It is well documented that Ras functions as a molecular switch for reentry into the cell cycle at the border between G0 and G1 by transducing extracellular growth stimuli into early G1 mitogenic...
Goto, K, Kasuya, Y, Matsuki, N, Takuwa, Y, Kurihara, H, Ishikawa, T, ...
Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the...
Takuwa, Y, Kasuya, Y, Takuwa, N, Kudo, M, Yanagisawa, M, Goto, K, ...
The mechanisms of endothelin-1 (ET) actions were investigated in cultured rat aortic vascular smooth muscle A-10 cells. The A-10 cells have a single class of high affinity binding sites for ET with...
Addition of norepinephrine, angiotensin II, or histamine leads to a transient rise in the cytoplasmic Ca2+ concentration ([Ca2+]i), as measured with aequorin, in rabbit aortic strips. Each induces a...
Nakaoka, T, Gonda, K, Ogita, T, Otawara-Hamamoto, Y, Okabe, F, Kira, Y, ...
Vascular proliferative disorders are characterized by the proliferation of vascular smooth muscle cells (SMCs) and excessive extracellular matrix synthesis. We found that bone morphogenetic protein-2...
Takuwa, N, Takuwa, Y, Rasmussen, H
Treatment of Swiss-mouse 3T3 fibroblasts with a tumour-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), increases the absolute amount of 1,2-diacylglycerol (1,2-DG) in a time- and...
Characterization of Na+-dependent phosphate uptake in cultured kidney cells (JTC-12) from monkey.
Phosphate uptake was studied in confluent monolayers of an epithelial-cell line (JTC-12) derived from monkey kidney. Phosphate uptake consisted of a saturable, Na+-dependent, component, which...
Gonda, K, Okamoto, H, Takuwa, N, Yatomi, Y, Okazaki, H, Sakurai, T, ...
In the present study, we determined the agonist specificity and the signalling mechanisms of a putative sphingosine 1-phosphate (S1P) receptor, AGR16. In CHO cells transiently transfected with an...
It is well documented that Ras functions as a molecular switch for reentry into the cell cycle at the border between G0 and G1 by transducing extracellular growth stimuli into early G1 mitogenic...
Goto, K, Kasuya, Y, Matsuki, N, Takuwa, Y, Kurihara, H, Ishikawa, T, ...
Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the...
Takuwa, Y, Kasuya, Y, Takuwa, N, Kudo, M, Yanagisawa, M, Goto, K, ...
The mechanisms of endothelin-1 (ET) actions were investigated in cultured rat aortic vascular smooth muscle A-10 cells. The A-10 cells have a single class of high affinity binding sites for ET with...
Addition of norepinephrine, angiotensin II, or histamine leads to a transient rise in the cytoplasmic Ca2+ concentration ([Ca2+]i), as measured with aequorin, in rabbit aortic strips. Each induces a...
Nakaoka, T, Gonda, K, Ogita, T, Otawara-Hamamoto, Y, Okabe, F, Kira, Y, ...
Vascular proliferative disorders are characterized by the proliferation of vascular smooth muscle cells (SMCs) and excessive extracellular matrix synthesis. We found that bone morphogenetic protein-2...
Takuwa, N, Takuwa, Y, Rasmussen, H
Treatment of Swiss-mouse 3T3 fibroblasts with a tumour-promoting phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), increases the absolute amount of 1,2-diacylglycerol (1,2-DG) in a time- and...
Characterization of Na+-dependent phosphate uptake in cultured kidney cells (JTC-12) from monkey.
Phosphate uptake was studied in confluent monolayers of an epithelial-cell line (JTC-12) derived from monkey kidney. Phosphate uptake consisted of a saturable, Na+-dependent, component, which...
Gonda, K, Okamoto, H, Takuwa, N, Yatomi, Y, Okazaki, H, Sakurai, T, ...
In the present study, we determined the agonist specificity and the signalling mechanisms of a putative sphingosine 1-phosphate (S1P) receptor, AGR16. In CHO cells transiently transfected with an...
Abe, J, Deguchi, J, Takuwa, Y, Hara, K, Ikari, Y, Tamura, T, ...
Background—Growth factors such as platelet derived growth factor (PDGF) have been postulated to be important mediators of neointimal proliferation observed in atherosclerotic plaques and restenotic...
A pertussis toxin-sensitive mechanism of endothelin action in porcine coronary artery smooth muscle.
Kasuya, Y., Takuwa, Y., Yanagisawa, M., Masaki, T., Goto, K.
1. Endothelin-1 (ET-1)-induced contraction of porcine coronary artery strips may be mediated via at least two intracellular signalling mechanisms, the activation of dihydropyridine-sensitive...