This paper describes a servo system with a digital signal processing which has been applied to a cesium frequency standard recently. In contrast to the former servo system which adopted an analogue...
Kuwahara, K., Angkawidjaja, C., Matsumura, H., Koga, Y., Takano, K., Kanaya, S.
A family I.3 lipase from Pseudomonas sp. MIS38 (PML) contains three Ca2+-binding sites (Ca1–Ca3) in the N-catalytic domain. Of them, the Ca1 site is formed only in an open conformation. To analyze...
Pulido, M.A., Koga, Y., Takano, K., Kanaya, S.
Tk-subtilisin from the hyperthermophilic archaeon Thermococcus kodakaraensis is synthesized in a prepro-form (prepro-Tk-subtilisin), secreted in a pro-form (pro-Tk-subtilisin), and matured to an...
Pulido, M.A., Koga, Y., Takano, K., Kanaya, S.
Tk-subtilisin from the hyperthermophilic archaeon Thermococcus kodakaraensis is synthesized in a prepro-form (prepro-Tk-subtilisin), secreted in a pro-form (pro-Tk-subtilisin), and matured to an...
Angkawidjaja, C., Kuwahara, K., Omori, K., Koga, Y., Takano, K., Kanaya, S.
Type I secretion system (TISS) of Gram-negative bacteria permits proteins to be secreted directly from the cytoplasm to the external medium by a single, energy-coupled step. To examine whether this...
Angkawidjaja, C., Kuwahara, K., Omori, K., Koga, Y., Takano, K., Kanaya, S.
Type I secretion system (TISS) of Gram-negative bacteria permits proteins to be secreted directly from the cytoplasm to the external medium by a single, energy-coupled step. To examine whether this...
Response of biological cell exposed on burst RF fields (2005)
Nomura, Naoyuki, Koga, Y., Abe, S., Uchida, Ichiro, Abe, K., Katsuki, Sunao, ...
Burst RF fields (BRFFs) were applied to Chinese Hamster Ovary (CHO) cells, and the cell response to the BRFF of two different frequencies, 20 kHz and 50 MHz, was investigated by means of the...
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X-N., ...
Indigenous microbiota have several beneficial effects on host physiological functions; however, little is known about whether or not postnatal microbial colonization can affect the development of...
Yoshida, N., Koga, Y., Mimaki, N., Kobayashi, K.
This study was designed to locate the centres of resistance of consolidated units of two, four, and six anterior teeth during retraction in two human subjects. Initial displacements of these units...
Yamada, T., Yoshimura, M., Nago, N., Asai, Y., Koga, Y., Inoue, Y., ...
Yamada, T., Yoshimura, M., Nago, N., Inoue, Y., Asai, Y., Koga, Y., ...
KOGA, Y., SATO, S., SODEYAMA, N., TAKAHASHI, M., KATO, M., IWATSUKI, N., ...
The mechanisms by which benzodiazepines produce muscle relaxation and respiratory depression are not know, but they may include actions on peripheral benzodiazepine receptors or central GABA...
INFLUENCE OF LOADING RATE ON ANISOTROPY OF COMPACT BONE (1991)
Tanabe, Y., Tanaka, S., Sakamoto, M., Hara, T., Takahashi, H., Koga, Y.
Impact compression experiments for bovine femoral compact bone (plexiform bone) are performed using the split-Hopkinson pressure-bar (SHPB) technique. A method is developed for the identification of...
INFLUENCE OF LOADING RATE ON ANISOTROPY OF COMPACT BONE (1991)
Tanabe, Y., Tanaka, S., Sakamoto, M., Hara, T., Takahashi, H., Koga, Y.
Impact compression experiments for bovine femoral compact bone (plexiform bone) are performed using the split-Hopkinson pressure-bar (SHPB) technique. A method is developed for the identification of...
INFLUENCE OF LOADING RATE ON ANISOTROPY OF COMPACT BONE (1991)
Tanabe, Y., Tanaka, S., Sakamoto, M., Hara, T., Takahashi, H., Koga, Y.
Impact compression experiments for bovine femoral compact bone (plexiform bone) are performed using the split-Hopkinson pressure-bar (SHPB) technique. A method is developed for the identification of...
MICRO-MECHANISM OF DYNAMIC CRACK PROPAGATION IN BRITTLE MATERIALS (1988)
Shioya, T., Koga, Y., Fujimoto, K., Ishida, R.
Micro-mechanism of dynamic crack propagation is experimentally studied. A running crack experiment in brittle PMMA plates is conducted under constant velocity condition by the use of a fixed grip...
MICRO-MECHANISM OF DYNAMIC CRACK PROPAGATION IN BRITTLE MATERIALS (1988)
Shioya, T., Koga, Y., Fujimoto, K., Ishida, R.
Micro-mechanism of dynamic crack propagation is experimentally studied. A running crack experiment in brittle PMMA plates is conducted under constant velocity condition by the use of a fixed grip...
MICRO-MECHANISM OF DYNAMIC CRACK PROPAGATION IN BRITTLE MATERIALS (1988)
Shioya, T., Koga, Y., Fujimoto, K., Ishida, R.
Micro-mechanism of dynamic crack propagation is experimentally studied. A running crack experiment in brittle PMMA plates is conducted under constant velocity condition by the use of a fixed grip...
THE CESIUM BEAM FREQUENCY STANDARD NRLM-II (1981)
Koga, Y., Nakadan, Y., Yoda, J.
Design and performance of the cesium beam frequency standard, NRLM-II, are reported. The interaction length 1 m is adopted from the viewpoints of the C-field homogeneity and the signal to noise ratio...
THE CESIUM BEAM FREQUENCY STANDARD NRLM-II (1981)
Koga, Y., Nakadan, Y., Yoda, J.
Design and performance of the cesium beam frequency standard, NRLM-II, are reported. The interaction length 1 m is adopted from the viewpoints of the C-field homogeneity and the signal to noise ratio...
THE CESIUM BEAM FREQUENCY STANDARD NRLM-II (1981)
Koga, Y., Nakadan, Y., Yoda, J.
Design and performance of the cesium beam frequency standard, NRLM-II, are reported. The interaction length 1 m is adopted from the viewpoints of the C-field homogeneity and the signal to noise ratio...
Umezawa, K, Ohnishi, N, Tanaka, K, Kamiya, S, Koga, Y, Nakazawa, H, ...
The pathophysiological roles of superoxide (O2.-) at the site of infection of facultative intracellular bacteria were examined in this study. To evaluate the actual in vivo generation of the...
The biosynthesis of the plasmalogen forms of phosphatidylethanolamine (plasmenylethanolamine) and phosphatidylglycerol (plasmenylglycerol) and of the glycerol acetal of plasmenylethanolamine has been...
Masucci, J P, Davidson, M, Koga, Y, Schon, E A, King, M P
Cytoplasts from patients with myoclonus epilepsy with ragged-red fibers harboring a pathogenic point mutation at either nucleotide 8344 or 8356 in the human mitochondrial tRNA(Lys) gene were fused...
Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.
Lu, Y Y, Koga, Y, Tanaka, K, Sasaki, M, Kimura, G, Nomoto, K
In a previous study (Y. Koga, M. Sasaki, H. Yoshida, H. Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, a precursor form of envelope...
Priming of immature thymocytes to CD3-mediated apoptosis by infection with murine cytomegalovirus.
Koga, Y, Tanaka, K, Lu, Y Y, Oh-Tsu, M, Sasaki, M, Kimura, G, ...
Cytomegalovirus (CMV) causes severe clinical manifestations in immunocompromised hosts; however, it remains unclear whether the virus itself is a cause of immunosuppression or whether it is involved...
Koga, Y, Sasaki, M, Nakamura, K, Kimura, G, Nomoto, K
Human CD4+ and CD4- monocytoid cell lines were transfected with a constructed plasmid that has the envelope gene of human immunodeficiency virus under the transcriptional control of human...
Koga, Y, Sasaki, M, Yoshida, H, Oh-Tsu, M, Kimura, G, Nomoto, K
An extensive cytopathic effect occurred in the CD4+ cells expressing gp160 of human immunodeficiency virus. A protein capable of nuclear location that was microinjected into such cells was not...
Kawamura, I, Koga, Y, Oh-Hori, N, Onodera, K, Kimura, G, Nomoto, K
A CD4+ human monocytoid cell line, U937, was transfected with a constructed plasmid which has the envelope gene of human immunodeficiency virus under the transcriptional control of the human...
Koga, Y, Lindstrom, E, Fenyo, E M, Wigzell, H, Mak, T W
Infection by human immunodeficiency virus (HIV-1) of a human T leukemia cell line (HUT 78) leads to a rapid accumulation at an elevated level (10- to 20-fold) of heterodisperse RNAs, revealed by...
Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus.
Tanaka, K, Koga, Y, Lu, Y Y, Zhang, X Y, Wang, Y, Kimura, G, ...
At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a...
Koga, Y, Davidson, M, Schon, E A, King, M P
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disorder associated with heteroplasmic point mutations in the mitochondrial tRNA(Leu)(UUR)...
Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes.
Koga, S, Ogawa, S, Kuwabara, K, Brett, J, Leavy, J A, Ryan, J, ...
To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. Exposure of...
Mita, S, Rizzuto, R, Moraes, C T, Shanske, S, Arnaudo, E, Fabrizi, G M, ...
Large-scale deletions of mitochondrial DNA (mtDNA) have been described in patients with progressive external ophthalmoplegia (PEO) and ragged red fibers. We have determined the exact deletion...
Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.
Koga, Y, Fabrizi, G M, Mita, S, Arnaudo, E, Lomax, M I, Aqua, M S, ...
Takadera, T, Leung, S, Gernone, A, Koga, Y, Takihara, Y, Miyamoto, N G, ...
The human T-cell- or lymphocyte-specific gene, lck, encodes a tyrosine kinase and is a member of the src family. In this report we demonstrate that there are two classes of human lck transcripts...
King, M P, Koga, Y, Davidson, M, Schon, E A
Cytoplasts from two unrelated patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) harboring an A----G transition at nucleotide position 3243 in the...
Ether polar lipids of methanogenic bacteria: structures, comparative aspects, and biosyntheses.
Koga, Y, Nishihara, M, Morii, H, Akagawa-Matsushita, M
Complete structures of nearly 40 ether polar lipids from seven species of methanogens have been elucidated during the past 10 years. Three kinds of variations of core lipids, macrocyclic archaeol and...
Ohta, H, Tsurudome, M, Matsumura, H, Koga, Y, Morikawa, S, Kawano, M, ...
Anti-FRP mAbs induced polykaryocyte formation of U2ME-7 cells (CD4+U937 cells transfected with the HIV gp160 gene). Anti-FRP-1 mAb immunoprecipitated gp80-85, gp120 and homodimers of these peptides,...
Tanaka, K, Nakazawa, H, Okada, K, Umezawa, K, Fukuyama, N, Koga, Y
4 wk after intraperitoneal inoculation of 0.2 LD50 (50% lethal dose) of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable in the salivary glands, but not in the lungs or...
Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes.
Tomita, M, Itoh, H, Ishikawa, N, Higa, A, Ide, H, Murakumo, Y, ...
A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid...
Effect of complete parenteral nutrition using fat emulsion on liver.
Koga, Y, Ikeda, K, Inokuchi, K
Four to 8 weeks of complete parenteral nutrition including fat emulsion, 10% Intralipid, from 2 to 4 gm/kg/day, was studied in puppies. The following conclusions were reached: At the end of 4-8 weeks...
Tomita, S, Kato, H, Fujimoto, T, Inoue, O, Koga, Y, Kuriya, N
Propionibacterium acnes may have a role in Kawasaki disease. Filtrates from cultures of P acnes isolated from cervical lymph node biopsy specimens and blood samples from patients with Kawasaki...
Umezawa, K, Ohnishi, N, Tanaka, K, Kamiya, S, Koga, Y, Nakazawa, H, ...
The pathophysiological roles of superoxide (O2.-) at the site of infection of facultative intracellular bacteria were examined in this study. To evaluate the actual in vivo generation of the...
The biosynthesis of the plasmalogen forms of phosphatidylethanolamine (plasmenylethanolamine) and phosphatidylglycerol (plasmenylglycerol) and of the glycerol acetal of plasmenylethanolamine has been...
Masucci, J P, Davidson, M, Koga, Y, Schon, E A, King, M P
Cytoplasts from patients with myoclonus epilepsy with ragged-red fibers harboring a pathogenic point mutation at either nucleotide 8344 or 8356 in the human mitochondrial tRNA(Lys) gene were fused...
Apoptosis induced in CD4+ cells expressing gp160 of human immunodeficiency virus type 1.
Lu, Y Y, Koga, Y, Tanaka, K, Sasaki, M, Kimura, G, Nomoto, K
In a previous study (Y. Koga, M. Sasaki, H. Yoshida, H. Wigzell, G. Kimura, and K. Nomoto, J. Immunol. 144:94-102, 1990), we demonstrated that the expression of gp160, a precursor form of envelope...
Priming of immature thymocytes to CD3-mediated apoptosis by infection with murine cytomegalovirus.
Koga, Y, Tanaka, K, Lu, Y Y, Oh-Tsu, M, Sasaki, M, Kimura, G, ...
Cytomegalovirus (CMV) causes severe clinical manifestations in immunocompromised hosts; however, it remains unclear whether the virus itself is a cause of immunosuppression or whether it is involved...
Koga, Y, Sasaki, M, Nakamura, K, Kimura, G, Nomoto, K
Human CD4+ and CD4- monocytoid cell lines were transfected with a constructed plasmid that has the envelope gene of human immunodeficiency virus under the transcriptional control of human...
Koga, Y, Sasaki, M, Yoshida, H, Oh-Tsu, M, Kimura, G, Nomoto, K
An extensive cytopathic effect occurred in the CD4+ cells expressing gp160 of human immunodeficiency virus. A protein capable of nuclear location that was microinjected into such cells was not...
Kawamura, I, Koga, Y, Oh-Hori, N, Onodera, K, Kimura, G, Nomoto, K
A CD4+ human monocytoid cell line, U937, was transfected with a constructed plasmid which has the envelope gene of human immunodeficiency virus under the transcriptional control of the human...
Koga, Y, Lindstrom, E, Fenyo, E M, Wigzell, H, Mak, T W
Infection by human immunodeficiency virus (HIV-1) of a human T leukemia cell line (HUT 78) leads to a rapid accumulation at an elevated level (10- to 20-fold) of heterodisperse RNAs, revealed by...
Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus.
Tanaka, K, Koga, Y, Lu, Y Y, Zhang, X Y, Wang, Y, Kimura, G, ...
At 4 wk after intraperitoneal inoculation of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable only in the salivary glands. When T cells of these mice were activated by a...
Koga, Y, Davidson, M, Schon, E A, King, M P
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disorder associated with heteroplasmic point mutations in the mitochondrial tRNA(Leu)(UUR)...
Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes.
Koga, S, Ogawa, S, Kuwabara, K, Brett, J, Leavy, J A, Ryan, J, ...
To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. Exposure of...
Mita, S, Rizzuto, R, Moraes, C T, Shanske, S, Arnaudo, E, Fabrizi, G M, ...
Large-scale deletions of mitochondrial DNA (mtDNA) have been described in patients with progressive external ophthalmoplegia (PEO) and ragged red fibers. We have determined the exact deletion...
Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.
Koga, Y, Fabrizi, G M, Mita, S, Arnaudo, E, Lomax, M I, Aqua, M S, ...
Takadera, T, Leung, S, Gernone, A, Koga, Y, Takihara, Y, Miyamoto, N G, ...
The human T-cell- or lymphocyte-specific gene, lck, encodes a tyrosine kinase and is a member of the src family. In this report we demonstrate that there are two classes of human lck transcripts...
King, M P, Koga, Y, Davidson, M, Schon, E A
Cytoplasts from two unrelated patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) harboring an A----G transition at nucleotide position 3243 in the...
Ether polar lipids of methanogenic bacteria: structures, comparative aspects, and biosyntheses.
Koga, Y, Nishihara, M, Morii, H, Akagawa-Matsushita, M
Complete structures of nearly 40 ether polar lipids from seven species of methanogens have been elucidated during the past 10 years. Three kinds of variations of core lipids, macrocyclic archaeol and...
Ohta, H, Tsurudome, M, Matsumura, H, Koga, Y, Morikawa, S, Kawano, M, ...
Anti-FRP mAbs induced polykaryocyte formation of U2ME-7 cells (CD4+U937 cells transfected with the HIV gp160 gene). Anti-FRP-1 mAb immunoprecipitated gp80-85, gp120 and homodimers of these peptides,...
Tanaka, K, Nakazawa, H, Okada, K, Umezawa, K, Fukuyama, N, Koga, Y
4 wk after intraperitoneal inoculation of 0.2 LD50 (50% lethal dose) of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable in the salivary glands, but not in the lungs or...
Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes.
Tomita, M, Itoh, H, Ishikawa, N, Higa, A, Ide, H, Murakumo, Y, ...
A cDNA encoding mouse intestinal trefoil factor (mITF) was successfully cloned and sequenced from the small intestine of C57BL/6 mouse by using the combination of reverse transcription-PCR and rapid...
Tomita, S, Kato, H, Fujimoto, T, Inoue, O, Koga, Y, Kuriya, N
Propionibacterium acnes may have a role in Kawasaki disease. Filtrates from cultures of P acnes isolated from cervical lymph node biopsy specimens and blood samples from patients with Kawasaki...
Effect of complete parenteral nutrition using fat emulsion on liver.
Koga, Y, Ikeda, K, Inokuchi, K
Four to 8 weeks of complete parenteral nutrition including fat emulsion, 10% Intralipid, from 2 to 4 gm/kg/day, was studied in puppies. The following conclusions were reached: At the end of 4-8 weeks...
Maeda, Y, Koga, Y, Tanaka, K, Zhang, X Y, Nomoto, K
It becomes increasingly clear that adhesion systems such as CD2/LFA-3 (lymphocyte function-associated antigen-3), LFA-1/ICAM-1 (intercellular adhesion molecule-1) and Thy-1/putative Thy-1 ligand...
Yokoyama, M, Koga, Y, Taniguchi, K, Nakano, H, Nomoto, K
We noted an increase of a splenic T-cell population in early postpartum normal mice, but not in thymectomized (Tx) postpartum mice. The T-cell population consisted mainly of Lyt-1+2- cells and...
Kawaguchi-Miyashita, M, Shimizu, K, Nanno, M, Shimada, S, Watanabe, T, Koga, Y, ...
Intraepithelial T lymphocytes in the small intestine (IEL) consist of alpha beta T-cell receptor (TCR)-bearing T cells (alpha beta-IEL) and gamma delta TCR-bearing T cells (gamma delta-IEL)....
Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.
Kabir, A M, Aiba, Y, Takagi, A, Kamiya, S, Miwa, T, Koga, Y
BACKGROUND: Helicobacter pylori is a bacterium which causes gastric inflammatory diseases. Oral inoculation of H pylori usually results in only a temporary colonisation without a successful infection...
Role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer
Kohda, K, Tanaka, K, Aiba, Y, Yasuda, M, Miwa, T, Koga, Y
a Department of Internal Medicine VI, Tokai University School of Medicine, Isehara, Kanagawa, Japan, b Department of Pathology, c Department of Infectious Diseases, d Research Department,...
Heterogeneous presentation in A3243G mutation in the mitochondrial tRNALeu(UUR) gene
Koga, Y., Akita, Y., Takane, N., Sato, Y., Kato, H.
AIMS—To clarify the phenotype-genotype relation associated with the A3243G mitochondrial DNA mutation. METHODS—Five unrelated probands harbouring the A3243G mutation but presenting different...
Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells
Ishikawa, H, Tanaka, K, Maeda, Y, Aiba, Y, Hata, A, Tsuji, N M, ...
When oral tolerance was induced in either specific pathogen-free (SPF) or germ-free (GF) mice, ovalbumin (OVA) feeding before immunization induced oral tolerance successfully in SPF mice. On the...