Y. Quan

Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products.

Quan, Y, Liang, C, Inouye, P, Wainberg, M A

We have studied the relationship between the length of HIV-1 reverse transcriptase (RT)-mediated nucleotide polymerization and inhibitors of these reactions in cell-free RT assays performed in the...

Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively.

Gu, Z, Li, X, Quan, Y, Parniak, M A, Wainberg, M A

We have assessed interactions between the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) and a neutralizing monoclonal antibody (1E8) that hinders binding of...

Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

Li, X, Quan, Y, Arts, E J, Li, Z, Preston, B D, De Rocquigny, H, ...

Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of...

Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1.

Quan, Y, Gu, Z, Li, X, Li, Z, Morrow, C D, Wainberg, M A

Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine...

The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity.

Liang, C, Li, X, Rong, L, Inouye, P, Quan, Y, Kleiman, L, ...

Nucleotide segment (+169)AAAA(+172) constitutes an A-rich loop within human immunodeficiency virus type 1 (HIV-1) (HXB2D) RNA and is able to interact with the anticodon loop (33)/USUU(36) of primer...

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

Li, X, Liang, C, Quan, Y, Chandok, R, Laughrea, M, Parniak, M A, ...

Reverse transcription of retroviruses is initiated from an 18-nucleotide (nt) primer binding site (PBS), located within the 5' region of viral genomic RNA, to which the host cell-derived tRNA primer...

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay.

Zhang, S, Ruiz-Echevarria, M J, Quan, Y, Peltz, S W

In both prokaryotes and eukaryotes, nonsense mutations in a gene can enhance the decay rate or reduce the abundance of the mRNA transcribed from that gene, and we call this process nonsense-mediated...

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.

Hagan, K W, Ruiz-Echevarria, M J, Quan, Y, Peltz, S W

Several lines of evidence indicate that the processes of mRNA turnover and translation are intimately linked and that understanding this relationship is critical to elucidating the mechanism of mRNA...

Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products.

Quan, Y, Liang, C, Inouye, P, Wainberg, M A

We have studied the relationship between the length of HIV-1 reverse transcriptase (RT)-mediated nucleotide polymerization and inhibitors of these reactions in cell-free RT assays performed in the...

Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively.

Gu, Z, Li, X, Quan, Y, Parniak, M A, Wainberg, M A

We have assessed interactions between the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) and a neutralizing monoclonal antibody (1E8) that hinders binding of...

Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

Li, X, Quan, Y, Arts, E J, Li, Z, Preston, B D, De Rocquigny, H, ...

Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of...

Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1.

Quan, Y, Gu, Z, Li, X, Li, Z, Morrow, C D, Wainberg, M A

Kinetic analysis showed that the Ki values and the Ki/Km ratios for mutated, recombinant M184V human immunodeficiency virus type 1 reverse transcriptase (RT) for (-)2'-dideoxy-3'-thiacytidine...

The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity.

Liang, C, Li, X, Rong, L, Inouye, P, Quan, Y, Kleiman, L, ...

Nucleotide segment (+169)AAAA(+172) constitutes an A-rich loop within human immunodeficiency virus type 1 (HIV-1) (HXB2D) RNA and is able to interact with the anticodon loop (33)/USUU(36) of primer...

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

Li, X, Liang, C, Quan, Y, Chandok, R, Laughrea, M, Parniak, M A, ...

Reverse transcription of retroviruses is initiated from an 18-nucleotide (nt) primer binding site (PBS), located within the 5' region of viral genomic RNA, to which the host cell-derived tRNA primer...

Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay.

Zhang, S, Ruiz-Echevarria, M J, Quan, Y, Peltz, S W

In both prokaryotes and eukaryotes, nonsense mutations in a gene can enhance the decay rate or reduce the abundance of the mRNA transcribed from that gene, and we call this process nonsense-mediated...

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.

Hagan, K W, Ruiz-Echevarria, M J, Quan, Y, Peltz, S W

Several lines of evidence indicate that the processes of mRNA turnover and translation are intimately linked and that understanding this relationship is critical to elucidating the mechanism of mRNA...