An Approach to Optical Air-Truth, (9999)
Muneyama,K., Sasaki,Y., Takahashi,Y.
Remote sensing data was measured over Tokyo Bay on November 24, 1981, which was a clear day. An aircraft with an MSS on board was used to collect the data (at an altitude of 4,000 m- about 12,000...
Fujita, K., Ichikawa, W., Yamamoto, W., Endo, H., Nagashima, F., Tanaka, R., ...
Background: S-1 is an oral anticancer agent that combines tegafur (FT) with 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate. The recommended initial dose of S-1 is 120 mg/day for patients...
Genetic testing for UGT1A1*28 and *6 in Japanese patients who receive irinotecan chemotherapy (2008)
Akiyama, Y., Fujita, K., Nagashima, F., Yamamoto, W., Endo, H., Sunakawa, Y., ...
A Relational Learner with Hierarchical Background Knowledge (2007)
eda, Grammar Rule Extension with Structured Background Knowledge of Paraphrases from Unparsable Sentences, Japanese Knowledge Acquisition for Knowledge-Based Systems (JKAW-94), pp.243-252,1994....
Terada, K., Sasaki, Y., Anand, M., Joy, K. H., Sano, Y.
Chronological studies of brecciated lunar meteorites have proved difficult, because they are mixtures of materials from various sources and the radiometric “clocks” are sometimes affected by the...
Hwang, I.H., Matsuto, T., Tanaka, N., Sasaki, Y., Tanaami, K.
Carbonization is a kind of pyrolysis process to produce char from organic materials under an inert atmosphere. In this work, chars derived from various solid wastes were characterized from the...
NMR of superfluid 3He in anisotropic aerogel (2006)
Kunimatsu, T., Sato, T., Izumina, K., Matsubara, A., Sasaki, Y., Kubota, M., ...
We report on orientation of the order parameter in the 3He-A and 3He-B phases caused by aerogel anisotropy. In 3He-A we have observed relatively homogeneous NMR line with an anomalously large...
Background: In advanced gastric cancer, the relationship between tumor response and prognosis is far from clear. Methods: We performed a pooled analysis on published data from 4593 patients in 25...
Ogawa, Y., Hotta, T., Tobinai, K., Watanabe, T., Sasaki, Y., Minami, H., ...
Background: The primary objective of this study was to investigate the tolerability, efficacy and pharmacokinetic profile of oral fludarabine phosphate in relapsed patients with indolent B-cell...
Background: In advanced gastric cancer, the relationship between tumor response and prognosis is far from clear. Methods: We performed a pooled analysis on published data from 4593 patients in 25...
Background: In advanced gastric cancer, the relationship between tumor response and prognosis is far from clear. Methods: We performed a pooled analysis on published data from 4593 patients in 25...
Characteristics of soluble sugar accumulation in commercially grown Fragaria chiloensis (2005)
Nishizawa, T., Nagasawa, S., Mori, Y., Kondo, Y., Sasaki, Y., Retamales, J.B., ...
Retamales, J.B. Facultad de Ciencias Agrarias and Centro de Investigación en Biotecnología Silvoagrícola, Universidad de Talca, Casilla 747, Talca, Chile
Adolfsson, J, Mansson, R, Buza-Vidas, N, Hultquist, A, Liuba, K, Jensen, CT, ...
Abstract not available
Shibakawa, Y. Saito, Sasaki, Y., Goshima, Y., Echigo, N., Kamiya, Y., Kurahashi, K., ...
Background. Ketamine has been reported to exert anti-inflammatory effects on macrophages stimulated with lipopolysaccharide (LPS) in vitro and in vivo. Several studies have reported conflicting...
EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 µmol kg-1 as a function of its route of administration was investigated in rats with a puncture wound...
Saito Shibakawa, Y., Sasaki, Y., Goshima, Y., Echigo, N., Kamiya, Y., Kurahashi, K., ...
Background. Ketamine has been reported to exert anti-inflammatory effects on macrophages stimulated with lipopolysaccharide (LPS) in vitro and in vivo. Several studies have reported conflicting...
Effect of calcium trisodium DTPA in rats with puncture wound contaminated by 90Y-chloride (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 μmol kg−1 as a function of its route of administration was investigated in rats with a puncture wound...
Ogawa, Y., Hotta, T., Tobinai, K., Watanabe, T., Sasaki, Y., Minami, H., ...
Background: The primary objective of this study was to investigate the tolerability, efficacy and pharmacokinetic profile of oral fludarabine phosphate in relapsed patients with indolent B-cell...
EFFECT OF CALCIUM TRISODIUM DTPA IN RATS WITH PUNCTURE WOUND CONTAMINATED BY 90Y-CHLORIDE (2005)
Watanabe, N., Tanada, S., Sasaki, Y.
The efficacy of diethylenetriaminepentaacetate calcium trisodium (CaNa3DTPA) in a dose of 34.7 µmol kg-1 as a function of its route of administration was investigated in rats with a puncture wound...
Vortex formation and annihilation in three textures of rotating superfluid 3He-A (2004)
Ishiguro, R, Ishikawa, O, Yamashita, M, Sasaki, Y, Fukuda, K, Kubota, M, ...
Sasaki, Y., Sakai, M., Miyazaki, S., Higuma, S., Shiozaki, A., Saito, S.
Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy....
Sasaki, Y., Sakai, M., Miyazaki, S., Higuma, S., Shiozaki, A., Saito, S.
Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy....
Sasaki, Y., Sakai, M., Miyazaki, S., Higuma, S., Shiozaki, A., Saito, S.
Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy....
Magnetization relaxation in (Ga,Mn)As ferromagnetic semiconductors (2003)
Sinova, Jairo, Jungwirth, T., Liu, X., Sasaki, Y., Furdyna, J. K., Atkinson, W. A., ...
We describe a theory of Mn local-moment magnetization relaxation due to p-d kinetic-exchange coupling with the itinerant-spin subsystem in the ferromagnetic semiconductor (Ga,Mn)As alloy. The...
Cosmic-Ray Detection System using Internet (2003)
Hamaguchi, T., Katsumata, M., Nakano, E., Takahashi, T., Teramoto, Y., Saito, Y., ...
A cosmic ray detection system, consisting of standardized detector stations connected through the Internet, is described. The system can be used for detecting air showers that arrive over a wide area...
Development of chemokine gene therapy against tumors (2003)
Wang, H., Sasaki, Y., Nemoto-Sasaki, Y., Nakamoto, Y., Kaneko, S., ...
High-Temperature Hall Effect in Ga(1-x)Mn(x)As (2003)
Ruzmetov, D., Scherschligt, J., Baxter, David V., Wojtowicz, T., Liu, X., Sasaki, Y., ...
The temperature dependence of the Hall coefficient of a series of ferromagnetic Ga(1-x)Mn(x)As samples is measured in the temperature range 80K < T < 500K. We model the Hall coefficient assuming a...
Tominaga, T., Adachi, I., Sasaki, Y., Tabei, T., Ikeda, T., Takatsuka, Y., ...
Background: To compare the efficacy, safety and tolerability of letrozole, an advanced non-steroidal aromatase inhibitor, and fadrozole hydrochloride, an older-generation drug in this class, we...
Thermodynamic limits to the maximum Curie temperature in Ga1-xMnxAs (2002)
Yu, K.M., Walukiewicz, W., Wojtowicz, T., Kuryliszyn, I., Liu, X., Sasaki, Y., ...
Glinka, Yu. D., Shahbazyan, T. V., Perakis, I. E., Tolk, N. H., Liu, X., Sasaki, Y., ...
We report first measurements of the ultrafast dynamics of interfacial electric fields in semiconductor multilayers using pump-probe second harmonic generation (SHG). A pump beam was tuned to excite...
Above-Room-Temperature Ferromagnetism in GaSb/Mn Digital Alloys (2002)
Chen, X., Na, M., Cheon, M., Wang, S., Luo, H., McCombe, B. D., ...
Digital alloys of GaSb/Mn have been fabricated by molecular beam epitaxy. Transmission electron micrographs showed good crystal quality with individual Mn-containing layers well resolved; no evidence...
Anisotropic Magnetoresistance in Ga$_{1-x}$Mn$_x$As (2002)
Baxter, David V., Ruzmetov, Dmitry, Scherschligt, Julia, Sasaki, Y., Liu, X., Furdyna, J. K., ...
We have measured the magnetoresistance in a series of Ga$_{1-x}$Mn$_x$As samples with 0.033$\le x \le$ 0.053 for three mutually orthogonal orientations of the applied magnetic field. The spontaneous...
Effect of the location of Mn sites in ferromagnetic GaMnAs on its Curie temperature (2002)
Yu, K.M., Walukiewicz, W., Wojtowicz, T., Kuryliszyn, I., Liu, X., Sasaki, Y., ...
Thunderstorm Gust Fonts--Observations and Modeling. (2002)
Lee,J. T., Stokes,J., Sasaki,Y., Baxter,T.
Gust front structures as observed and as modeled are reviewed and a mean model presented. Integrated observations from the 461 m meteorologically instrumented tower at Oklahoma City, OK, aircraft,...
Itoh, K., Ohtsu, T., Fukuda, H., Sasaki, Y., Ogura, M., Morishima, Y., ...
Background: CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) is accepted as the best available standard treatment for first-line chemotherapy in aggressive non-Hodgkin’s lymphoma...
Igarashi, T., Kobayashi, Y., Ogura, M., Kinoshita, T., Ohtsu, T., Sasaki, Y., ...
Background The aim of the study was to determine factors affecting the toxicity and efficacy of rituximab monotherapy in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma...
Glinka, Yu. D., Shahbazyan, T. V., Perakis, I. E., Tolk, N. H., Liu, X., Sasaki, Y., ...
We report the first application of pump-probe second harmonic generation (SHG) measurements to characterize optically-induced magnetization in non-magnetic multilayer semiconductors. In the...
Electromagnetic E2 transition probabilities in 120Xe and 118Te - N=66 nuclei (2001)
Pasternak, A. A., Efimov, A. D., Podsvirova, E. O., Mikhajlov, V. M., Srebrny, J., Morek, T., ...
Lifetimes of the yrast states in 120Xe and ground state band below and above band crossing in 118Te have been measured by DSAM in the 111Cd(12C,3n) reaction and by DSAM and RDM in the 109Ag(13C,p3n)...
Itoh, K., Ohtsu, T., Wakita, H., Igarashi, T., Ishizawa, K., Onozawa, Y., ...
Background: CHOP is accepted as the gold standard for first line chemotherapy of aggressive non-Hodgkin's lymphoma (NHL). A dose-escalation study of CHOP was conducted to determine the maximal...
THE ULTRASONIC TESTING OF HOT STEEL PRODUCTS (1998)
AN APPARATUS FOR ULTRASONIC TESTING AT HIGH TEMPERATURE WAS CONSTRUCTED IN THE BLOOMING MILL SO AS TO DETECT MECHANICAL'PIPE' IN A BLOOM OR SLAB. THE TRANSDUCERS WERE PROTECTED FROM HEAT BY USING...
Sensory Feedback System for Prosthetic Hand by Using Interferential Current (1998)
The purpose of this study was to develop a new type of sensory feedback system for myoelectrically controlled biomimetic prosthetic band. One of the characteristic features of the neuromuscular...
Abe, Y., Kakegawa, K., Sasaki, Y.
Many solid solutions with the perovskite structure (ABO3) are utilized widely for electronic devices because of their excellent ferroelectricity, pyoelectricity and piezoelectricity. The solid...
Determination of cytosol c-erbB-2 protein in breast cancer by sandwich enzyme immunoassay (1998)
Imoto, S, Ohkura, H, Sugano, K, Sasaki, Y, Ito, K, Igarashi, T, ...
Recurrence of a germ cell tumor 12 years after initial treatment: a case report (1998)
Sekine, I, Sasaki, Y, Hasebe, T, Mukai, K, Kinoshita, T, Amano, A, ...
Tobinai, K., Kobayashi, Y., Narabayashi, M., Ogura, M., Kagami, Y., Morishima, Y., ...
Background In clinical trials in the USA, IDEC-C2B8 (a mouse-human chimeric anti-CD20 monoclonal antibody) has demonstrated high response rates with only mild toxic effects in relapsed B-cell...
Sekine, I., Kubota, K., Nishiwaki, Y., Sasaki, Y., Tamura, T., Saijo, N.
Background: Response rate (RR) has been used as a defining endpoint of new-agent phase II trials for non-small-cell lung cancer (NSCLC). However, tumor responses to chemotherapy do not always result...
Igarashi, T, Shimizu, S, Morishita, K, Ohtsu, T, Itoh, K, Minami, H, ...
Itoh, K, Yamashita, T, Wakita, H, Watanabe, Y, Kodama, K, Fujii, H, ...
Takashima, S, Saeki, T, Adachi, I, Watanabe, T, Sasaki, Y, Murai, H, ...
Ohtsu, T, Igarashi, T, Wakita, H, Itoh, K, Fujii, H, Yoshida, J, ...
Mott Spin Polarimeter with Spherical Acceleration Electrodes (1994)
Sueoka, K, Sasaki, M, Hamanaka, I, Hori, Y, Mukasa, K, Hayakawa, K, ...
Nishio, M, Ohata, M, Kobayashi, H, Suruda, T, Uetani, K, Funasako, M, ...
Morita, M., Sasaki, Y., Saijo, N.
Some in vitro studies demonstrate cross-resistance between chemotherapy (CT) and radiation therapy (RT) but there is no in vivo data showing the same effect. Several studies have estimated the...
Chemotherapy-induced anemia in patients with primary lung cancer (1992)
Okamoto, H., Saijo, N., Shinkai, T., Eguchi, K., Sasaki, Y., Tamura, T., ...
To elucidate the factors which influence the value of hemoglobin, the nadir value of hemoglobin, frequency of blood transfusion and prognostic value of blood transfusion in patients with primary lung...
LOW FREQUENCY LIGHT SCATTERING SPECTRA OF AgI (1981)
Sasaki, W., Sasaki, Y., Ushioda, S., Taylor, W.
The Rayleigh-Brillouin spectra of α- and β-AgI have been measured with a Fabry-Perot interferometer in a back scattering geometry. The longitudinal acoustic phonon frequency in the...
VIBRATIONAL SPECTRA OF SOLID AND LIQUID SULFUR (1981)
We have measured the Raman spectra of intermolecular vibrations of sulfur in the temperature regions of orthorhombic-monoclinic, solid-liquid, and polymerization transitions. The evolution of the...
LOW FREQUENCY LIGHT SCATTERING SPECTRA OF AgI (1981)
Sasaki, W., Sasaki, Y., Ushioda, S., Taylor, W.
The Rayleigh-Brillouin spectra of α- and β-AgI have been measured with a Fabry-Perot interferometer in a back scattering geometry. The longitudinal acoustic phonon frequency in the...
VIBRATIONAL SPECTRA OF SOLID AND LIQUID SULFUR (1981)
We have measured the Raman spectra of intermolecular vibrations of sulfur in the temperature regions of orthorhombic-monoclinic, solid-liquid, and polymerization transitions. The evolution of the...
LOW FREQUENCY LIGHT SCATTERING SPECTRA OF AgI (1981)
Sasaki, W., Sasaki, Y., Ushioda, S., Taylor, W.
The Rayleigh-Brillouin spectra of α- and β-AgI have been measured with a Fabry-Perot interferometer in a back scattering geometry. The longitudinal acoustic phonon frequency in the...
VIBRATIONAL SPECTRA OF SOLID AND LIQUID SULFUR (1981)
We have measured the Raman spectra of intermolecular vibrations of sulfur in the temperature regions of orthorhombic-monoclinic, solid-liquid, and polymerization transitions. The evolution of the...
Nagano, Y, Okada, Y, Narita, H, Asaka, Y, Sasaki, Y
YPT/rab proteins are ras-like small GTP-binding proteins that serve as key regulators of vesicular transport. The mRNA levels of two YPT/rab genes in pea plants are repressed by light, with the...
Acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) catalyzes the synthesis of malonyl-CoA, the first intermediate in fatty acid synthesis. We studied the localization of two forms, the prokaryote and the...
Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y, Murakami, M, Kudo, I, ...
Both 2-lysophosphatidylcholine and cis-unsaturated fatty acids were previously shown to intensify agonist-induced cellular responses by enhancing the diacylglycerol-dependent activation of protein...
Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y
2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC...
Phytochrome-regulated expression of the genes encoding the small GTP-binding proteins in peas.
Yoshida, K, Nagano, Y, Murai, N, Sasaki, Y
We examined the effect of light on the mRNA levels of 11 genes (pra1-pra9A, pra9B, and pra9C) encoding the small GTP-binding proteins that belong to the ras superfamily in Pisum sativum. When the...
Asaoka, Y, Oka, M, Yoshida, K, Sasaki, Y, Nishizuka, Y
2-Lysophosphatidylcholine (lysoPtdCho), a product of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2, greatly potentiates the activation of human resting T lymphocytes that is...
Satoh, E, Ito, Y, Sasaki, Y, Sasaki, T
Streptococcus thermophilus ATCC 19258, Lactobacillus delbrueckii subsp. bulgaricus T-11, and Lactococcus lactis subsp. lactis IL1403 were transformed with the alpha-amylase gene (amyA) from...
Sasaki, Y, Blanchard, A, Watson, H L, Garcia, S, Dulioust, A, Montagnier, L, ...
Mycoplasma penetrans is a mycoplasma species newly isolated from the urine of human immunodeficiency virus (HIV)-infected individuals and presents the only case in which an association has been found...
Sasaki, Y, Taketomo, N, Sasaki, T
Conjugal transfer of streptococcal plasmid pAM beta 1 to Lactobacillus plantarum by a filter mating method was examined under various conditions. The transfer frequency depended greatly on the type,...
Distribution of mannosamine and mannosaminuronic acid among cell walls of Bacillus species.
Yoneyama, T, Koike, Y, Arakawa, H, Yokoyama, K, Sasaki, Y, Kawamura, T, ...
The distribution of mannosamine, mannosaminuronic acid, and the enzymes responsible for the formation of these saccharides was studied in nine species (18 strains) of Bacillus. Whereas...
Takai, S, Ikeda, T, Sasaki, Y, Watanabe, Y, Ozawa, T, Tsubaki, S, ...
During a survey of the prevalence of virulent Rhodococcus equi at horse-breeding farms by plasmid and protein profiles, cryptic plasmids of various sizes were found in 66 (3.8%) of 1,725 isolates...
Sasaki, T, Kenri, T, Okazaki, N, Iseki, M, Yamashita, R, Shintani, M, ...
Two hundred fifty strains of Mycoplasma pneumoniae isolated during the past 20 years in Japan were classified into two groups (I and II) based upon different PCR-restriction fragment length...
Identification of intermediately virulent Rhodococcus equi isolates from pigs.
Takai, S, Fukunaga, N, Ochiai, S, Imai, Y, Sasaki, Y, Tsubaki, S, ...
We recently reported the existence of Rhodococcus equi isolates with at least three virulence levels, isolated from AIDS patients: virulent R. equi having 15- to 17-kDa antigens that kills mice with...
Emergence of rifampin-resistant Rhodococcus equi in an infected foal.
Takai, S, Takeda, K, Nakano, Y, Karasawa, T, Furugoori, J, Sasaki, Y, ...
To investigate the emergence of rifampin resistance in Rhodococcus equi strains isolated from foals and their environment in Japan, we compared the in vitro antimicrobial susceptibilities to rifampin...
The receptor insulin substrate 1 protein (IRS-1) is a specific substrate for insulin receptor tyrosine kinase. Expression and tyrosyl phosphorylation of IRS-1 play an important role during normal...
Yuki, N, Hayashi, N, Mita, E, Hagiwara, H, Ohkawa, K, Katayama, K, ...
We studied factors which influence the detection of hepatitis C virus genotypes by the group-specific PCR of the sequence within the core region gene and by the newly developed genotype-specific NS4...
Virulence of Rhodococcus equi isolates from patients with and without AIDS.
Takai, S, Sasaki, Y, Ikeda, T, Uchida, Y, Tsubaki, S, Sekizaki, T
Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. Thirty-nine isolates of R. equi from immunocompromised patients with and without AIDS were...
Sasaki, T, Sasaki, Y, Kita, M, Suzuki, K, Watanabe, H, Honda, M
Mycoplasma fermentans incognitus has attracted much interest either as a cofactor for the progression of AIDS or as a pathogenic agent in non-AIDS-related diseases (S.-C. Lo, M. S. Dawson, P. B....
Takai, S, Iie, M, Kobayashi, C, Morishita, T, Nishio, T, Ishida, T, ...
Virulent Rhodococcus equi produces 15- to 17-kDa surface protein antigens. These antigens are used as markers to identify virulent R. equi isolates from foals and their environment by Western blot...
A chloroplast gene encoding a protein with one zinc finger.
Sasaki, Y, Nagano, Y, Morioka, S, Ishikawa, H, Matsuno, R
We have sequenced a pea chloroplast gene encoding a protein with a zinc finger (zfp A). The putative protein is conserved in chloroplast DNA and shows sequence homology to the E. coli protein...
Hidaka, H, Sasaki, Y, Tanaka, T, Endo, T, Ohno, S, Fujii, Y, ...
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities....
Enomoto, T, Sasaki, Y, Shiba, Y, Kanno, Y, Yamasaki, H
The effect of tumor promoters on electrical coupling between human FL cells was investigated with a microelectrode technique. When a low concentration (100 ng/ml) of 12-O-tetradecanoylphorbol...
Plastidic acetyl-CoA carboxylase (ACCase; EC 6.4.1.2), which catalyses the synthesis of malonyl-CoA and is the regulatory enzyme of fatty acid synthesis, is activated by light, presumably under redox...
Weber, L P, Seto, M, Sasaki, Y, Swärd, K, Walsh, M P
Myosin light-chain phosphorylation is the primary mechanism for activating smooth-muscle contraction and occurs principally at Ser-19 of the 20 kDa light chains of myosin (LC(20)). In some...
Ito, T, Yokota, T, Sasaki, Y, Suzuki, N, Sowa, T
Several 8-substituted alkylthio and alkylamino cyclic adenosine 3',5'-monophosphate (cAMP) derivatives were tested for their ability to stimulate beta-galactosidase synthesis in Estherichia coli in...
Ishikawa, O, Ohigashi, H, Imaoka, S, Furukawa, H, Sasaki, Y, Fujita, M, ...
This retrospective study attempted to determine the indications for extended pancreatectomy for locally advanced carcinoma of the pancreas, in terms of postoperative prognosis. An extended...
Insulin response to secretogogues in sheep exposed to cold.
1. The effects of cold exposure on insulin secretion in response to intravenous injections of glucose, butyrate, arginine, glucagon and tolbutamide were examined in ten sheep exposed to a temperature...
Insulin secretion in sheep exposed to cold.
1. Cold exposure caused a marked decrease in insulin response to intravenous injection of glucose, with a sharply declining response over the first 4 days of cold exposure followed by a constant low...
Regional therapy in the management of intrahepatic recurrence after surgery for hepatoma.
Sasaki, Y, Imaoka, S, Fujita, M, Miyoshi, Y, Ohigashi, H, Ishikawa, O, ...
The significance of regional therapy against the intrahepatic recurrence for hepatocellular carcinoma (HCC) was evaluated. During the past 6 years, 101 patients who had radical operations for HCC...
Ishikawa, O, Ohhigashi, H, Sasaki, Y, Kabuto, T, Fukuda, I, Furukawa, H, ...
We performed a retrospective review of 59 pancreatic resections for ductal carcinoma of the pancreas head performed between 1971 and 1983. In addition to pancreaticoduodenectomy, 37 consecutive...
Development of chemokine gene therapy against tumors
Wang, H., Sasaki, Y., Nemoto-Sasaki, Y., Nakamoto, Y., Kaneko, S., ...
Nagano, Y, Okada, Y, Narita, H, Asaka, Y, Sasaki, Y
YPT/rab proteins are ras-like small GTP-binding proteins that serve as key regulators of vesicular transport. The mRNA levels of two YPT/rab genes in pea plants are repressed by light, with the...
Acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) catalyzes the synthesis of malonyl-CoA, the first intermediate in fatty acid synthesis. We studied the localization of two forms, the prokaryote and the...
Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y, Murakami, M, Kudo, I, ...
Both 2-lysophosphatidylcholine and cis-unsaturated fatty acids were previously shown to intensify agonist-induced cellular responses by enhancing the diacylglycerol-dependent activation of protein...
Asaoka, Y, Yoshida, K, Sasaki, Y, Nishizuka, Y
2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC...
Phytochrome-regulated expression of the genes encoding the small GTP-binding proteins in peas.
Yoshida, K, Nagano, Y, Murai, N, Sasaki, Y
We examined the effect of light on the mRNA levels of 11 genes (pra1-pra9A, pra9B, and pra9C) encoding the small GTP-binding proteins that belong to the ras superfamily in Pisum sativum. When the...
Asaoka, Y, Oka, M, Yoshida, K, Sasaki, Y, Nishizuka, Y
2-Lysophosphatidylcholine (lysoPtdCho), a product of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2, greatly potentiates the activation of human resting T lymphocytes that is...
Satoh, E, Ito, Y, Sasaki, Y, Sasaki, T
Streptococcus thermophilus ATCC 19258, Lactobacillus delbrueckii subsp. bulgaricus T-11, and Lactococcus lactis subsp. lactis IL1403 were transformed with the alpha-amylase gene (amyA) from...
Sasaki, Y, Blanchard, A, Watson, H L, Garcia, S, Dulioust, A, Montagnier, L, ...
Mycoplasma penetrans is a mycoplasma species newly isolated from the urine of human immunodeficiency virus (HIV)-infected individuals and presents the only case in which an association has been found...
Sasaki, Y, Taketomo, N, Sasaki, T
Conjugal transfer of streptococcal plasmid pAM beta 1 to Lactobacillus plantarum by a filter mating method was examined under various conditions. The transfer frequency depended greatly on the type,...
Distribution of mannosamine and mannosaminuronic acid among cell walls of Bacillus species.
Yoneyama, T, Koike, Y, Arakawa, H, Yokoyama, K, Sasaki, Y, Kawamura, T, ...
The distribution of mannosamine, mannosaminuronic acid, and the enzymes responsible for the formation of these saccharides was studied in nine species (18 strains) of Bacillus. Whereas...
Ito, T, Yokota, T, Sasaki, Y, Suzuki, N, Sowa, T
Several 8-substituted alkylthio and alkylamino cyclic adenosine 3',5'-monophosphate (cAMP) derivatives were tested for their ability to stimulate beta-galactosidase synthesis in Estherichia coli in...
Takai, S, Ikeda, T, Sasaki, Y, Watanabe, Y, Ozawa, T, Tsubaki, S, ...
During a survey of the prevalence of virulent Rhodococcus equi at horse-breeding farms by plasmid and protein profiles, cryptic plasmids of various sizes were found in 66 (3.8%) of 1,725 isolates...
Sasaki, T, Kenri, T, Okazaki, N, Iseki, M, Yamashita, R, Shintani, M, ...
Two hundred fifty strains of Mycoplasma pneumoniae isolated during the past 20 years in Japan were classified into two groups (I and II) based upon different PCR-restriction fragment length...
Identification of intermediately virulent Rhodococcus equi isolates from pigs.
Takai, S, Fukunaga, N, Ochiai, S, Imai, Y, Sasaki, Y, Tsubaki, S, ...
We recently reported the existence of Rhodococcus equi isolates with at least three virulence levels, isolated from AIDS patients: virulent R. equi having 15- to 17-kDa antigens that kills mice with...
Emergence of rifampin-resistant Rhodococcus equi in an infected foal.
Takai, S, Takeda, K, Nakano, Y, Karasawa, T, Furugoori, J, Sasaki, Y, ...
To investigate the emergence of rifampin resistance in Rhodococcus equi strains isolated from foals and their environment in Japan, we compared the in vitro antimicrobial susceptibilities to rifampin...
The receptor insulin substrate 1 protein (IRS-1) is a specific substrate for insulin receptor tyrosine kinase. Expression and tyrosyl phosphorylation of IRS-1 play an important role during normal...
Yuki, N, Hayashi, N, Mita, E, Hagiwara, H, Ohkawa, K, Katayama, K, ...
We studied factors which influence the detection of hepatitis C virus genotypes by the group-specific PCR of the sequence within the core region gene and by the newly developed genotype-specific NS4...
Virulence of Rhodococcus equi isolates from patients with and without AIDS.
Takai, S, Sasaki, Y, Ikeda, T, Uchida, Y, Tsubaki, S, Sekizaki, T
Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. Thirty-nine isolates of R. equi from immunocompromised patients with and without AIDS were...
Sasaki, T, Sasaki, Y, Kita, M, Suzuki, K, Watanabe, H, Honda, M
Mycoplasma fermentans incognitus has attracted much interest either as a cofactor for the progression of AIDS or as a pathogenic agent in non-AIDS-related diseases (S.-C. Lo, M. S. Dawson, P. B....
Takai, S, Iie, M, Kobayashi, C, Morishita, T, Nishio, T, Ishida, T, ...
Virulent Rhodococcus equi produces 15- to 17-kDa surface protein antigens. These antigens are used as markers to identify virulent R. equi isolates from foals and their environment by Western blot...
A chloroplast gene encoding a protein with one zinc finger.
Sasaki, Y, Nagano, Y, Morioka, S, Ishikawa, H, Matsuno, R
We have sequenced a pea chloroplast gene encoding a protein with a zinc finger (zfp A). The putative protein is conserved in chloroplast DNA and shows sequence homology to the E. coli protein...
Hidaka, H, Sasaki, Y, Tanaka, T, Endo, T, Ohno, S, Fujii, Y, ...
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities....
Enomoto, T, Sasaki, Y, Shiba, Y, Kanno, Y, Yamasaki, H
The effect of tumor promoters on electrical coupling between human FL cells was investigated with a microelectrode technique. When a low concentration (100 ng/ml) of 12-O-tetradecanoylphorbol...
Insulin response to secretogogues in sheep exposed to cold.
1. The effects of cold exposure on insulin secretion in response to intravenous injections of glucose, butyrate, arginine, glucagon and tolbutamide were examined in ten sheep exposed to a temperature...
Plastidic acetyl-CoA carboxylase (ACCase; EC 6.4.1.2), which catalyses the synthesis of malonyl-CoA and is the regulatory enzyme of fatty acid synthesis, is activated by light, presumably under redox...
Weber, L P, Seto, M, Sasaki, Y, Swärd, K, Walsh, M P
Myosin light-chain phosphorylation is the primary mechanism for activating smooth-muscle contraction and occurs principally at Ser-19 of the 20 kDa light chains of myosin (LC(20)). In some...
Ishikawa, O, Ohigashi, H, Imaoka, S, Furukawa, H, Sasaki, Y, Fujita, M, ...
This retrospective study attempted to determine the indications for extended pancreatectomy for locally advanced carcinoma of the pancreas, in terms of postoperative prognosis. An extended...
Insulin secretion in sheep exposed to cold.
1. Cold exposure caused a marked decrease in insulin response to intravenous injection of glucose, with a sharply declining response over the first 4 days of cold exposure followed by a constant low...
Regional therapy in the management of intrahepatic recurrence after surgery for hepatoma.
Sasaki, Y, Imaoka, S, Fujita, M, Miyoshi, Y, Ohigashi, H, Ishikawa, O, ...
The significance of regional therapy against the intrahepatic recurrence for hepatocellular carcinoma (HCC) was evaluated. During the past 6 years, 101 patients who had radical operations for HCC...
Ishikawa, O, Ohhigashi, H, Sasaki, Y, Kabuto, T, Fukuda, I, Furukawa, H, ...
We performed a retrospective review of 59 pancreatic resections for ductal carcinoma of the pancreas head performed between 1971 and 1983. In addition to pancreaticoduodenectomy, 37 consecutive...
Development of chemokine gene therapy against tumors
Wang, H., Sasaki, Y., Nemoto-Sasaki, Y., Nakamoto, Y., Kaneko, S., ...
Kanto, T, Hayashi, N, Takehara, T, Katayama, K, Ito, A, Mochizuki, K, ...
In hepatitis C virus (HCV) infection, immune complex (IC)-type virus particles are frequently observed in circulation. The IC leads to cross-linking of Fcgamma receptors (FcgammaR) on monocytes and...
Sasaki, Y, Suehiro, S, Becker, A, Kinoshita, H, Ueda, M
OBJECTIVE—To provide better insights into the genesis of neointimal thickening in human vein grafts early after surgery. DESIGN—Retrospective study. SETTING—Tertiary referral...
Yoshimura, T, Shimoyama, T, Tanaka, M, Sasaki, Y, Fukuda, S, Munakata, A
Background—Infection with a virulent Helicobacter pylori strain is associated with gastric mucosal damage and the increased risk of gastric cancer.
Serum granulysin is a marker for Th1 type immunity in pre-eclampsia
SAKAI, M, OGAWA, K, SHIOZAKI, A, YONEDA, S, SASAKI, Y, NAGATA, K, ...
Recent studies suggest that pre-eclampsia is associated with a Th1 predominant state and may be considered a failure of tolerance. Granulysin is a cytotoxic granule protein of natural killer (NK)...
Saito, S, Sakai, M, Sasaki, Y, Tanebe, K, Tsuda, H, Michimata, T
We calculated the percentage of Th1, Th2, Th0 cells and the Th1:Th2 cell ratio of peripheral blood from normal pregnant subjects and preeclampsia patients using flow cytometry which can analyse both...
Sasaki, Y, Ami, Y, Nakasone, T, Shinohara, K, Takahashi, E, Ando, S, ...
Using an established SIV/HIV-C2/1-infected cynomolgus monkey model displaying stable CD4+ T cell depletion, the kinetics of apoptosis and the levels of expression of CD95 membrane-associated CD95L on...
Chaki, K., Kawamura, S., Kisara, K., Sakurada, S., Sakurada, T., Sasaki, Y., ...
1. The antinociceptive effects of [D-Arg2] dermorphin tetrapeptide analogues, H-Tyr-D-Arg-Phe-Gly-NH2 and H-Tyr-D-Arg-Phe-beta-Ala-OH when administered subcutaneously (s.c.) in rats were measured by...
Ikemura, T., Okarmura, K., Sasaki, Y., Ishi, H., Ohmori, K.
1. Sensory mechanisms play an important role in the vagal regulation of tracheobronchial smooth muscle tone. We examined the effect of KW-4679, an anti-allergic drug, on guinea-pig...
Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice.
Kisara, K., Sakurada, S., Sakurada, T., Sasaki, Y., Sato, T., Suzuki, K., ...
The antinociceptive effects of synthetic dermorphin and its analogues containing D-Arg in position 2 injected into the lateral cerebroventricle were examined in conscious mice....
Structure-antinociceptive activity studies with neurotensin.
Furuta, S., Kisara, K., Sakurada, S., Sakurada, T., Sasaki, Y., Suzuki, K.
The antinociceptive effects of synthetic neurotensin (NT), its fragments and analogues administered into the lateral cerebroventricle have been compared in the conscious mouse....
Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes
Senda, C, Yamaura, Y, Kobayashi, K, Fujii, H, Minami, H, Sasaki, Y, ...
Kasuga-Aoki, H, Takai, S, Sasaki, Y, Tsubaki, S, Madarame, H, Nakane, A
Rhodococcus equi is a facultative intracellular bacterial pathogen that causes pneumonia in foals and immunosuppressed humans. There are at least three virulence levels of R. equi and these...
Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia
Sasaki, Y, Darmochwal-Kolarz, D, Suzuki, D, Sakai, M, Ito, M, Shima, T, ...
CD4+ CD25bright regulatory T (Treg) cells have been identified as a principle regulator of tolerance during pregnancy. In the setting of pre-eclampsia, however, little is known about the dynamics of...
Ando, M., Watanabe, T., Sasaki, Y., Ying, D. F., Omuro, Y., Katsumata, N., ...
To determine the maximum-tolerated doses (MTDs), the dose-limiting toxicities (DLTs) and the recommended doses for further trials of docetaxel in combination with a 5-day continuous infusion of...
Itoh, K., Sasaki, Y., Fujii, H., Ohtsu, T., Wakita, H., Igarashi, T., ...
We attempted to characterize the motivation, comprehension and expectations of patients who had given informed consent to participate in phase I trials of anti-cancer agents at the National Cancer...
Yamada, Y, Tahara, M, Miya, T, Satoh, T, Shirao, K, Shimada, Y, ...
Two phase II studies of S-1 monotherapy have shown promising response rates (RR) of 35–40% with good tolerability in patients with untreated metastatic colorectal cancer. To investigate the...
Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours
Murai, M, Toyota, M, Satoh, A, Suzuki, H, Akino, K, Mita, H, ...
Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved...
Okada, S, Sakata, Y, Matsuno, S, Kurihara, M, Sasaki, Y, Ohashi, Y, ...
Tokuda, Y, Watanabe, T, Omuro, Y, Ando, M, Katsumata, N, Okumura, A, ...
We conducted a phase I pharmacokinetic dose escalation study of a recombinant humanized anti-p185HER2 monoclonal antibody (MKC-454) in 18 patients with metastatic breast cancer refractory to...
Satoh, A, Toyota, M, Itoh, F, Kikuchi, T, Obata, T, Sasaki, Y, ...
Death-associated protein kinase is a positive regulator of programmed cell death induced by interferon γ. To investigate the role of epigenetic inactivation of death-associated protein kinase in...
Ichikawa, W, Uetake, H, Shirota, Y, Yamada, H, Takahashi, T, Nihei, Z, ...