHK) wave bands were carried out for nearby Seyfert1 galaxies of NGC 5548, NGC 4051, NGC 3227, and NGC 7469....

59Co-NMR Knight Shift of Superconducting Three-Layer NaxCoO2.yH2O (2005)

Watanabe, H., Kobayashi, Y., Sato, M.

The superconducting state of NaxCoO2.yH2O with three CoO2 layers in a unit cell has been studied by 59Co-NMR. The Knight shift measured for a peak of the NMR spectra corresponding to the external...

N=1/2 supersymmetric four-dimensional non-linear sigma-models from non-anti-commutative superspace (2005)

Hatanaka, T., Ketov, S. V., Kobayashi, Y., Sasaki, S.

The component structure of a generic N=1/2 supersymmetric Non-Linear Sigma-Model (NLSM) defined in the four-dimensional (Euclidean) Non-Anti-Commutative (NAC) superspace is investigated in detail.The...

Inelastic neutron scattering study of phonons and magnetic excitations in LaCoO$_{3}$ (2005)

Kobayashi, Y., Naing, Thant Sin, Suzuki, M., Akimitsu, M., Asai, K., Yamada, K., ...

We have investigated the phonon and the magnetic excitations in LaCoO3 by inelastic neutron scattering measurements. The acoustic phonon dispersions show some characteristic features of the folded...

襟裳岬におけるゼニガタアザラシ(Phoca vitulina stejnegeri)の標識と計測 (2005)

藤井, 啓, 石川, 朋子, 渡邊, 有希子, 齋藤, 幸子, 中川, 恵美子, 小林, 由美, ...

138 harbor seals (Phoca vitulina stejnegeri), 3 larga seals (P. Largha), 1 ringed seal (P. hispida) and 3 undiscriminated seal were measured from 1990 to 2004 in Erimo Cape, Japan. They were captured...

Non-Anti-Commutative deformation of effective potentials in supersymmetric gauge theories (2005)

Hatanaka, T., Ketov, S. V., Kobayashi, Y., Sasaki, S.

We studied a nilpotent Non-Anti-Commutative (NAC) deformation of the effective superpotentials in supersymmetric gauge theories, caused by a constant self-dual graviphoton background. We derived the...

Development of Neospora caninum Cultured with Human Serum In Vitro and In Vivo (2005)

Y. Omata, R. Kano, Y. Masukata, Y. Kobayashi, M. Igarashi, R. Maeda, ...

Because there has been no report of symptomatic Neospora caninum infection in humans, we examined the effect of human serum on the parasite's growth in either a bovine angioendothelial cell or Caco-2...

Inelastic neutron scattering study of phonons and magnetic excitations in LaCoO3 (2005)

Kobayashi, Y, Naing, T S, Suzuki, M, Akimitsu, M, Asai, K, Yamada, K, ...

We have investigated the phonon and the magnetic excitations in LaCoO3 by inelastic neutron scattering measurements. The acoustic phonon dispersions show some characteristic features of the folded...

Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells (2005)

Hirano, S., Kobayashi, Y., Hayakawa, T., Cui, X., Yamamoto, M., Kanno, S., ...

Clark 1 (diphenylarsine chloride) and Clark 2 ( diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and...

Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells (2005)

Hirano, S., Kobayashi, Y., Hayakawa, T., Cui, X., Yamamoto, M., Kanno, S., ...

Clark 1 (diphenylarsine chloride) and Clark 2 ( diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and...

P.1. Supraventricular Arrhythmias: P.1.8 Carto System Reduced Chronic Recurrence Rate of Typical AFL Ablations (2005)

Asano, T., Kobayashi, Y., Miyushi, F., Matsuyama, T., Watanabe, N., Ryu, S., ...

Background The recurrence rate after ablation of typical atrial flutter (AFL) is still higher than that of other supraventricular tachyarrhythmias. The purpose of the present study was to determine...

3. Vasovagal Syncope, Tilt Testing: 3.5 Comparison of Adenosine and Isoproterenol Tilt Testing in Patients with Unexplained Syncope (2005)

Watanabe, N., Kobayashi, Y., Ito, H., Onuki, T., Miyoshi, F., Ryu, S., ...

Objective It is not clear whether a 3-minute single– stage Adenosine tilt (ATP tilt) test is useful to diagnose patients with unexplained syncope. Isoproterenol (ISP) is often utilized to induce...

Long-term follow-up results of no initial therapy for ocular adnexal MALT lymphoma (2005)

Tanimoto, K., Kaneko, A., Suzuki, S., Sekiguchi, N., Maruyama, D., Kim, S. W., ...

Background: The majority of lymphomas in the ocular adnexa are low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma). Although radiotherapy is the most frequently applied...

Subchronic Exposure to Arsenic Through Drinking Water Alters Expression of Cancer-Related Genes in Rat Liver (2004)

Cui, X., Li, S., Shraim, A., Kobayashi, Y., Hayakawa, T., Kanno, S., ...

Although arsenic exposure causes liver disease and/or hepatoma, little is known about molecular mechanisms of arsenic-induced liver toxicity or carcinogenesis. We investigated the effects of arsenic...

Japanese multicenter phase II and pharmacokinetic study of rituximab in relapsed or refractory patients with aggressive B-cell lymphoma (2004)

Tobinai, K., Igarashi, T., Itoh, K., Kobayashi, Y., Taniwaki, M., Ogura, M., ...

Background: To evaluate the efficacy and feasibility of rituximab monotherapy in Japanese patients with relapsed or refractory aggressive B-cell lymphoma. Patients and methods: Sixty-eight patients...

Impurity Effects on the Superconducting Transition Temperature of NazCoO2.yH2O (2003)

Yokoi, M., Watanabe, H., Mori, Y., Moyoshi, T., Kobayashi, Y., Sato, M.

Superconducting transition temperature Tc of NazCo1-xMxO2.yH2O has been studied for M=Ir and Ga, which can substitute for Co. It has been found that Tc is suppressed by the M-atom doping. The...

Inner Size of a Dust Torus in the Seyfert 1 Galaxy NGC 4151 (2003)

Minezaki, T., Yoshii, Y., Kobayashi, Y., Enya, K., Suganuma, M., Tomita, H., ...

The most intense monitoring observations yet made were carried out on the Seyfert 1 galaxy NGC 4151 in the optical and near-infrared wave-bands. A lag from the optical light curve to the...

Eimeria stiedai Merozoite 49-kDa Soluble Antigen Induces Protection Against Infection (2003)

S. Hanada, Y. Umemoto, Y. Omata, T. Koyama, K. Nishiyama, Y. Kobayashi, ...

A soluble antigen isolated from Eimeria stiedai merozoites with a molecular mass of 49 kDa was detected in the bile of infected rabbits. Rabbits immunized with the antigen shed a lower number of...

A Two-Component Model for the Light Curves of Hypernovae (2003)

Maeda, K., Mazzali, P. A., Deng, J., Nomoto, K., Yoshii, Y., Tomita, H., ...

The light curves of 'hypernovae', i.e. very energetic supernovae with $E_{51} \equiv E/10^{51}$ergs $\gsim 5-10$ are characterized at epochs of a few months by a phase of linear decline. Classical,...

The Optical/Near-Infrared Light Curves of SN 2002ap for the First 140 Days after Discovery (2003)

Yoshii, Y., Tomita, H., Kobayashi, Y., Deng, J., Maeda, K., Nomoto, K., ...

Supernova (SN) 2002ap in M74 was observed in the $UBVRIJHK$ bands for the first 40 days following its discovery (2002 January 29) until it disappeared because of solar conjunction, and then in June...

Rigorous simulation of exposure over nonplanar wafers (2003)

Erdmann, A., Kalus, C.K., Schmöller, T., Klyonova, Y., Sato, T., Endo, A., ...

Standard simulations of optical projection systems for lithography with scalar or vector methods of Fourier optics make the assumption that the wafer stack consists of homogeneous layers. We...

G-language Genome Analysis Environment: a workbench for nucleotide sequence data mining (2003)

Arakawa, K., Mori, K., Ikeda, K., Matsuzaki, T., Kobayashi, Y., Tomita, M.

Summary: G-language Genome Analysis Environment (G-language GAE) is an open source generic software package aimed for higher efficiency in bioinformatics analysis. G-language GAE has an interface as...

The Type Ic Hypernova SN 2002ap (2002)

Mazzali, P. A., Deng, J., Maeda, K., Nomoto, K., Umeda, H., Hatano, K., ...

Photometric and spectroscopic data of the energetic Type Ic supernova (SN) 2002ap are presented, and the properties of the SN are investigated through models of its spectral evolution and its light...

Quenching of neutron E2 effective charge in neutron-rich nuclei and the ground-state spin-parity of C-17 (2002)

Asahi, K, Ueno, H, Sakai, H, Miyoshi, H, Kameda, D, ...

The electric quadrupole moment of B-17 and the g-factor of C-17 were measured by using the fragmentation-induced nuclear polarization technique combined with the beta-NMR method. The experimental...

{gamma}{delta} T-cell neoplasms: a clinicopathological study of 11 cases (2002)

Saito, T., Matsuno, Y., Tanosaki, R., Watanabe, T., Kobayashi, Y., Tobinai, K.

Background: The majority of T-cell neoplasms express T-cell antigen receptor (TCR) α&bgr; on their cell surface, and a few cases show the TCR &ggr;δ phenotype. Recently, a variety of &ggr;δ T-cell...

Factors affecting toxicity, response and progression-free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab: a Japanese phase II study (2002)

Igarashi, T., Kobayashi, Y., Ogura, M., Kinoshita, T., Ohtsu, T., Sasaki, Y., ...

Background The aim of the study was to determine factors affecting the toxicity and efficacy of rituximab monotherapy in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma...

Isolation of Neospora caninum From the Brain of a Pregnant Sheep (2001)

T. Koyama, Y. Kobayashi, Y. Omata, M. Yamada, H. Furuoka, R. Maeda, ...

Neospora caninum was isolated from the brain of a naturally infected pregnant sheep by inoculation of immunodeficient mice with a homogenate of the brain tissue. The ewe showed no clinical signs....

The effect of bolus size on the chewing cycle in humans (2001)

Shiga, H., Stohler, C. S., Kobayashi, Y.

No general agreement exists regarding the effect that bolus size has on masticatory movement, probably because both the size and texture of food change during mastication. In this experiment, in...

Naturally-Occurring Neospora caninum Infection in an Adult Sheep and Her Twin Fetuses (2001)

Y. Kobayashi, M. Yamada, Y. Omata, T. Koyama, A. Saito, T. Matsuda, ...

Neospora caninum tissue cysts were found in the brains of surgically delivered twin fetuses at 119 days of gestation. In the brains of both fetuses, there was an inflammatory reaction involving...

Non-symmetric metamagnetic transition in UNiAl (2000)

Sechovsky, V., Kobayashi, Y., Sato, H., Aoki, H., Prokes, K., Bruck, E.H.

The electrical resistivity (o) and the Hall resistivity (oH) as a function of magnetic "eld was studied on a UNiAl single crystal at 2.9 and 4.2 K. Below 10 K, UNiAl undergoes a metamagnetic...

Temporal and spatial dispersion of repolarization during premature impulse propagation in human intact ventricular muscle: Comparison between single vs double premature stimulation (2000)

Shimizu, S., Kobayashi, Y., Miyauchi, Y., Ohmura, K., Atarashi, H., Takano, T.

Aims This study was performed to determine whether or not the kinetics of action potential duration restitution during double premature stimuli (S3) differ from that during single premature stimuli...

THE VISCOSITY OF FOUR BINARY, GASEOUS MIXTURES AT 20 AND 30C. (1998)

Kestin,J., Kobayashi,Y., Wood,R. T.

The binary mixtures consisted of the following systems: He-Kr, He-N2, N2-CO2, and Ar-CO2.

Factors Affecting Corrosion Resistance of Duplex Stainless Steel Line Pipes in H2S Containing Environments. (1998)

Fujita, S., Kobayashi, Y., Suga, M., Honda, M.

Effects of alloy contents, alpha/gamma ratios and welding of 22%Cr and 25%Cr containing Duplex Stainless Steels (DSS) on corrosion resistance have been investigated in H(2)S containing and H(2)S free...

Feasibility and pharmacokinetic study of a chimeric anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab) in relapsed B-cell lymphoma (1998)

Tobinai, K., Kobayashi, Y., Narabayashi, M., Ogura, M., Kagami, Y., Morishima, Y., ...

Background In clinical trials in the USA, IDEC-C2B8 (a mouse-human chimeric anti-CD20 monoclonal antibody) has demonstrated high response rates with only mild toxic effects in relapsed B-cell...

The Interpretation of Near-Infrared Star Counts at the South Galactic Pole (1997)

Minezaki, T., Cohen, M., Kobayashi, Y., Yoshii, Y., Peterson, B. A.

We present new deep $K'$ counts of stars at the South Galactic Pole (SGP) taken with the NAOJ PICNIC camera to $K'=17.25$. Star-galaxy separation to $K'=17.5$ was accomplished effectively using image...

K-Band Galaxy Counts in the South Galactic Pole Region (1997)

Minezaki, T., Kobayashi, Y., Yoshii, Y., Peterson, B. A.

We present new K-band galaxy number counts from K=13 to 20.5 obtained from $K'$-band surveys in the south galactic pole region, which cover 180.8 arcmin$^2$ to a limiting magnitude of K=19, and 2.21...

The complete genome sequence of the Gram-positive bacterium Bacillus subtilis (1997)

Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., ...

Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are...

Properties of Monoids That Are Presented By Finite Convergent String-Rewriting Systems - a Survey (1997)

F. Otto, Y. Kobayashi

In recent years a number of conditions has been established that a monoid must necessarily satisfy if it is to have a presentation through some finite convergent stringrewriting system. Here we give...

Equivalence principle in the new general relativity (1996)

Shirafuji, T., Nashed, G. G. L., Kobayashi, Y.

We study the problem of whether the active gravitational mass of an isolated system is equal to the total energy in the tetrad theory of gravitation. The superpotential is derived using the...

Normal host prion protein necessary for scrapie-induced neurotoxicity. (1996)

Brandner, S, Isenmann, S, Raeber, A, Fischer, M B, Sailer, A, Kobayashi, Y, ...

Accumulation of the prion protein PrPSc, a pathological and protease-resistant isoform of the normal host protein PrPC, is a feature of prion disease such as scrapie. It is still unknown whether...

Uterus and endometrium: In-vitro model of uterine leiomyomas: formation of ball-like aggregates (1996)

Kobayashi, Y., Nikaido, T., Zhai, Y.L., Iinuma, M., Shiozawa, T., Shirota, M., ...

To clarify the biological characteristics of uterine leiomyomas, cells explanted and cultured from uterine leiomyomas and from normal myometrlal tissue were observed by time- lapse cinemicrography...

Physical properties of epoxy and free volume evaluated by positron annihilation spectroscopy (1993)

Okada, T., Nishijima, S., Honda, Y., Kobayashi, Y.

The macroscopic physical properties of commercially available bisphenol -A epoxy resins cured by acid anhydride in which amount of the plasticizer, polypropyleneglycol was changed systematically have...

Positronium chemical reactions in solutions : magnetic quenching of ortho-positronium in solutions of nitrobenzene in n- and iso-octane (1993)

Zhang, Q., Kobayashi, Y., Hellmuth, E., Jean, Y.

The magnetic quenching of ortho-positronium (o-Ps) has been studied for the solutions of nitrobenzene in n- and iso-octane (2, 2, 4-trimethylpentane). Static magnetic fields up to 20 kG were applied...

Physical properties of epoxy and free volume evaluated by positron annihilation spectroscopy (1993)

Okada, T., Nishijima, S., Honda, Y., Kobayashi, Y.

The macroscopic physical properties of commercially available bisphenol -A epoxy resins cured by acid anhydride in which amount of the plasticizer, polypropyleneglycol was changed systematically have...

Positronium chemical reactions in solutions : magnetic quenching of ortho-positronium in solutions of nitrobenzene in n- and iso-octane (1993)

Zhang, Q., Kobayashi, Y., Hellmuth, E., Jean, Y.

The magnetic quenching of ortho-positronium (o-Ps) has been studied for the solutions of nitrobenzene in n- and iso-octane (2, 2, 4-trimethylpentane). Static magnetic fields up to 20 kG were applied...

Physical properties of epoxy and free volume evaluated by positron annihilation spectroscopy (1993)

Okada, T., Nishijima, S., Honda, Y., Kobayashi, Y.

The macroscopic physical properties of commercially available bisphenol -A epoxy resins cured by acid anhydride in which amount of the plasticizer, polypropyleneglycol was changed systematically have...

Positronium chemical reactions in solutions : magnetic quenching of ortho-positronium in solutions of nitrobenzene in n- and iso-octane (1993)

Zhang, Q., Kobayashi, Y., Hellmuth, E., Jean, Y.

The magnetic quenching of ortho-positronium (o-Ps) has been studied for the solutions of nitrobenzene in n- and iso-octane (2, 2, 4-trimethylpentane). Static magnetic fields up to 20 kG were applied...

Study of Lupus Nephritis in Males (1991)

TATENO, S, HIKI, Y, HAMAGUCHI, K, TSUCHIDA, H, SHIGEMATSU, H, KOBAYASHI, Y

Clinical and pathological findings were studied in 23 male patients with lupus nephritis who were followed up for a period of 41±36 months after renal biopsy. Age at renal biopsy was 31±14 years...

NARROW STRUCTURES OBSERVED IN THE p-p ANALYZING POWER AND NARROW RESONANCES (1990)

Shimizu, H., Glass, G., Hiebert, J., Hiramatsu, S., Holt, J., Imai, K., ...

Small but rather narrow structures have been observed in the momentum dependence of the analyzing power in proton-proton elastic scattering around 1 GeV/c. A possible explanation for the structures...

NARROW STRUCTURES OBSERVED IN THE p-p ANALYZING POWER AND NARROW RESONANCES (1990)

Shimizu, H., Glass, G., Hiebert, J., Hiramatsu, S., Holt, J., Imai, K., ...

Small but rather narrow structures have been observed in the momentum dependence of the analyzing power in proton-proton elastic scattering around 1 GeV/c. A possible explanation for the structures...

NARROW STRUCTURES OBSERVED IN THE p-p ANALYZING POWER AND NARROW RESONANCES (1990)

Shimizu, H., Glass, G., Hiebert, J., Hiramatsu, S., Holt, J., Imai, K., ...

Small but rather narrow structures have been observed in the momentum dependence of the analyzing power in proton-proton elastic scattering around 1 GeV/c. A possible explanation for the structures...

Experimental membranous glomerulonephritis in rats induced with gp 700, a glomerular protein (1990)

Kamata, K., Sato, N., Horata, E., Kobayashi, Y., Okubo, M.

To Investigate the antigenlcity of glomerular cell products for the induction of Heymann nephritis (HN), eight Lewis rats were immunized with an isolated glomerular protein (GLP) with only limited...

WHAT DIFFERENCE EXISTS IN THE STRUCTURE OF SiO2 AND GeO2 BETWEEN MELT-QUENCHED BULK GLASS AND SPUTTER-DEPOSITED AMORPHOUS FILM (1985)

Suzuki, K., Misawa, M., Kobayashi, Y.

The [SiO4]- tetrahedral structure unit is still preserved in sputter-deposited SiO2 amorphous film as well as in melt-quenched SiO2 glass. The angle distribution for mutual connection...

WHAT DIFFERENCE EXISTS IN THE STRUCTURE OF SiO2 AND GeO2 BETWEEN MELT-QUENCHED BULK GLASS AND SPUTTER-DEPOSITED AMORPHOUS FILM (1985)

Suzuki, K., Misawa, M., Kobayashi, Y.

The [SiO4]- tetrahedral structure unit is still preserved in sputter-deposited SiO2 amorphous film as well as in melt-quenched SiO2 glass. The angle distribution for mutual connection...

WHAT DIFFERENCE EXISTS IN THE STRUCTURE OF SiO2 AND GeO2 BETWEEN MELT-QUENCHED BULK GLASS AND SPUTTER-DEPOSITED AMORPHOUS FILM (1985)

Suzuki, K., Misawa, M., Kobayashi, Y.

The [SiO4]- tetrahedral structure unit is still preserved in sputter-deposited SiO2 amorphous film as well as in melt-quenched SiO2 glass. The angle distribution for mutual connection...

A simulation of a minicomputer controlled system and its use as a debugging tool (1979)

Kobayashi, Y., Kunii, T. L.

This paper establishes a general principle that all devices and computers embedded in a system should be considered equal from the viewpoint of the simulation design of a computer controlled system....

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

Hanabuchi, S, Koyanagi, M, Kawasaki, A, Shinohara, N, Matsuzawa, A, Nishimura, Y, ...

To investigate the mechanisms of T-cell-mediated cytotoxicity, we estimated the involvement of apoptosis-inducing Fas molecule on the target cells and its ligand on the effector cells. When...

A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.

Chintamaneni, C D, Halaban, R, Kobayashi, Y, Witkop, C J, Kwon, B S

We have determined a molecular defect to be the likely basis for inactivity of the tyrosinase (EC 1.14.18.1) from a patient with tyrosinase-negative oculocutaneous albinism. A single base (thymine)...

Ultra-small-angle x-ray-scattering study: preliminary experiments in colloidal suspensions.

Matsuoka, H, Kakigami, K, Ise, N, Kobayashi, Y, Machitani, Y, Kikuchi, T, ...

We report here a multiple-reflection type ultra-small-angle x-ray-scattering apparatus constructed according to the principle proposed by Bonse and Hart. The ultra-small-angle x-ray scattering...

A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

Kwon, B S, Chintamaneni, C, Kozak, C A, Copeland, N G, Gilbert, D J, Jenkins, N, ...

Melanocytes preferentially express an mRNA species, Pmel 17, whose protein product cross-reacts with anti-tyrosinase antibodies and whose expression correlates with the melanin content. We have now...

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

Kobayashi, Y, Yamamoto, K, Saido, T, Kawasaki, H, Oppenheim, J J, Matsushima, K

We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1...

Translational attenuation of the Bacillus subtilis spo0B cistron by an RNA structure encompassing the initiation region.

Asayama, M, Saito, K I, Kobayashi, Y

The spo0B gene, which exists as an operon with the obg gene, is required to initiate sporulation (stage 0) of Bacillus subtilis . This gene encodes a phosphotransferase in the multicomponent...

Enumeration of transconjugated Ruminococcus albus and its survival in the goat rumen microcosm.

Miyagi, T, Kaneichi, K, Aminov, R I, Kobayashi, Y, Sakka, K, Hoshino, S, ...

A transconjugant Ruminococcus albus A3 culture was released into a goat rumen, and the extent of its survival in the rumen microcosm was measured by distinguishing this bacterium from indigenous...

Sequence analysis and characterization of pOM1, a small cryptic plasmid from Butyrivibrio fibrisolvens, and its use in construction of a new family of cloning vectors for Butyrivibrios.

Hefford, M A, Kobayashi, Y, Allard, S E, Forster, R J, Teather, R M

As a preliminary step in the development of vector systems, we have isolated and begun to characterize small, cryptic plasmids from several strains of the rumen bacterium Butyrivibrio fibrisolvens....

Penetration of cefuzoname into the cerebrospinal fluid of rabbits.

Haruta, T, Yamamoto, H, Okura, K E, Kuroki, S, Kobayashi, Y

Concentrations of cefuzoname in cerebrospinal fluid (CSF) were determined in a total of 16 rabbits, 5 with healthy meninges, 5 with Staphylococcus aureus meningitis, and 6 with Escherichia coli...

Analysis of a suppressor mutation ssb (kinC) of sur0B20 (spo0A) mutation in Bacillus subtilis reveals that kinC encodes a histidine protein kinase.

Kobayashi, K, Shoji, K, Shimizu, T, Nakano, K, Sato, T, Kobayashi, Y

sur0B20 is a mutation that suppresses the effects of spo0B delta B or spo0F221 mutations in Bacillus subtilis, sur0B20 is an allele of the spo0A gene (Glu-14 to Val-14 conversion) and restores the...

Analysis of suppressor mutations of spoIVCA mutations: occurrence of DNA rearrangement in the absence of site-specific DNA recombinase SpoIVCA in Bacillus subtilis.

Sato, T, Harada, K, Kobayashi, Y

The spoIVCA gene of Bacillus subtilis encodes a site-specific recombinase, which excises a 48-kb skin element from the chromosomal DNA by DNA rearrangement and creates a new composite gene, sigK, on...

The dnaK operon of Bacillus subtilis is heptacistronic.

Homuth, G, Masuda, S, Mogk, A, Kobayashi, Y, Schumann, W

In 1992, we described the cloning and sequencing of the dnaK locus of Bacillus subtilis which, together with transcriptional studies, implied a tetracistronic structure of the operon consisting of...

The pst operon of Bacillus subtilis has a phosphate-regulated promoter and is involved in phosphate transport but not in regulation of the pho regulon.

Qi, Y, Kobayashi, Y, Hulett, F M

Genes from Bacillus subtilis predicted to encode a phosphate-specific transport (Pst) system were shown by mutation to affect high-affinity Pi uptake but not arsenate resistance or phosphate (Pho)...

Rapid method for determination of kanamycin and dibekacin in serum by use of high-pressure liquid chromatography.

Kubo, H, Kobayashi, Y, Nishikawa, T

A rapid, simple, and accurate method for the determination of kanamycin and dibekacin in serum by use of high-pressure liquid chromatography is described. The serum proteins were precipitated with...

Diffusion of beta-lactam antibiotics through liposome membranes containing purified porins.

Kobayashi, Y, Takahashi, I, Nakae, T

A method to determine the diffusion of cephalosporins through porin pores in vitro was developed, using liposomes reconstituted from phospholipids, lipopolysaccharides, and purified porin trimers....

Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.

Mima, T, Saeki, Y, Ohshima, S, Nishimoto, N, Matsushita, M, Shimizu, M, ...

To investigate the pathogenicity of T cells infiltrating in the rheumatoid joints, mononuclear cells (MNC), predominantly T cells, isolated from either synovial fluid or synovial tissues of the...

In vivo expression of the Bacillus subtilis spoVE gene.

Theeragool, G, Miyao, A, Yamada, K, Sato, T, Kobayashi, Y

In vivo expression of the Bacillus subtilis spoVE gene was studied by S1 nuclease mapping and spoVE gene fusion analysis. Transcription of spoVE is induced at about the second hour of sporulation...

Bacillus subtilis spoVE gene is transcribed by sigma E-associated RNA polymerase.

Miyao, A, Theeragool, G, Takeuchi, M, Kobayashi, Y

Expression of the Bacillus subtilis sporulation gene spoVE was examined by runoff transcription assay with an RNA polymerase preparation obtained from vegetative and sporulating cells. Transcripts...

Expression of the Bacillus subtilis spoIVCA gene, which encodes a site-specific recombinase, depends on the spoIIGB product.

Sato, T, Harada, K, Ohta, Y, Kobayashi, Y

The Bacillus subtilis spoIVCA gene encodes a site-specific recombinase which creates a sigK gene by DNA rearrangement. We have determined the transcription initiation point of the spoIVCA gene and...

The cisA cistron of Bacillus subtilis sporulation gene spoIVC encodes a protein homologous to a site-specific recombinase.

Sato, T, Samori, Y, Kobayashi, Y

The nucleotide sequence of the sporulation gene spoIVC cisA in Bacillus subtilis was determined and found to encode a protein of 500 amino acid residues with a calculated molecular weight of 57,481,...

Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.

Ikeda, M, Sato, T, Wachi, M, Jung, H K, Ishino, F, Kobayashi, Y, ...

The Escherichia coli cell division gene ftsW (2 min) was cloned and sequenced. It encodes a hydrophobic protein(s) with 414 and/or 384 amino acid residues. The deduced amino acid sequence and the...

Cloning of sporulation gene spoIIG in Bacillus subtilis.

Ayaki, H, Kobayashi, Y

Two specialized transducing phages carrying a sporulation gene, spoIIG , of Bacillus subtilis were constructed from B. subtilis temperate phages p11 and phi 105 by the "prophage transformation"...

New mutation affecting the synthesis of some membrane proteins and sporulation in Bacillus subtilis.

Matsuzaki, S, Kobayashi, Y

A new mutation, mpo, which affects the synthesis of some membrane proteins and sporulation in Bacillus subtilis was identified. The mpo mutation was tightly linked to the overproduction of membrane...

Revised restriction maps of Bacillus subtilis bacteriophage phi 105 DNA.

Anaguchi, H, Fukui, S, Kobayashi, Y

Physical mapping of Bacillus subtilis temperate phage phi 105 DNA was carried out by using restriction endonucleases EcoRI, SmaI, and KpnI, and a new revised EcoRI cleavage map is presented. In...

Genetic heterogeneity in the cysA-fus region of the Bacillus subtilis chromosome: identification of the hos gene.

Matsuzaki, S, Kobayashi, Y

We identified a new gene, hos, which exerts different sporulation phenotypes in Bacillus subtilis strains with different genetic backgrounds. The hos+ gene showed normal sporulation in the genetic...

Cloning of sporulation gene spoOB of Bacillus subtilis and its genetic and biochemical analysis.

Hirochika, H, Kobayashi, Y, Kawamura, F, Saito, H

A specialized transducing phage carrying a sporulation gene (spoOB) was constructed from Bacillus subtilis temperate phage rho 11 by in vitro and in vivo recombinations. Transformation experiments...

Isolation and characterization of fusidic acid-resistant, sporulation-defective mutants of Bacillus subtilis.

Kobayashi, H, Kobayashi, K, Kobayashi, Y

Fusidic acid-resistant, sporulation-defective mutants were isolated from Bacillus subtilis 168 thy trp. About two-thirds of the fusidic acid-resistant (fusr) mutants were defective in sporulation...

Further characterization of the R plasmid Rts1 and its mutant pTW2: replication and incompatibility of the plasmid.

Terawaki, Y, Kobayashi, Y

Incompatibility of the R plasmid Rts1 and its replication mutant pTW2 was studied in recA host cells of Escherichia coli. When the R plasmid R401, belonging to the same incompatibility group as Rts1,...

Kasugamycin-resistant mutants of Bacillus subtilis

Tominaga, A, Kobayashi, Y

Kasugamycin-resistant mutants of Bacillus subtilis were isolated and classified into two groups, one of which had resistance to kasugamycin in in vitro protein synthesis and mapped in the ribosomal...

Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones.

Yakushijin, Y, Yasukawa, M, Kobayashi, Y

In order to clarify the protective immune responses against a newly identified herpesvirus, human herpesvirus 6 (HHV-6), we established HHV-6-specific human T-cell clones and examined their...

Causative agent of spotted fever group rickettsiosis in Japan.

Okada, T, Tange, Y, Kobayashi, Y

Since 1984, it has been known that spotted fever group rickettsiosis exists in Japan. We isolated three strains of the causative rickettsiae, designated Katayama, Misaka, and Abe, from patients with...

Establishment and characterization of a T-cell line specific for Rickettsia tsutsugamushi.

Kodama, K, Kawamura, S, Yasukawa, M, Kobayashi, Y

To study the immunological protective system against rickettsial infection, a T-cell line specific for Rickettsia tsutsugamushi antigen was established by long-term culture of splenocytes from mice...

Antigenic analysis of Japanese encephalitis virus by using monoclonal antibodies.

Kobayashi, Y, Hasegawa, H, Oyama, T, Tamai, T, Kusaba, T

Hybridoma cells were produced by fusing P3X63Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with Japanese encephalitis (JE) virus, Nakayama-RFVL strain. The resulting 26...

HLA-restricted T lymphocyte-mediated cytotoxicity against herpes simplex virus-infected cells in humans.

Yasukawa, M, Shiroguchi, T, Kobayashi, Y

Cytotoxic T lymphocytes (CTL) against herpes simplex virus (HSV) were induced in vitro from human peripheral blood lymphocytes by stimulation with HSV antigen. CTL generated by HSV type 1 (HSV-1)...

Adhesion of Helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals.

Kobayashi, Y, Okazaki, K, Murakami, K

Of 35 strains of Helicobacter pylori tested, 5 were found to adhere well to HEp-2 cells. We selected three of these adhesive strains and four from the remaining strains to examine their ability to...

Two developmental genes encoding sigma factor homologs are arranged in tandem in Bacillus subtilis.

Masuda, E S, Anaguchi, H, Yamada, K, Kobayashi, Y

The sporulation-essential gene spoIIG of the Gram-positive bacterium Bacillus subtilis encodes the sporulation-specific sigma factor sigma 29(sigma E). We report here the initial characterization of...

Domain structure of a human general transcription initiation factor, TFIIF.

Yonaha, M, Aso, T, Kobayashi, Y, Vasavada, H, Yasukochi, Y, Weissman, S M, ...

The structural and functional domains of a general transcription initiation factor, TFIIF (RAP30/74, FC), have been investigated using various deletion mutants of each subunit, both in vivo and in...

Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin.

Uesugi, S, Shida, T, Ikehara, M, Kobayashi, Y, Kyogoku, Y

To elucidate the mechanism of DNA strand scission by bleomycin, a d(C-G-C-G-C-G) duplex was treated with the bleomycin-iron ion complex in the presence of H2O2 and degradation products (1, 2,...

Synthesis and conformational studies of ribooligonucleotides which contain an alternating C-G sequence and show unusual circular dichroism spectra.

Uesugi, S, Ohkubo, M, Ohtsuka, E, Ikehara, M, Kobayashi, Y, Kyogoku, Y

The poly [r(C-G)] duplex shows an unusually large negative CD band in the long wavelength region. In order to elucidate this phenomenon, r(C-G-C-G) and r(C-G-C-G-C-G) were synthesized by a...

Purification of BsuE methyltransferase and its application in genome mapping.

Shukla, H, Kobayashi, Y, Arenstorf, H, Yasukochi, Y, Weissman, S M

We have used a combination of BsuE methyltransferase (M-BsuE) and NotI restriction enzyme to cut genomic DNA at a subset of NotI sites. The usefulness of this system is shown in a re-examination of...

Heat-inducible translational coupling in Bacillus subtilis.

Fujiwara, S, Tsubokura, N, Kurusu, Y, Minami, K, Kobayashi, Y

Bacillus subtilis plasmid pGR71 is a promoter-probe shuttle vector derived from pUB110. The expression of the cat gene on pGR71 in B. subtilis requires the insertion of a Bacillus promoter and a...

Revised assignment for the Bacillus subtilis spo0F gene and its homology with spo0A and with two Escherichia coli genes.

Yoshikawa, H, Kazami, J, Yamashita, S, Chibazakura, T, Sone, H, Kawamura, F, ...

The nucleotide sequences of spo0F mutant genes which block the early sporulation process of Bacillus subtilis were determined. The mutation sites together with the results of complementation tests...

Early sporulation gene spo0F: nucleotide sequence and analysis of gene product.

Shimotsu, H, Kawamura, F, Kobayashi, Y, Saito, H

We have determined the sequence of a 1,162-base-pair DNA fragment containing a spo0F gene which is required for an early stage of sporulation in Bacillus subtilis. The sequence has only one long open...

Purification of complement-fixing antigens of Rickettsia sennetsu by ether treatment.

Tachibana, N, Kusaba, T, Matsumoto, I, Kobayashi, Y

Soluble and particulate complement-fixing antigens of Rickettsia sennetsu were prepared from spleen suspensions of mice infected with the rickettsia and treated with cyclophosphamide. The medium used...

Rapid diagnosis of methicillin-resistant Staphylococcus aureus bacteremia by nested polymerase chain reaction.

Kitagawa, Y, Ueda, M, Ando, N, Endo, M, Ishibiki, K, Kobayashi, Y, ...

OBJECTIVE: The purpose of this study was to establish a rapid and sensitive diagnostic method for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in postoperative patients. SUMMARY...

The relation between carcinoma of the gallbladder and an anomalous connection between the choledochus and the pancreatic duct.

Nagata, E, Sakai, K, Kinoshita, H, Kobayashi, Y

An anomalous connection between the choledochus and the pancreatic duct may be associated etiologically or pathogenetically with congenital biliary dilation and carcinoma of the dilated bile duct....

Respiration-deficient cells are caused by a single point mutation in the mitochondrial tRNA-Leu (UUR) gene in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS).

Kobayashi, Y, Momoi, M Y, Tominaga, K, Shimoizumi, H, Nihei, K, Yanagisawa, M, ...

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) is a major subgroup of heterogeneous mitochondrial diseases. For identifying a mutation in the mitochondrial...

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

Hanabuchi, S, Koyanagi, M, Kawasaki, A, Shinohara, N, Matsuzawa, A, Nishimura, Y, ...

To investigate the mechanisms of T-cell-mediated cytotoxicity, we estimated the involvement of apoptosis-inducing Fas molecule on the target cells and its ligand on the effector cells. When...

A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.

Chintamaneni, C D, Halaban, R, Kobayashi, Y, Witkop, C J, Kwon, B S

We have determined a molecular defect to be the likely basis for inactivity of the tyrosinase (EC 1.14.18.1) from a patient with tyrosinase-negative oculocutaneous albinism. A single base (thymine)...

Ultra-small-angle x-ray-scattering study: preliminary experiments in colloidal suspensions.

Matsuoka, H, Kakigami, K, Ise, N, Kobayashi, Y, Machitani, Y, Kikuchi, T, ...

We report here a multiple-reflection type ultra-small-angle x-ray-scattering apparatus constructed according to the principle proposed by Bonse and Hart. The ultra-small-angle x-ray scattering...

A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

Kwon, B S, Chintamaneni, C, Kozak, C A, Copeland, N G, Gilbert, D J, Jenkins, N, ...

Melanocytes preferentially express an mRNA species, Pmel 17, whose protein product cross-reacts with anti-tyrosinase antibodies and whose expression correlates with the melanin content. We have now...

Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

Kobayashi, Y, Yamamoto, K, Saido, T, Kawasaki, H, Oppenheim, J J, Matsushima, K

We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1...

Translational attenuation of the Bacillus subtilis spo0B cistron by an RNA structure encompassing the initiation region.

Asayama, M, Saito, K I, Kobayashi, Y

The spo0B gene, which exists as an operon with the obg gene, is required to initiate sporulation (stage 0) of Bacillus subtilis . This gene encodes a phosphotransferase in the multicomponent...

Enumeration of transconjugated Ruminococcus albus and its survival in the goat rumen microcosm.

Miyagi, T, Kaneichi, K, Aminov, R I, Kobayashi, Y, Sakka, K, Hoshino, S, ...

A transconjugant Ruminococcus albus A3 culture was released into a goat rumen, and the extent of its survival in the rumen microcosm was measured by distinguishing this bacterium from indigenous...

Sequence analysis and characterization of pOM1, a small cryptic plasmid from Butyrivibrio fibrisolvens, and its use in construction of a new family of cloning vectors for Butyrivibrios.

Hefford, M A, Kobayashi, Y, Allard, S E, Forster, R J, Teather, R M

As a preliminary step in the development of vector systems, we have isolated and begun to characterize small, cryptic plasmids from several strains of the rumen bacterium Butyrivibrio fibrisolvens....

Penetration of cefuzoname into the cerebrospinal fluid of rabbits.

Haruta, T, Yamamoto, H, Okura, K E, Kuroki, S, Kobayashi, Y

Concentrations of cefuzoname in cerebrospinal fluid (CSF) were determined in a total of 16 rabbits, 5 with healthy meninges, 5 with Staphylococcus aureus meningitis, and 6 with Escherichia coli...

Analysis of a suppressor mutation ssb (kinC) of sur0B20 (spo0A) mutation in Bacillus subtilis reveals that kinC encodes a histidine protein kinase.

Kobayashi, K, Shoji, K, Shimizu, T, Nakano, K, Sato, T, Kobayashi, Y

sur0B20 is a mutation that suppresses the effects of spo0B delta B or spo0F221 mutations in Bacillus subtilis, sur0B20 is an allele of the spo0A gene (Glu-14 to Val-14 conversion) and restores the...

Analysis of suppressor mutations of spoIVCA mutations: occurrence of DNA rearrangement in the absence of site-specific DNA recombinase SpoIVCA in Bacillus subtilis.

Sato, T, Harada, K, Kobayashi, Y

The spoIVCA gene of Bacillus subtilis encodes a site-specific recombinase, which excises a 48-kb skin element from the chromosomal DNA by DNA rearrangement and creates a new composite gene, sigK, on...

The dnaK operon of Bacillus subtilis is heptacistronic.

Homuth, G, Masuda, S, Mogk, A, Kobayashi, Y, Schumann, W

In 1992, we described the cloning and sequencing of the dnaK locus of Bacillus subtilis which, together with transcriptional studies, implied a tetracistronic structure of the operon consisting of...

The pst operon of Bacillus subtilis has a phosphate-regulated promoter and is involved in phosphate transport but not in regulation of the pho regulon.

Qi, Y, Kobayashi, Y, Hulett, F M

Genes from Bacillus subtilis predicted to encode a phosphate-specific transport (Pst) system were shown by mutation to affect high-affinity Pi uptake but not arsenate resistance or phosphate (Pho)...

Rapid method for determination of kanamycin and dibekacin in serum by use of high-pressure liquid chromatography.

Kubo, H, Kobayashi, Y, Nishikawa, T

A rapid, simple, and accurate method for the determination of kanamycin and dibekacin in serum by use of high-pressure liquid chromatography is described. The serum proteins were precipitated with...

Diffusion of beta-lactam antibiotics through liposome membranes containing purified porins.

Kobayashi, Y, Takahashi, I, Nakae, T

A method to determine the diffusion of cephalosporins through porin pores in vitro was developed, using liposomes reconstituted from phospholipids, lipopolysaccharides, and purified porin trimers....

Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints.

Mima, T, Saeki, Y, Ohshima, S, Nishimoto, N, Matsushita, M, Shimizu, M, ...

To investigate the pathogenicity of T cells infiltrating in the rheumatoid joints, mononuclear cells (MNC), predominantly T cells, isolated from either synovial fluid or synovial tissues of the...

In vivo expression of the Bacillus subtilis spoVE gene.

Theeragool, G, Miyao, A, Yamada, K, Sato, T, Kobayashi, Y

In vivo expression of the Bacillus subtilis spoVE gene was studied by S1 nuclease mapping and spoVE gene fusion analysis. Transcription of spoVE is induced at about the second hour of sporulation...

Bacillus subtilis spoVE gene is transcribed by sigma E-associated RNA polymerase.

Miyao, A, Theeragool, G, Takeuchi, M, Kobayashi, Y

Expression of the Bacillus subtilis sporulation gene spoVE was examined by runoff transcription assay with an RNA polymerase preparation obtained from vegetative and sporulating cells. Transcripts...

Expression of the Bacillus subtilis spoIVCA gene, which encodes a site-specific recombinase, depends on the spoIIGB product.

Sato, T, Harada, K, Ohta, Y, Kobayashi, Y

The Bacillus subtilis spoIVCA gene encodes a site-specific recombinase which creates a sigK gene by DNA rearrangement. We have determined the transcription initiation point of the spoIVCA gene and...

The cisA cistron of Bacillus subtilis sporulation gene spoIVC encodes a protein homologous to a site-specific recombinase.

Sato, T, Samori, Y, Kobayashi, Y

The nucleotide sequence of the sporulation gene spoIVC cisA in Bacillus subtilis was determined and found to encode a protein of 500 amino acid residues with a calculated molecular weight of 57,481,...

Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.

Ikeda, M, Sato, T, Wachi, M, Jung, H K, Ishino, F, Kobayashi, Y, ...

The Escherichia coli cell division gene ftsW (2 min) was cloned and sequenced. It encodes a hydrophobic protein(s) with 414 and/or 384 amino acid residues. The deduced amino acid sequence and the...

Cloning of sporulation gene spoIIG in Bacillus subtilis.

Ayaki, H, Kobayashi, Y

Two specialized transducing phages carrying a sporulation gene, spoIIG , of Bacillus subtilis were constructed from B. subtilis temperate phages p11 and phi 105 by the "prophage transformation"...

New mutation affecting the synthesis of some membrane proteins and sporulation in Bacillus subtilis.

Matsuzaki, S, Kobayashi, Y

A new mutation, mpo, which affects the synthesis of some membrane proteins and sporulation in Bacillus subtilis was identified. The mpo mutation was tightly linked to the overproduction of membrane...

Revised restriction maps of Bacillus subtilis bacteriophage phi 105 DNA.

Anaguchi, H, Fukui, S, Kobayashi, Y

Physical mapping of Bacillus subtilis temperate phage phi 105 DNA was carried out by using restriction endonucleases EcoRI, SmaI, and KpnI, and a new revised EcoRI cleavage map is presented. In...

Genetic heterogeneity in the cysA-fus region of the Bacillus subtilis chromosome: identification of the hos gene.

Matsuzaki, S, Kobayashi, Y

We identified a new gene, hos, which exerts different sporulation phenotypes in Bacillus subtilis strains with different genetic backgrounds. The hos+ gene showed normal sporulation in the genetic...

Cloning of sporulation gene spoOB of Bacillus subtilis and its genetic and biochemical analysis.

Hirochika, H, Kobayashi, Y, Kawamura, F, Saito, H

A specialized transducing phage carrying a sporulation gene (spoOB) was constructed from Bacillus subtilis temperate phage rho 11 by in vitro and in vivo recombinations. Transformation experiments...

Isolation and characterization of fusidic acid-resistant, sporulation-defective mutants of Bacillus subtilis.

Kobayashi, H, Kobayashi, K, Kobayashi, Y

Fusidic acid-resistant, sporulation-defective mutants were isolated from Bacillus subtilis 168 thy trp. About two-thirds of the fusidic acid-resistant (fusr) mutants were defective in sporulation...

Further characterization of the R plasmid Rts1 and its mutant pTW2: replication and incompatibility of the plasmid.

Terawaki, Y, Kobayashi, Y

Incompatibility of the R plasmid Rts1 and its replication mutant pTW2 was studied in recA host cells of Escherichia coli. When the R plasmid R401, belonging to the same incompatibility group as Rts1,...

Kasugamycin-resistant mutants of Bacillus subtilis

Tominaga, A, Kobayashi, Y

Kasugamycin-resistant mutants of Bacillus subtilis were isolated and classified into two groups, one of which had resistance to kasugamycin in in vitro protein synthesis and mapped in the ribosomal...

Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones.

Yakushijin, Y, Yasukawa, M, Kobayashi, Y

In order to clarify the protective immune responses against a newly identified herpesvirus, human herpesvirus 6 (HHV-6), we established HHV-6-specific human T-cell clones and examined their...

Causative agent of spotted fever group rickettsiosis in Japan.

Okada, T, Tange, Y, Kobayashi, Y

Since 1984, it has been known that spotted fever group rickettsiosis exists in Japan. We isolated three strains of the causative rickettsiae, designated Katayama, Misaka, and Abe, from patients with...

Establishment and characterization of a T-cell line specific for Rickettsia tsutsugamushi.

Kodama, K, Kawamura, S, Yasukawa, M, Kobayashi, Y

To study the immunological protective system against rickettsial infection, a T-cell line specific for Rickettsia tsutsugamushi antigen was established by long-term culture of splenocytes from mice...

Antigenic analysis of Japanese encephalitis virus by using monoclonal antibodies.

Kobayashi, Y, Hasegawa, H, Oyama, T, Tamai, T, Kusaba, T

Hybridoma cells were produced by fusing P3X63Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with Japanese encephalitis (JE) virus, Nakayama-RFVL strain. The resulting 26...

HLA-restricted T lymphocyte-mediated cytotoxicity against herpes simplex virus-infected cells in humans.

Yasukawa, M, Shiroguchi, T, Kobayashi, Y

Cytotoxic T lymphocytes (CTL) against herpes simplex virus (HSV) were induced in vitro from human peripheral blood lymphocytes by stimulation with HSV antigen. CTL generated by HSV type 1 (HSV-1)...

Adhesion of Helicobacter pylori to gastric epithelial cells in primary cultures obtained from stomachs of various animals.

Kobayashi, Y, Okazaki, K, Murakami, K

Of 35 strains of Helicobacter pylori tested, 5 were found to adhere well to HEp-2 cells. We selected three of these adhesive strains and four from the remaining strains to examine their ability to...

Two developmental genes encoding sigma factor homologs are arranged in tandem in Bacillus subtilis.

Masuda, E S, Anaguchi, H, Yamada, K, Kobayashi, Y

The sporulation-essential gene spoIIG of the Gram-positive bacterium Bacillus subtilis encodes the sporulation-specific sigma factor sigma 29(sigma E). We report here the initial characterization of...

Domain structure of a human general transcription initiation factor, TFIIF.

Yonaha, M, Aso, T, Kobayashi, Y, Vasavada, H, Yasukochi, Y, Weissman, S M, ...

The structural and functional domains of a general transcription initiation factor, TFIIF (RAP30/74, FC), have been investigated using various deletion mutants of each subunit, both in vivo and in...

Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin.

Uesugi, S, Shida, T, Ikehara, M, Kobayashi, Y, Kyogoku, Y

To elucidate the mechanism of DNA strand scission by bleomycin, a d(C-G-C-G-C-G) duplex was treated with the bleomycin-iron ion complex in the presence of H2O2 and degradation products (1, 2,...

Synthesis and conformational studies of ribooligonucleotides which contain an alternating C-G sequence and show unusual circular dichroism spectra.

Uesugi, S, Ohkubo, M, Ohtsuka, E, Ikehara, M, Kobayashi, Y, Kyogoku, Y

The poly [r(C-G)] duplex shows an unusually large negative CD band in the long wavelength region. In order to elucidate this phenomenon, r(C-G-C-G) and r(C-G-C-G-C-G) were synthesized by a...

Purification of BsuE methyltransferase and its application in genome mapping.

Shukla, H, Kobayashi, Y, Arenstorf, H, Yasukochi, Y, Weissman, S M

We have used a combination of BsuE methyltransferase (M-BsuE) and NotI restriction enzyme to cut genomic DNA at a subset of NotI sites. The usefulness of this system is shown in a re-examination of...

Heat-inducible translational coupling in Bacillus subtilis.

Fujiwara, S, Tsubokura, N, Kurusu, Y, Minami, K, Kobayashi, Y

Bacillus subtilis plasmid pGR71 is a promoter-probe shuttle vector derived from pUB110. The expression of the cat gene on pGR71 in B. subtilis requires the insertion of a Bacillus promoter and a...

Revised assignment for the Bacillus subtilis spo0F gene and its homology with spo0A and with two Escherichia coli genes.

Yoshikawa, H, Kazami, J, Yamashita, S, Chibazakura, T, Sone, H, Kawamura, F, ...

The nucleotide sequences of spo0F mutant genes which block the early sporulation process of Bacillus subtilis were determined. The mutation sites together with the results of complementation tests...

Early sporulation gene spo0F: nucleotide sequence and analysis of gene product.

Shimotsu, H, Kawamura, F, Kobayashi, Y, Saito, H

We have determined the sequence of a 1,162-base-pair DNA fragment containing a spo0F gene which is required for an early stage of sporulation in Bacillus subtilis. The sequence has only one long open...

Purification of complement-fixing antigens of Rickettsia sennetsu by ether treatment.

Tachibana, N, Kusaba, T, Matsumoto, I, Kobayashi, Y

Soluble and particulate complement-fixing antigens of Rickettsia sennetsu were prepared from spleen suspensions of mice infected with the rickettsia and treated with cyclophosphamide. The medium used...

Rapid diagnosis of methicillin-resistant Staphylococcus aureus bacteremia by nested polymerase chain reaction.

Kitagawa, Y, Ueda, M, Ando, N, Endo, M, Ishibiki, K, Kobayashi, Y, ...

OBJECTIVE: The purpose of this study was to establish a rapid and sensitive diagnostic method for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in postoperative patients. SUMMARY...

The relation between carcinoma of the gallbladder and an anomalous connection between the choledochus and the pancreatic duct.

Nagata, E, Sakai, K, Kinoshita, H, Kobayashi, Y

An anomalous connection between the choledochus and the pancreatic duct may be associated etiologically or pathogenetically with congenital biliary dilation and carcinoma of the dilated bile duct....

Respiration-deficient cells are caused by a single point mutation in the mitochondrial tRNA-Leu (UUR) gene in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS).

Kobayashi, Y, Momoi, M Y, Tominaga, K, Shimoizumi, H, Nihei, K, Yanagisawa, M, ...

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) is a major subgroup of heterogeneous mitochondrial diseases. For identifying a mutation in the mitochondrial...

Production of lymphotoxin and tumour necrosis factor by a T-cell hybridoma.

Kobayashi, Y, Asada, M, Osawa, T

It is known that two major cytotoxins, lymphotoxin (LT) and tumour necrosis factor (TNF), are produced by T cells and macrophages, respectively. We report in this paper that a human T-cell hybridoma,...

Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens.

Kobayashi, Y

For initiation of the contact hypersensitivity response, epidermal Langerhans' cells (LC) migrate from the epidermis to draining nodes via afferent lymphatics by passing through the basement...

Guinea-pig lymphotoxin resistant L-cell sublines.

Kobayashi, Y, Sawada, J, Osawa, T

Guinea-pig lymphotoxin (GLT)-resistant L-cell sublines were isolated, and the altered properties were characterized. Two of them (No. 1 and No. 2 cells) showed the lowest capacity to absorb GLT and...

Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients.

Aster, J. C., Kobayashi, Y., Shiota, M., Mori, S., Sklar, J.

Follicular lymphoma shows a wide geographic variation in incidence, occurring more frequently in the U.S. than in Japan. A translocation involving the bcl-2 gene on chromosome 18 and the...

Assessment of myocardial viability using coronary zero flow pressure after successful angioplasty in patients with acute anterior myocardial infarction

Shimada, K, Sakanoue, Y, Kobayashi, Y, Ehara, S, Hirose, M, Nakamura, Y, ...

Objectives: To investigate the relation between coronary flow reserve (CFR), coronary zero flow pressure (Pzf), and residual myocardial viability in patients with acute myocardial infarction.

Implications of plasma concentrations of adiponectin in patients with coronary artery disease

Nakamura, Y, Shimada, K, Fukuda, D, Shimada, Y, Ehara, S, Hirose, M, ...

Objective: To investigate whether concentrations of plasma adiponectin constitute a significant coronary risk factor, with particular focus on the relation between plasma concentrations of...

Characterization of homologous restriction factor (HRF20) in human skin and leucocytes.

Sayama, K, Shiraishi, S, Shirakata, Y, Kobayashi, Y, Okada, N, Okada, H, ...

Homologous restriction factor with a molecular weight of 20 kD (HRF20) is a membrane protein that inhibits assembly of the membrane attack complex of homologous complement. Distribution of HRF20 in...

Rotavirus induces proliferative response and augments non-specific cytotoxic activity of lymphocytes in humans.

Yasukawa, M, Nakagomi, O, Kobayashi, Y

In vitro cell-mediated immune responses to rotavirus in humans were studied. Peripheral blood mononuclear cells (PBMC) of healthy adults proliferated in response to stimulation with the infectious...

Human double-negative (CD4-CD8-) T cells bearing alpha beta T cell receptor possess both helper and cytotoxic activities.

Matsumoto, M, Yasukawa, M, Inatsuki, A, Kobayashi, Y

Expression of CD4 or CD8 on the cell surface is an important guide for discriminating the immunological functions of T cells. However, a minor T cell subset, which lacks both CD4 and CD8 molecules...

Limiting dilution analysis of specific in vitro anti-herpes simplex virus antibody production by human lymphocytes.

Yasukawa, M, Kobayashi, Y

An enzyme linked immunosorbent assay (ELISA) system to study specific anti-herpes simplex virus (HSV) antibody production in vitro by human peripheral blood mononuclear cells (PBMC) has been...

A novel and effective approach of developing aggressive experimental autoimmune gastritis in neonatal thymectomized BALB/c mouse by polyinosinic:polycytidylic acid

KOBAYASHI, Y, MURAKAMI, H, AKBAR, S M F, MATSUI, H, ONJI, M

Neonatal thymectomy induces autoimmune gastritis (AIG) in 40–70% of BALB/c mice. We presumed that induction of autoimmunity by polyinosinic:polycytidylic acid (poly I:C) might allow development of...

Effect of immunoglobulin therapy on phagocytosis by polymorphonuclear leucocytes in whole blood of neonates

FUJIWARA, T, TANIUCHI, S, HATTORI, K, KOBAYASHI, T, KINOSHITA, Y, KOBAYASHI, Y

There has been some disagreement as to the clinical effect of intravenous immunoglobulin (IVIG) therapy on neonatal bacterial infections. We therefore evaluated the effect of IVIG therapy on neonatal...

Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis

Yamano, T, Higashi, T, Nouso, K, Nakatsukasa, H, Kariyama, K, Yumoto, E, ...

Primary biliary cirrhosis is an autoimmune disease of the liver in which T helper 1 cytokines predominate over those of T helper 2 in the pathogenesis. Interleukin-18 (IL-18), for which the gene was...

Role of reactive oxygen species in neutrophil apoptosis following ingestion of heat-killed Staphylococcus aureus

Yamamoto, A, Taniuchi, S, Tsuji, S, Hasui, M, Kobayashi, Y

Neutrophils, short-lived leucocytes that die by apoptosis, play an important role in the first stage of defense against bacterial infections. It has been reported that phagocytosis of intact bacteria...

Pancreas Acinar Cell Regeneration: IX. Effect of Actinomycin D on Microstructure

Yamaguchi, K., Kobayashi, Y., Sato, T., Herman, L., Marsh, W. H., Rosenstock, L., ...

The morphologic effects of actinomycin D (ACTD) on normal and regenerating rat pancreas at three dosage levels were studied. ACTD at 1.0 and 0.5 μg/g total body weight produced reversible nucleolar...

Electromagnetic interference of an external temporary pacemaker during maxillofacial and neck surgery.

Seo, K., Takayama, H., Araya, Y., Miura, K., Tanaka, Y., Kobayashi, Y., ...

Indirect inhibition of an external temporary pacemaker by electrocautery is reported. Before induction of general anesthesia for a hemimaxillectomy and radical neck dissection, a temporary...

Smoking prevalence of female nurses in the national hospitals of Japan

Ohida, T., Osaki, Y., Kobayashi, Y., Sekiyama, M., Minowa, M.

OBJECTIVE—To estimate the prevalence of smoking and the attitudes towards the restriction of smoking at work among female nurses in the national hospitals in Japan.
DESIGN—Questionnaires mailed...

Visceral larva migrans caused by Trichuris vulpis.

Sakano, T, Hamamoto, K, Kobayashi, Y, Sakata, Y, Tsuji, M, Usui, T

Two brothers with visceral larva migrans caused by Trichuris vulpis were diagnosed after they had been investigated for an eosinophilia. Both patients were almost asymptomatic. The diagnosis of...

Relation between plasma nitrate and mean pulmonary arterial pressure in ventricular septal defect

Takaya, J, Teraguchi, M, Nogi, S, Ikemoto, Y, Kobayashi, Y

BACKGROUND—Nitric oxide (NO) is known to modulate myocardial contraction and coronary tone, and its inhalation reduces pulmonary vascular resistance in patients with pulmonary...

Effects of perinatal asphyxia and myoglobinuria on development of acute, neonatal renal failure.

Kojima, T, Kobayashi, T, Matsuzaki, S, Iwase, S, Kobayashi, Y

Thirty four consecutive neonates with birth asphyxia or respiratory problems were examined in the first week of life to clarify the relation between neonatal myoglobinuria and acute renal failure....

Plasma atrial natriuretic peptide and spontaneous diuresis in sick neonates.

Kojima, T, Hirata, Y, Fukuda, Y, Iwase, S, Kobayashi, Y

Plasma concentrations of immunoreactive human atrial natriuretic peptide (human ANP) were sequentially determined in 12 infants with respiratory distress syndrome (RDS) or meconium aspiration...

Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders.

Kondo, N, Kobayashi, Y, Shinoda, S, Kasahara, K, Kameyama, T, Iwasa, S, ...

Proliferative responses of cord blood lymphocytes (CBLs) to food antigens and cord blood IgE concentrations were measured in 37 full term newborn infants for the prediction of allergic disorders. In...

Analysis of histamine‐producing cells at the late phase of allergic inflammationin rats

Shiraishi, M, Hirasawa, N, Oikawa, S, Kobayashi, Y, Ohuchi, K

To identify histamine-producing cells at the late phase of allergic inflammation, the expression of l-histidine decarboxylase (HDC) was examined in the infiltrating leucocytes in the inflammatory...

Preferentially expressed genes in stomach adenocarcinoma cells.

Shiosaka, T., Tanaka, Y., Kobayashi, Y.

cDNA clones complementary to mRNA of neoplastic cells of human stomach tissue were used to examine quantitative changes in the mRNA levels of specific genes in neoplastic cells. Poly(A)+ RNA from...

Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration.

Hirose, K., Hakozaki, M., Nyunoya, Y., Kobayashi, Y., Matsushita, K., Takenouchi, T., ...

To study the effect of localised secretion of chemokines on tumour growth, the genes for human (hu) interleukin 8 (IL-8), hu-MCP-1 (MCAF), hu-MIP-1 alpha (LD78), murine (mu)-MCP-1 (JE), mu-MIP-1...

Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C

Tanaka, H, Fujita, N, Sugimoto, R, Urawa, N, Horiike, S, Kobayashi, Y, ...

Although the oxidative stress frequently occurs in patients with chronic hepatitis C, its role in future hepatocellular carcinoma (HCC) development is unknown. Hepatic 8-hydroxydeoxyguanosine...

Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis

Nouso, K, Ito, Y M, Kuwaki, K, Kobayashi, Y, Nakamura, S, Ohashi, Y, ...

The aim of this study is to elucidate the prognostic factors and the treatment effect on survival in hepatocellular carcinoma (HCC) patients with Child C cirrhosis. Out of 3330 newly discovered HCC...

Expression of MAGE-1 and -3 genes and gene products in human hepatocellular carcinoma

Kariyama, K, Higashi, T, Kobayashi, Y, Nouso, K, Nakatsukasa, H, Yamano, T, ...

MAGE gene family encodes peptides recognized by autologous cytotoxic T lymphocytes in a major histocompatibility complex (MHC) class-I restricted fashion. In the present study, we have performed...

Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma

Toshikuni, N, Nouso, K, Higashi, T, Nakatsukasa, H, Onishi, T, Kaneyoshi, T, ...

To know whether two protein components of human telomerase (human telomerase-associated protein 1 (hTEP1) and human telomerase reverse transcriptase (hTERT) are useful markers for telomerase...

Abnormalities of the FHIT gene in human oral carcinogenesis

Tanimoto, K, Hayashi, S, Tsuchiya, E, Tokuchi, Y, Kobayashi, Y, Yoshiga, K, ...

The abnormalities of the fragile histidine triad (FHIT) gene in tissue samples of oral squamous cell carcinomas (SCCs) along with several leukoplakias and an erythroplakia were examined to determine...