Scientific Commons: Y. Takai

A-axis oriented epitaxial REBa2Cu3Oy (RE123) thin film performs excellent superconducting properties in magnetic field. Recently, we reported that a critical current density (Jc) in the RE123 thin...

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis (2005)

Yamaguchi, T., Goto, H., Yokoyama, T., Sillje, H., Hanisch, A., Uldschmid, A., ...

High-critical-current-density epitaxial films of SmBa2Cu3O7-x in high fields (2005)

Yoshida, Y, Matsumoto, K, Ichino, Y, Itoh, M, Ichinose, A, Horii, S, ...

J(c) characteristics in high magnetic field and microstructure of RE1+xBa2-xCu3O6+y films (2005)

Yoshida, Y, Matsumoto, K, Miura, M, Ichino, Y, Takai, Y, Ichinose, A, ...

Effect of substituted rare earth element in (Yb1-xNd,)Ba2CU30Y thin film on growth orientation and superconducting properties (2005)

Honda, R, Ichino, Y, Yoshida, Y, Takai, Y, Matsumoto, K, Ichinose, A, ...

Microstructure and field angle dependence of critical current densities in REBa2Cu3Oy thin films prepared by PLD method (2005)

Ichino, Y, Honda, R, Miura, M, Itoh, M, Yoshida, Y, Takai, Y, ...

In-plane alignment and superconducting properties in high-J(c) Sm1+xBa2-xCu3O6+delta thin films (2005)

Miura, M, Itoh, M, Yoshida, Y, Ichino, Y, Takai, Y, Matsumoto, K, ...

High critical current density in high field in Sm1+xBa2-xCu3O6+y thin films (2005)

Yoshida, Y, Ichino, Y, Miura, M, Takai, Y, Matsumoto, K, Ichinose, A, ...

Effect of Sm/Ba substitution on the J(c) in magnetic field of SmBCO thin films by low temperature growth technique (2005)

Miura, M, Itoh, M, Ichino, Y, Yoshida, Y, Takai, Y, Matsumoto, K, ...

Low temperature growth of high-J(c) Sm1+xBa2-xCu3Oy films (2004)

Itoh, M, Yoshida, Y, Ichino, Y, Miura, M, Takai, Y, Matsumoto, K, ...

Influences of oxygen pressure and substrate temperature on the quality of NdBa2Cu3Ox thin films prepared by pulsed laser deposition (2004)

Ichino, Y, Yoshida, Y, Takai, Y, Matsumoto, K, Ikuta, H, Mizutani, U

Magnetic field dependence of critical current density in Sm/sub 1+x/Ba/sub 2-x/Cu/sub 3/O/sub 6+/spl delta// films prepared by pulsed laser deposition (2003)

Sudoh, K., Ichino, Y., Yoshida, Y., Takai, Y., Hirabayashi, I., 一野, 祐亮, ...

We have investigated Sm1+ Ba2 Cu3O6+ (SmBCO) films deposited by pulsed laser deposition technique using stoichiometric and Sm-rich SmBCO (x = 0.08) laser targets. In the SmBCO films deposited using...

The advantages of YbBa2CU3Oy thin films for superconducting wire application (2003)

Ichino, Y, Honda, R, Sudoh, K, Yoshida, Y, Matsumoto, K, Kita, R, ...

Growth mechanism of YBa2Cu3O7-y thin films on the metallic tapes by MOCVD (2001)

Yoshida, Y., Hirabayashi, I., Kurosaki, H., Akata, H., Higashiyama, K., Takai, Y.

We fabricated the YBa,Cu,O,-y (YBCO) thin film on the MgO single crystalline substrate and the cube textured (CUTE-Ag)-tape using metal organic chemical vapor deposition (MOCVD) method. It was...

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

Huber, L A, Ullrich, O, Takai, Y, Lütcke, A, Dupree, P, Olkkonen, V, ...

For identification of Rab, Rac, Rho, Ral, Rap, and Arf proteins on two-dimensional polyacrylamide gels, we have expressed full-length cDNAs of members of these protein families with the T7 RNA...

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

Itoh, T, Kaibuchi, K, Masuda, T, Yamamoto, T, Matsuura, Y, Maeda, A, ...

To identify the direct target molecule of ras p21 in higher eukaryotes, we have recently developed the cell-free system in which ras p21 activates mitogen-activated protein (MAP) kinase/extracellular...

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

Farnsworth, C C, Kawata, M, Yoshida, Y, Takai, Y, Gelb, M H, Glomset, J A

smg p25A, also known as the rab3A protein, is a small GTP-binding protein that has been implicated in intracellular vesicle transport and the secretion of neurotransmitters. It has been shown to bind...

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

Mizuno, T, Kaibuchi, K, Yamamoto, T, Kawamura, M, Sakoda, T, Fujioka, H, ...

We have purified a stimulatory GDP/GTP exchange protein for smg p21A and -B, ras p21-like small GTP-binding proteins (G proteins), cloned its cDNA, and named it GDP dissociation stimulator (smg p21...

Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.

Kawata, M, Farnsworth, C C, Yoshida, Y, Gelb, M H, Glomset, J A, Takai, Y

smg p21A and -B are small GTP-binding proteins that share putative effector and consensus C-terminal sequences with ras p21 proteins. In the present report, we showed that human platelet smg p21B...

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G.

Gotoh, T, Hattori, S, Nakamura, S, Kitayama, H, Noda, M, Takai, Y, ...

C3G, which was identified as a Crk SH3 domain-binding guanine nucleotide-releasing factor, shows sequence similarity to CDC25 and Sos family proteins (S. Tanaka, T. Morishita, Y. Hashimoto, S....

ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae.

Hirano, H, Tanaka, K, Ozaki, K, Imamura, H, Kohno, H, Hihara, T, ...

The RHO1 gene encodes a homolog of the mammalian RhoA small GTP-binding protein in the yeast Saccharomyces cerevisiae. Rho1p is localized at the growth site and is required for bud formation. The...

Model for clonal elimination in the thymus.

Kosaka, H, Ogata, M, Hikita, I, Maruo, S, Sugihara, S, Matsubara, H, ...

A thymic stromal cell clone, MRL104.8a, expresses class I as well as class II H-2k antigens after exposure to gamma-interferon. This clone also produces thymic stroma-derived T-cell growth factor...

Direct evidence for a receptor-ligand interaction between the T-cell surface antigen CD2 and lymphocyte-function-associated antigen 3.

Takai, Y, Reed, M L, Burakoff, S J, Herrmann, S H

The recognition of foreign antigen by T lymphocytes requires direct contact with cells expressing the antigen. It has recently become clear that T lymphocytes can form conjugates with other cells in...

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

Nishiyama, T, Sasaki, T, Takaishi, K, Kato, M, Yaku, H, Araki, K, ...

Insulin and hepatocyte growth factor (HGF) induced morphologically different membrane rufflings in KB cells. Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an...

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

Takaishi, K, Kikuchi, A, Kuroda, S, Kotani, K, Sasaki, T, Takai, Y

Evidence is accumulating that rho p21, a ras p21-related small GTP-binding protein (G protein), regulates the actomyosin system. The actomyosin system is known to be essential for cell motility. In...

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

Kaibuchi, K, Mizuno, T, Fujioka, H, Yamamoto, T, Kishi, K, Fukumoto, Y, ...

We have recently purified to near homogeneity the stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like GTP-binding proteins) from bovine brain cytosol. This regulatory protein, named GDP...

A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.

Sasaki, T, Kaibuchi, K, Kabcenell, A K, Novick, P J, Takai, Y

Evidence is accumulating that smg p25A, a small GTP-binding protein, may be involved in the regulated secretory processes of mammalian cells. The SEC4 protein is known to be required for constitutive...

The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.

Horiuchi, H, Kaibuchi, K, Kawamura, M, Matsuura, Y, Suzuki, N, Kuroda, Y, ...

Mammalian ras genes substitute for the yeast RAS gene, and their products activate adenylate cyclase in yeast cells, although the direct target protein of mammalian ras p21s remains to be identified....

Tissue and subcellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s.

Kim, S, Mizoguchi, A, Kikuchi, A, Takai, Y

We have made a specific antiserum recognizing both smg p21A (the rap1A/Krev-1 protein) and -B (the rap1B protein), ras p21-like GTP-binding proteins having the same putative effector domain as ras...

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein.

Matsui, Y, Kikuchi, A, Araki, S, Hata, Y, Kondo, J, Teranishi, Y, ...

We recently purified to near homogeneity a novel type of regulatory protein for smg p25A, a ras p21-like GTP-binding protein, from bovine brain cytosol. This regulatory protein, named smg p25A GDP...

RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae.

Ruggieri, R, Bender, A, Matsui, Y, Powers, S, Takai, Y, Pringle, J R, ...

The Saccharomyces cerevisiae ras-like gene RSR1 is particularly closely related to the mammalian gene Krev-1 (also known as smg21A and rap1A). RSR1 was originally isolated as a multicopy suppressor...

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

Yoshida, Y, Kawata, M, Miura, Y, Musha, T, Sasaki, T, Kikuchi, A, ...

Microinjection of either Ki-rasVal-12 p21 or the GDP-bound form of Ki-ras p21 plus smg GDP dissociation stimulator (GDS), a stimulatory GDP/GTP exchange protein for Ki-ras p21, smg/rap1/Krev-1 p21,...

Role of the C-terminal region of smg p25A in its interaction with membranes and the GDP/GTP exchange protein.

Araki, S, Kaibuchi, K, Sasaki, T, Hata, Y, Takai, Y

smg p25A is a ras p21-like small GTP-binding protein which is implicated in the regulated secretory processes. We have recently found that bovine brain smg p25A is geranylgeranylated at its...

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

Nonaka, H, Tanaka, K, Hirano, H, Fujiwara, T, Kohno, H, Umikawa, M, ...

The RHO1 gene in Saccharomyces cerevisiae encodes a homolog of the mammalian RhoA small GTP-binding protein, which is implicated in various actin cytoskeleton-dependent cell functions. In yeast,...

Enhancement of secretagogue-induced phosphoinositide turnover and amylase secretion by bile acids in isolated rat pancreatic acini.

Takeyama, Y, Nakanishi, H, Ohyanagi, H, Saitoh, Y, Kaibuchi, K, Takai, Y

Small amounts (0.1-0.5 mM) of deoxycholate enhanced amylase secretion, which had been induced by submaximal doses of carbachol or cholecystokinin octapeptide, without affecting the maximal levels of...

Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

Ozaki, K, Tanaka, K, Imamura, H, Hihara, T, Kameyama, T, Nonaka, H, ...

The RHO1 gene encodes a homolog of the mammalian RhoA small GTP binding protein in the yeast Saccharomyces cerevisiae. Rho1p is localized at the growth site and is required for bud formation....

Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

Kohno, H, Tanaka, K, Mino, A, Umikawa, M, Imamura, H, Fujiwara, T, ...

The RHO1 gene encodes a homolog of mammalian RhoA small GTP binding protein in the yeast Saccharomyces cerevisiae. Rho1p is localized at the growth sites, including the bud tip and the cytokinesis...

Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae.

Imamura, H, Tanaka, K, Hihara, T, Umikawa, M, Kamei, T, Takahashi, K, ...

The RHO1 gene encodes a homologue of mammalian RhoA small G-protein in the yeast Saccharomyces cerevisiae. Rho1p is required for bud formation and is localized at a bud tip or a cytokinesis site. We...

Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain.

Hibino, H, Inanobe, A, Tanemoto, M, Fujita, A, Doi, K, Kubo, T, ...

Anchoring proteins cluster receptors and ion channels at postsynaptic membranes in the brain. They also act as scaffolds for intracellular signaling molecules including synGAP and NO synthase. Here...

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

Shirataki, H, Kaibuchi, K, Sakoda, T, Kishida, S, Yamaguchi, T, Wada, K, ...

In a previous study (H. Shirataki, K. Kaibuchi, T. Yamaguchi, K. Wada, H. Horiuchi, and Y. Takai, J. Biol. Chem. 267:10946-10949, 1992), we highly purified from bovine brain crude membranes the...