Gingras, A C, Svitkin, Y, Belsham, G J, Pause, A, Sonenberg, N
Infection of cells with picornaviruses, such as poliovirus and encephalomyocarditis virus (EMCV), causes a shutoff of host protein synthesis. The molecular mechanism of the shutoff has been partly...
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.
Haghighat, A, Svitkin, Y, Novoa, I, Kuechler, E, Skern, T, Sonenberg, N
The 2A proteinases (2Apro) of certain picornaviruses induce the cleavage of the eIF4G subunit of the cap-binding protein complex, eIF4F. Several reports have demonstrated that 2Apro of rhinovirus and...
Pause, A, Méthot, N, Svitkin, Y, Merrick, W C, Sonenberg, N
Eukaryotic translation initiation factor-4A (eIF-4A) plays a critical role in binding of eukaryotic mRNAs to ribosomes. It has been biochemically characterized as an RNA-dependent ATPase and RNA...
Gingras, A C, Svitkin, Y, Belsham, G J, Pause, A, Sonenberg, N
Infection of cells with picornaviruses, such as poliovirus and encephalomyocarditis virus (EMCV), causes a shutoff of host protein synthesis. The molecular mechanism of the shutoff has been partly...
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.
Haghighat, A, Svitkin, Y, Novoa, I, Kuechler, E, Skern, T, Sonenberg, N
The 2A proteinases (2Apro) of certain picornaviruses induce the cleavage of the eIF4G subunit of the cap-binding protein complex, eIF4F. Several reports have demonstrated that 2Apro of rhinovirus and...
Pause, A, Méthot, N, Svitkin, Y, Merrick, W C, Sonenberg, N
Eukaryotic translation initiation factor-4A (eIF-4A) plays a critical role in binding of eukaryotic mRNAs to ribosomes. It has been biochemically characterized as an RNA-dependent ATPase and RNA...